ethoprophos ** ethoprop ** phosethoprop ** mocap ** Translations

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GENERAL INFORMATION
for ethoprophos

Description: A broad-spectrum nematicide and insecticide used pre-planting to control nematodes and soil dwelling insects

Example pests controlled: Free-form nematodes; Millipedes; Centipedes; Weevils; Wireworms; Cutworms; Noctuids larvae; Symphylids; Caterpillars; White grubs

Example applications: Ornamentals; Fruit including bananas, pineapples; Tobacco; Potatoes; Vegetables; Sugarcane

Efficacy & activity: Research and testing has shown ethoprophos to offer effective control for soil nematodes and insects when used according to label guidelines.

Availability status: Current

Introduction & key dates: 1966, first reported

EC Regulation 1107/2009 (repealing 91/414):

Status	Approved
Dossier rapporteur/co-rapporteur	Italy/Ireland
Date inclusion expires	31/07/2019
EU Candidate for substitution (CfS)	Yes - low ADI / ARfD / AOEL
Listed in EU database	Yes

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure:

Isomerism	-
Chemical formula	C8H19O2PS2
Canonical SMILES	CCCSP(=O)(OCC)SCCC
Isomeric SMILES	No data
International Chemical Identifier key (InChIKey)	VJYFKVYYMZPMAB-UHFFFAOYSA-N
International Chemical Identifier (InChI)	InChI=1S/C8H19O2PS2/c1-4-7-12-11(9,10-6-3)13-8-5-2/h4-8H2,1-3H3
2D structure diagram/image available?	Yes

General status:

Pesticide type	Insecticide, Nematicide
Substance group	Organophosphate
Minimum active substance purity	940 g/kg
Known relevant impurities	EU dossier - None declared
Substance origin	Synthetic
Mode of action	Non-systemic with contact action. Acetylcholinesterase (AChE) inhibitor.
CAS RN	13194-48-4
EC number	236-152-1
CIPAC number	218
US EPA chemical code	041101
PubChem CID	3289
Molecular mass (g mol-1)	242.3
PIN (Preferred Identification Name)	O-ethyl S,S-dipropyl phosphorodithioate
IUPAC name	O-ethyl S,S-dipropyl phosphorodithioate
CAS name	O-ethyl S,S-dipropyl phosphorodithioate
Other status information	Marine Pollutant
Relevant Environmental Water Quality Standards	-
Herbicide Resistance Classification (HRAC)	Not applicable
Herbicide Resistance Classification (WSSA)	Not applicable
Insecticide Resistance Classification (IRAC)	1B
Fungicide Resistance Classification (FRAC)	Not applicable
Examples of recorded resistance	None recorded
Physical state	Clear to pale yellow liquid
Related substances & organisms	-

Formulations:

Property	Value
Example manufacturers & suppliers of products using this active now or historically	Bayer CropScience Mobil Chemicals Rhone-Poulenc
Example products using this active	Mocap 10G Mocap 15G Sanimul Prophos
UK LERAP status	None
Formulation and application details	Often supplied as granules that are applied directly to the soil or incorporated. It is also available as an emulsifiable concentrate.

ENVIRONMENTAL FATE
for ethoprophos

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		1300	A5	High
Solubility - In organic solvents at 20oC (mg l-1)		500000	A5 - Acetone	-
		500000	A5 - Methanol	-
		500000	A5 - Ethyl acetate	-
		500000	A5 - Toluene	-
Melting point (oC)		70	A5	-
Boiling point (oC)		244.3	A5	-
Degradation point (oC)		244.3	A5	-
Flashpoint (oC)		141	A5	-
Octanol-water partition coefficient at pH 7, 20oC	P	9.77 X 1002	Calculated	-
	Log P	2.99	A5	Moderate
Bulk density (g ml-1)/Specific gravity		1.09	A5	-
Dissociation constant (pKa) at 25oC		Not applicable	A5	-
		Note: No dissociation
Vapour pressure at 20oC (mPa)		78.0	A5	Highly volatile
Henry's law constant at 25oC (Pa m3 mol-1)		1.35 X 10-02	A5	Non-volatile
GUS leaching potential index		2.22	Calculated	Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	6.50 X 10-02	Calculated	-
	Note	-
Potential for particle bound transport index		-	Calculated	Low
Maximum UV-vis absorption L mol-1 cm-1		Neutral soln: 231.0nm=725 Acid soln: 269.0nm=1724 Basic soln: 268.0nm=3815	A5	-
Surface tension (mN m-1)		45.1	A5 at 20oC	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
General biodegradability		-
Soil degradation (days) (aerobic)	DT50 (typical)	13.6	A5	Non-persistent
	DT50 (lab at 20oC)	13.6	A5	Non-persistent
	DT50 (field)	1.3	A5	Non-persistent
	DT90 (lab at 20oC)	63.0	A5	-
	DT90 (field)	15.1	A5	-
	DT50 modelling endpoint	13.6	A5 normalised geometric mean	-
	Note	EU 2017 dossier Lab studies DT50 range 4.8-21.1 days, DT90 range 26.2-89.9 days, Soils = 5; Field study DT50 range 0.61-2.1 days, DT90 range 9.3-20.8 days, Soils =2
Dissipation rate RL50 on plant matrix	Value	-	-	-
	Note	-
Dissipation rate RL50 on and in plant matrix	Value	-	-	-
	Note	-
Aqueous photolysis DT50 (days) at pH 7	Value	Stable	A5	-
	Note	Stable
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	Stable	A5	-
	Note	Stable pH 5 to pH 7, DT50 83 days at pH 9, 25 degC
Water-sediment DT50 (days)		83	A5	Moderately fast
Water phase only DT50 (days)		20	A5	Slow

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	-	DW3	Mobile
	Koc	70.0
	Notes and range	-
Freundlich	Kf	2.0	A5	Moderately mobile
	Kfoc	111
	1/n	0.894
	Notes and range	EU dossier kf range 0.56-5.60, Kfoc range 38-186 mL/g,1/n range 0.82-0.96, Soils=11
pH sensitivity		No

Other known metabolites:

Metabolite name and reference	Aliases	Formation medium / Rate	Estimated maximum occurrence fraction	Metabolising enzymes
ethyl phosphate	-	Plant; Animal	-	-
O-ethyl-S-propyl-phosphorothioate Note: Rat LD50 246 mg kg-1 bw	EPPA	Plant; Animal	-	-
O-ethyl-S-methyl-S-propyl-phosphorothioate Note: Rat LD50 41.0 mg kg-1 bw	SME	Plant	-	-
O-ethyl-O-methyl-S-propyl-phosphorothioate Note: Rat LD50 19.2 mg kg-1 bw	OME	Plant	-	-
O-ethyl-S-propylphosphorothioic acid	AE 0592496	Soil (Aerobic, Anaerobic)	-	-
N-propyl mercaptan	-	Rat	-	-

ECOTOXICOLOGY
for ethoprophos

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF (l kg-1)	225	Q2 Estimated	Threshold for concern
	CT50 (days)	Not available		-
Mammals - Acute oral LD50 (mg kg-1)		40	A4 Rat	High
Mammals - Short term dietary NOEL	(mg kg-1)	0.1	A5 Rat	High
	(ppm diet)	-		-
Birds - Acute LD50 (mg kg-1)		6.04	A5 Colinus virginianus	High
Birds - Short term dietary (LC50/LD50)		6.51 mg kg bw-1 day-1	A5 Colinus virginianus	-
Fish - Acute 96 hour LC50 (mg l-1)		0.32	A5 Lepomis macrochirus	Moderate
Fish - Chronic 21 day NOEC (mg l-1)		0.064	A5 Oncorhynchus mykiss	Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		0.2	A5 Daphnia magna	Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		-	-	-
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		0.015	F3 Americamysis bahia	High
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		-	-	-
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		-	-	-
Non-target plants		-	-	-
		-	-	-
Algae - Acute 72 hour EC50, growth (mg l-1)		28.3	K3 Unknown species	Low
Algae - Chronic 96 hour NOEC, growth (mg l-1)		3.2	Q2 Unknown species	Low
Honeybees	Contact acute 48 hour LD50 (μg bee-1)	5.56	A5	Moderate
	Oral acute 48 hour LD50 (μg bee-1)	-	-	-
	Unknown mode acute 48 hour LD50 (μg bee-1)	-	-	-
Earthworms - Acute 14 day LC50 (mg kg-1)		39.6	A5 Eisenia foetida	Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		8.3	A5 Eisenia foetida, 56 days	Moderate
Other soil macro-organisms - e.g. Collembola	LR50 / EC50 / NOEC / % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	-	-	-
	% Effect	100	Mortality Dose: 7 kg ha-1 A5 Poecilus cupreus, adult	-
Other arthropod (2)	LR50 g ha-1	-	-	-
	% Effect	100	Mortality Dose: 10 kg ha-1 A5 Aleochara bilineata, adult	-
Soil micro-organisms		Nitrogen mineralisation: No significant adverse effect Carbon mineralisation: No significant adverse effect	A5 Dose: 33.3 mg kg-1 soil, 44 days	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION
for ethoprophos

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Threshold of Toxicological Concern (Cramer Class)		High (class III)	-	-
Mammals - Acute oral LD50 (mg kg-1)		40	A4 Rat	High
Mammals - Dermal LD50 (mg kg-1 body weight)		7.9	A5 Rabbit	-
Mammals - Inhalation LC50 (mg l-1)		0.123	A5 Rat, 4 hr (nose only)	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.0004	A5 Rat, SF=100	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		0.01	A5 Rat, SF=100	-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1)		-	-	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		0.001	A5 Dog, SF=100	-
Dermal penetration studies (%)		10	A5	-
Dangerous Substances Directive 76/464		List I; List II	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	No unacceptable risks to bystanders identified
	Occupational	Exposure possible but acceptable under label recommendations for use concerning personal protection clothing and equipment Dermal exposure likely to be low
European MRLs		Click here for the EU MRL pesticide database
Drinking Water Standards		-	-	-
Drinking Water MAC (μg l-1)		-	-	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Cholinesterase inhibitor	Neurotoxicant
			-
Respiratory tract irritant	Skin irritant	Skin sensitiser	Eye irritant	Phototoxicant
-
General human health issues		Very toxic by inhalation and dermal absorption USEPA - probable human carcinogen

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		Not explosive IMDG Transport Code is usually 6.1
CLP classification 2013		Health: H301, H310, H317, H330 Environment: H400, H410
EC Risk Classification		T+ - Very toxic: R26/27 T - Toxic: R25 Xn - Harmful: R43 N - Dangerous for the environment: R50, R53
EC Safety Classification		S1/2, S27/28, S36/37/39, S45, S60, S61
WHO Classification		Ia	-	Extremely hazardous
US EPA Classification (formulation)		II	-	Warning - Moderately toxic
UN Number		3018
Waste disposal & packaging		Packaging Group II (medium danger)

TRANSLATIONS
for ethoprophos

Language	Name
English	ethoprophos
French	ethoprophos
German	Ethoprophos
Danish	ethoprophos
Italian	etoprofos
Spanish	etoprofos; etoprop
Greek	ethoprophos
Slovenian	etoprofos
Polish	etoprofos
Swedish	-
Hungarian	-
Dutch	ethoprofos

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Record last updated: Thursday 23 August 2018
Contact: aeru@herts.ac.uk