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fenitrothion (Ref: OMS 43)
** MEP ** OMS 223 ** ENT 25715 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION
for fenitrothion

Description: An insecticide used to control chewing, sucking and boring pests on a range of crops

Introduction: 1960, first reported

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur UK
Date inclusion expires Expired

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also registered in: Australia

General status:
Pesticide type Insecticide
Substance group Organophosphate
Substance origin Synthetic
Mode of action Non-systemic, broad spectrum with contact and stomach action. Acetylcholinesterase (AChE) inhibitor.
CAS RN 122-14-5
EC number 204-524-2
CIPAC number 35
US EPA chemical code 105901
Chiral molecule No
Chemical formula C9H12NO5PS
SMILES S=P(Oc1cc(c(cc1)[N+]([O-])=O)C)(OC)OC
International Chemical Identifier key (InChIKey) -
International Chemical Identifier (InChI) InChI=1/C9H12NO5PS/c1-7-6-8(4-5-9(7)10(11)12)15-16(17,13-2)14-3/h4-6H,1-3H3
Structure diagram/image available? Yes
Molecular mass (g mol-1) 277.23
PIN (Preferred Identification Name) O,O-dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate
IUPAC name O,O-dimethyl O-4-nitro-m-tolyl phosphorothioate
CAS name O,O-dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate
Other status information -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 1B
Fungicide Resistance Classification (FRAC) Not applicable
Physical state Yellow brown liquid
Related substances & organisms

Formulations:
Property Value
Example manufacturers & suppliers of products using this active
  • FCC
  • Agropharm
  • King Tech Corp
Example products using this active
  • IPM 400
  • Fenitrocap IPM400
  • Fenifos
  • Nition
UK LERAP status No UK approval for use or outside scope
Formulation and application details Often supplied as a capsule suspension that is mixed with water and used as a spray.


ENVIRONMENTAL FATE

for fenitrothion

Property Value Source/Quality Score/Other Information Interpretation
Solubility - In water at 20oC (mg l-1) 19 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 25000 A5 - n-Hexane -
500000 A5 - Methanol -
500000 A5 - Acetone -
500000 A5 - Ethyl acetate -
Melting point (oC) 1 A3 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 210 A5 -
Flashpoint (oC) 157 L3 -
Octanol-water partition coefficient at pH 7, 20oC P 2.09 X 1003 Calculated -
Log P 3.32 A5 High
Bulk density (g ml-1)/Specific gravity 1.33 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 25oC (mPa) 0.676 A5 Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1) 9.86 X 10-03 A5 Non-volatile
Henry's law constant at 20oC (dimensionless) 3.00 X 10-06 K3 Moderately volatile
GUS leaching potential index 0.48 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Value 1.25 X 10-03 Calculated -
Note -
Potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 290nm = 4210; [Acidic solution: 290nm = 4390; [Basic solution: 290nm = 2370 A5 -
Surface tension (mN m-1) 68.5 A5 -

Degradation:
Property Value Source/Quality Score/Other Information Interpretation
Soil degradation (days) (aerobic) DT50 (typical) 2.7 A5 Non-persistent
DT50 (lab at 20oC) 2.7 A5 Non-persistent
DT50 (field) - - -
DT90 (lab at 20oC) 4.48 A5 -
DT90 (field) - - -
Note EU dossier lab studies DT50 range 0.04-1.98 days, DT90 range 2.16-6.58 days
Aqueous photolysis DT50 (days) at pH 7 Value 3.5 A5 Moderately fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 183 A5 Persistent
Note Slightly sensitive to pH: DT50 195 days at pH5, 100 days at pH 9
Water-sediment DT50 (days) 1.57 A5 Fast
Water phase only DT50 (days) 1.1 A5 Moderately fast

Soil adsorption and mobility:
Property Value Source/Quality Score/Other Information Interpretation
Linear Kd - DW2 Slightly mobile
Koc 2000
Notes and range -
Freundlich Kf 180 A5 Slightly mobile
Kfoc 791
1/n 0.982
Notes and range EU dossier Kf range 4.9-830 mL/g, Kfoc range 252-1966 mL/g, 1/n range 0.86-1.10, Soils=5
pH sensitivity Some indication that adsorption may increase with decreasing pH

