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acetamiprid
** ethanimidamide ** NI-25 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Acetamiprid is an insecticide that is currently approved for EU use. It is highly soluble in water and is volatile. Based on its chemical properties it would not be expected to leach to groundwater. It is not persistence in soil systems but may be very persistent in aquatic systems under certain conditions. It has a moderate mammalian toxicity and it has a high potential for bioaccumulation. Acetamiprid is a recognised irritant. It is highly toxic to birds and earthworms and moderately toxic to most aquatic organisms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for acetamiprid

Description: A pyridylmethylamine insecticide used for the control of Hemiptera spp. especially aphids.

Example pests controlled: Aphids; Thrips; Mirids; Spider mites; Whiteflies; European pine sawflies; Leaf miners; Leaf hoppers

Example applications: Leafy Vegetables; Fruiting Vegetables; Fruit including citrus, apples, pears, grapes; Cotton; Ornamental Plants and Flowers

Availability status: Current

Introduction & key dates: 1995, Japan

EC Regulation 1107/2009 (repealing 91/414):
Status Approved (RAR active)
Dossier rapporteur/co-rapporteur Netherlands/Spain
Date inclusion expires 30/04/2017

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: USA

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide
Substance group Neonicotinoid
Minimum active substance purity 990 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Systemic with translaminar activity having both contact and stomach action. Acetylcholine receptor (nAChR) agonist.
CAS RN 135410-20-7
EC number None allocated
CIPAC number 649
US EPA chemical code 099050
Chiral molecule No
Chemical formula C10H11ClN4
SMILES Clc1ncc(cc1)CN(\C(=N\C#N)C)C
International Chemical Identifier key (InChIKey) WCXDHFDTOYPNIE-RIYZIHGNSA-N
International Chemical Identifier (InChI) InChI=1S/C10H11ClN4/c1-8(14-7-12)15(2)6-9-3-4-10(11)13-5-9/h3-5H,6H2,1-2H3/b14-8+
Structure diagram/image available? Yes
Molecular mass (g mol-1) 222.67
PIN (Preferred Identification Name) (1E)-N-[(6-chloropyridin-3-yl)methyl]-N'-cyano-N-methylethanimidamide
IUPAC name (E)-N1-[(6-chloro-3-pyridyl)methyl]-N2-cyano-N1-methylacetamidine
CAS name (1E)-N-[(6-chloro-3-pyridinyl)methyl]-N'-cyano-N-methylethanimidamide
Other status information NOTE ban or usage restriction may be in place for use on flowering crops in some Member States
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 4A
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Acarus siro
Bemisia tabaci
Leptinotarsa decemlineata
Physical state A white to pale yellow crystalline solid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • AgroCare
  • Certis
  • Aventis
  • Nisso Chemical Europe
Example products using this active
  • Acetamiprid WP
  • Gazelle
  • Insyst
  • Beticol
  • Mospilan 20 SG
  • Antilop SG
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details Usually formulated as soluble granules for spray application.


ENVIRONMENTAL FATE

for acetamiprid

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 2950 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 6.54 A5 - Hexane -
200000 A5 - Chloroform -
200000 A5 - Dichloromethane -
200000 A5 - Acetone -
Melting point (oC) 98.9 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 200 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 6.31 X 1000 Calculated -
Log P 0.8 A5 Low
Bulk density (g ml-1)/Specific gravity 1.33 A5 -
Dissociation constant (pKa) at 25oC 0.7 A5 -
Note: Strong acid
Vapour pressure at 25oC (mPa) 1.73 X 10-04 A5 Volatile
Henry's law constant at 25oC (Pa m3 mol-1) 5.30 X 10-08 A5 Non-volatile
Henry's law constant at 20oC (dimensionless) 5.36 X 10-12 Calculated Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.40 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 9.83 X 10-04 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 247nm = 19700, 217nm = 12100 A5 -
Surface tension (mN m-1) 70.9 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
Soil degradation (days) (aerobic) DT50 (typical) 1.6 A5 Non-persistent
DT50 (lab at 20oC) 1.6 A5 Non-persistent
DT50 (field) 3 A5 Non-persistent
DT90 (lab at 20oC) 8.8 A5 -
DT90 (field) 20.2 A5 -
Note EU dossier Lab studies DT50 range 0.8-5.4 days, DT90 range 2.8-67.3 days, field studies (2015 RAR) DT50 range 0.8-4.7 days, DT90 range 2.7-28 days; Other sources: 2-20 days
Plant matrix DT50 (days) Value 5.2 R4 -
Note DT50 range 1.0 - 19.3 days, 14 plants/crops, various matrices
Aqueous photolysis DT50 (days) at pH 7 Value 34 A5 Stable
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 4 to pH 7 at temps 22-45 deg C. Degradation does occur at higher pHs and elevated temps e.g. DT50 420 days at pH 9, 25 degC, 13 days pH9, 45 degC
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) 4.7 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - US3 Moderately mobile
Koc 200
Notes and range -
Freundlich Kf 1.58 A5 Moderately mobile
Kfoc 106.5
1/n 0.86
Notes and range EU dossier (2015 RAR) Kf range 0.6-3.13 mL/g, Kfoc range 71.38-138.39 mL/g, 1/n range 0.825-0.807, Soils=5
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 91/414 relevancy Click here for further information on 91/414 relevancy
N-methyl(6-chloro-3-pyridyl)methylamine This metabolite may cause environmental pollution, click here for further information Soil   0.720   Major fraction, Relevant
(E)-N2-carbamoyl-N1-(6-chloro-3-pyridyl)methyl-N2-cyano-N1-methylacetamidine This metabolite may cause environmental pollution, click here for further information Soil   0.549   Major fraction, Relevant
6-chloro-nicotinic acid This metabolite may cause environmental pollution, click here for further information Soil   0.113   Major fraction, Relevant
N-(6-chloropyridin-3-ylmethyl)-N-methyl-acetamidine This metabolite may cause environmental pollution, click here for further information Soil   0.200   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
(Ref: IB-1-1) - - - -
6-chloro-pyridilmethyl alcohol
(Ref: IM-0)
Note: Toxic
- Animal; Plant - -
N-{(6-chloro-3-pyridyl)methyl}-N-methylacetamide
(Ref: IM-1-3)
Note: Toxic
- Animal; Water (Hydrolysis) - -
(Ref: IM-2-3)
Note: Toxic
- Animal - -


ECOTOXICOLOGY

for acetamiprid

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk A5 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) 146 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) 15 A5 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 98 A5 Anas platyrhynchos High
Birds - Short term dietary (LC50/LD50) > 741 mg kg bw-1 day-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) > 100 A5 Oncorhynchus mykiss Low
Fish - Chronic 21 day NOEC (mg l-1) 19.2 A5 Pimephales promelas, 32 day Low
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 49.8 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 5 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.005 A5 Chironomus riparius High
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 1 A5 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) > 98.3 A4 Scenedemus subspicatus, 72 hour Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) 8.09 A5 Moderate
Oral acute 48 hour LD50 (μg bee-1) 14.53 A5 Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 9 A5 Eisenia foetida High
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 1.26 A5 Eisenia foetida Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: 0.2-0.4 kg ha-1
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: 0.09-0.18 kg ha-1
A5 Typhlodromus pyri, protonymph
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 0.2 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for acetamiprid

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 146 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 1.15 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.025 A5 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.025 A5 Rat, SF=100 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.07 A5 -
Dermal penetration studies (%) 15.9-33.7 A5 concentration dependant -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Minimal risk from dietary exposure
Source: US EPA/EU
Occupational Occupational exposure may occur through inhalation and dermal contact. Operator health should be monitored
European MRLs Click here for the EU MRL pesticide database
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues No further information available

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Combustable
Not explosive or oxidising
IMDG Transport Code is usually 6.1
CLP classification 2013 Health: H302
Environment: H412
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R22
N - Dangerous for the environment: R52/53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S46, S61
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number Usually 2588
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for acetamiprid

Language Name
English acetamiprid
French acetamipride
German Acetamiprid
Danish acetamiprid
Italian acetamiprid
Spanish acetamiprid
Greek -
Slovenian acetamiprid
Polish acetamipryd
Swedish acetamiprid
Hungarian acetamiprid
Dutch acetamiprid

Record last updated: Saturday 20 August 2016
Contact: aeru@herts.ac.uk