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GET ADDITIONAL DATA HERE!
PhD Oportunity with Syngenta & the University of Hertfordshire

cyromazine (Ref: OMS 2014)
** CGA 72662 ** cyclopropylmelamine ** cyromazinum ** AI3-52713 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
Further data may be found in the VSDB

SUMMARY

Cyromazine is an insecticide approved for use in the EU and in other countries. It is highly soluble in water and considered relatively volatile. Its persistence in soil and water systems is highly dependant on local conditions. Cyromazine has a low mammalian toxicity but may cause adverse effects on reproduction and development if ingested and is also a skin irritant. It is moderately toxic to birds, fish, aquatic invertebrates and earthworms but less so to honeybees.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for cyromazine

Description: An insect larvicide used mainly to control Diptera larvae and flies on livestock and other insect pests in the field and greenhouse

Example pests controlled: Leafminers; Colorado beetle; Fungas gnats; Sciarid flies; Shore flies

Example applications: Vegetables including cabbage, onions, beans, lentils, peppers, turnips; Lupins; Curcubits; Tomatoes; Potatoes

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1980, first reported

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Greece
Date inclusion expires 31/12/2019

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, USA

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide, Veterinary substance
Substance group Triazine
Minimum active substance purity 950 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Contact action, interfering with moulting and pupation. Chitin synthesiser.
CAS RN 66215-27-8
EC number 266-257-8
CIPAC number 420
US EPA chemical code 121301
Chiral molecule No
Chemical formula C6H10N6
SMILES n1c(nc(nc1N)NC2CC2)N
International Chemical Identifier key (InChIKey) LVQDKIWDGQRHTE-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C6H10N6/c7-4-10-5(8)12-6(11-4)9-3-1-2-3/h3H,1-2H2,(H5,7,8,9,10,11,12)
Structure diagram/image available? Yes
Molecular mass (g mol-1) 166.18
PIN (Preferred Identification Name) N1-cyclopropyl-1,3,5-triazine-2,4,6-triamine
IUPAC name N-cyclopropyl-1,3,5-triazine-2,4,6-triamine
CAS name N-cyclopropyl-1,3,5-triazine-2,4,6-triamine
Other status information -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 17
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Drosophila melanogaster
Liriomyza trifolii
Lucilia cuprina
Musca domestica
Physical state White powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Syngenta
  • Novartis Animal Health
Example products using this active
  • Trigard
  • Larvadex
UK LERAP status No UK approval for use or outside scope
Formulation and application details Often supplied as a wettable powder that is mixed with water and used as a pour-on.


ENVIRONMENTAL FATE

for cyromazine

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 13000 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 1400 A5 - Acetone -
210 A5 - Dichloromethane -
100 A5 - Hexane -
17000 A5 - Methanol -
Melting point (oC) 223.2 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 223.2 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.17 X 1000 Calculated -
Log P 0.069 A5 Low
Bulk density (g ml-1)/Specific gravity 1.35 B5 -
Dissociation constant (pKa) at 25oC 5.22 A5 -
Note: Weak base
Vapour pressure at 25oC (mPa) 4.48 X 10-04 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 5.80 X 10-09 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.09 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 8.21 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 208nm = 39070; [Acidic solution: 215.5nm = 29540, 241.3nm = 17340; [Basic solution: 230nm = 11540 A5 -
Surface tension (mN m-1) 59.0 A5 at 20oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 93 K4 Moderately persistent
DT50 (lab at 20oC) 31.8 A5 Moderately persistent
DT50 (field) 9.7 A3 Non-persistent
DT90 (lab at 20oC) 101 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range: 1.8-56 days, DT90 range 9.6-186 days, field studies DT50 range 2.3 (Switzerland) - 17 (France) days; Other sources: 150 days (DW4)
Dissipation rate RL50 on plant matrix Value 14.3 R3 -
Note Cucumber fruit, n=1
Dissipation rate RL50 on and in plant matrix Value 17.7 R3 -
Note Green bean, whole plant, hydroponics system, n=1
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 5 to pH 9 at temperatures between 30 and 70 degC
Water-sediment DT50 (days) 228 A5 Slow
Water phase only DT50 (days) 15 A5 Slow

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 7.62 A5 Moderately mobile
Kfoc 409
1/n 0.81
Notes and range EU dossier Kf range 0.52-50.38 mL/g, Kfoc range 40.2-1784 mL/g, 1/n range 0.714-0.92, Soils=11
pH sensitivity Yes

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
melamine (Ref: CGA 235129) This metabolite may cause environmental pollution, click here for further information Soil   0.745   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
1-methyl-cyromazine - Rat; Plant - -
- hydroxy-cyromazine Animal - -
(Ref: NOA 435343) carboxylic acid of cyromazine Soil (Aerobic) 0.107 -


ECOTOXICOLOGY

for cyromazine

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 1 A5 Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 3387 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 15 B5 Rat High
(ppm diet) 300 -
Birds - Acute LD50 (mg kg-1) > 1785 A5 Colinus virginianus Moderate
Birds - Short term dietary (LC50/LD50) > 1370 mg kg bw-1 day-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) > 100 A5 Oncorhynchus mykiss Low
Fish - Chronic 21 day NOEC (mg l-1) > 1 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 100 A5 Daphnia magna Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 4.6 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) > 120 A5 Chironomus riparius Low
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.025 A4 Chironomus riparius, whole system Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 124 A5 Scenedemus subspicatus Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) > 100 Q1 Unknown species Low
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 200 A5 Low
Oral acute 48 hour LD50 (μg bee-1) 186 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Eisenia foetida Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 333 A5 Eisenia foetida, 58 day Low
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 891 >, EC50 reproduction
A5 Aphidius rhopalosiphi
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 47 A5 Typhlodromus pyri -
% Effect - - -
Soil micro-organisms [Microbial soil respiration and nitrification: NOEC=100 mg kg-1] A5 -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for cyromazine

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 3387 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 3100 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 3.6 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.06 A5 Dog, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.1 A5 Rabbit, SF=100 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.06 A5 Dog, SF=100 -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Negligible risk to bystanders
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Hgh dose can cause nausea, vomiting, abdominal distress and diarrhoea

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 None allocated at this time
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R20/22
Xi - Irritant: R36/37/38
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification III - Slightly hazardous
US EPA Classification (formulation) III - Caution - Slightly toxic
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for cyromazine

Language Name
English cyromazine
French cyromazine
German Cyromazin
Danish cyromazin
Italian ciromazina
Spanish ciromazina
Greek -
Slovenian ciromazin
Polish cyromazyna
Swedish -
Hungarian -
Dutch -

Record last updated: Monday 30 October 2017
Contact: aeru@herts.ac.uk