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endothal
** endothall ** endothal acid ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Endothal is a herbicide that does not have regulatory approval for use in the EU. It is highly soluble in water and semi-volatile. Based on its chemical properties it is not expected to leach to groundwater. It is generally non-persistent in soils. Endothal is highly toxic to mammals but is not expected to bioaccumulate. It is a recognised irritant. It is moderately toxic to fish and aquatic organisms but is less toxic to birds.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for endothal

Description: An unclassified herbicide, defoliant plant growth regulator and algicide used to control annual grasses, broad-leaved and aquatic weeds

Example pests controlled: Plankton; Pondweed; Coontail; Milfoil; Algae; Fathen; Chickweed

Example applications: Aquatic situations; Sugarbeet; Spinach; Turf; Alfalfa; Potatoes; Cotton

Efficacy & activity: -

Availability status: Current

Introduction & key dates: circa 1952

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Expired
EU Candidate for substitution (CfS) -
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule with 4 theoretical stereoisomers. The rel-(1R,2S,3R,4S)- isomer is the most effective herbicide.
Chemical formula C8H10O5
Canonical SMILES C1CC2C(C(C1O2)C(=O)O)C(=O)O
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) GXEKYRXVRROBEV-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C8H10O5/c9-7(10)5-3-1-2-4(13-3)6(5)8(11)12/h3-6H,1-2H2,(H,9,10)(H,11,12)
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide, Algicide, Plant growth regulator
Substance group Dicarboxylic acid
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Selective, contact, absorbed through leaves and roots
CAS RN 145-73-3
EC number 205-660-5
CIPAC number 154
US EPA chemical code 038901
PubChem CID 3225
Molecular mass (g mol-1) 186.16
PIN (Preferred Identification Name) (1E,2E,3E,4E)-7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
IUPAC name 7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
CAS name 7-oxabicyclo[2.2.1]heptane-2,3-dicarboxylic acid
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not known
Herbicide Resistance Classification (WSSA) -
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Colourless to white crystals
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Cerexagri
  • Pennwalt
Example products using this active
  • Hydout
  • Herbicide 273
  • Tribetol
  • Des-I-Cate
  • Aquathol
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually supplied as an aquatic suspension or a granular formulation.


ENVIRONMENTAL FATE

for endothal

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 100000 G4 High
Solubility - In organic solvents at 20oC (mg l-1) 280000 L3 - Methanol -
76000 L3 - Dioxane -
70000 L3 - Acetone -
100 L3 - Benzene -
Melting point (oC) 144 L3 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) Not expected to self ignite; Not highly flammable L3 -
Octanol-water partition coefficient at pH 7, 20oC P 8.13 X 1001 Calculated -
Log P 1.91 V3 Low
Bulk density (g ml-1)/Specific gravity 1.43 L3 -
Dissociation constant (pKa) at 25oC 3.4 L3 -
Note: pKa(2) 6.7
Vapour pressure at 20oC (mPa) 2.09 X 10-05 G4 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 3.90 X 10-11 V3 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.45 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 4.12 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 5 G4 Non-persistent
DT50 (lab at 20oC) - - -
DT50 (field) 7 F3 Non-persistent
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note Best available data
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value - - -
Note -
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - H3 Moderately mobile
Koc 85
Notes and range Other sources: Koc 124 mL/g (US3, DW3)
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -


ECOTOXICOLOGY

for endothal

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 0.4 F4 Whole fish Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 51 G4 Rat High
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 5000 F4 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 78 F2 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 32.5 F4 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 150 F4 Americamysis bahia Low
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 50 F2 Pseudokirchneriella subcapitata, 10 day Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) - - -
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for endothal

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 51 G4 Rat High
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 L3 Rabbit -
Mammals - Inhalation LC50 (mg l-1) 0.68 L3 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) - - -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Toxic
Corrosive effects on gastrointestinal tract

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes No information available
CLP classification 2013 Health: H301, H312, H315, H319, H335
EC Risk Classification Click here to view information omn the EU risk phrases T - Toxic: R25
Xn - Harmful: R21
Xi - Irritant: R36/37/38
EC Safety Classification Click here to view information omn the EU safety phrases S1/2, S36/37/39, S45
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) II - Warning - Moderately toxic
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for endothal

Language Name
English endothal
French endothal
German Endothal
Danish endothal
Italian endotal
Spanish endotal
Greek endothal
Slovenian endotal
Polish endotal
Swedish -
Hungarian -
Dutch endothal

Record last updated: Wednesday 23 May 2018
Contact: aeru@herts.ac.uk