Lactofen (Ref: PPG 844) |
![]() Last updated: 16/02/2021 |
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(Not known by any other names) |
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Used for the post-emergence control of weeds in cotton, soybeans and other crops | |
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Broad-leaved weeds | |
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Cotton; Soybeans; Snap beans; Cotton; Forestry | |
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Unknown | |
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1987 |
UK regulatory status |
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Not approved | ||
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Expired | ||
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No UK approval for use |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Not applicable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Expired | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Not applicable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Also used in |
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Chemical structure |
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Lactofen is a chiral molecule with an asymmetrically substituted C atom resulting in a pair of of enantiomers. The herbicidal activity predominately comes from the S-isomer. | |
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C₁₉H₁₅ClF₃NO₇ | |
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CCOC(=O)C(C)OC(=O)C1=C(C=CC(=C1)OC2=C(C=C(C=C2)C(F)(F)F)Cl)[N+](=O)[O-] | |
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No data | |
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CONWAEURSVPLRM-UHFFFAOYSA-N | |
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InChI=1S/C19H15ClF3NO7/c1-3-29-17(25)10(2)30-18(26)13-9-12(5-6-15(13)24(27)28)31-16-7-4-11(8-14(16)20)19(21,22)23/h4-10H,3H2,1-2H3 | |
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Yes |
General status |
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Herbicide | |
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Diphenyl ether | |
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Synthetic | |
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Protoporphyrinogen oxidase inhibition, absorbed by foliage with limited translocation | |
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77501-63-4 | |
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None allocated | |
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128888 | |
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62276 | |
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461.80 | |
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rac-(2R)-1-ethoxy-1-oxopropan-2-yl 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate | |
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ethyl O-[5-(2-chloro-α,α,α-trifluoro-p-tolyloxy)-2-nitrobenzoyl]-DL-lactate | |
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2-ethoxy-1-methyl-2-oxoethyl 5-[2-chloro-4-(trifluoromethyl)phenoxy]-2-nitrobenzoate | |
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E | |
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14 | |
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Not applicable | |
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Not applicable | |
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Amaranthus rudis, Euphorbia heterophylla | |
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Brown coloured solid |
Formulations |
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Usually supplied as an emulsifiable concentrate |
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0.5 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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45 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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1.391 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
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0.0093 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Low volatility | ||||||||
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4.56 X 10-03 | L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source |
Non-volatile | ||||||||
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Degradation |
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4 | G3 G = Extension Toxicology network database EXTOXNET (click here ) 3 = Unverified data of known source |
Non-persistent | |||||||
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Literature DT₅₀ studies range 1-7 days | ||||||||||
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Soil adsorption and mobility |
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- | G3 G = Extension Toxicology network database EXTOXNET (click here ) 3 = Unverified data of known source |
Non-mobile | |||||||
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10000 | ||||||||||
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Best available data | ||||||||||
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Fate indices |
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0.00 | Calculated | Low leachability | ||||||||||||||||||||||||||
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5.35 X 10-03 | Calculated | - | |||||||||||||||||||||||||
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Estimated concentrations of chemicals with Koc values greater than 9995 ml g⁻¹ are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW | ||||||||||||||||||||||||||||
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Medium | Calculated | - | ||||||||||||||||||||||||||
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Non-mobile | Calculated | - |
Key metabolites |
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Soil | - | - |
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380 | G3 G = Extension Toxicology network database EXTOXNET (click here ) whole fish3 = Unverified data of known source |
Threshold for concern | |||||||
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1.0 | - | |||||||||
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> 5000 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
Low | ||||||||
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> 2510 | G3 G = Extension Toxicology network database EXTOXNET (click here ) Colinus virginianus3 = Unverified data of known source |
Low | ||||||||
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> 0.10 | L3 L = Pesticide manuals and hard copy reference books / other sources Lepomis macrochirus3 = Unverified data of known source |
Moderate | ||||||||
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> 8.4 | L3 L = Pesticide manuals and hard copy reference books / other sources Daphnia magna3 = Unverified data of known source |
Moderate | ||||||||
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> 160 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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General |
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High (class III) | - | - | ||||||||
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> 5000 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
Low | ||||||||
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2000 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
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5.3 | L3 L = Pesticide manuals and hard copy reference books / other sources Rat3 = Unverified data of known source |
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0.0015 | G3 G = Extension Toxicology network database EXTOXNET (click here ) 3 = Unverified data of known source |
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List II | - | - | ||||||||
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Health issues |
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Slightly toxic via all exposure routes May cause allergic reaction USEPA - probable human carcinogen at high doses |
Handling issues |
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Corrosive | |||
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Health: H302, H312 Environment: H411, H413 |
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Xi - Irritant: R36/37/39 H - Handlings risks: R34 |
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S26, S36/37/39, S45 | |||
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NL (Not listed) | |||
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lactofen | ||
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lactofen | ||
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laktofen | ||
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Record last updated: | 16/02/2021 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |