Amicarbazone (Ref: BAY MKH 3586)
Last updated: 13/01/2023
(Also known as: BAY 314666)
Amicarbazone is a triazolone herbicide. It is highly soluble and there is a high risk of leaching to groundwater. It is volatile, non-persistent in soil but persistent in aquatic systems. It is moderately toxic to mammals and their is some risk of bioaccumulation. It is a respiratory tract and eye irritant but no other serious human health issues have been reported. It is moderately toxic to birds and honeybees.
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
A triazolone, selective herbicide for pre- and post-emergence control of annual dicotyledonous weeds and grasses
Creeping bentgrass; Kentucky bluegrass; Fescue; Ryegrass
Turf including golf courses, sod farms, lawns, sports fields; Ornamentals including Christmas trees; Sugarcane
-
Current
1988, discovered; 2005, USA first registered
Not approved
Not applicable
No UK approval for use
EC Regulation 1107/2009 (repealing 91/414)
Not approved
Not applicable
Not applicable
Not applicable
Yes
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
 
 
 
 
 
 
 
 
 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
 
 
 
 
 
 
 
 
 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
 
 
 
 
 
 
 
 
 
None
C₁₀H₁₉N₅O₂
CC(C)C1=NN(C(=O)N1N)C(=O)NC(C)(C)C
No data
ORFPWVRKFLOQHK-UHFFFAOYSA-N
InChI=1S/C10H19N5O2/c1-6(2)7-13-15(9(17)14(7)11)8(16)12-10(3,4)5/h6H,11H2,1-5H3,(H,12,16)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
amicarbazone
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Herbicide
Triazolone herbicide; Amide herbicide
-
-
Synthetic
Contact action, absorbed by foliage, photosynthesis II inhibition
129909-90-6
603-373-3
799
114004
153920
No data found
241.29
4-amino-N-tert-butyl-5-oxo-3-(propan-2-yl)-4,5-dihydro-1H-1,2,4-triazole-1-carboxamide
4-amino-N-tert-butyl-4,5-dihydro-3-isopropyl-5-oxo-1H-1,2,4-triazole-1-carboxamide
4-amino-N-(1,1-dimethylethyl)-4,5-dihydro-3-(1-methylethyl)-5-oxo-1H-1,2,4-triazole-1-carboxamide
-
-
C1
5
Not applicable
Not applicable
-
Colourless crystalline solid
Amicarbazone Technical Amicarbazone DF Dinamic Ary Herbicide Xonerate 2SC Herbicide
Available in a variety of formulations
4600
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
High
-
-
-
137.5
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
-
-
-
-
-
-
-
-
-
-
1.70 X 1001
Calculated
-
1.23
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Low
-
-
-
-
-
-
1.12
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
-
Not applicable
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
-
No dissociation
0.0013
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Low volatility
6.78 X 10-08
Non-volatile
-
-
-
-
-
-
-
21
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Non-persistent
50
Moderately persistent
87
Moderately persistent
-
-
-
-
-
-
-
-
-
General literature DT₅₀ studies range 15-87 days; field studies 18-24 days (CB3)
-
-
-
-
-
-
-
-
60
Stable
-
64
Moderately persistent
-
-
-
-
-
-
-
Soil adsorption and mobility
-
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Mobile
30
Literature Koc values range 23-44 mL g⁻¹ (Q3, CB3)
-
-
-
-
-
-
-
4.89
Calculated
High leachability
3.77 X 1000
Calculated
-
-
Low
Calculated
-
Mobile
Calculated
-
Low risk
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
Based on LogP < 3
Low risk
-
-
Known soil and groundwater metabolites
None
N-(1,1-dimethylethyl)-4,5-dihydro-3-(1-methylethyl)-5- oxo-1H-1,2,4-triazole-1-carboxamide
des-amino amicarbazone
-
-
-
N-(1,1-dimethylethyl)-4,5-dihydro-4-methyl-3-(1-methylethyl)-5-oxo-1H-1,2,4-triazole-carboxamide
N-methyl des-amino amicarbazone
-
-
-
4-amino-2,4-dihydro-5-(1-methylethyl)-3H-1,2,4-triazol-3-one
decarboxamide amicarbazone
-
-
-
Terrestrial ecotoxicology
1015
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rat
Moderate
-
-
-
-
-
-
-
-
1965
Colinus virginianus
Moderate
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
> 24.4
Moderate
Low
Low
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
> 120
Oncorhynchus mykiss
Low
7.3
P3 P = Other governments and regulators 3 = Unverified data of known source
Pimephales promelas growth
Moderate
> 40.8
Daphnia magna
Moderate
< 0.252
P3 P = Other governments and regulators 3 = Unverified data of known source
Daphnia magna
Moderate
110
Americamysis bahia
Low
-
-
-
-
-
-
-
-
-
0.21
Lemna gibba
Moderate
-
-
-
-
-
-
-
-
-
-
-
-
HUMAN HEALTH AND PROTECTION
High (class III)
-
-
1015
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rat
Moderate
2000
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rat
-
2.24
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rat
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
May be absorbed through the skin - PPC required
EU MRL pesticide database 
-
-
-
-
-
-
-
-
-
-
Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
XNo, known not to cause a problem
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
Harmful if swallowed Possible liver toxicant
No information available
Health: H302, H332
NL (Not listed)
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amicarbazone
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amicarbazona
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amikarbazon
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Record last updated:
13/01/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242