Fluazifop-P-butyl (Ref: R154875)

Fluazifop-P-butyl (Ref: R154875)	Last updated: 24/07/2025
(Also known as: PP 005; SL 118)

SUMMARY

Fluazifop-P-butyl is a post-emergence herbicide used to control grass weeds in a range of cropping situations. It has a low aqueous solubility, miscible in many organic solvents and is not considered to be volatile. It is not expected to be persistent in either soil or water-sediment systems. It is unlikely to leach to groundwater. Toxicity to biodiversity is low to moderate. Fluazifop-P-butyl also has a low oral mammalian toxicity.

Data alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.

Environmental fate	Ecotoxicity	Human health
Environmental fate Moderate alert: Drainflow: Slightly mobile; Potential for particle bound transport: Medium	Ecotoxicity Moderate alert: Birds chronic ecotoxicity: Moderate; Fish acute ecotoxicity: Moderate; Fish chronic ecotoxicity: Moderate; Daphnia acute ecotoxicity: Moderate; Earthworms acute ecotoxicity: Moderate	Human health High alert: Mammals chronic toxicity: High

GENERAL INFORMATION

Description

A post-emergence herbicide used to control grass weeds mainly in broadleaved crops.

Example pests controlled

Volunteer cereals; Annual and perennial grass weeds

Example applications

Soybeans; Carrots; Spinach; Potatoes; Ornamentals

Efficacy & activity

Availability status

Current

Introduction & key dates

1981, first marketed

GB regulatory status

GB COPR regulatory status

Approved

Date COPR inclusion expires

31/12/2026

GB LERAP status

None

EC Regulation 1107/2009 (repealing 91/414)

EC Regulation 1107/2009 status

Approved

Dossier rapporteur/co-rapporteur

France/Italy

Date EC 1107/2009 inclusion expires

31/05/2026

EU Candidate for substitution (CfS)

Listed in EU database

Yes

Approved for use (✓) under EC 1107/2009 in the following EU Member States

ATAustria	BEBelgium	BGBulgaria	CYCyprus	CZCzech Republic	DEGermany	DKDenmark	EEEstonia	ELGreece
✓	✓	✓	✓	✓	✓		✓	✓
ESSpain	FIFinland	FRFrance	HRCroatia	HUHungary	IEIreland	ITItaly	LTLithuania	LULuxembourg
✓	✓	✓	✓	✓	✓	✓	✓	✓
LVLatvia	MTMalta	NLNetherlands	PLPoland	PTPortugal	RORomania	SESweden	SISlovenia	SKSlovakia
✓	✓	✓	✓	✓	✓	✓	✓	✓

Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries

ISIceland	NONorway

Additional information

Also used in

Australia; USA

Chemical structure

Isomerism

Fluazifop-P-butyl is the stereospecific R-isomer of the chiral herbicide fluazifop-butyl

Chemical formula

C₁₉H₂₀F₃NO₄

Canonical SMILES

CCCCOC(=O)C(C)OC1=CC=C(C=C1)OC2=NC=C(C=C2)C(F)(F)F

Isomeric SMILES

CCCCOC(=O)[C@@H](C)OC1=CC=C(C=C1)OC2=NC=C(C=C2)C(F)(F)F

International Chemical Identifier key (InChIKey)

VAIZTNZGPYBOGF-CYBMUJFWSA-N

International Chemical Identifier (InChI)

InChI=1S/C19H20F3NO4/c1-3-4-11-25-18(24)13(2)26-15-6-8-16(9-7-15)27-17-10-5-14(12-23-17)19(20,21)22/h5-10,12-13H,3-4,11H2,1-2H3/t13-/m1/s1

2D structure diagram/image available?

Yes

General status

Pesticide type

Herbicide

Substance groups

Aryloxyphenoxypropionate herbicide

Minimum active substance purity

900 g kg⁻¹

Known relevant impurities

EU dossier - 2-chloro-5-(trifluoromethyl)pyridine <1.5g kg⁻¹

Substance origin

Synthetic

Mode of action

Selective, absorbed through leaf surface. Acetyl CoA carboxylase inhibitor (ACCase) - distrupts fatty acid biosynthesis and lipid formation.

