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GET ADDITIONAL DATA HERE!

fenpropidin (Ref: CGA 114900)
** fenpropadine ** Ro-123049/000 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for fenpropidin

Description: A piperidine contact fungicide used to control a range of diseases in cereals

Example pests controlled: Powdery mildew, Rhynchosporium, Brown and yellow rusts, Leaf spots

Example applications: Cereals including wheat and barley

Efficacy & activity: Wheat/Mildew=Moderate; Wheat/Septoria=Low; Wheat/Rust=Low; Barley/Rhynchosporium=Low; Barley/Mildew=Low; Barley/Rust=Low; Barley/Net blotch=Low

Availability status: Current

Introduction & key dates: 1986

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Czech Republic/Germany
Date inclusion expires 31/12/2018
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule, fenpropidin is an isomeric mixture.
Chemical formula C19H31N
Canonical SMILES CC(CC1=CC=C(C=C1)C(C)(C)C)CN2CCCCC2
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) MGNFYQILYYYUBS-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C19H31N/c1-16(15-20-12-6-5-7-13-20)14-17-8-10-18(11-9-17)19(2,3)4/h8-11,16H,5-7,12-15H2,1-4H3
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Unclassified
Minimum active substance purity 960 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Systemic with curative and protective action. Inhibits sterol biosynthesis in membranes.
CAS RN 67306-00-7
EC number -
CIPAC number 520
US EPA chemical code 012305
PubChem CID 91694
Molecular mass (g mol-1) 273.46
PIN (Preferred Identification Name) rac-1-[(2R)-3-(4-tert-butylphenyl)-2-methylpropyl]piperidine
IUPAC name 1-[(RS)-3-(4-tert-butylphenyl)-2-methylpropyl]piperidine
CAS name 1-(3-(4-(1,1-dimethylethyl)phenyl)-2-methylpropyl)piperidine
Other status information PAN listed Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 5
Examples of recorded resistance -
Physical state Pale yellow viscous liquid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Headland
  • Makhteshim-Agan
  • Syngenta
Example products using this active
  • Alpha Fenpropidin
  • Instinct
  • Spyrale
  • Tern
UK LERAP status None
Formulation and application details Often supplied as an emulsifiable concentrate that is mixed with water and applied as a spray.


ENVIRONMENTAL FATE

for fenpropidin

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 530 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 250000 A5 - Heptane -
250000 A5 - Xylene -
250000 A5 - Acetone -
250000 A5 - Ethyl acetate -
Melting point (oC) -64.6 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 243 A5 -
Flashpoint (oC) 156 L3 -
Octanol-water partition coefficient at pH 7, 20oC P 3.98 X 1002 Calculated -
Log P 2.6 B5 Low
Bulk density (g ml-1)/Specific gravity 0.91 L3 -
Dissociation constant (pKa) at 25oC 10.13 A5 -
Note: Very weak acid
Vapour pressure at 20oC (mPa) 17.0 A5 Highly volatile
Henry's law constant at 25oC (Pa m3 mol-1) 10.7 A5 Moderately volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.85 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 1.68 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: Maxima at 218.2 & 263.7nm; [Acidic solution: Maxima at 217.9 & 262.9nm; [Basic solution: Maxima at 219.2 & 263.9; [No absorbance maxima >290nm A5 -
Surface tension (mN m-1) 51.6-52.1 A5 at 20oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability R3
Soil degradation (days) (aerobic) DT50 (typical) 90 B4 Moderately persistent
DT50 (lab at 20oC) 109 A5 Persistent
DT50 (field) 49.2 A5 Moderately persistent
DT90 (lab at 20oC) 289 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 58-217 days, DT90 range 192-365 days, field studies DT50 range 7-116 days; Other studies: DT50 lab 87-98 days, field 89-112 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value - Wh - at straw, n=1 -
Note 3.2
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note Insignificant route of degradation
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 3 to pH 9 at 50 degC
Water-sediment DT50 (days) 34 A5 Moderately fast
Water phase only DT50 (days) 1.8 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 51.1 A5 Slightly mobile
Kfoc 3808
1/n 0.71
Notes and range EU dossier Kf range 17.4-117.1, Kfoc range 2105-5194 mL/g, 1/n 0.56-0.80, Soils=6
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
2-methyl-2-(4-(2-methyl-3-piperidin-1-yl-propyl)-phenyl)-propionic acid (Ref: CGA 289267) This metabolite may cause environmental pollution, click here for further information Soil   0.106   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
1-[3-(4-tert-butyl-phenyl)-2-methyl-propyl]-piperidine-1-oxide
(Ref: CGA 289263)
- Soil - -
2-methyl-2-[4-(2-methyl-3-piperidin-1-yl-propyl)-phenyl]-propan-1-ol
(Ref: CGA 289268)
- a = Rat (Faeces, Bile); b= Animal a=0.270 -
3-hydroxy-2-methyl-2-[4-(2-methyl-3-piperidin-1-yl-propyl)-phenyl]-propionic acid
(Ref: SYN 515213)
- Animal (Tissue) - -


ECOTOXICOLOGY

for fenpropidin

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 163 A5 Threshold for concern
CT50 (days) 0.7 -
Mammals - Acute oral LD50 (mg kg-1) 1452 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) 20 B5 Rat High
(ppm diet) 60 -
Birds - Acute LD50 (mg kg-1) 1899 A5 Anas platyrhynchos Moderate
Birds - Short term dietary (LC50/LD50) > 1417 mg kg bw-1 day-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 1.9 A5 Lepomis macrochirus Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.32 A5 Salmo gairdneri Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.54 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.32 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 1.0 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) 40.0 A5 Chironomus riparius Moderate
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.0057 A5 Scenedemus subspicatus, 96 hour High
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.0014 Q2 Unknown species Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) - - -
Oral acute 48 hour LD50 (μg bee-1) > 10 A5 Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A4 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 10 A5 Eisenia foetida, 56 days Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect 93.0 A5 Folsomia candida, 28 day NOEC mg kg-1 -
Other arthropod (1) LR50 g ha-1 - - -
% Effect Harmless AA2 Typhlodromus pyri -
Other arthropod (2) LR50 g ha-1 750 A5 Aphidius rhopalosiphi -
% Effect 100 Mortality
Dose: 750 g ha-1
A5 Aphidius rhopalosiphi
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 1.1 mg kg-1, 28 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for fenpropidin

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 1452 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 4000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 1.22 A5 Rat, 4 hr -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.02 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.02 A5 Dog, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.02 A5 Dog, SF=100 -
Dermal penetration studies (%) 2.5-6.4 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Minimal risk to bystanders
Occupational Possible risk to operators and other farm workers - PPE advised
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues Harmful by inhalation, in contact with skin and if swallowed
USEPA - some evidence to suggest possible human carcinogen

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is variable depending upon product, often either 6.1 or 9
CLP classification 2013 Health: H302, H317, H318, H332, H335, H373
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R20/22, R41, R43, R48/22
Xi - Irritant: R36/38
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number Variable with product, usually 2902 or 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for fenpropidin

Language Name
English fenpropidin
French fenpropidine
German Fenpropidin
Danish fenpropidin
Italian fenpropidin
Spanish fenpropidin
Greek -
Slovenian fenpropidin
Polish fenpropidyna
Swedish fenpropidin
Hungarian -
Dutch -

Record last updated: Thursday 13 September 2018
Contact: aeru@herts.ac.uk