| fenoxycarb (Ref: OMS 3010) |
 |
Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
GENERAL INFORMATION 
for fenoxycarb
Description: An insect specific growth regulator used to control moths, scale insects and other insects on fruit, vines and ornamentals
Example pests controlled: Fire ants; Fleas; Mosquitoes; Coachroach; Lepidoptera moths; Scale insects
Example applications: Olives; Vines; Cotton; Various fruits; Stored produce; Ornamentals; Turf
Availability status: Current
Introduction & key dates: 1981, first reported; 1985, first marketed
EC Regulation 1107/2009 (repealing 91/414):
| Status | Approved |
| Dossier rapporteur/co-rapporteur | Netherlands |
| Date inclusion expires | 31/05/2021 |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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Also used in: Australia, USA
General status:
| Pesticide type | Insecticide | |||
| Substance group | Carbamate | |||
| Minimum active substance purity | 960 g/kg | |||
| Known relevant impurities | EU dossier - Toluene <1g/kg | |||
| Substance origin | Synthetic | |||
| Mode of action | Non-neurotoxic with contact and stomach action, acts by mimicing the action of the juvenile hormone keeping the insect in an immature state | |||
| CAS RN | 79127-80-3 | |||
| EC number | 276-696-7 | |||
| CIPAC number | 425 | |||
| US EPA chemical code | 125301 | |||
| Chiral molecule | No | |||
| Chemical formula | C17H19NO4 | |||
| SMILES | O=C(OCC)NCCOc2ccc(Oc1ccccc1)cc2 | |||
| International Chemical Identifier key (InChIKey) | HJUFTIJOISQSKQ-UHFFFAOYSA-N | |||
| International Chemical Identifier (InChI) | InChI=1S/C17H19NO4/c1-2-20-17(19)18-12-13-21-14-8-10-16(11-9-14)22-15-6-4-3-5-7-15/h3-11H,2,12-13H2,1H3,(H,18,19) | |||
| Structure diagram/image available? | Yes | |||
| Molecular mass (g mol-1) | 301.34 | |||
| PIN (Preferred Identification Name) | ethyl [2-(4-phenoxyphenoxy)ethyl]carbamate | |||
| IUPAC name | ethyl 2-(4-phenoxyphenoxy)ethylcarbamate | |||
| CAS name | ethyl (2-(4-phenoxyphenoxy)ethyl)carbamate | |||
| Other status information | - | |||
| Herbicide Resistance Classification (HRAC) | Not applicable | |||
| Herbicide Resistance Classification (WSSA) | Not applicable | |||
| Insecticide Resistance Classification (IRAC) | 7B | |||
| Fungicide Resistance Classification (FRAC) | Not applicable | |||
| Examples of recorded resistance | Cydia pomonella | |||
| Physical state | White flaky powder | |||
| Related substances & organisms | - | |||
Formulations:
| Property |
Value | |||
| Example manufacturers & suppliers of products using this active now or historically |
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| Example products using this active |
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| UK LERAP status | Buffer probably required in UK - see product label | |||
| Formulation and application details | Supplied as wettable granules, micro-emulsions, emulsifiable concentrates, granules and dusts. | |||
ENVIRONMENTAL FATE
for fenoxycarb
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Solubility - In water at 20oC (mg l-1) | 7.9 | A5 | Low | |
| Solubility - In organic solvents at 20oC (mg l-1) | 500000 | A5 - Ethyl acetate | - | |
| 500000 | A5 - Acetone | - | ||
| 500000 | A5 - Toluene | - | ||
| 4600 | A5 - n-Hexane | - | ||
| Melting point (oC) | 53.6 | A5 | - | |
| Boiling point (oC) | 100.4 | A3 | - | |
| Degradation point (oC) | 248 | A5 | - | |
| Flashpoint (oC) | Not expected to self ignite; Not highly flammable | A5 | - | |
| Octanol-water partition coefficient at pH 7, 20oC | P | 1.17 X 1004 | Calculated | - |
| Log P | 4.07 | A5 | High | |
| Bulk density (g ml-1)/Specific gravity | 1.23 | B5 | - | |
| Dissociation constant (pKa) at 25oC | Not applicable | A5 | - | |
| Note: No dissociation | ||||
| Vapour pressure at 25oC (mPa) | 8.67 X 10-04 | A5 | Low volatility | |
| Henry's law constant at 25oC (Pa m3 mol-1) | 3.3 X 10-05 | A5 | Non-volatile | |
| Henry's law constant at 20oC (dimensionless) | 1.89 X 10-08 | Q2 | Non-volatile | |
GUS leaching potential index  |
0.14 | Calculated | Low leachability | |
| SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Value | 3.47 X 10-04 | Calculated | - |
| Note | - | |||
| Potential for particle bound transport index |
- | Calculated | Medium | |
| Maximum UV-vis absorption L mol-1 cm-1 | Neutral solution: 228nm = 15219, 278nm = 2453, 300nm = 745; [Acidic solution: 228nm = 15062, 278nm = 2357, 300nm = 643; [Basic solution: 228nm = 14879, 278nm = 2374, 300nm = 664 | A5 | - | |
| Surface tension (mN m-1) | 56.7-57.6 | A5 at 20oC | - | |
Degradation:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Soil degradation (days) (aerobic) | DT50 (typical) | 1.55 | A5 | Non-persistent |
| DT50 (lab at 20oC) | 1.55 | A5 | Non-persistent | |
| DT50 (field) | 5.94 | A5 | Non-persistent | |
| DT90 (lab at 20oC) | 26.1 | A5 | - | |
| DT90 (field) | 22.4 | A5 | - | |
| Note | EU dossier lab studies DT50 range 0.75-2.27 days, DT90 range 4.87-66.5 days; field studies DT50 range 4.08-8.89 days, DT90 range 13.55-29.53 | |||
| Plant matrix DT50 (days) | Value | 12.0 | R4 | - |
| Note | DT50 range 5.0 - 26.0 days, 3 crops/plants, fruit matrices | |||
| Aqueous photolysis DT50 (days) at pH 7 | Value | 16.1 | A5 | Slow |
| Note | - | |||
| Aqueous hydrolysis DT50 (days) at 20oC and pH 7 | Value | Stable | A5 | - |
| Note | Stable pH 3 to pH 9 up to 50 degC | |||
| Water-sediment DT50 (days) | 15 | A5 | Fast | |
| Water phase only DT50 (days) | 4.13 | A5 | Moderately fast | |
Soil adsorption and mobility:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Linear | Kd | - | - | - |
| Koc | - | |||
| Notes and range | - | |||
| Freundlich | Kf | 24.5 | A5 | Slightly mobile |
| Kfoc | 1816 | |||
| 1/n | 0.89 | |||
| Notes and range | EU dossier kf range 4.4-46.7 mL/g, Kfoc range 1251-2599 mL/g, 1/n range 0.84-0.96, Soils=5; Other literature studies: Mean of 4 soils. Sandy loam Kf=18-77; Loam Kf=77 | |||
| pH sensitivity | No | |||
Other known metabolites:
| Metabolite name and reference | Aliases | Formation medium / Rate | Estimated maximum occurrence fraction | Metabolising enzymes |
| ethyl [2-(p-(p-hydroxy phenoxy)ethyl) carbamate] | - | Soil (Aerobic) | - | - |
| ethyl [2-(p-(p-hydroxy phenoxy)phenoxy)ethyl) carbamate) | - | Soil (Aerobic) | - | - |
| (Ref: CGA 294847) | - | Water (Photolysis) | 0.169 | - |
| [2-[4,4-glucoronoxy-phenoxy)-phenoxyl]-ethyl]carbamic acid ethyl ester (Ref: CGA 294848) |
- | Rat (Urinary, Faeces); Soil (Aerobic) | - | - |
| (Ref: CGA 294850) Note: Minor metabolite |
Ro-16-8797 | Soil | - | - |
| (Ref: CGA 294851) | Ro-16-3192 | Rat (Liver) | - | - |
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Bio-concentration factor | BCF (l kg-1) | 215 | A5 Whole fish | Threshold for concern |
| CT50 (days) | 0.86 | - | ||
| Mammals - Acute oral LD50 (mg kg-1) | > 10000 | A5 Rat | Low | |
| Mammals - Short term dietary NOEL | (mg kg-1) | > 40 | A5 Rat | High |
| (ppm diet) | - | - | ||
| Birds - Acute LD50 (mg kg-1) | > 3000 | A5 Anas platyrhynchos | Low | |
| Birds - Short term dietary (LC50/LD50) | > 5885 mg kg bw-1 day-1 | A5 Anas platyrhynchos | - | |
| Fish - Acute 96 hour LC50 (mg l-1) | 0.66 | A5 Oncorhynchus mykiss | Moderate | |
| Fish - Chronic 21 day NOEC (mg l-1) | 0.048 | A5 Oncorhynchus mykiss | Moderate | |
| Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) | 0.5 | A5 Daphnia magna | Moderate | |
| Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) | 0.0032 | A5 Daphnia magna | High | |
| Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) | 0.00075 | A5 Chironomus riparius | High | |
| Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) | - | - | - | |
| Aquatic plants - Acute 7 day EC50, biomass (mg l-1) | - | - | - | |
| Non-target plants | > 450 | A5 Maize, Wild oat, OSR, Soybean Vegetative vigour, ER50 as g/ha |
- | |
| > 450 | A5 Maize, Wild oat, OSR, Soybean Seedling emergence, ER50 as g/ha |
- | ||
| Algae - Acute 72 hour EC50, growth (mg l-1) | 0.38 | A3 Pseudokirchneriella subcapitata, as product | Moderate | |
| Algae - Chronic 96 hour NOEC, growth (mg l-1) | - | - | - | |
| Honeybees | Contact acute 48 hour LD50 (μg bee-1) | > 204 | A4 | Low |
| Oral acute 48 hour LD50 (μg bee-1) | > 204 | A4 | Low | |
| Unknown mode acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Earthworms - Acute 14 day LC50 (mg kg-1) | > 425 | A5 Eisenia foetida | Moderate | |
| Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) | - | - | - | |
| Other soil macro-organisms - e.g. Collembola | LR50 / EC50 / NOEC / % Effect | 3052 | R4 Folsomia candida, NOEC: 12.5 mg kg-1 | - |
| Other arthropod (1) | LR50 g ha-1 | >463 | A5 Aphidius rhopalosiphi, adult | - |
| % Effect | - | - | - | |
| Other arthropod (2) | LR50 g ha-1 | >463 | A5 Typhlodromus pyri, protonymph | - |
| % Effect | - | - | - | |
| Soil micro-organisms | Nitrogen mineralisation: No significant adverse effect Carbon mineralisation: No significant adverse effect |
A5 Dose: 3.0 mg kg-1, 28days |
- | |
| Mesocosm study data | NOEAEC mg l-1 | 0.00032 | A4 Fish and aquatic invertebrates | - |
| NOEAEC mg l-1 | - | - | - | |
HUMAN HEALTH AND PROTECTION
for fenoxycarb
General:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Threshold of Toxicological Concern (Cramer Class) |
High (class III) | - | - | |
| Mammals - Acute oral LD50 (mg kg-1) | > 10000 | A5 Rat | Low | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | > 2000 | A5 Rat | - | |
| Mammals - Inhalation LC50 (mg l-1) | > 4.4 | A5 Rat 4 hr, (nose only) | - | |
| Other Mammal toxicity endpoints | - | - | ||
| ADI - Acceptable Daily Intake (mg kg-1bw day-1) | 0.053 | A2 Mouse, SF=100 | - | |
| ARfD - Acute Reference Dose (mg kg-1bw day-1) | 2.0 | A5 Rabbit, SF=100 | - | |
| AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | 0.1 | A2 Rat, SF=100 | - | |
| Dermal penetration studies (%) | 0.2-28.0 | A5 concentration dependant | - | |
| Dangerous Substances Directive 76/464 | - | - | - | |
| Exposure Limits | - | - | - | |
| Exposure Routes | Public | Negligible risk to bystanders | ||
| Occupational | Negligible risk to operators and workers | |||
| European MRLs | Click here for the EU MRL pesticide database | |||
| Drinking Water MAC (μg l-1) | - | - | - | |
Health issues:
| Carcinogen | Mutagen | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | |||
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| Respiratory tract irritant | Skin irritant | Skin sensitiser | Eye irritant | Phototoxicant | ||||
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| General human health issues | Possible liver, thyroid and kidney toxicant USEPA - probable human carcinogen Endocrine issues - Interference with testosterone metabolism |
|||||||
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found
Handling issues:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| General |
Emits toxic fumes in a fire Not explosive or oxidising IMDG Transport Code is usually 9 |
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| CLP classification 2013 | Health: H351 Environment: H400, H410 |
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| EC Risk Classification |
Carcinogen category 3: R40 N - Dangerous for the environment: R50, R53 |
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| EC Safety Classification |
- | |||
| WHO Classification | U | - | Unlikely to present an acute hazard | |
| US EPA Classification (formulation) | III | - | Caution - Slightly toxic | |
| UN Number | Usually 3077 | |||
| Waste disposal & packaging |
Packaging Group III (minor danger) | |||
| Language | Name |
| English | fenoxycarb |
| French | fenoxycarbe |
| German | Fenoxycarb |
| Danish | fenoxycarb |
| Italian | fenoxicarb |
| Spanish | fenoxicarb |
| Greek | - |
| Slovenian | fenoksikarb |
| Polish | fenoksykarb |
| Swedish | - |
| Hungarian | fenoxikarb |
| Dutch | - |
Record last updated: Thursday 20 April 2017
Contact: aeru@herts.ac.uk