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GET ADDITIONAL DATA HERE!

flupyradifurone (Ref: BYI 02960)
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for flupyradifurone

Description: A novel insecticide used to control sucking pests in a variety of cropping situations.

Example pests controlled: Aphids, Hoppers, Whiteflies, Cicadas

Example applications: Vegetables; Fruits; Grapes; Date palm; Coffee; Cocoa

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 2012 discovered

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Netherlands
Date inclusion expires 09/12/2025
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C12H11ClF2N2O2
Canonical SMILES C1C(=CC(=O)O1)N(CC2=CN=C(C=C2)Cl)CC(F)F
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) QOIYTRGFOFZNKF-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C11H9ClF2N2O2/c12-9-2-1-7(4-15-9)16(5-10(13)14)8-3-11(17)18-6-8/h1-4,10H,5-6H2
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide
Substance group Butenolide
Minimum active substance purity >960 g/kg
Known relevant impurities EU Dossier: none delcared
Substance origin Synthetic
Mode of action Systemic, a nicotinic AChR agonist active via ingestion and contact. It is an adult knockdown product that also offers some control of nymph and egg stages.
CAS RN 951659-40-8
EC number -
CIPAC number -
US EPA chemical code 122304
PubChem CID 16752772
Molecular mass (g mol-1) 288.68
PIN (Preferred Identification Name) 4-([(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino)furan-2(5H)-one
IUPAC name 4-((6-chloro-3-pyridylmethyl)(2,2-difluoroethyl)amino)furan-2(5H)-one
CAS name 4-(((6-chloro-3-pyridinyl)methyl)(2,2-difluoroethyl)amino)-2(5H)-furanone
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Unknown
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state White powder with weak, uncharacteristic odour at 99.4% purity
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Bayer CropScience
Example products using this active
  • Sivanto
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details The main available formulations are those for foliar and drench/drip use and a seed treatment.


ENVIRONMENTAL FATE

for flupyradifurone

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 3200 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 0.05 E4 - n-Heptane -
3700 E4 - Toluene -
250000 E4 - Ethyl acetate -
250000 E4 - Methanol -
Melting point (oC) 69.0 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 270 A5 -
Flashpoint (oC) Not expected to self-ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.58 X 1001 Calculated -
Log P 1.2 A5 - @ 25 DegC Low
Bulk density (g ml-1)/Specific gravity 1.43 A5 -
Dissociation constant (pKa) at 25oC - n/ - -
Note: No dissociation
Vapour pressure at 20oC (mPa) 9.1 X 10-04 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 8.2 X 10-08 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 3.53 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 6.15 X 10-01 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 pH 7.0: 213nm=9615; 259nm=25800
pH 2.0: 214nm=9389, 259nm=26577
pH 10.0: 213nm=9996; 259nm=25955
A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 57.1 A5 Moderately persistent
DT50 (lab at 20oC) 57.1 A5 Moderately persistent
DT50 (field) 130 R4 Persistent
DT90 (lab at 20oC) 522.5 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 38.6-210 days, DT90 range 209-898 days, Soils =16; Manufacturers data DT50 lab studies range 33-371 days; DT50 field ranges 8.3 - 251 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 0.35 E3 Fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value - - -
Note -
Water-sediment DT50 (days) 230 E4 Slow
Water phase only DT50 (days) 31.4 E4 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - E4 Moderately mobile
Koc 98.4
Notes and range Data for European and US soils; Brazilian soils Koc = 333 mL/g
Freundlich Kf 2.26 A5 Moderately mobile
Kfoc 98.4
1/n 0.866
Notes and range EU dossier Kf range 0.597-3.822 mL/g, Kfoc range 85.2-132.2 mL/g, 1/n range 0.845-0.902, Soils=6
pH sensitivity None

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
6-chloronicotinic acid This metabolite may cause environmental pollution, click here for further information Soil   0.171   Major fraction; Relevant
difluoroacetic acid This metabolite may cause environmental pollution, click here for further information Soil   0.339   Major fraction; Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
4-[(2,2-difluoroethyl)amino]furan-2(5H)-one DFEAF Plants; Livestock; Soil; Water - -
(6-chloropyridin-3-yl)methanol CHMP - - -
flupyradifuronehydroxy BYI 02960-hydroxy - - -
flupyradifuronesuccinamide BYI 02960-succinamide - - -
flupyradifuroneazabicyclosuccinamide BYI 02960-azabicyclosuccinamide - - -


ECOTOXICOLOGY

for flupyradifurone

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) - - -
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) > 300 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 232 A5 Colinus virgianus Moderate
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) > 70.5 A5 Pimephales promelas Moderate
Fish - Chronic 21 day NOEC (mg l-1) 4.4 E4 Pimephales promelas Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 77.6 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 3.2 E4 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) > 67.7 A5 Lemna gibba Low
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) > 100 A5 Pseudokirchneriella subcapitata Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 200 A5 Low
Oral acute 48 hour LD50 (μg bee-1) 1.2 A5 Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 185.6 A5 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 0.5 <
E4 Aphidius rhopalosiphi
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 17.3 E4 Typhlodromus pyri -
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 3.34 mg kg-1 soil, 28 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for flupyradifurone

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 300 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 4.67 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.064 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.15 A5 Rabbit, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.06 A5 Rat, SF=100 -
Dermal penetration studies (%) 0.4-17 A4 Concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

General human health issues Liver and thyroid target organs

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 None allocated at this time
EC Risk Classification Click here to view information omn the EU risk phrases None allocated at this time
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification NL - Not listed
US EPA Classification (formulation) - -
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for flupyradifurone

Language Name
English flupyradifurone
French flupyradifurone
German -
Danish -
Italian -
Spanish -
Greek -
Slovenian -
Polish -
Swedish -
Hungarian -
Dutch -

Record last updated: Thursday 31 May 2018
Contact: aeru@herts.ac.uk