Tetraniliprole	Last updated: 18/12/2020
(Not known by any other names)

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GENERAL INFORMATION

Description	A novel insecticide for the control of various insect pests on certain fruit and nuts
Example pests controlled	Lepidopteran, Dipteran and Coleopteran pests
Example applications	Nuts including almonds, macadamias; Pome and stone fruit
Efficacy & activity	-
Availability status	Novel
Introduction & key dates	-

UK regulatory status

UK COPR regulatory status	Not approved
Date COPR inclusion expires	Not applicable
UK LERAP status	No UK approval for use

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status	Not approved
Dossier rapporteur/co-rapporteur	Not applicable
Date EC 1107/2009 inclusion expires	Not applicable
EU Candidate for substitution (CfS)	Not applicable
Listed in EU database	No
Approved for use (✓) under EC 1107/2009 in the following EU Member States	ATAustria BEBelgium BGBulgaria CYCyprus CZCzech Republic DEGermany DKDenmark EEEstonia ELGreece                   ESSpain FIFinland FRFrance HRCroatia HUHungary IEIreland ITItaly LTLithuania LULuxembourg                   LVLatvia MTMalta NLNetherlands PLPoland PTPortugal RORomania SESweden SISlovenia SKSlovakia

Also used in

Also used in	Australia, Canada, USA, Zimbabwe, Korea and Cambodia

Chemical structure

Isomerism	None
Chemical formula	C₂₂H₁₆ClF₃N₁₀O₂
Canonical SMILES	CC1=CC(=CC(=C1NC(=O)C2=CC(=NN2C3=C(C=CC=N3)Cl)CN4N=C(N=N4)C(F)(F)F)C(=O)NC)C#N
Isomeric SMILES	Not applicable
International Chemical Identifier key (InChIKey)	KNDVJPKNBVIKML-UHFFFAOYSA-N
International Chemical Identifier (InChI)	InChI=1S/C22H16ClF3N10O2/c1-11-6-12(9-27)7-14(19(37)28-2)17(11)30-20(38)16-8-13(10-35-33-21(31-34-35)22(24,25)26)32-36(16)18-15(23)4-3-5-29-18/h3-8H,10H2,1-2H3,(H,28,37)(H,30,38)
2D structure diagram/image available?	Yes

General status

Pesticide type	Insecticide
Substance group	Anthranilamide
Minimum active substance purity	-
Known relevant impurities	-
Substance origin	Synthetic
Mode of action	Acts by ingestion. It interferes with the ryanodine-sensitive calcium release channels which lead to loss of muscle control and subsequent insect immobility.
CAS RN	1229654-66-3
EC number	810-161-6
CIPAC number	-
US EPA chemical code	-
PubChem CID	-
Molecular mass	544.88
PIN (Preferred Identification Name)	1-(3-chloropyridin-2-yl)-N-[4-cyano-2-methyl-6-(methylcarbamoyl)phenyl]-3-([5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl)-1H-pyrazole-5-carboxamide
IUPAC name	1-(3-chloro-2-pyridyl)-4′-cyano-2′-methyl-6′-(methylcarbamoyl)-3-([5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl)-1H-pyrazole-5-carboxanilide
CAS name	1-(3-chloro-2-pyridinyl)-N-[4-cyano-2-methyl-6-[(methylamino)carbonyl]phenyl]-3-[[5-(trifluoromethyl)-2H-tetrazol-2-yl]methyl]-1H-pyrazole-5-carboxamide
Other status information	-
Relevant Environmental Water Quality Standards	-
Herbicide Resistance Classification (HRAC)	Not applicable
Herbicide Resistance Classification (WSSA)	Not applicable
Insecticide Resistance Classification (IRAC)	28
Fungicide Resistance Classification (FRAC)	Not applicable
Examples of recorded resistance	None identified
Physical state	Beige, solid powder

Formulations

Property	Value
Example manufacturers & suppliers of products using this active now or historically	Vayego 200SC
Example products using this active	Bayer CropScience
Formulation and application details	-

