Flupyradifurone (Ref: BYI 02960) |
![]() Last updated: 12/01/2021 |
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(Not known by any other names) |
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A novel insecticide used to control sucking pests in a variety of cropping situations. | |
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Aphids, Hoppers, Whiteflies, Cicadas, Colorado potato beetle, Squash bugs, Psyllids. | |
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Vegetables; Fruits; Grapes; Date palm; Coffee; Cocoa | |
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Current | |
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2012 discovered |
UK regulatory status |
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Approved | ||
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09/12/2025 | ||
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None |
EC Regulation 1107/2009 (repealing 91/414) |
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Approved | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Netherlands | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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09/12/2025 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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No | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Also used in |
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USA |
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Chemical structure |
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C₁₂H₁₁ClF₂N₂O₂ | |
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C1C(=CC(=O)O1)N(CC2=CN=C(C=C2)Cl)CC(F)F | |
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No data | |
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QOIYTRGFOFZNKF-UHFFFAOYSA-N | |
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InChI=1S/C11H9ClF2N2O2/c12-9-2-1-7(4-15-9)16(5-10(13)14)8-3-11(17)18-6-8/h1-4,10H,5-6H2 | |
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Yes |
General status |
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Insecticide | |
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Butenolide | |
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>960 g kg⁻¹ | |
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EU Dossier: none delcared | |
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Synthetic | |
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Systemic, a nicotinic AChR agonist active via ingestion and contact. It is an adult knockdown product that also offers some control of nymph and egg stages. | |
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951659-40-8 | |
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122304 | |
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16752772 | |
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288.68 | |
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4-([(6-chloropyridin-3-yl)methyl](2,2-difluoroethyl)amino)furan-2(5H)-one | |
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4-((6-chloro-3-pyridylmethyl)(2,2-difluoroethyl)amino)furan-2(5H)-one | |
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4-(((6-chloro-3-pyridinyl)methyl)(2,2-difluoroethyl)amino)-2(5H)-furanone | |
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Not applicable | |
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Not applicable | |
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4D | |
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Not applicable | |
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White powder with weak, uncharacteristic odour at 99.4% purity |
Formulations |
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The main available formulations are those for foliar and drench/drip use and a seed treatment |
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3200 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
High | ||||||||
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0.05 | E4 E = Manufacturers safety data sheets n-Heptane4 = Verified data |
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3700 | E4 E = Manufacturers safety data sheets Toluene4 = Verified data |
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250000 | E4 E = Manufacturers safety data sheets Ethyl acetate4 = Verified data |
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250000 | E4 E = Manufacturers safety data sheets Methanol4 = Verified data |
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69.0 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Decomposes before boiling | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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270 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Not expected to self-ignite; Not highly flammable | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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1.58 X 1001 | Calculated | - | |||||||
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1.2 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) at 25 °C5 = Verified data used for regulatory purposes |
Low | ||||||||
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1.43 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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No dissociation | |||||||||||
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9.1 X 10-04 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Low volatility | ||||||||
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8.2 X 10-08 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Non-volatile | ||||||||
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pH 7.0: 213nm=9615; 259nm=25800 pH 2.0: 214nm=9389, 259nm=26577 pH 10.0: 213nm=9996; 259nm=25955 |
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Degradation |
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57.1 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Moderately persistent | |||||||
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57.1 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Moderately persistent | ||||||||
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130 | R4 R = Peer reviewed scientific publications 4 = Verified data |
Persistent | ||||||||
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522.5 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Very persistent | ||||||||
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EU dossier lab studies DT₅₀ range 38.6-210 days, DT₉₀ range 209-898 days, Soils =16; Manufacturers data DT₅₀ lab studies range 33-371 days; DT₅₀ field ranges 8.3 - 251 days | ||||||||||
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0.35 | E3 E = Manufacturers safety data sheets 3 = Unverified data of known source |
Fast | |||||||
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230 | E4 E = Manufacturers safety data sheets 4 = Verified data |
Slow | ||||||||
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31.4 | E4 E = Manufacturers safety data sheets 4 = Verified data |
Stable |
Soil adsorption and mobility |
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- | E4 E = Manufacturers safety data sheets 4 = Verified data |
Moderately mobile | |||||||
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98.4 | ||||||||||
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Data for European and US soils; Brazilian soils Koc = 333 mL g⁻¹ | ||||||||||
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2.26 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
Moderately mobile | |||||||
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98.4 | ||||||||||
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0.866 | ||||||||||
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EU dossier Kf range 0.597-3.822 mL g⁻¹, Kfoc range 85.2-132.2 mL g⁻¹, 1/n range 0.845-0.902, Soils=6 | ||||||||||
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None |
Fate indices |
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4.24 | Calculated | High leachability | ||||||||||||||||||||||||||
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1.77 X 1000 | Calculated | - | |||||||||||||||||||||||||
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Medium | Calculated | - | ||||||||||||||||||||||||||
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Moderately mobile | Calculated | - |
Key metabolites |
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Soil | 0.171 | Major fraction; Relevant | |||||
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Soil | 0.339 | Major fraction; Relevant |
Other known metabolites |
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4-[(2,2-difluoroethyl)amino]furan-2(5H)-one | DFEAF | Plants; Livestock; Soil; Water | - | - | |||||
(6-chloropyridin-3-yl)methanol | CHMP | - | - | - | |||||
flupyradifuronehydroxy | BYI 02960-hydroxy | - | - | - | |||||
flupyradifuronesuccinamide | BYI 02960-succinamide | - | - | - | |||||
flupyradifuroneazabicyclosuccinamide | BYI 02960-azabicyclosuccinamide | - | - | - |
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> 300 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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232 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Colinus virgianus5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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> 70.5 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Pimephales promelas5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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4.4 | E4 E = Manufacturers safety data sheets Pimephales promelas4 = Verified data |
Moderate | ||||||||
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> 77.6 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Daphnia magna5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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3.2 | E4 E = Manufacturers safety data sheets Daphnia magna4 = Verified data |
Moderate | ||||||||
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> 67.7 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Lemna gibba5 = Verified data used for regulatory purposes |
Low | ||||||||
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> 100 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Pseudokirchneriella subcapitata5 = Verified data used for regulatory purposes |
Low | ||||||||
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> 200 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Apis mellifera5 = Verified data used for regulatory purposes |
Low | |||||||
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1.2 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Apis mellifera5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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> 100 | R3 R = Peer reviewed scientific publications Bombus terrestris3 = Unverified data of known source |
Low | |||||||
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10.59 | R4 R = Peer reviewed scientific publications Osmia bicornis4 = Verified data |
Moderate | |||||||
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185.6 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Eisenia foetida5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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0.5 | < E4 E = Manufacturers safety data sheets Aphidius rhopalosiphi4 = Verified data |
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17.3 | E4 E = Manufacturers safety data sheets Typhlodromus pyri4 = Verified data |
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Nitrogen mineralisation: No significant adverse effect Carbon mineralisation: No significant adverse effect |
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes Dose: 3.34 mg kg⁻¹ soil 28 days |
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General |
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High (class III) | - | - | ||||||||
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> 300 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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2000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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> 4.67 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat5 = Verified data used for regulatory purposes |
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0.064 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat SF=1005 = Verified data used for regulatory purposes |
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0.15 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rabbit SF=1005 = Verified data used for regulatory purposes |
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0.06 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat SF=1005 = Verified data used for regulatory purposes |
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0.4-17 | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) concentration dependent4 = Verified data |
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Health issues |
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Liver and thyroid target organs |
Handling issues |
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Not explosive or oxidising | |||
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Health: H302, H373 Environment: H400, H410, H412 |
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None allocated at this time | |||
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NL (Not listed) | |||
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flupyradifurone | ||
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flupyradifurone | ||
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Record last updated: | 12/01/2021 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |