1,2-benzisothiazolin-3-one
Last updated: 15/01/2023
(Also known as: IPX; BIT; benzisothiazolin)
This biocide compound does not appear to have been extensively studied and hence little data is available. Data suggests it has a low aqueous solubility and is rapidly broken down in the environment. The little data that is available suggests it has a moderate to low tocicity to woldlife and humans.
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
Substance with biocidal, bactericidal and fungicidal properties that is sometimes used as a preservative in product formulations.
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Current
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Not approved
Not applicable
No UK approval for use
EC Regulation 1107/2009 (repealing 91/414)
Not applicable - not a ppp. May be authorised at national level under different legislation
Not applicable
Not applicable
Not applicable
No
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
 
 
 
 
 
 
 
 
 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
 
 
 
 
 
 
 
 
 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
 
 
 
 
 
 
 
 
 
None
C₇H₅NOS
C1=CC=C2C(=C1)C(=O)NS2
No data
DMSMPAJRVJJAGA-UHFFFAOYSA-N
InChI=1S/C7H5NOS/c9-7-5-3-1-2-4-6(5)10-8-7/h1-4H,(H,8,9)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
1,2-benzisothiazolin-3-one
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Microbiocide, Other substance
Preservative
Isothiazolone biocide
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Synthetic
Inert
2634-33-5
220-120-9
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098901
17520
613-088-00-6
151.18
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1,2-benzisothiazol-3(2H)-one
1,2-benzisothiazolin-3-one
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Not applicable
Not applicable
Not applicable
Not applicable
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Very pale yellow to brown coloured crystals
Proxel Nipacide Troysan Vanquish 100 Proxel
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0.5
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Low
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156
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
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1.17
P3 P = Other governments and regulators 3 = Unverified data of known source
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15.065
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Highly volatile
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1.0
Non-persistent
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Limited published data but most suggest substance rapidly breaksdown <1.0 day sandy soils.
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Stable
Q2 Q = Miscellaneous internet resources 2 = Unverified data of unknown source
Stable
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Soil adsorption and mobility
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Moderately mobile
300
Kd range from 1.5 to 8.0 mL g⁻¹ in general literature
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0.00
Calculated
Low leachability
3.39 X 10-04
Calculated
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Low
Calculated
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Moderately mobile
Calculated
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None
Terrestrial ecotoxicology
1020
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
Moderate
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617
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Colinus virginianus
Moderate
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278
Eisenia foetida
Moderate
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Nitrogen mineralisation: No significant adverse effect Carbon mineralisation: No significant adverse effect
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1.6
Oncorhynchus mykiss
Moderate
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4.4
Daphnia magna
Moderate
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52.0
Chironomus riparius
Moderate
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> 0.38
Pseudokirchneriella subcapitata
Moderate
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HUMAN HEALTH AND PROTECTION
High (class III)
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1020
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
Moderate
2000
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
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0.1
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
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May be absorbed through the skin.
EU MRL pesticide database 
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Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A0 A = Chromosome aberration (EFSA database) 0 = No data
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
?Possibly, status not identified
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
Immunotoxicant May cause allergic dermatitis Harmful if ingested May damage eyes
Prevent generation of dust Corrosive
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NL (Not listed)
Usually 3077
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1,2-benzisothiazolin-3-one
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Record last updated:
15/01/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242