Indaziflam |
![]() Last updated: 04/01/2021 |
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(Not known by any other names) |
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Novel pre-emergence herbicide that controls a broad spectrum of weeds, including species which are difficult to eliminate | |
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Annual grasses and broad-leaved weeds including annual bluegrass, goosegrass, ryegrass and goosefoot. | |
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Residential; Turf & lawns; Sports fields; Field grown ornamentals; Landscapes; Pome and stone fruit; Citrus; Grapes; Tree nuts; Bananas; Tea; Coffee; Olives | |
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Current | |
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2010, first registered USA |
UK regulatory status |
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Not approved | ||
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Not applicable | ||
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No UK approval for use |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Not applicable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Not applicable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Not applicable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Also used in |
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Japan; Canada; USA; Indonesia; Argentina; Mexico; Philippines; Vietnam |
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Chemical structure |
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Indaziflam is a chiral molecule with three asymmetric carbons and two of eight possible isomers (isomer A - IR,2S,1R- and Isomer B - 1R,2S,1S-) are present in the active constituents of indaziflam. | |
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C₁₆H₂₀FN₅ | |
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CC1CC2=C(C1NC3=NC(=NC(=N3)N)C(C)F)C=C(C=C2)C | |
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C[C@H]1CC2=C([C@@H]1NC3=NC(=NC(=N3)N)C(C)F)C=C(C=C2)C | |
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YFONKFDEZLYQDH-BOURZNODSA-N | |
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InChI=1S/C16H20FN5/c1-8-4-5-11-7-9(2)13(12(11)6-8)19-16-21-14(10(3)17)20-15(18)22-16/h4-6,9-10,13H,7H2,1-3H3,(H3,18,19,20,21,22)/t9-,10?,13+/m0/s1 | |
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Yes |
General status |
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Herbicide | |
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Fluoroalkyltriazine | |
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Synthetic | |
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Inhibits cellulose biosynthesis (CB Inhibitor). Long lasting action and non-selective. | |
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950782-86-2 | |
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080818 | |
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44146693 | |
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301.36 | |
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N2-[(1R,2S)-2,6-dimethyl-2,3-dihydro-1H-inden-1-yl]-6-[(1?)-1-fluoroethyl]-1,3,5-triazine-2,4-diamine | |
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N-[(1R,2S)-2,3-dihydro-2,6-dimethyl-1H-inden-1-yl]-6-[(1RS)-1-fluoroethyl]-1,3,5-triazine-2,4-diamine | |
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N-[(1R,2S)-2,3-dihydro-2,6-dimethyl-1H-inden-1-yl]-6-(1-fluoroethyl)-1,3,5-triazine-2,4-diamine | |
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Potential groundwater contaminant; Marine pollutant | |
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L | |
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29 | |
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Not applicable | |
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Not applicable | |
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None identified | |
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Beige coloured powdery solid |
Formulations |
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Number of different formulations are emerging world-wide including wettable powders, liquid suspensions, water soluble bags, fertiliser additives, ready-to-use products and granules |
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2.8 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) at pH 94 = Verified data |
Low | ||||||||
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55000 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Acetone4 = Verified data |
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7600 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Acetonitrile4 = Verified data |
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13000 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Ethanol4 = Verified data |
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32 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Heptane4 = Verified data |
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183 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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6.31 X 1002 | Calculated | - | |||||||
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2.8 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
Moderate | ||||||||
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1.23 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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3.5 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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2.5 X 10-05 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
Low volatility | ||||||||
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2.69 X 10-06 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
Non-volatile | ||||||||
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Max @ 213nm, 268nm, 291nm | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
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Degradation |
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150 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source |
Persistent | |||||||
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General literature gives DT₅₀ >150 days (aerobic soil), >200 days (anaerobic soils) | ||||||||||
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5 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
Moderately fast | |||||||
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Data for clear shallow water | ||||||||||
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Soil adsorption and mobility |
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- | - | Slightly mobile | |||||||
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1000 | ||||||||||
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Fate indices |
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2.18 | Calculated | Transition state | ||||||||||||||||||||||||||
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1.06 X 10-01 | Calculated | - | |||||||||||||||||||||||||
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High | Calculated | - | ||||||||||||||||||||||||||
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Slightly mobile | Calculated | - |
Other known metabolites |
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fluoroethyldiaminotriazine Note: Koc <50 mL/g |
FDAT | Humans, Soil | - | - | |||||
triazine-indanone | - | Environment | - | - | |||||
indaziflam-carboxylic acid | - | Environment; Humans | - | - | |||||
indaziflam-hydroxyethyl | - | Soil; Water | - | - | |||||
indaziflam-olefin | - | Soil; Water | - | - | |||||
fluoroethyltriazinanedione | - | Environment | - | - |
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Low risk | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Based on LogP < 33 = Unverified data of known source |
Low risk | |||||||
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> 2000 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
Low | ||||||||
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> 2000 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Colinus virginianus4 = Verified data |
Low | ||||||||
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> 0.42 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Oncorhynchus mykiss4 = Verified data |
Moderate | ||||||||
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0.464 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Pimephales promelas4 = Verified data |
Moderate | ||||||||
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< 9.88 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna4 = Verified data |
Moderate | ||||||||
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0.34 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Daphnia magna4 = Verified data |
Moderate | ||||||||
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0.000019 | R3 R = Peer reviewed scientific publications Lemna gibba NOEC3 = Unverified data of known source |
High | ||||||||
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0.75 | E3 E = Manufacturers safety data sheets Pseudokirchneriella subcapitata as formulation3 = Unverified data of known source |
Moderate | ||||||||
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> 100 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) 4 = Verified data |
Low | |||||||
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> 1000 | P3 P = Other governments and regulators Eisenia foetida3 = Unverified data of known source |
Low | ||||||||
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34.0 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Eisenia foetida for NOAEC3 = Unverified data of known source |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 2000 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
Low | ||||||||
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2000 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Rabbit4 = Verified data |
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> 2.3 | F4 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Rat4 = Verified data |
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Health issues |
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Possible liver and thyroid toxicant Harmful is swallowed |
Handling issues |
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IMDG Transport Code is usually 9 | |||
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Xn - Harmful: R22 | |||
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NL (Not listed) | |||
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3082 | |||
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Packaging Group III (minor danger) |
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indaziflam | ||
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Record last updated: | 04/01/2021 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |