Thiophanate |
![]() Last updated: 16/03/2021 |
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(Also known as: thiophanate; thiofanate; banrot; thiophanate ethyl) |
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A systemic fungicide effective with protective and curative activity against a broad spectrum of diseases in fruit, vegetables and other crops | |
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Eyespot; Scab; Powdery mildew; Grey mould; Leaf spot; Rusts; brown spot; Brown Rot; Root rots | |
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Apples & pears; Small grains; Curcubits; Soybeans; Peanuts, Pecans; Garlic & onions; Almonds; Strawberries | |
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Wheat/Ear blight=Low | |
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Current | |
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1971, first registered Japan |
UK regulatory status |
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Not approved | ||
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Expired | ||
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None (may vary with mixtures) |
EC Regulation 1107/2009 (repealing 91/414) |
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Not approved | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Germany | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Expired | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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No | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Yes | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Also used in |
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Chemical structure |
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C₁₄H₁₈N₄O₄S₂ | |
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CCOC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OCC | |
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No data | |
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YFNCATAIYKQPOO-UHFFFAOYSA-N | |
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InChI=1S/C14H18N4O4S2/c1-3-21-13(19)17-11(23)15-9-7-5-6-8-10(9)16-12(24)18-14(20)22-4-2/h5-8H,3-4H2,1-2H3,(H2,15,17,19,23)(H2,16,18,20,24) | |
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Yes |
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Common Name | Relationship | Link |
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thiophanate | - | ![]() |
General status |
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Fungicide | |
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Benzimidazole | |
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Synthetic | |
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Inhibition of mitosis and cell division (Beta-tubulin assembly in mitosis). | |
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23564-06-9 | |
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245-741-2 | |
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262 | |
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103401 | |
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3032792 | |
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370.45 | |
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diethyl N,N'-(1,2-phenylenebis(azanediylcarbonothioyl))dicarbamate | |
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diethyl 4,4'-(o-phenylene)bis(3-thioallophanate) | |
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diethyl N,N'-(1,2-phenylenebis(iminocarbonothioyl))bis(carbamate) | |
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Not applicable | |
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Not applicable | |
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Not applicable | |
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Colourless crystals | |
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Formulations |
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Usually formulated as a wettable powder |
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Degradation |
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Soil adsorption and mobility |
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Fate indices |
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Key metabolites |
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Soil | - | Major fraction, Relevant | |||||
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Soil | - | - |
Other known metabolites |
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- | 5-OH-MBC-sulfate | Animal | - | - | |||||
- | 5-OH-MBC | Animal | - | - | |||||
- | 4-OH-thiophanate-methyl, MBC | Animal | - | - |
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> 5000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat as methyl variant5 = Verified data used for regulatory purposes |
Low | ||||||||
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- | L3 L = Pesticide manuals and hard copy reference books / other sources Rat as methyl variant3 = Unverified data of known source |
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> 2.5 | - | |||||||||
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> 4640 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Anas platyrhynchos as methyl variant5 = Verified data used for regulatory purposes |
Low | ||||||||
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> 10000 mg kg feed⁻¹ | A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Unknown species as methyl variant4 = Verified data |
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11.0 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Oncorhynchus mykiss as methyl variant5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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0.32 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Salmo gairdneri as methyl variant5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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5.4 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Daphnia magna as methyl variant5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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0.18 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Daphnia magna as methyl variant5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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1.0 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Americamysis bahia as methyl variant3 = Unverified data of known source |
Moderate | ||||||||
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0.5 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Chironomus riparius as methyl variant5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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4.7 | F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents (US EPA Databases Related to Pesticide Risk Assessment ) Lemna gibba as methyl variant3 = Unverified data of known source |
Moderate | ||||||||
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> 25.4 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Pseudokirchneriella subcapitata as methyl variant5 = Verified data used for regulatory purposes |
Low | ||||||||
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> 100 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) as methyl variant5 = Verified data used for regulatory purposes |
Low | |||||||
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> 100 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) as methyl variant5 = Verified data used for regulatory purposes |
Low | ||||||||
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> 13.2 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Eisenia foetida as methyl variant5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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0.85 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Eisenia foetida as methyl variant5 = Verified data used for regulatory purposes |
Moderate | ||||||||
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General |
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High (class III) | - | - | ||||||||
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> 5000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat as methyl variant5 = Verified data used for regulatory purposes |
Low | ||||||||
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2000 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat as methyl variant5 = Verified data used for regulatory purposes |
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1.7 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rat as methyl variant5 = Verified data used for regulatory purposes |
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0.08 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Dog SF=100 as methyl variant5 = Verified data used for regulatory purposes |
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0.2 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Rabbit SF=100 as methyl variant5 = Verified data used for regulatory purposes |
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0.08 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) Dog SF=100 as methyl variant5 = Verified data used for regulatory purposes |
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10 | A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications ) 5 = Verified data used for regulatory purposes |
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Health issues |
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Mutagenic potential |
Handling issues |
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Prevent generation of dust Some explosive potential IMDG Transport Code is usually 9 |
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Health: H317, H332, H341 Environment: H400, H410 |
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Mutagenic category 3: R68 Xn - Harmful: R20, R43 N - Dangerous for the environment: R50, R53 |
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S2, S36/37, S46, S60, S61 | |||
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U (Unlikely to present an acute hazard) | |||
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Usually 3077 | |||
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Packaging Group III (minor danger) |
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thiophanate | ||
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thiophanate | ||
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Thiophanat-methyl | ||
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thiophanate-methyl | ||
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tiofanato-metile | ||
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tiofanato de metilo | ||
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tiofanat metylowy | ||
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tiofanatmetyl | ||
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tiophanate-methyl | ||
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thiofanaat-methyl |
Record last updated: | 16/03/2021 |
Contact: | aeru@herts.ac.uk |
Please cite as: | Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242 |