Cycloheximide |
![]() Last updated: 05/01/2021 |
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(Also known as: naramycin; U-4527; isocycloheximide ) |
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An obsolete antibiotic fungicide used in horticultural mainly in combination with other fungicides | |
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Powdery mildew; Rusts; Leafspot; Petal blight | |
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Ornamentals including roses, azaleas, lawn grass; Citrus | |
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Obsolete | |
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1946, first reported |
UK regulatory status |
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Not approved | ||
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Not applicable | ||
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No UK approval for use |
EC Regulation 1107/2009 (repealing 91/414) |
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Not applicable | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Also used in |
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Chemical structure |
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A chiral molecule | |
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C₁₅H₂₃NO₄ | |
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CC1CC(C(=O)C(C1)C(CC2CC(=O)NC(=O)C2)O)C | |
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C[C@H]1C[C@@H](C(=O)[C@@H](C1)[C@@H](CC2CC(=O)NC(=O)C2)O)C | |
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YPHMISFOHDHNIV-FSZOTQKASA-N | |
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InChI=1S/C15H23NO4/c1-8-3-9(2)15(20)11(4-8)12(17)5-10-6-13(18)16-14(19)7-10/h8-12,17H,3-7H2,1-2H3,(H,16,18,19) | |
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Yes |
General status |
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Fungicide, Plant growth regulator | |
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Unclassified | |
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Synthetic | |
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A protein biosynthesis inhibitor | |
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66-81-9 | |
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043401 | |
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6197 | |
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613-140-00-8 | |
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281.16 | |
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4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione | |
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4-{(2R)-2-[(1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl]-2-hydroxyethyl}piperidine-2,6-dione | |
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4-((2R)-2-((1S,3S,5S)-3,5-dimethyl-2-oxocyclohexyl)-2-hydroxyethyl)-2,6-piperidinedione | |
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Not applicable | |
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Not applicable | |
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Not applicable | |
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Not known | |
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Colourless crystalline solid |
Formulations |
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Usually formulated as a wettable powder or concentrated liquid |
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21000 | CA3 CA = Medical and toxicological databases and information systems e.g. TOXNET (click here ) 3 = Unverified data of known source |
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70000 | CA3 CA = Medical and toxicological databases and information systems e.g. TOXNET (click here ) Amyl acetate3 = Unverified data of known source |
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330000 | CA3 CA = Medical and toxicological databases and information systems e.g. TOXNET (click here ) Acetone3 = Unverified data of known source |
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190000 | CA3 CA = Medical and toxicological databases and information systems e.g. TOXNET (click here ) Cyclohexanone3 = Unverified data of known source |
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120 | Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source |
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492 | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) 3 = Unverified data of known source |
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251 | V3 V = ChemID online databases / IPCS INCHEM (ChemID; IPCS INCHEM ) 3 = Unverified data of known source |
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3.55 X 1000 | Calculated | - | |||||||
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0.55 | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
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Degradation |
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1.1 | R3 R = Peer reviewed scientific publications 3 = Unverified data of known source |
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Cherry fruits, n=1 | ||||||||||
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Soil adsorption and mobility |
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- | CA2 CA = Medical and toxicological databases and information systems e.g. TOXNET (click here ) 2 = Unverified data of unknown source |
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Estimated | ||||||||||
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Fate indices |
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Low risk | Q3 Q = Miscellaneous internet resources Based on LogP < 33 = Unverified data of known source |
Low risk | |||||||
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82.5 | CA3 CA = Medical and toxicological databases and information systems e.g. TOXNET (click here ) Anas platyrhynchos3 = Unverified data of known source |
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General |
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High (class III) | - | - | ||||||||
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Health issues |
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Highly toxic Bone marrow toxicant |
Handling issues |
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Avoid generation of dust Gives off irritating or toxic fumes in a fire |
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T = Toxic: R26, R27, R28 | |||
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S45, S53, S61 | |||
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O (Obsolete substance) | |||
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2588 (solid); 2902 (liquid) | |||
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cycloheximide | ||
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Record last updated: | 05/01/2021 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |