Select Option
A to Z
Terms & Conditions
Support Information
Purchasing & Other Services
Video User Guides

fenitrothion (Ref: OMS 43)
** MEP ** OMS 223 ** ENT 25715 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home


Fenitrothion is an insecticide that is no longer approved for use in the EU. It has a low aqueous solubility, is highly soluble in many organic solvents and is volatile. Fenitrothion has a low potential for leaching to groundwater and is not expected to be persistent in soil or water systems. It is moderately toxic to mammals, considered to be an endocrine disrupter and a cholinesterase inhibitor. It is highly toxic to birds, aquatic invertebrates and honeybees, and moderately toxic to fish, algae and earthworms.

for fenitrothion

Description: An insecticide used to control chewing, sucking and boring pests on a range of cr

Example pests controlled: Leafminers, Locusts, Stem borers, Wheat bugs, Flour beetles, Grain beetles, Grain weevils

Example applications: Cereals; Cotton; Rice; Top fruit; Vegetables; Forestry; Ornamentals

Availability status: Current

Introduction & key dates: 1960, first reported

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur UK
Date inclusion expires Expired

Approved for use () or known to be used () in the following European countries:





























Also used in: Australia

General status:
Pesticide type Insecticide
Substance group Organophosphate
Minimum active substance purity 930 g/kg
Known relevant impurities EU dossier - S-methyl fenitrothion <5g/Kg
Substance origin Synthetic
Mode of action Non-systemic with contact and stomach action. Cholinesterase inhibitor.
EC number 204-524-2
CIPAC number 35
US EPA chemical code 105901
Chiral molecule No
Chemical formula C9H12NO5PS
SMILES S=P(Oc1cc(c(cc1)[N+]([O-])=O)C)(OC)OC
International Chemical Identifier key (InChIKey) ZNOLGFHPUIJIMJ-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C9H12NO5PS/c1-7-6-8(4-5-9(7)10(11)12)15-16(17,13-2)14-3/h4-6H,1-3H3
Structure diagram/image available? Yes
Molecular mass (g mol-1) 277.23
PIN (Preferred Identification Name) O,O-dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate
IUPAC name O,O-dimethyl O-4-nitro-m-tolyl phosphorothioate
CAS name O,O-dimethyl O-(3-methyl-4-nitrophenyl) phosphorothioate
Other status information Chemical subject to PIC regulations
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 1B
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Many recorded cases
Adoxophyes orana
Boophilus microplus
Lucilia cuprina
Myzus persicae
Spodoptera littoralis
Physical state Yellow brown liquid
Related substances & organisms

Property Value
Example manufacturers & suppliers of products using this active now or historically
  • FCC
  • Agropharm
  • King Tech Corp
  • Bayer
  • Sumitomo
  • Denka
Example products using this active
  • IPM 400
  • Fenitrocap IPM400
  • Fenifos
  • Nition
  • Accothion
  • Novathion
UK LERAP status No UK approval for use or outside scope
Formulation and application details Supplied in a variety of formulations including emulsifiable concentrates, wettable powders, granules and dusts as well as ULV .


for fenitrothion

Property Value Source/Quality Score/Other Information Interpretation
Solubility - In water at 20oC (mg l-1) 19 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 25000 A5 - n-Hexane -
500000 A5 - Methanol -
500000 A5 - Acetone -
500000 A5 - Ethyl acetate -
Melting point (oC) 1 A3 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 210 A5 -
Flashpoint (oC) 157 L3 -
Octanol-water partition coefficient at pH 7, 20oC P 2.09 X 1003 Calculated -
Log P 3.32 A5 High
Bulk density (g ml-1)/Specific gravity 1.33 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 25oC (mPa) 0.676 A5 Volatile
Henry's law constant at 25oC (Pa m3 mol-1) 9.86 X 10-03 A5 Non-volatile
Henry's law constant at 20oC (dimensionless) 3.00 X 10-06 K3 Moderately volatile
GUS leaching potential index 0.48 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Value 1.25 X 10-03 Calculated -
Note -
Potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 290nm = 4210; [Acidic solution: 290nm = 4390; [Basic solution: 290nm = 2370 A5 -
Surface tension (mN m-1) 68.5 A5 -

Property Value Source/Quality Score/Other Information Interpretation
Soil degradation (days) (aerobic) DT50 (typical) 2.7 A5 Non-persistent
DT50 (lab at 20oC) 2.7 A5 Non-persistent
DT50 (field) - - -
DT90 (lab at 20oC) 4.48 A5 -
DT90 (field) - - -
Note EU dossier lab studies DT50 range 0.04-1.98 days, DT90 range 2.16-6.58 days
Plant matrix DT50 (days) Value 5.6 R4 -
Note DT50 range 0.5 - 28.9 days, 19 crops/plants, various matrices
Aqueous photolysis DT50 (days) at pH 7 Value 3.5 A5 Moderately fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 183 A5 Persistent
Note Slightly sensitive to pH: DT50 195 days at pH5, 100 days at pH 9
Water-sediment DT50 (days) 1.57 A5 Fast
Water phase only DT50 (days) 1.1 A5 Moderately fast

Soil adsorption and mobility:
Property Value Source/Quality Score/Other Information Interpretation
Linear Kd - DW2 Slightly mobile
Koc 2000
Notes and range -
Freundlich Kf 180 A5 Slightly mobile
Kfoc 791
1/n 0.982
Notes and range EU dossier Kf range 4.9-830 mL/g, Kfoc range 252-1966 mL/g, 1/n range 0.86-1.10, Soils=5
pH sensitivity Some indication that adsorption may increase with decreasing pH

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 91/414 relevancy
3-methyl-4-nitrophenol Soil   0.445   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
desmethylfenitrothion - Water - -
aminofenitrothion - Soil (Aerobic) - -
fenitrooxon - Soil (Aerobic); Water - -
formylaminofenitrothion - Soil (Aerobic) - -
desmethylfenitrooxon - Soil (Aerobic) - -
acetylaminofenitrothion - Water - -
o-methyl o-hydrogen o-(3-methyl-4-nitrophenyl)phosphate DM-SMO Water (Photolysis) - -
o-methyl s-methyl o-(3-methyl-4-nitrophenyl)phosphorothioate SCH3-SMT Water (Photolysis) - -
o,o-dimethyl o-(3-methyl-4-nitrophenyl)phosphorothioate SMO Water (Photolysis) - -
carboxyfenitrothion - Water (Photolysis) - -
O,O-dimethyl O-(3-carboxy-4-nitrophenyl)phosphate COOH-SMO Water (Photolysis) - -
3-methyl-4-nitroanisole - Soil (Aerobic) - -


for fenitrothion

Property Value Source/Quality Score/Other Information Interpretation
Bio-concentration factor BCF (l kg-1) 29 A5 (Other literature values Log BCF ranger 0.8-2.9 (R3)) Low potential
CT50 (days) 0.19 -
Mammals - Acute oral LD50 (mg kg-1) 330 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - L2 Rat, 2 year -
(ppm diet) > 10 -
Birds - Acute LD50 (mg kg-1) 2.3 A5 Phasianidae High
Birds - Short term dietary (LC50/LD50) 23 mg kg bw-1 day-1 A4 Unknown species -
Fish - Acute 96 hour LC50 (mg l-1) 1.3 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.088 A3 Oncorhynchus mykiss, 96 day Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.0086 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.000087 A5 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.0017 A5 Chironomus riparius High
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 1.3 A5 Raphidocelis subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.1 Q1 Unknown species Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) 0.16 A5 High
Oral acute 48 hour LD50 (μg bee-1) 0.20 A5 High
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 231 A5 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 25 A5 Eisenia foetida Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 10.8 Mortality
Dose: 2 x 750 g ha-1
A5 Aphidius rhopalosiphi, adult
Other arthropod (2) LR50 g ha-1 - - -
% Effect 5.6 Mortality
Dose: 2 x 750 g ha-1
A5 Typhlodromus pyri, protonymph
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
Dose: 10 mg kg-1 soil
Mesocosm study data NOEAEC mg l-1 0.017 A5 Aquatic invertebrates -
NOEAEC mg l-1 - - -


for fenitrothion

Property Value Source/Quality Score/Other Information Interpretation
Threshold of Toxicological Concern (Cramer Class) High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 330 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) 890 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 2.2 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.005 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.013 A5 Rat, SF=100 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) None allocated A5 -
Dermal penetration studies (%) 3.9-20.9 A5 concentration dependant -
Dangerous Substances Directive 76/464 List I; List II - -
Exposure Limits - - -
Exposure Routes Public -
Occupational Possible risk when applied inside glasshouses
Re-entry after application should be avoided
European MRLs Click here for the EU MRL pesticide database
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant



General human health issues Risk of serious eye damage

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Value Source/Quality Score/Other Information Interpretation
General Potentially explosive under certain conditions
Prevent generation of mists
IMDG Transport Code is usually 6.1
CLP classification 2013 Health: H302
Environment: H400, H410
EC Risk Classification Xn - Harmful: R22
N - Dangerous for the environment: R50, R53
EC Safety Classification S2, S60, S61
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) II - Warning - Moderately toxic
UN Number Usually 3018
Waste disposal & packaging Packaging Group III (minor danger)


for fenitrothion

Language Name
English fenitrothion
French fenitrothion
German Fenitrothion
Danish fenitrothion
Italian fenitrotion
Spanish fenitrotion
Greek fenitrothion
Slovenian fenitrotion
Polish fenitrotion
Swedish fenitrotion
Hungarian fenitrothion
Dutch fenitrothion

Record last updated: Saturday 13 August 2016