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8-hydroxyquinoline
** 8-hydroxychinoline ** hydroxybenzopyridine ** quinophenol ** 1-azanaphthalene-8-ol ** HQ ** oxyquinoline ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

An EU approved fungicide with applications mainly in horticulture. It has a high aqueous solubility, moderate volatility and a low risk of leaching to groundwater. It is not persistent in soil systems but may be persistent in aqueous systems under some conditions. It has a moderate oral rat toxicity and may have some negative impacts on human health. it is a potential mutagen and may cause damage to reproduction and development. It is toxic to birds and moderately toxic to most aquatic life, honeybees and earthworms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for 8-hydroxyquinoline

Description: A quinoline preventative and curative fungicide used to control various pathogens on vines and other crops

Example pests controlled: Grey mould; Downy mildew; Fusarium; Verticillium

Example applications: Vines; Tomatoes; Hops

Efficacy & activity: -

Availability status: Current

Introduction & key dates: circa 1940

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Spain/Netherlands
Date inclusion expires 31/12/2021
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C9H7NO
Canonical SMILES C1=CC2=C(C(=C1)O)N=CC=C2
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) MCJGNVYPOGVAJF-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C9H7NO/c11-8-5-1-3-7-4-2-6-10-9(7)8/h1-6,11H
2D structure diagram/image available? Yes

Click to access the Cambridge Crystallographic Data Centre (CCDC) website
Cambridge Crystallographic Data Centre diagrams:
Common Name Relationship Link
8-hydroxyquinoline - Click here for the CCDC structure diagram

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide, Bactericide
Substance group Quinoline
Minimum active substance purity 99%, 990 g/Kg
Known relevant impurities EU dossier: None declared
Substance origin Synthetic
Mode of action Systemic, preventative and curative - chelates various metals required by micro-organisms for their metabolism.
CAS RN 148-24-3
EC number 205-711-1
CIPAC number 677
US EPA chemical code 059803
PubChem CID 1923
Molecular mass (g mol-1) 145.16
PIN (Preferred Identification Name) 8-quinolinol
IUPAC name 8-quinolinol
CAS name 8-quinolinol
Other status information Potential groundwater pollutant
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not known
Examples of recorded resistance -
Physical state Pure substance (99.9%) is a crystalline solid with characteristic odour and slightly yellowish colour
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Probelte SA
Example products using this active
  • Beltanol-L
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually supplied as a soluble concentrate and often applied by drip irrigation.


ENVIRONMENTAL FATE

for 8-hydroxyquinoline

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 633 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 10000 A4 - n-Heptane -
250000 A4 - 1,2-Dichloroethane -
250000 A4 - Acetone -
250000 A4 - Ethyl acetate -
Melting point (oC) 73.1 A5 -
Boiling point (oC) 265.6 A5 -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 8.22 X 1001 Calculated -
Log P 1.915 A5 - @ 22 DegC Low
Bulk density (g ml-1)/Specific gravity 1.03 Q3 -
Dissociation constant (pKa) at 25oC 4.88 A5 -
Note: pKa(2) = 9.45
Vapour pressure at 20oC (mPa) 0.0670 A4 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.83 X 10-03 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.39 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 pH 1.5: 251.5nm = 42971.4, 357nm = 1657.1; [pH 6.9: 239.5nm = 34832.1, 306nm = 2603.6; [pH 10.1: 253nm = 29096.4, 333.5nm = 2521.4 A5 -
Surface tension (mN m-1) 71.2 A5 at 20 degC, 99.9% -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 0.3 Click here to see a warning relating to modelling and this active substance A5 Non-persistent
DT50 (lab at 20oC) 0.3 A5 Non-persistent
DT50 (field) - - -
DT90 (lab at 20oC) 19.6 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier Lab studies DT50 range 0.0002-0.9 days, DT90 range 0.3-37.7 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note -
Water-sediment DT50 (days) 230 A5 Slow
Water phase only DT50 (days) 1.0 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 1105.6 A5 Non-mobile
Kfoc 55460
1/n 1.06
Notes and range EU dossier Kf range 286-2965 mL/g, Kfoc range 12796-111459 mL/g, 1/n range 0.66-1.39, Soils=5
pH sensitivity No


ECOTOXICOLOGY

for 8-hydroxyquinoline

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) Low risk A5 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) 790 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 311 A5 Coturnix japonica Moderate
Birds - Short term dietary (LC50/LD50) > 5000 mg kg feed-1 A5 Coturnix japonica -
Fish - Acute 96 hour LC50 (mg l-1) 2.00 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) > 0.0079 A4 Oncorhynchus mykiss, 28 days High
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 3.32 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 124.92 A5 Chironomus riparius Low
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 1.42 A5 Desmodesmus subspicatus, /i> growth rate Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 100 A5, as HQ-sulphate Low
Oral acute 48 hour LD50 (μg bee-1) > 68.6 A5, as HQ-sulphate Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 204.3 A5 Eisenia foetida, as sulphate, corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) > 417.3 A5 Eisenia foetida, as sulphate, corr Low
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 16 >, as L/ha
A5 Typhlodromus pyri
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 16 >, as L/ha
A5 Aphidius rhopalosiphi
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 43 mg ha-1, 28days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for 8-hydroxyquinoline

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 790 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 10000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) - - -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.05 A5 Rabbit, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.05 A5 Rabbit, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.05 A5 Rabbit, SF=100 -
Dermal penetration studies (%) 100 A3 default -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Negligible if used as prescribed
Occupational PPE/PPC advised
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues May cause irreversible eye damage
Possible kidney & spleen toxicant
Allergen & skin sensitiser

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
Prevent generation of dust
CLP classification 2013 Health: H360D, H301, H308, H317
EC Risk Classification Click here to view information omn the EU risk phrases Xi - Irritant: R36/R37/R38
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification NL - Not listed
US EPA Classification (formulation) III - Caution - Slightly toxic
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for 8-hydroxyquinoline

Language Name
English 8-hydroxyquinoline
French -
German 8-Hydroxy-chinolin
Danish -
Italian -
Spanish -
Greek -
Slovenian -
Polish -
Swedish -
Hungarian -
Dutch -

Record last updated: Wednesday 31 October 2018
Contact: aeru@herts.ac.uk