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hexaconazole (Ref: PP 523)
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for hexaconazole

Description: A conazole (imidazole) fungicide used to control both seed-borne and soil-borne diseases especially Ascomycetes and Basidiomycetes spp.

Example pests controlled: Powdery mildew, Scabs, Rusts

Example applications: Vines; Apples; Pears,; Bananas; Vegetables; Some small grain cereals

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1986

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Italy
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) -
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule existing in the R- and S-forms. The R-enantiomer exhibts the greatest fungicial activity.
Chemical formula C14H17Cl2N3O
Canonical SMILES CCCCC(CN1C=NC=N1)(C2=C(C=C(C=C2)Cl)Cl)O
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) STMIIPIFODONDC-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C14H17Cl2N3O/c1-2-3-6-14(20,8-19-10-17-9-18-19)12-5-4-11(15)7-13(12)16/h4-5,7,9-10,20H,2-3,6,8H2,1H3
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide, Other substance
Other constituent type Wood preservative
Substance group Triazole
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Broad spectrum, systemic with protective and curative action. Disrupts membrane function. Sterol biosynthesis inhibitor.
CAS RN 79983-71-4
EC number 413-050-7
CIPAC number 465
US EPA chemical code 128925
PubChem CID 66461
Molecular mass (g mol-1) 314.21
PIN (Preferred Identification Name) -
IUPAC name (RS)-2-(2,4-dichlorophenyl)-1-(1H-1,2,4-triazol-1-yl)hexan-2-ol
CAS name α-butyl-α-(2,4-dichlorophenyl)-1H-1,2,4-triazole-1-ethanol
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 3
Examples of recorded resistance -
Physical state White crystalline solid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • AgroCare
  • FCC
  • Syngenta
Example products using this active
  • Passport
  • Manage
  • Anvil
  • Planete Aster
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Available in a variety of formulations including oil miscible liquids, soluble grains and suspension concentrates.


ENVIRONMENTAL FATE

for hexaconazole

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 18 P4 Low
Solubility - In organic solvents at 20oC (mg l-1) 120000 C4 - Ethyl acetate -
164000 C4 - Acetone -
810 C4 - Hexane -
246000 C4 - Methanol -
Melting point (oC) 111 L3 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 7.94 X 1003 Calculated -
Log P 3.9 P4 High
Bulk density (g ml-1)/Specific gravity 1.29 L3 -
Dissociation constant (pKa) at 25oC 2.3 P4 -
Note: Strong acid
Vapour pressure at 20oC (mPa) 0.018 P4 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 3.33 X 10-04 L3 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.05 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 8.85 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 122 K4 Persistent
DT50 (lab at 20oC) - - -
DT50 (field) 225 P3 Persistent
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note Sandy loam DT50 ~ 10 months, clay loam ~ 5 months; General literature DT50 range 49-200 days (R3)
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 5.5 R4 -
Note Published literature RL50 range 1.7-7.8 days, 6 field crops, various matrices, n=8
Aqueous photolysis DT50 (days) at pH 7 Value 10 K4 Moderately fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable K4 -
Note Not greatly sensitive to pH
Water-sediment DT50 (days) 112 K4 Slow
Water phase only DT50 (days) 112 K4 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - DW3 Slightly mobile
Koc 1040
Notes and range -
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
1,2,4-triazole (Ref: CGA 71019) Soil   -   Not relevant
1H-1,2,4-triazol-1-ylacetic acid (Ref: CGA 142856) Soil   -   -


ECOTOXICOLOGY

for hexaconazole

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 412 Q2 Estimated Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 2189 P4 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 5 L3 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 4000 L3 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 3.4 L3 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 2.9 P4 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) > 1.7 K3 Unknown species Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) - - -
Oral acute 48 hour LD50 (μg bee-1) > 100 L3 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 414 L3 Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect Harmless Dose: 120 g ha-1
AA2 Typhlodromus pyri
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect Harmless Dose: 120 g ha-1
AA2 Chrysoperla carnea
-
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for hexaconazole

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 2189 P4 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 L3 Rat -
Mammals - Inhalation LC50 (mg l-1) 5.9 L3 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.005 JMPR 1990 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues USEPA - possible human carcinogen
Endocrine issues - Inhibition of aromatase activity, decrease of the estrogens production

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes No information available
CLP classification 2013 Health: H302, H317
Environment: H411
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R22, R43
N - Dangerous for the environment: R51, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S24, S37, S61
WHO Classification III - Slightly hazardous
US EPA Classification (formulation) IV - Caution - Not acutely toxic
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for hexaconazole

Language Name
English hexaconazole
French hexaconazole
German Hexaconazol
Danish hexaconazol
Italian esaconozolo
Spanish hexaconazol
Greek -
Slovenian heksakonazol
Polish heksakonazol
Swedish -
Hungarian hexakonazol
Dutch -

Record last updated: Wednesday 31 October 2018
Contact: aeru@herts.ac.uk
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