CAS RN

79241-46-6

EC number

274-125-6

CIPAC number

467.205

US EPA chemical code

122809

PubChem CID

3033674

CLP index number

607-305-00-3

Molecular mass

383.36

PIN (Preferred Identification Name)

butyl (2R)-2-(4-{[5-(trifluoromethyl)pyridin-2-yl]oxy}phenoxy)propanoate

IUPAC name

butyl (R)-2-{4-[5-(trifluoromethyl)-2-pyridyloxy]phenoxy}propionate

CAS name

butyl (2R)-2-(4-((5-(trifluoromethyl)-2-pyridinyl)oxy)phenoxy)propanoate

Other status information

Relevant Environmental Water Quality Standards

Herbicide Resistance Class (HRAC MoA class)

Herbicide Resistance Class (WSSA MoA class)

Insecticide Resistance Class (IRAC MoA class)

Not applicable

Fungicide Resistance Class (FRAC MOA class)

Not applicable

Examples of recorded resistance

Many recorded cases, Alopecurus myosuroides, Avena fatua, Avena sterilis, Digitaria sanguinalis

Physical state

Straw coloured liquid

Related substances & organisms

fluazifop

fluazifop-butyl

fluazifop-P

Formulations

Property

Value

Example manufacturers & suppliers of products using this active now or historically

Clayton
Greencrop
Syngenta
BOC Sciences

Example products using this active

Fusilade Max
Greencrop Bantry

Formulation and application details

Often supplied as an emulsifiable concentrate which is mixed with water and applied as a spray

ENVIRONMENTAL FATE

Property

Value

Source; quality score; and other information

Interpretation

Solubility - In water at 20 °C (mg l⁻¹)

0.93

Low

Solubility - In organic solvents at 20 °C (mg l⁻¹)

Miscible

Xylene

Miscible

Acetone

Miscible

Methanol

Miscible

Toluene

Melting point (°C)

-46

Boiling point (°C)

Decomposes before boiling

Degradation point (°C)

216

Flashpoint (°C)

Octanol-water partition coefficient at pH 7, 20 °C

3.16 X 10⁰⁴

Calculated

Log P

4.5

High

Fat solubility of residues

Solubility

Insoluble

Data type

Regulatory data - no accumulation of residues in fat were observed in livestock feeding studies

Density (g ml⁻¹)

1.22

Dissociation constant pKa) at 25 °C

Not applicable

No pka identified

Vapour pressure at 20 °C (mPa)

0.12

Low volatility. If applied directly to plants, drift is a concern & mitigation is advisable

Henry's law constant at 25 °C (Pa m³ mol⁻¹)

0.049

Non-volatile

Volatilisation as max % of applied dose lost

From plant surface

23.9

Volatilisation is potentially a concern for short and long range air transport

From soil surface

15.1

Volatilisation is not considered critical for air pollution

Maximum UV-vis absorption L mol⁻¹ cm⁻¹

207.2nm = 6160, 255.4nm = 4590, 223.7nm = 16600

Surface tension (mN m⁻¹)

66.1

at 20°C

Degradation

Property

Value

Source; quality score; and other information

Interpretation

General biodegradability

Soil degradation (days) (aerobic)

DT₅₀ (typical)

1.0

Non-persistent

DT₅₀ (lab at 20 °C)

1.0

Non-persistent

DT₅₀ (field)

8.2

Non-persistent

DT₉₀ (lab at 20 °C)

3.4

Non-persistent

DT₉₀ (field)

DT₅₀ modelling endpoint

Note

EU dossier lab studies DT₅₀ range 0.3-3.3 days, DT₉₀ range 1.1-11.1 days, field studies DT₅₀ range: 2.1-38.0 days, DT₉₀ range 12-126 days; Other sources: DT₅₀ 15 days (DW4)

Dissipation rate RL₅₀ (days) on plant matrix

Value

Note

Dissipation rate RL₅₀ (days) on and in plant matrix

Value

3.9

Note

Published literature RL₅₀ range 1.3-11.0 days, leaves of 7 field crops, n=13

Aqueous photolysis DT₅₀ (days) at pH 7

Value

Moderately fast

Note

Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7

Value

Moderately persistent

Note

pH sensitive: stable at pH 5, DT₅₀ 29 hours at pH 9 all at 25 °C

Water-sediment DT₅₀ (days)

0.1

Fast

Water phase only DT₅₀ (days)

0.1

Fast

Sediment phase only DT₅₀ (days)

Air degradation

As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.

