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GET ADDITIONAL DATA HERE!

penflufen (Ref: BYF-14182)
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for penflufen

Description: A new fungicidal seed treatment of numerous crops including potatoes

Example pests controlled: Black scurf; Stem & stolon canker; Fusarium rot

Example applications: Potatoes; Cereal grains including wheat, barley; Oilseeds; Alfalfa; Legumes; Rice

Efficacy & activity: -

Availability status: Current

Introduction & key dates: -

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur UK
Date inclusion expires 31/01/2024
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: USA; Canada

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C18H24FN3O
Canonical SMILES CC1=NN(C(=C1C(=O)NC2=CC=CC=C2C(C)CC(C)C)F)C
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) GOFJDXZZHFNFLV-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C18H24FN3O/c1-11(2)10-12(3)14-8-6-7-9-15(14)20-18(23)16-13(4)21-22(5)17(16)19/h6-9,11-12H,10H2,1-5H3,(H,20,23)
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Pyrazolium
Minimum active substance purity 980 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Succinate DeHydrogenase Inhibitor.
CAS RN 494793-67-8
EC number -
CIPAC number 826
US EPA chemical code 100249
PubChem CID 11674113
Molecular mass (g mol-1) 317.41
PIN (Preferred Identification Name) rac-5-fluoro-1,3-dimethyl-N-{2-[(2R)-4-methylpentan-2-yl]phenyl}-1H-pyrazole-4-carboxamide
IUPAC name 2'-[(RS)-1,3-dimethylbutyl]-5-fluoro-1,3-dimethylpyrazole-4-carboxanilide
CAS name N-[2-(1,3-dimethylbutyl)phenyl]-5-fluoro-1,3-dimethyl-1H-pyrazole-4-carboxamide
Other status information Potential marine pollutant; PAN listed Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 7
Examples of recorded resistance None identified
Physical state Off-white coloured powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically -
Example products using this active
  • EverGol prime
  • Emesto Quantum
  • EverGol Extend
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually applied as a seed treatment.


ENVIRONMENTAL FATE

for penflufen

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 10.9 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 126000 A5 - Methanol -
1600 A5 - n-Heptane -
62000 A5 - Toluene -
139000 A5 - Acetone -
Melting point (oC) 111 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 320 A4 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 2.00 X 1003 Calculated -
Log P 3.3 A5 High
Bulk density (g ml-1)/Specific gravity - - -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 4.1 X 10-04 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.05 X 10-05 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 3.55 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 7.10 X 10-01 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 Neutral soln: 209nm=23724, 232nm=10939 shoulder; [Acidic soln: 202nm=25030, 230nm=11784 shoulder; [Basic soln: 204nm=23010, 234nm=9868 shoulder A5 -
Surface tension (mN m-1) 61.6 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 192 A5 Persistent
DT50 (lab at 20oC) 192 A5 Persistent
DT50 (field) 113 A5 Persistent
DT90 (lab at 20oC) 837 A5 -
DT90 (field) 595 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 115-458 days, DT90 range 382-1521 days; Field studies DT50 range 68-224 days, DT90 range 331->1000 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 17.3 A5 Slow
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable at pH 4,7 & 9 @ 50 DegC
Water-sediment DT50 (days) 21 A5 Fast
Water phase only DT50 (days) 246 A5 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 4.78 A5 Moderately mobile
Kfoc 279.9
1/n 0.920
Notes and range EU dossier Kf range 2.705-6.10 mL/g, Kfoc range 209.6-409.5 mL/g, 1/n range 0.875-0.974, soils=5
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
penflufen-3-hydroxy-butyl This metabolite may cause environmental pollution, click here for further information Soil   0.17   Major fraction, Relevant
penflufen-pyrazolyl-AAP This metabolite may cause environmental pollution, click here for further information Soil   0.115   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
- BYF-14182-3,4-dihydroxy-keto-glucuronide Animal - -
- BYF-14182-3,4-dihydroxy-ketone Animal - -
- BYF-14182-homoglutathione Plant - -
- BYF-14182-pyrazole-4-carboximide Plant - -
- BYF-14182-bis-desmethyl-3-carboxylic acid Plant - -
- BYF-14182-4-hydroxy-butyl-malonyl-glucoside Plant - -
- BYF-14182-2,3,4-trihydroxy Animal - -
- BYF-14182-3,4-dihydroxy-glucuronide Animal - -
- BYF-14182-3,4-dihydroxy Animal - -
- BYF-14182-pentanoic acid Animal - -


ECOTOXICOLOGY

for penflufen

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 142 A5 Threshold for concern
CT50 (days) 0.53 -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 4000 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 1697 mg kg-1 BW/day A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 0.103 A5 Cyprinus carpio Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.023 A4 Pimephales promelas, 35 days Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 4.66 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 1.53 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) > 4.7 A5 Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) > 5.1 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 108.2 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 , corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 16.5 A5 , corr Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 250 >
A5 Typhlodromus pyri
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 250 >
A5 Aphidius rhopalosiphi
-
% Effect - - -
Soil micro-organisms Carbon mineralisation: No significant adverse effect A5
Dose: 3.18 mg kg-1 soil, 28 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for penflufen

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 2.02 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.04 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.5 A5 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.077 A5 Dog, SF=100 -
Dermal penetration studies (%) 0.21-1.45 A5 Concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Acceptable for intended uses
Occupational Acceptable with PPC/PPE
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Possible liver and thyroid toxicant
USEPA - some evidence to suggest possible human carcinogen

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Health: H351
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 3: R40
N - Dangerous for the environment: R50/53
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification NL - Not listed
US EPA Classification (formulation) - -
UN Number 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for penflufen

Language Name
English penflufen
French -
German -
Danish -
Italian -
Spanish -
Greek -
Slovenian -
Polish -
Swedish -
Hungarian -
Dutch -

Record last updated: Friday 14 September 2018
Contact: aeru@herts.ac.uk