ENVIRONMENTAL FATE

Property		Value	Source; quality score; and other information	Interpretation
Solubility - In water at 20 °C (mg l⁻¹)		1.0	P5 P = Other governments and regulators 5 = Verified data used for regulatory purposes	Low
Solubility - In organic solvents at 20 °C (mg l⁻¹)		170	P5 P = Other governments and regulators 5 = Verified data used for regulatory purposes Toluene	-
		2900	P5 P = Other governments and regulators 5 = Verified data used for regulatory purposes Methanol	-
		6400	P5 P = Other governments and regulators 5 = Verified data used for regulatory purposes Ethyl acetate	-
		21800	P5 P = Other governments and regulators 5 = Verified data used for regulatory purposes Acetone	-
Melting point (°C)		-	-	-
Boiling point (°C)		-	-	-
Degradation point (°C)		-	-	-
Flashpoint (°C)		Not expected to self-ignite, Not highly flammable	-	-
Octanol-water partition coefficient at pH 7, 20 °C	P	3.98 X 1002	Calculated	-
	Log P	2.6	P5 P = Other governments and regulators 5 = Verified data used for regulatory purposes	Low
Bulk density (g ml⁻¹)		1.52	P5 P = Other governments and regulators 5 = Verified data used for regulatory purposes	-
Dissociation constant pKa) at 25 °C		9.1	P5 P = Other governments and regulators 5 = Verified data used for regulatory purposes	-
		-
Vapour pressure at 20 °C (mPa)		3.2 X 10-03	P5 P = Other governments and regulators 5 = Verified data used for regulatory purposes	Low volatility
Henry's law constant at 25 °C (Pa m³ mol⁻¹)		1.7 X 10-03	P5 P = Other governments and regulators 5 = Verified data used for regulatory purposes	Non-volatile
Maximum UV-vis absorption L mol⁻¹ cm⁻¹		Neutral S=soln: 204nm=45774, 267nm=17237 Acidic soln: 204nm=47357, 267nm=17172 Basic soln: 204nm=38595, 267nm=15969, 316nm=9645	P5 P = Other governments and regulators 5 = Verified data used for regulatory purposes	-
Surface tension (mN m⁻¹)		-	-	-

Degradation

Property		Value	Source; quality score; and other information	Interpretation
General biodegradability		Not readily biodegradable
Soil degradation (days) (aerobic)	DT₅₀ (typical)	86	P5 P = Other governments and regulators 5 = Verified data used for regulatory purposes	Moderately persistent
	DT₅₀ (lab at 20 °C)	86	P5 P = Other governments and regulators 5 = Verified data used for regulatory purposes	Moderately persistent
	DT₅₀ (field)	165	P5 P = Other governments and regulators 5 = Verified data used for regulatory purposes	Persistent
	DT₉₀ (lab at 20 °C)	-	-	-
	DT₉₀ (field)	-	-	-
	DT₅₀ modelling endpoint	86	P5 P = Other governments and regulators 5 = Verified data used for regulatory purposes Geometric mean	-
	Note	Australian dossier: Lab studies DT₅₀ range 28 to 171 days; Field studies DT₅₀ 25-433 days
Dissipation rate RL₅₀ on plant matrix	Value	-	-	-
	Note	-
Dissipation rate RL₅₀ on and in plant matrix	Value	-	-	-
	Note	-
Aqueous photolysis DT₅₀ (days) at pH 7	Value	-	-	-
	Note	-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7	Value	58.0	P5 P = Other governments and regulators 5 = Verified data used for regulatory purposes	Moderately persistent
	Note	265 days at pH 4; 1.27 days at pH 9
Water-sediment DT₅₀ (days)		-	-	-
Water phase only DT₅₀ (days)		-	-	-

Soil adsorption and mobility

Property		Value	Source; quality score; and other information	Interpretation
Linear	Kd	ND	E4 E = Manufacturers safety data sheets 4 = Verified data	Moderately mobile
	Koc	224
	Notes and range	Koc range: 195 - 252 mL g⁻¹
Freundlich	Kf	5.9	P4 P = Other governments and regulators 4 = Verified data	-
	Kfoc	-
	1/n	-
	Notes and range	Australian dossier: Kf range 1.2-10 mL g⁻¹
pH sensitivity		-

Fate indices

Property		Value	Source; quality score; and other information	Interpretation
GUS leaching potential index		3.66	Calculated	High leachability
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate	Value	8.22 X 10-01	Calculated	-
	Note	-
Potential for particle bound transport index		Medium	Calculated	-
Potential for loss via drain flow		Moderately mobile	Calculated	-