Decay in stored produce DT₅₀

Soil adsorption and mobility

Property

Value

Source; quality score; and other information

Interpretation

Linear

K_d (mL g⁻¹)

41.4

Slightly mobile

K_oc (mL g⁻¹)

3394

Notes and range

Data for only one soil - loamy sand

Freundlich

K_f (mL g⁻¹)

K_foc (mL g⁻¹)

¹/_n

Notes and range

pH sensitivity

Fate indices

Property

Value

Source; quality score; and other information

Interpretation

GUS leaching potential index

0.43

Calculated

Low leachability

SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate

Value

7.14 X 10^-03

Calculated

Note

Potential for particle bound transport index

Medium

Calculated

Potential for loss via drain flow

Slightly mobile

Calculated

Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk

4.3

Calculated using the Atkinson method

Below the level of concern for long-range air transport

Bio-concentration factor

BCF (l kg⁻¹)

320

Threshold for concern

CT₅₀ (days)

Known soil metabolites

Metabolite

Major/Minor fraction

$Click here for further information on Major/Minor fraction$

Estimated maximum occurrence fraction

Notes

fluazifop-P (Ref: R156172)

Major fraction

0.834

5-trifluoromethyl-2-(1H) pyridone (Ref: R154719)

5-trifluoromethyl-pyrid-2-one

2-(4-hydroxyphenoxy)-5-trifluoromethyl pyridine

Known groundwater metabolites

None

Other known metabolites

Metabolite name and reference

Aliases

Formation medium / Rate

Estimated maximum occurrence fraction

2-(4-hydroxyphenoxy)-5-trifluoromethyl pyridine

Compound 4; Compound 1V

Surface water; Sediment

N-(1-carboxy-2-(5-trifluoromethyl-2-pyridylthio)ethyl)malonmalic acid

Compound 28

Unknown

2-(4-(5-trifluoromethyl-2-pyridyloxy)phenoxy)propanol

Compound 34

Unknown

2-(4-(3-hydroxy-5-trifluoromethyl-2-pyridyloxy)phenoxy propionic acid

Compound 40

Unknown

5-trifluoromethyl-2-(1H) pyridone (Ref: R154719)
Note: Major metabolite; Molecular wt = 163

Compound X

Rat; Water

5-trifluoromethyl-pyrid-2-one

Compound 10

Surface water; Sediment

ECOTOXICOLOGY

Terrestrial ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

2451

Rat

Low

Mammals - Short term dietary NOEL

(mg kg⁻¹)

Rat

(ppm diet)

> 100

Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)

6.72

Rat Reproductive NOAEL

High

Birds - Acute LD₅₀ (mg kg⁻¹)

> 3960

Anas platyrhynchos

Low

Birds - Short term dietary (LC₅₀/LD₅₀)

> 942 mg kg bw⁻¹ day⁻¹

Anas platyrhynchos

Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)

86.8

Colinus virginianus

Moderate

Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)

> 500

Eisenia foetida corr

Moderate

Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)

Soil micro-organisms

Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect

Dose: 3.75 kg ha⁻¹ 28 Day

Collembola

Acute LC₅₀ (mg kg⁻¹)

Chronic NOEC (mg kg⁻¹)

Non-target plants

Vegetative vigour ER₅₀ (g ha⁻¹)

9.1

Zea mays

Seedling emergence ER₅₀ (g ha⁻¹)

37.1

Echinochloa crus-galli

Honeybees (Apis spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 200

Apis mellifera

Low

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

> 200

Apis mellifera

Low

Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Chronic

Notes

Bumblebees (Bombus spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Mason bees (Osmia spp.)

Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)

Other bee species (1)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Other bee species (2)

Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)

Mode of exposure

Beneficial insects (Ladybirds)

Beneficial insects (Lacewings)

Beneficial insects (Parasitic wasps) as Mortality LR₅₀ g ha⁻¹, Std lab test

177

Aphidius rhopalosiphi

Beneficial insects (Predatory mites) as Mortality LR₅₀ g ha⁻¹, Std lab test

5.6

Typhlodromus pyri

Beneficial insects (Ground beetles)

Aquatic ecotoxicology

Property

Value

Source; quality score; and other information

Interpretation

Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

> 1.41

Oncorhynchus mykiss

Moderate

Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)

0.077

Pimephales promelas

Moderate

Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)

1.96

Danio rerio EC₅₀ Embryo

Moderate

Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

> 0.62

Daphnia magna

Moderate

Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)

Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)

Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)

0.54

Americamysis bahia 48 hr

Moderate

Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)

Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)

Aquatic Plants (free-floating, fonds growth, fresh) - 7 day (mg l⁻¹) (EC₅₀, Static)

> 0.0136

Lemna gibba

Moderate

Aquatic plants (rooted, growth rate, fresh) - 14 day (mg l⁻¹)

Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)

> 0.18

Pseudokirchneriella subcapitata

Moderate

Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)

0.3

Unknown species

Moderate

Mesocosm study data

NOEAEC mg l⁻¹

Marine bivalves

HUMAN HEALTH AND PROTECTION

General

Property

Value

Source; quality score; and other information

Interpretation

Threshold of Toxicological Concern (Cramer Class)

High (class III)

Mammals - Acute oral LD₅₀ (mg kg⁻¹)

2451

Rat

Low

Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)

2110

Rat

Mammals - Inhalation LC₅₀ (mg l⁻¹)

> 5.2

Rat 4 hr (nose only)

Other Mammal toxicity endpoints

ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)

0.01

Rat SF=100

ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)

0.017

Rat SF=100

AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)

AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)

0.02

Rat SF=100

Dermal penetration studies (%)

1.0-6.5

concentration dependent

Dangerous Substances Directive 76/464

List II

Exposure Routes

Public

No unacceptable risks to bystanders identified

Occupational

No unacceptable risks to operators or other workers identified

MRLs

European

EU MRL pesticide database

Great Britain

GB MRL Register

Notes

Drinking Water Standards

Drinking Water MAC (μg l⁻¹)

0.1

EU Dir 89/778/EC limit

Mammalian dose elimination route and rate

Health issues

Specific human health issues

Carcinogen

Genotoxic

Endocrine disruptor

; ; ; ;

Reproduction / development effects

Acetyl cholinesterase inhibitor

Neurotoxicant

No data found

Respiratory tract irritant

Skin irritant

Skin sensitiser

Eye irritant

Phototoxicant

No data found

General human health issues

Harmful if inhaled or ingested
Kidney, spleen and liver toxicant
May cause eye cataracts

Handling issues

Property

Value and interpretation

General

Not explosive or oxidising
IMDG Transport Hazard Class 3
Not expected to auto-ignite; Not highly flammable

CLP classification 2013

Health: H361d, H373, H317

WHO Classification

III (Slightly hazardous)

UN Number

UN1993

Waste disposal & packaging

Packaging Group III (minor danger)

Shelf-life, storage, stability and reactivity

Chemically stable under standard ambient conditions. Limited shelf-life.

TRANSLATIONS

Language

Name

English

fluazifop-P-butyl

French

fluazifop-P-butyl

German

Fluazifop-P-butyl

Danish

fluazifop-P-butyl

Italian

fluazifop-P-butile

Spanish

fluazifop-P-butil

Greek

fluazifop-P-butyl

Polish

fluazyfop-P butylowy

Swedish

Hungarian

fluazifop-P-butyl

Dutch

fluazifop-P-butyl

Norwegian

Record last updated:	24/07/2025
Contact:	aeru@herts.ac.uk
Please cite as:	Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242