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aminopyralid (Ref: XDE 750)
** 4-amino-3,6-dichloropicolinic acid ** DE 750 ** XR 750 ** GF-839 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Aminopyralid is a pyridine carboxylic acid herbicide that is currently under approval consideration for use in the EU. It is non-volatile, highly soluble in water and, based on its chemical properties, is mobile and has a high potential for leaching to groundwater. It may be moderately persistent in soil systems but would not be expected to persistent in surface water under normal conditions. It has a low mammalian toxicity and there is some concern regarding its potential for bioaccumulation. Aminopyralid has a low to moderate toxicity to most terrestrial and aquatic species.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for aminopyralid

Description: A pyridine carboxylic acid herbicide for the long-term control of noxious and invasive broad-leaved weeds in grassland

Example pests controlled: Broomweed; Buttercups; Cocklebur; Daisy; Fleabane; Knapweed; Ragweed; Ragwort; Lambsquarter

Example applications: Rangeland; Permanent grass; Non-cropped areas including paths; roadways

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 2005

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur UK
Date inclusion expires 31/12/2024
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, USA (pending)

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C6H4Cl2N2O2
Canonical SMILES C1=C(C(=C(N=C1Cl)C(=O)O)Cl)N
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) NIXXQNOQHKNPEJ-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C6H4Cl2N2O2/c7-3-1-2(9)4(8)5(10-3)6(11)12/h1H,(H2,9,10)(H,11,12)/f/h11H,9H2
2D structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Pyridine compound
Minimum active substance purity 920 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Systemic, post-emergence action, absorbed by leaves and roots, some residual action
CAS RN 150114-71-9
EC number -
CIPAC number 771
US EPA chemical code 005100
PubChem CID 213012
Molecular mass (g mol-1) 207.03
PIN (Preferred Identification Name) 4-amino-3,6-dichloropyridine-2-carboxylic acid
IUPAC name 4-amino-3,6-dichloropyridine-2-carboxylic acid
CAS name 4-amino-3,6-dichloro-2-pyridinecarboxylic acid
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not known
Herbicide Resistance Classification (WSSA) -
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Off-white powder
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Dow Agrosciences
Example products using this active
  • CleanWave
  • Forefront
  • Pharoah
  • Milestone
  • Banish
UK LERAP status None
Formulation and application details Often available as an oil in water concentrate that is mixed with water and used as a spray.


ENVIRONMENTAL FATE

for aminopyralid

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 2480 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 29200 A5 - Acetone -
3940 A5 - Ethyl acetate -
52200 A5 - Methanol -
40 A5 - Xylene -
Melting point (oC) 163.5 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 334 A3 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.35 X 10-03 Calculated -
Log P -2.87 A5 Low
Bulk density (g ml-1)/Specific gravity 1.76 A5 -
Dissociation constant (pKa) at 25oC 2.56 A5 -
Note: Strong acid
Vapour pressure at 20oC (mPa) 2.59 X 10-09 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 9.61 X 10-12 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 5.37 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 4.99 X 10+00 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 At pH 1.4 maxima = 217nm; [At pH 5 maxima = 217nm; [At pH 12.6 maxima = 220nm A5 -
Surface tension (mN m-1) 71.0 A5 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 35 E4 Moderately persistent
DT50 (lab at 20oC) 55.5 A5 Moderately persistent
DT50 (field) 21.1 A5 Non-persistent
DT90 (lab at 20oC) 287.8 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 26.4-146.9 days, DT90 range 87.6-488 days, field studies DT50 range 8-35 days; Manufacturer lab data DT50 9-54 days; Other literature Lab studies range 31.5-533.2 days, 5 soils
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value 0.6 E4 Fast
Note DT50: 0.6 days at pH 5. Main route of degradation on aquatic environments
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 5 to pH 9 at temps 20 and 50 DegC
Water-sediment DT50 (days) 712 A5 Stable
Water phase only DT50 (days) 250 A5 Stable

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 0.17 A5 Very mobile
Kfoc 8.3
1/n 0.852
Notes and range EU dossier Kf range 0.01-0.73 mL/g, Kfoc range 0.31-21.7 mL/g, 1/n range 0.32-1.52, Soils=8
pH sensitivity Adsorption higher at low pH


ECOTOXICOLOGY

for aminopyralid

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 100 F4 Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 5000 F4 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) > 465 F4 Rat Moderate
(ppm diet) > 1000 -
Birds - Acute LD50 (mg kg-1) > 2250 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) > 100 A5 Oncorhynchus mykiss Low
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 100 A5 Daphnia magna Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 100 E4 Daphnia magna Low
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 100 E4 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 130 A5 Chironomus riparius Low
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) 46.7 A5 Chironomus riparius Moderate
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 88 A5 Lemna gibba Low
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 30 F4 Pseudokirchneriella subcapitata Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 6.26 A5 Moderate
Oral acute 48 hour LD50 (μg bee-1) > 3.13 A5 Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 21.5 Mortality
Dose: 0.03 kg ha-1
A5 Aphidius rhopalosiphi
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 12.6 Mortality
Dose: 0.08 kg ha-1
A5 Typhlodromus pyri
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 100x field rate for grassland
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for aminopyralid

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 F4 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 5.5 A5 Rat, 4 hr -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.26 A3 proposed Rabbit, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.26 A3 proposed Rabbit, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.26 A3 proposed Rabbit, SF=100 -
Dermal penetration studies (%) 50 UK ACP -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Low risk to bystanders
Occupational Acceptable risk to operators with PPE/PPC
Low risk to other farm workers
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 0.1 EU Dir 89/778/EC limit; A5 Calc MAC=4260 μg l-1 -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

General human health issues May damage the corneal resulting in permanent impairment of vision and blindness

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Flammable
Corrosive
CLP classification 2013 Health: H302
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R41
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) IV - Caution - Not acutely toxic
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for aminopyralid

Language Name
English aminopyralid
French aminopyralid
German Aminopyralid
Danish aminopyralid
Italian aminopyralid
Spanish aminopiralida
Greek -
Slovenian aminopiralid
Polish aminopiralid
Swedish aminopyralid
Hungarian -
Dutch -

Record last updated: Thursday 13 September 2018
Contact: aeru@herts.ac.uk