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chlorethoxyfos (Ref: DPX 43898)
** chlorethoxyphos ** WL 208304 ** SD 208304 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Chlorethoxyfos is an organophosphate insecticide without EU regulatory approval. It has a low aqueous solubility and, based on its chemical properties, it should not leach to groundwater. It is not persistent in soil systems but may be moderately persistent in aqueous systems under certain conditions. It is highly toxic to humans and there is some concern that it may bioaccumulate. It is highly toxic to most aquatic life, honey bees and earthworms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for chlorethoxyfos

Description: An organophosphate insecticide used to control soil pests

Example pests controlled: Corn rootworm; Cutworms; Wireworms; Seed maggots; White grubs; Symphylans

Example applications: Corn; Row crops; Forage; Small grains

Efficacy & activity: -

Availability status: Unknown

Introduction & key dates: circa 1995, USA

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) -
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule
Chemical formula C6H11Cl4O3PS
Canonical SMILES CCOP(=S)(OCC)OC(C(Cl)(Cl)Cl)Cl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) XFDJMIHUAHSGKG-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C6H11Cl4O3PS/c1-3-11-14(15,12-4-2)13-5(7)6(8,9)10/h5H,3-4H2,1-2H3
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide
Substance group Organophosphate
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Cholinesterase inhibitor, vapour action
CAS RN 54593-83-8
EC number -
CIPAC number None allocated
US EPA chemical code 129006
PubChem CID 91655
Molecular mass (g mol-1) 336.0
PIN (Preferred Identification Name) rac-O,O-diethyl O-[(1R)-1,2,2,2-tetrachloroethyl] phosphorothioate
IUPAC name O,O-diethyl (RS)-O-(1,2,2,2-tetrachloroethyl) phosphorothioate
CAS name O,O-diethyl O-(1,2,2,2-tetrachloroethyl) phosphorothioate
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 1B
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance None recorded
Physical state Gray to brown granules formulated as a liquid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Amvac Chemical Corp
  • Du Pont de nemours
Example products using this active
  • Fortress Insecticide 5G
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually supplied in a granular formulation and with tamper-proof delivery systems (SmartBox).


ENVIRONMENTAL FATE

for chlorethoxyfos

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.1 DW4 Low
Solubility - In organic solvents at 20oC (mg l-1) - - -
Melting point (oC) - - -
Boiling point (oC) 80 F3 -
Degradation point (oC) - - -
Flashpoint (oC) 230 L3 -
Octanol-water partition coefficient at pH 7, 20oC P 9.33 X 1003 Calculated -
Log P 3.97 K3 High
Bulk density (g ml-1)/Specific gravity 0.64 Q2 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 20oC (mPa) - - -
Henry's law constant at 25oC (Pa m3 mol-1) 7.67 X 10-03 Q2 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.24 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 6.78 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 21 Q2 Non-persistent
DT50 (lab at 20oC) 13.5 L3 Non-persistent
DT50 (field) 3 F3 Non-persistent
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note Best available data; DT50 USA range 1-23 days; Lab studies 7 days sandy loam and 20 days loam (L3)
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 27 F3 Slow
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 59 Q2 Moderately persistent
Note pH sensitive: DT50 4.3 days at pH 5, 72 days pH 9
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - F3 Non-mobile
Koc 6100
Notes and range Medium of 4 soil types; Other data source: 9000 mL/g (DW3)
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
trichloracetaldehyde This metabolite may cause environmental pollution, click here for further information Soil   0.5   Not assessed under 91/414 or 1107/2009
dichloracetic acid (Ref: DCA) Soil   -   Not assessed under 91/414 or 1107/2009
trichloroacetic acid (Ref: TCA) Soil   -   Not assessed under 91/414 or 1107/2009
O,O-diethyl phosphorothionate (Ref: DETP) Soil   -   Not assessed under 91/414


ECOTOXICOLOGY

for chlorethoxyfos

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 2500 Q2 Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 1.8 F4 Rat High
Mammals - Short term dietary NOEL (mg kg-1) 25 Q2 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 486 F5 Colinus virginianus Moderate
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 0.089 J4 Oncorhynchus mykiss High
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.00041 L3 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 0.000054 F3 Americamysis bahia High
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) - - -
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) 0.04 F5 High
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 0.39 F5 High
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for chlorethoxyfos

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 1.8 F4 Rat High
Mammals - Dermal LD50 (mg kg-1 body weight) > 20 F3 Rat -
Mammals - Inhalation LC50 (mg l-1) 0.58 L3 Rat -
Other Mammal toxicity endpoints > 12.5 F3 Rabbit -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) - - -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 List I - -
Exposure Limits - - -
Exposure Routes Public Dietary risks from food and drinking water are not of concern
Occupational PPE/PPC required to mitigate expsoure risks
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Highly toxic
Chronic exposure may cause respiratory paralysis and death
Flammable

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes IMDG Transport Code is 6.1
CLP classification 2013 -
EC Risk Classification Click here to view information omn the EU risk phrases T+- Very toxic: R26/27/28
Xi - Irritant: R36
N - Dangerous for the environment: R50/53
EC Safety Classification Click here to view information omn the EU safety phrases S26, S28, S36/37, S45, S60, S61
WHO Classification Ia - Extremely hazardous
US EPA Classification (formulation) I - Danger - Highly toxic
UN Number Active 2783, liquid products 3018
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for chlorethoxyfos

Language Name
English chlorethoxyfos
French chlorethoxyfos
German Chlorethoxyfos
Danish chlorethoxyfos
Italian clorethoxyfos
Spanish cloretoxifos
Greek -
Slovenian klortoksifos
Polish chloretoksyfos
Swedish -
Hungarian -
Dutch -

Record last updated: Tuesday 22 May 2018
Contact: aeru@herts.ac.uk