metamifop (Ref: DBH-129) ** K-12974 ** Translations

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GENERAL INFORMATION
for metamifop

Description: A post-emergent herbicide used for the control of a wide range of annual grass weeds in cereal crops and rice

Introduction: 2002

EC Regulation 1107/2009 (repealing 91/414):

Status	Not listed
Dossier rapporteur/co-rapporteur	Not applicable
Date inclusion expires	Not applicable

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

General status:

Pesticide type	Herbicide
Substance group	Aryloxyphenoxy propionate
Substance origin	Synthetic
Mode of action	ACCase inhibitor, causes chlorosis leading to growth retardation
CAS RN	256412-89-2
EC number	-
CIPAC number	-
US EPA chemical code	-
Chiral molecule	Chiral or specific isomer of chiral molecule
Chemical formula	C23H18ClFN2O4
SMILES	c1c(N(C)C(=O)[C@H](Oc2ccc(cc2)Oc2nc3ccc(cc3o2)Cl)C)c(ccc1)F
International Chemical Identifier (InChI)	InChI=1/C23H18ClFN2O4/c1-14(22(28)27(2)20-6-4-3-5-18(20)25)29-16-8-10-17(11-9-16)30-23-26-19-12-7-15(24)13-21(19)31-23/h3-14H,1-2H3/t14-/m1/s1
Structure diagram/image available?	Yes
Molecular mass (g mol-1)	440.86
IUPAC name	(R)-2-[4-(6-chloro-1,3-benzoxazol-2-yloxy)phenoxy]-2'-fluoro-N-methylpropionanilide
CAS name	(2R)-2-[4-[(6-chloro-2-benzoxazolyl)oxy]phenoxy]-N-(2-fluorophenyl)-N-methylpropanamide
Other status information	-
Herbicide Resistance Classification (HRAC)	Not known
Insecticide Resistance Classification (IRAC)	Not applicable
Fungicide Resistance Classification (FRAC)	Not applicable
Physical state	Beige coloured powder
Related substances & organisms	haloxyfop-P-methyl

Formulations:

Property	Value
Example manufacturers of products using this active	Dongbu Hannong Chemical Co Ltd
Example products using this active	-
UK LERAP status	No UK approval for use or outside scope
Formulation and application details	Available in a variety of formulations including granules and emulsifiable concentrates.

ENVIRONMENTAL FATE
for metamifop

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		0.687	L3	Low
Solubility - In organic solvents at 20oC (mg l-1)		250000	L3 - Acetone	-
		250000	L3 - Methanol	-
		250000	L3 - Xylene	-
		250000	L3 - Ethyl acetate	-
Melting point (oC)		77.5	L3	-
Boiling point (oC)		Decomposes before boiling	L3	-
Degradation point (oC)		-	-	-
Flashpoint (oC)		-	-	-
Octanol-water partition coefficient at pH 7, 20oC	P	2.95 X 1005	Calculated	-
	Log P	5.47	L3	High
Bulk density (g ml-1)/Specific gravity		1.39	L3	-
Dissociation constant (pKa) at 25oC		-	-	-
		Note:
Vapour pressure at 25oC (mPa)		0.151	L3	Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1)		0.0635	L3	Non-volatile
Henry's law constant at 20oC (dimensionless)		3.98 X 10-05	Calculated	Volatile
GUS leaching potential index		-	-	-
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	-	-	-
	Note	-
Potential for particle bound transport index		-	-	-
Maximum UV-vis absorption L mol-1 cm-1		-	-	-
Surface tension (mN m-1)		-	-	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
Soil degradation (days) (aerobic)	DT50 (typical)	70	L3	Moderately persistent
	DT50 (lab at 20oC)	18	L3	Non-persistent
	DT50 (field)	-	-	-
	DT90 (lab at 20oC)	-	-	-
	DT90 (field)	-	-	-
	Note	General literature states DT50 18-120 days
Aqueous photolysis DT50 (days) at pH 7	Value	-	-	-
	Note	-
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	-	-	-
	Note	-
Water-Sediment DT50 (days)		-	-	-
Water phase only DT50 (days)		-	-	-

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	-	-	-
	Koc	-
	Notes and range	-
Freundlich	Kf	-	-	-
	Kfoc	-
	1/n	-
	Notes and range	-
pH sensitivity		-

ECOTOXICOLOGY
for metamifop

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF	-	-	-
	CT50 (days)	-		-
Bioaccumulation potential		-	-	-
Mammals - Acute oral LD50 (mg kg-1)		> 2000	L3 Rat	Moderate
Mammals - Short term dietary NOEL	(mg kg-1)	-	-	-
	(ppm diet)	-		-
Birds - Acute LD50 (mg kg-1)		-	-	-
Birds - Short term dietary (LC50/LD50)		-	-	-
Fish - Acute 96 hour LC50 (mg l-1)		0.307	L3 Oncorhynchus mykiss	Moderate
Fish - Chronic 21 day NOEC (mg l-1)		-	-	-
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		0.288	L3 Daphnia magna	Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		-	-	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		-	-	-
Algae - Acute 72 hour EC50, growth (mg l-1)		2.03	L2 Unknown species	Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1)		-	-	-
Honeybees - Acute 48 hour LD50 (μg bee-1)		100	L3 Oral	Moderate
Earthworms - Acute 14 day LC50 (mg kg-1)		1000	L3	Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		-	-	-
Other soil macro-organisms - e.g. Collembola	LR50 / EC50 / NOEC / % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	-	-	-
	% Effect	-	-	-
Other arthropod (2)	LR50 g ha-1	-	-	-
	% Effect	-	-	-
Soil micro-organisms		-	-	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION
for metamifop

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Mammals - Acute oral LD50 (mg kg-1)		> 2000	L3 Rat	Moderate
Mammals - Dermal LD50 (mg kg-1 body weight)		> 2000	L3 Rat	-
Mammals - Inhalation LC50 (mg l-1)		2.61	L3 Rat	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		-	-	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		-	-	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		-	-	-
Dermal penetration studies (%)		-	-	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	-
	Occupational	-
Examples of European MRLs (mg kg-1)	Value	-
	Note	For the EU pesticides database click here
Drinking Water MAC (μg l-1)		-	-	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Acetyl cholinesterase inhibitor	Neurotoxicant	Respiratory tract irritant	Skin irritant	Eye irritant
-	-	-	-	-	-	-
General human health issues		May cause skin sensitisation

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		No information available
CLP classification 2013		-
EC Risk Classification		-
EC Safety Classification		-
WHO Classification		NL	-	Not listed
US EPA Classification (formulation)		-	-	-
UN Number		-
Waste disposal & packaging		-

TRANSLATIONS
for metamifop