ECOTOXICOLOGY

Property		Value	Source; quality score; and other information	Interpretation
Bio-concentration factor	BCF (l kg⁻¹)	-	-	-
	CT₅₀ (days)	-		-
Mammals - Acute oral LD₅₀ (mg kg⁻¹)		> 200	P5 P = Other governments and regulators 5 = Verified data used for regulatory purposes Rat	Moderate
Mammals - Short term dietary NOEL	(mg kg⁻¹)	-	-	-
	(ppm diet)	-		-
Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)		-	-	-
Birds - Acute LD₅₀ (mg kg⁻¹)		-	-	-
Birds - Short term dietary (LC₅₀/LD₅₀)		-	-	-
Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)		-	-	-
Fish - Acute 96 hour LC₅₀ (mg l⁻¹)		> 541	E4 E = Manufacturers safety data sheets 4 = Verified data Oncorhynchus mykiss	Low
Fish - Chronic 21 day NOEC (mg l⁻¹)		-	-	-
Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)		> 0,382	E4 E = Manufacturers safety data sheets 4 = Verified data Daphnia magna	Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)		-	-	-
Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)		> 541.0	E4 E = Manufacturers safety data sheets 4 = Verified data Raphidocelis subcapitata	Low
Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)		-	-	-
Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)		-	-	-
Non-target plants		-	-	-
		-	-	-
Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)		-	-	-
Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)		-	-	-
Honeybees (Apis spp.)	Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
	Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
	Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
Bumblebees (Bombus spp.)	Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
		-
	Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
		-
Mason bees (Osmia spp.)	Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
	Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)	-	-	-
Other pollinators (1)	Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)	-	-	-
	Mode of exposure	-
Other pollinators (2)	Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)	-	-	-
	Mode of exposure	-
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)		-	-	-
Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)		-	-	-
Other soil macro-organisms	Acute LC₅₀ (mg kg⁻¹)	-	-	-
	Chronic NOEC (mg kg⁻¹)	-	-	-
Other arthropod (1)	LR₅₀ g ha⁻¹	-	-	-
	% Effect	-	-	-
Other arthropod (2)	LR₅₀ g ha⁻¹	-	-	-
	% Effect	-	-	-
Soil micro-organisms		-	-	-
Mesocosm study data	NOEAEC mg l⁻¹	-	-	-
	NOEAEC mg l⁻¹	-	-	-

HUMAN HEALTH AND PROTECTION

General

Property		Value	Source; quality score; and other information	Interpretation
Threshold of Toxicological Concern (Cramer Class)		High (Class III)	-	-
Mammals - Acute oral LD₅₀ (mg kg⁻¹)		> 200	P5 P = Other governments and regulators 5 = Verified data used for regulatory purposes Rat	Moderate
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)		2000	P5 P = Other governments and regulators 5 = Verified data used for regulatory purposes Rat	-
Mammals - Inhalation LC₅₀ (mg l⁻¹)		> 4.5	E4 E = Manufacturers safety data sheets 4 = Verified data Rat 4 hr	-
Other Mammal toxicity endpoints		-	-	-
ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)		-	-	-
ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)		-	-	-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)		-	-	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)		-	-	-
Dermal penetration studies (%)		-	-	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Routes	Public	-
	Occupational	-
MRLs	European	EU MRL pesticide database
	Notes	-
Drinking Water Standards		-	-	-
Drinking Water MAC (μg l⁻¹)		-	-	-

Health issues

Specific human health issues		Carcinogen Genotoxic Endocrine disruptor XNo, known not to cause a problem A0 A = Chromosome aberration (EFSA database) 0 = No data ; B0 B = DNA damage/repair (EFSA database) 0 = No data ; C0 C = Gene mutation (EFSA database) 0 = No data ; D0 D = Genome mutation (EFSA database) 0 = No data ; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative No data found Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant XNo, known not to cause a problem No data found No data found Respiratory tract irritant Skin irritant Skin sensitiser No data found XNo, known not to cause a problem ?Possibly, status not identified Eye irritant Phototoxicant   ?Possibly, status not identified No data found
General human health issues		No information available

Handling issues

Property	Value and interpretation
General	Not explosive or oxidising IMDG Transport Code is 9
CLP classification 2013	-
EC Risk Classification	{Environment: H400, H410
EC Safety Classification	-
WHO Classification	-
UN Number	3082
Waste disposal & packaging	Packaging Group III (minor danger)

TRANSLATIONS

Language	Name
English	tetraniliprole
French	tétraniliprole
German	-
Danish	-
Italian	-
Spanish	-
Greek	-
Polish	-
Swedish	-
Hungarian	-
Dutch	-

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Record last updated:	18/12/2020
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242