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 91/414 relevancy
3-methyl-4-nitrophenol Soil   0.445   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
desmethylfenitrothion - Water - -
aminofenitrothion - Soil (Aerobic) - -
fenitrooxon - Soil (Aerobic); Water - -
formylaminofenitrothion - Soil (Aerobic) - -
desmethylfenitrooxon - Soil (Aerobic) - -
acetylaminofenitrothion - Water - -
o-methyl o-hydrogen o-(3-methyl-4-nitrophenyl)phosphate DM-SMO Water (Photolysis) - -
o-methyl s-methyl o-(3-methyl-4-nitrophenyl)phosphorothioate SCH3-SMT Water (Photolysis) - -
o,o-dimethyl o-(3-methyl-4-nitrophenyl)phosphorothioate SMO Water (Photolysis) - -
carboxyfenitrothion - Water (Photolysis) - -
O,O-dimethyl O-(3-carboxy-4-nitrophenyl)phosphate COOH-SMO Water (Photolysis) - -
3-methyl-4-nitroanisole - Soil (Aerobic) - -


ECOTOXICOLOGY

for fenitrothion

Property Value Source/Quality Score/Other Information Interpretation
Bio-concentration factor BCF 29 A5 (Other literature values Log BCF ranger 0.8-2.9 (R3)) Low potential
CT50 (days) 0.19 -
Bioaccumulation potential - Calculated Low
Mammals - Acute oral LD50 (mg kg-1) 330 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - L2 Rat, 2 year -
(ppm diet) > 10 -
Birds - Acute LD50 (mg kg-1) 2.3 A5 Phasianidae High
Birds - Short term dietary (LC50/LD50) 23 mg kg bw-1 day-1 A4 Unknown species -
Fish - Acute 96 hour LC50 (mg l-1) 1.3 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.088 A3 Oncorhynchus mykiss, 96 day -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.0086 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.000087 A5 Daphnia magna -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.0017 A5 Chironomus riparius High
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Algae - Acute 72 hour EC50, growth (mg l-1) 1.3 A5 Raphidocelis subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.1 Q1 Unknown species Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) 0.16 A5 High
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 231 A5 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 25 A5 Eisenia foetida Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 10.8 Mortality
Dose: 2 x 750 g ha-1
A5 Aphidius rhopalosiphi, adult
Harmless
Other arthropod (2) LR50 g ha-1 - - -
% Effect 5.6 Mortality
Dose: 2 x 750 g ha-1
A5 Typhlodromus pyri, protonymph
Harmless
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 10 mg kg-1 soil
-
Mesocosm study data NOEAEC mg l-1 0.017 A5 Aquatic invertebrates -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for fenitrothion

General:
Property Value Source/Quality Score/Other Information Interpretation
Mammals - Acute oral LD50 (mg kg-1) 330 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) 890 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 2.2 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.005 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.013 A5 Rat, SF=100 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) None allocated A5 -
Dermal penetration studies (%) 3.9-20.9 A5 concentration dependant -
Dangerous Substances Directive 76/464 List I; List II - -
Exposure Limits - - -
Exposure Routes Public -
Occupational Possible risk when applied inside glasshouses
Re-entry after application should be avoided
Examples of European MRLs (mg kg-1) Value Vegetables and fruit: 0.01
Note Current May 2007.
For the EU pesticides database click here
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant Respiratory tract irritant Skin irritant Eye irritant

-

-

General human health issues Skin sensitiser
Risk of serious eye damage
Bioaccumulates

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:
Property Value Source/Quality Score/Other Information Interpretation
General Potentially explosive under certain conditions
Prevent generation of mists
IMDG Transport Code is usually 6.1
CLP classification 2013 -
EC Risk Classification Xn - Harmful: R22
N - Dangerous for the environment: R50, R53
EC Safety Classification S2, S60, S61
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) II - Warning - Moderately toxic
UN Number Usually 3018
Waste disposal & packaging Packaging Group III (minor danger)


TRANSLATIONS

for fenitrothion

Language Name
English fenitrothion
French fenitrothion
German Fenitrothion
Danish fenitrothion
Italian fenitrotion
Spanish fenitrotion
Greek fenitrothion
Slovenian fenitrotion
Polish fenitrotion
Swedish fenitrotion
Hungarian fenitrothion
Dutch fenitrothion

Record last updated: Saturday 02 August 2014
Contact: aeru@herts.ac.uk