fluquinconazole (Ref: AE C597265) ** SN 597265 ** Translations

Environmental Fate - Ecotoxicology - Human Health

GENERAL INFORMATION

Description: A fungicide used to control Ascomycetes, Deuteromycetes and Basidiomycetes spp. on cereals, beets and fruit

Introduction: circa 1995

EC Directive 1107/2009 (repealing 91/414):

Status	Pending (Re-submitted)
Dossier rapporteur/co-rapporteur	Ireland
Date inclusion expires	12/2011

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also registered in: Australia

General status:

Pesticide type	Fungicide
Substance group	Triazole
Substance origin	Synthetic
Mode of action	Systemic with protectant and eradicant activity. Disrupts membrane function.
CAS RN	136426-54-5
EC number	411-960-9
CIPAC number	474
US EPA chemical code	-
Chemical formula	C16H8Cl2FN5O
SMILES	Clc1ccc(c(Cl)c1)N3C(=N\c2c(cc(F)cc2)C3=O)/n4ncnc4
International Chemical Identifier (InChI)	InChI=1/C16H8Cl2FN5O/c17-9-1-4-14(12(18)5-9)24-15(25)11-6-10(19)2-3-13(11)22-16(24)23-8-20-7-21-23/h1-8H
Structure diagram/image available?	Yes
Molecular mass (g mol-1)	376.17
IUPAC Name	3-(2,4-dichlorophenyl)-6-fluoro-2-(1H-1,2,4-triazol-1-yl)quinazolin-4(3H)-one
CAS Name	3-(2,4-dichlorophenyl)-6-fluoro-2-(1H-1,2,4-triazol-1-yl)-4(3H)-quinazolinone
Other status information	-
Herbicide Resistance Classification (HRAC)	Not applicable
Insecticide Resistance Classification (IRAC)	Not applicable
Fungicide Resistance Classification (FRAC)	3
Physical state	Cream to white crystalline solid depending upon purity
Related substances & organisms	prochloraz

Formulations:

Property	Value
Example manufacturers of products using this active	BASF Bayer CropScience
Example products using this active	Jockey Galmano Sahara, Flamenco
UK LERAP status	None
Formulation and application details	Often supplied as a soluble concentrate which is mixed with water and applied as a spray. Other formulations include those specific for seed treatments.

ENVIRONMENTAL FATE

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		1.15	A5	Low
Solubility - In organic solvents at 20oC (mg l-1)		44000	A4 - Acetone	-
		34000	A4 - Ethyl acetate	-
		3480	A5 - Ethanol	-
		114	A5 - Hexane	-
Melting Point (oC)		191	A5	-
Boiling Point (oC)		-	-	-
Degradation point (oC)		320	A5	-
Flashpoint (oC)		Not highly flammable	A5	-
Octanol-water partition coefficient at pH 7, 20oC	P	1.74 X 1003	Calculated	-
	Log P	3.24	A5	High
Bulk density (g ml-1)/Specific gravity		1.58	A5	-
Dissociation constant (pKa) at 25oC		0.9	A5	-
		Note: Strong acid, pKa(2) -4.4, Very strong acid
Vapour pressure at 25oC (mPa)		6.40 X 10-06	A5	Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1)		2.90 X 10-06	A5	Non-volatile
Henry's law constant at 20oC (dimensionless)		8.80 X 10-10	Q2	Non-volatile
GUS leaching potential index		2.70	Calculated	Transition state
SCI-GROW groundwater index (µg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	2.22 X 10-01	Calculated	-
	Note	-
Potential for particle bound transport index		-	Calculated	Medium
Maximum UV-vis absorption L mol-1 cm-1		Neutral solution: 307nm = 4928; [Acidic solution: 307nm = 4894; [Basic solution: 321nm = 3876	A5	-
Surface tension (mN m-1)		70.91	A5 at 20oC	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	350	B5	Persistent
	DT50 (lab at 20oC)	347	A5	Persistent
	DT50 (field)	378	A5	Very persistent
	DT90 (lab at 20oC)	319	A5	-
	DT90 (field)	4083	A5	-
	Note	EU dossier lab studies DT50 range 186-441 days, field studies DT50 range 17.5-777.4 days, DT90 range 261-9585 days; Other studies: lab DT50 range 211-562 days, field range 300-400 days (B5)
Aqueous photolysis DT50 (days) at pH 7	Value	Stable	A5	Stable
	Note	-
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	21.9	A5	Non-persistent
	Note	pH sensitive: DT50 194 days at pH 4, 2024 days at pH 5, 0.4 days at pH 9, all at 25 degC
Water-Sediment DT50 (days)		13.7	A5	Fast
Water phase only DT50 (days)		3.5	A5	Moderately fast

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	-	-	-
	Koc	-
	Notes and range	-
Freundlich	Kf	14.8	A5	Slightly mobile
	Kfoc	870
	1/n	0.891
	Notes and range	EU dossier Kf range 5.3-25.9, Kfoc range 750-1153 mL/g, 1/n range 0.836-0.921, Soils=4
pH sensitivity		No

Key metabolites:

Metabolite		Formation Medium	Estimated Maximum Occurrence Fraction	91/414 Relevancy
3-(2,4-dichlorophenyl)-6-fluoro-quinazolin-2,4(3H)-dione (Ref: AE C596912)		Soil	0.287	Major fraction, Relevant
1,2,4-triazole (Ref: CGA 71019)		Soil	0.189	Major fraction, Relevant

Other known metabolites:

Metabolite name and reference	Aliases	Formation Medium / Rate	Estimated Maximum Occurrence Fraction	Metabolising Enzymes
2-{[(2,4-dichlorophenyl)carbamoyl]amino}-5-fluorobenzoic acid	SN 616368	-	-	-
3-(1H-1,2,4-triazol-1-yl)-DL-alanine	triazolyl alanine	Plant	-	-
1H-1,2,4-triazol-1-ylacetic acid	triazolyl acetic acid	Plant	-	-

ECOTOXICOLOGY

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF	87	A5	Low potential
	CT50 (days)	0.25		-
Bioaccumulation potential		-	Calculated	Low
Mammals - Acute oral LD50 (mg kg-1)		112	A5 Rat	Moderate
Mammals - Short term dietary NOEL	(mg kg-1)	0.36	B5 Rat	High
	(ppm diet)	5		-
Birds - Acute LD50 (mg kg-1)		> 2000	A5 Anas platyrhynchos	Moderate
Birds - Short term dietary (LC50/LD50)		> 5200 mg kg feed-1	A5 Anas platyrhynchos	-
Fish - Acute 96 hour LC50 (mg l-1)		1.9	A5 Oncorhynchus mykiss	Moderate
Fish - Chronic 21 day NOEC (mg l-1)		0.3	A5 Oncorhynchus mykiss	-
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		> 5.0	A5 Daphnia magna	Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		0.648	A5 Daphnia magna	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		1.4	A5 Lemna minor	Moderate
Algae - Acute 72 hour EC50, growth (mg l-1)		0.046	B5 Pseudokirchneriella subcapitata	Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1)		-	-	-
Honeybees - Acute 48 hour LD50 (µg bee-1)		> 100	A5 Oral	Moderate
Earthworms - Acute 14 day LC50 (mg kg-1)		> 500	A5 Eisenia foetida corr	Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		-	-	-
Other soil macro-organisms - e.g. Collembola	LR50product ha EC50product ha NOECproduct ha % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	<149.4	<149.4A5 Typhlodromus pyri	Harmless at 1 kg ha-1
	% Effect	-	-	-
Other arthropod (2)	LR50 g ha-1	<149.4	A5 Aphidius rhopalosiphi	Harmless at 1 kg ha-1
	% Effect	-	-	-
Soil micro-organisms		Nitrogen mineralisation: No significant effect Carbon mineralisation: No significant effect	A5 Dose: 2.5 kg/ha	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Mammals - Acute oral LD50 (mg kg-1)		112	A5 Rat	Moderate
Mammals - Dermal LD50 (mg kg-1 body weight)		625	A5 Rat	-
Mammals - Inhalation LC50 (mg l-1)		0.514	A5 Rat, 4hr (head only)	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.002	A4 Dog, SF=100	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		0.02	A2 Dog, SF=100	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		0.001	A2 Dog, SF=167	-
Dermal penetration studies (%)		1-4	A5 concentration dependant	-
Dangerous Substances Directive 76/464		List II	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	[Risk to bystanders acceptable for proposed uses]
	Occupational	[Possible risk to operators and other farm workers - PPE/PPC advised]
Examples of European MRLs (mg kg-1)	Value	Wheat grains: 0.1
	Note	[A5 EU dossier proposals] For the EU pesticides database click here
Drinking Water MAC (µg l-1)		0.1	EU Dir 89/778/EC limit; Calc MAC=0.9 µg/l; A5	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Acetyl cholinesterase inhibitor	Neurotoxicant	Respiratory tract irritant	Skin irritant	Eye irritant
	-	-	-
General human health issues		[No further information available]

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		[Prevent generation of mists], [Not explosive or oxidising], [IMDG Transport Code is usually 9]
EC Risk Classification		[T - Toxic: R23/25, R48/25], [Xn - Harmful: R21], [Xi - Irritant: R38], [N - Dangerous for the environment: R50, R53]
EC Safety Classification		S1/2, S36/37/39, S38, S45, S60, S61
WHO Classification		NL	-	Not listed
US EPA Classification (formulation)		No consensus across products or no products available	-	-
UN Number		Usually 3082
Waste disposal & packaging		[Usually Packaging Group III (minor danger)]

TRANSLATIONS