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nitenpyram (Ref: CGA 246916)
** (E)-nitenpyram ** TI 204 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
Further data may be found in the VSDB

GENERAL INFORMATION
for nitenpyram

Description: An insecticide used mainly to kill external parasites in livestock and domestic pets buts also used to control sucking insects on rice and in greenhouse crops

Introduction: 1989 discovered, 1995 launched

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Never notified

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

General status:
Pesticide type Insecticide, Veterinary substance
Substance group Neonicotinoid
Substance origin Synthetic
Mode of action Systemic with translaminar activity, stomach and contact action affecting insects nervous system. No long term activity. Acetylcholine receptor (nAChR) agonist.
CAS RN 150824-47-8
EC number -
CIPAC number -
US EPA chemical code -
Chiral molecule No
Chemical formula C11H15ClN4O2
SMILES C(\[N+]([O-])=O)=C(\N(Cc1cnc(cc1)Cl)CC)NC
International Chemical Identifier key (InChIKey) CFRPSFYHXJZSBI-DHZHZOJOSA-N
International Chemical Identifier (InChI) InChI=1S/C11H15ClN4O2/c1-3-15(11(13-2)8-16(17)18)7-9-4-5-10(12)14-6-9/h4-6,8,13H,3,7H2,1-2H3/b11-8+
Structure diagram/image available? Yes
Molecular mass (g mol-1) 270.72
PIN (Preferred Identification Name) (1E)-N-[(6-chloropyridin-3-yl)methyl]-N-ethyl-N'-methyl-2-nitroethene-1,1-diamine
IUPAC name (E)-N-(6-chloro-3-pyridylmethyl)-N-ethyl-N'-methyl-2-nitrovinylidenediamine
CAS name (1E)-N-[(6-chloro-3-pyridinyl)methyl]-N-ethyl-N'-methyl-2-nitro-1,1-ethenediamine
Other status information -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 4C
Fungicide Resistance Classification (FRAC) Not applicable
Physical state Pale yellow crystalline solid
Related substances & organisms -

Formulations:
Property Value
Example manufacturers & suppliers of products using this active
  • Sumitomo
  • Novartis Animal Health
Example products using this active
  • BestGuard
  • Capstar
UK LERAP status No UK approval for use or outside scope
Formulation and application details Usually supplied as a dusting powder, granules, drops and impregnated collars for topical use and as tablets for oral treatments.


ENVIRONMENTAL FATE

for nitenpyram

Property Value Source/Quality Score/Other Information Interpretation
Solubility - In water at 20oC (mg l-1) 590000 L3 High
Solubility - In organic solvents at 20oC (mg l-1) 1000000 L3 - Methanol -
700000 L3 - Chloroform -
290000 L3 - Acetone -
4500 L3 - Xylene -
Melting point (oC) 82 L3 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 2.19 X 10-01 Calculated -
Log P -0.66 L3 - @ 25 degC Low
Bulk density (g ml-1)/Specific gravity 1.4 L2 -
Dissociation constant (pKa) at 25oC 3.1 L3 -
Note:
Vapour pressure at 25oC (mPa) 0.0011 L3 Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1) 3.54 X 10-13 L3 Non-volatile
Henry's law constant at 20oC (dimensionless) 2.07 X 10-13 Calculated Non-volatile
GUS leaching potential index 2.01 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Value 2.22 X 10-02 Calculated -
Note -
Potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Value Source/Quality Score/Other Information Interpretation
Soil degradation (days) (aerobic) DT50 (typical) 8 L3 Non-persistent
DT50 (lab at 20oC) - - -
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
Note General literature states DT50 1-15 days
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable L3 Very persistent
Note Stable pH 3-7 at 25 degC; pH9 DT50 = 2.9 days
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Value Source/Quality Score/Other Information Interpretation
Linear Kd - Q2 Mobile
Koc 60
Notes and range Estimated
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
2-(N-(6-chloro-3-pyridylmethyl)-N-ethyl)amino-2-methyliminoacetic acid 2-CPMA Plant - -
2-(N-(6-chloro-3-pyridylmethyl)-N-ethyl-N-methylformamidine 3-CPMF Plant - -


ECOTOXICOLOGY

for nitenpyram

Property Value Source/Quality Score/Other Information Interpretation
Bio-concentration factor BCF Low risk Q3 Based on LogP < 3 High potential
CT50 (days) - -
Bioaccumulation potential - Calculated Low
Mammals - Acute oral LD50 (mg kg-1) 1575 L3 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 1124 L3 Anas platyrhynchos Moderate
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 10 L3 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 10000 L3 Daphnia magna Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Algae - Acute 72 hour EC50, growth (mg l-1) 26 L3 Pseudokirchneriella subcapitata Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) - - -
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) 0.138 R4 High
Earthworms - Acute 14 day LC50 (mg kg-1) 32.2 L3 Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for nitenpyram

General:
Property Value Source/Quality Score/Other Information Interpretation
Mammals - Acute oral LD50 (mg kg-1) 1575 L3 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 L3 Rat -
Mammals - Inhalation LC50 (mg l-1) 5.8 L3 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) - - -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
Examples of European MRLs (mg kg-1) Value 0.01
Note Default MRL according to Art 18(1)(b) Reg 396 / 2005.
For the EU pesticides database click here
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant Respiratory tract irritant Skin irritant Eye irritant

-

-

-

-

-

General human health issues No further information available

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:
Property Value Source/Quality Score/Other Information Interpretation
General Corrosive
CLP classification 2013 -
EC Risk Classification Xn - Harmful: R22
Xi - Irritant: R36, R37, R38
EC Safety Classification S26, S36
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) - -
UN Number -
Waste disposal & packaging -


TRANSLATIONS

for nitenpyram

Language Name
English nitenpyram
French -
German -
Danish -
Italian -
Spanish -
Greek -
Slovenian -
Polish -
Swedish -
Hungarian -
Dutch -

Record last updated: Tuesday 29 July 2014
Contact: aeru@herts.ac.uk