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GET ADDITIONAL DATA HERE!
PhD Oportunity with Syngenta & the University of Hertfordshire

niclosamide (Ref: ENT 25823 )
** clonitralide ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
Further data may be found in the VSDB

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for niclosamide

Description: A relatively selective substance used to control aquatic pests and as an antiparasitic control agent for humans and animals

Example pests controlled: Aquatic snails; Sea lamprey

Example applications: Aquatic situations

Efficacy & activity: -

Availability status: Unknown

Introduction & key dates: -

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) Not applicable
Listed in EU database No

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C13H8Cl2N2O4
Canonical SMILES C1=CC(=C(C=C1[N+](=O)[O-])Cl)NC(=O)C2=C(C=CC(=C2)Cl)O
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) RJMUSRYZPJIFPJ-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C13H8Cl2N2O4/c14-7-1-4-12(18)9(5-7)13(19)16-11-3-2-8(17(20)21)6-10(11)15/h1-6,18H,(H,16,19)
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide, Molluscide, Nematicide, Veterinary substance, Teniacide
Substance group Chloronitrophenol
Minimum active substance purity >96%
Known relevant impurities -
Substance origin Synthetic
Mode of action Respiratory & stomach action. Acts by uncoupling oxidative phosphorylation in the tapeworm
CAS RN 50-65-7
EC number 200-056-8
CIPAC number 599
US EPA chemical code -
PubChem CID 4477
Molecular mass (g mol-1) 327.12
PIN (Preferred Identification Name) 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
IUPAC name 2'5-dichloro-4'-nitrosalicylanilide
CAS name 5-chloro-N-(2-chloro-4-nitrophenyl)-2-hydroxybenzamide
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Yellow-grey coloured crystalline solid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Bayer
Example products using this active
  • Bayluscid
  • Bayluscide
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Available in a variety of formulations for oral administration as a veterinary treatment and as an emulsifiable concentrate for aquatic use.


ENVIRONMENTAL FATE

for niclosamide

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 5.0 F4 Low
Solubility - In organic solvents at 20oC (mg l-1) - - -
Melting point (oC) 224 F4 -
Boiling point (oC) - - -
Degradation point (oC) 208 L3 -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 3.63 X 1004 Calculated -
Log P 4.56 F4 - Other data: 1.0 @ pH 9.6 High
Bulk density (g ml-1)/Specific gravity - - -
Dissociation constant (pKa) at 25oC 5.6 F4 -
Note:
Vapour pressure at 20oC (mPa) 8.0 X 10-08 L3 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) - - -
GUS leaching potential index Click here for a note on the limitations of the GUS index - - -
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value - - -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - - -
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) - - -
DT50 (lab at 20oC) - - -
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note: -
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 2.6 R4 -
Note Pakchoi leaves, n=1
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value - - -
Note -
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 106 R4 Slightly mobile
Koc 3112
Notes and range Literature values for sediments: Kd range 52.2-186.5 mL/g, Koc range 1742-4980 mL/g, soils=5
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity Yes

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
2,5-dichloro-4-aminosalicylanilide - Rat (Urinary) - -


ECOTOXICOLOGY

for niclosamide

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 250 E3 Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 5000 F4 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2000 F4 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 0.34 F4 Oncorhynchus mykiss, @ 13 DegC Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.2 L3 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) 1.6 F3 Chironomus riparius, 48 hour Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 5.0 L3 Scendesmus subspicatus Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) - - -
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for niclosamide

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 F4 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) 2000 F4 Rat -
Mammals - Inhalation LC50 (mg l-1) - - -
Other Mammal toxicity endpoints Intraperitoneal LD50 = 250 mg kg-1 V3 Rat -
Intravenous LD50 = 7.5 mg kg-1 V3 Mouse -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) - - -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational May be absorbed through the skin or mucous membranes
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues May cause gastrointestinal problems, anorexia, irritability & alopecia
Salts may cause occular irritation
Harmful if swallowed

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Avoid formation of dust
IMDG Transport Code is usually 9
CLP classification 2013 -
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R22
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) II - Warning - Moderately toxic
UN Number 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for niclosamide

Language Name
English niclosamide
French niclosamide
German clonitralid
Danish -
Italian -
Spanish niclosamida
Greek -
Slovenian -
Polish -
Swedish -
Hungarian -
Dutch -

Record last updated: Saturday 26 May 2018
Contact: aeru@herts.ac.uk