Top Environmental Fate Ecotoxicology Human Health Translations
Home
A to Z: All
A to Z: Insecticides
A to Z: Herbicides
A to Z: Fungicides
A to Z: Other related substances
Search
Support information
Edit history
Purchasing and licensing
NEW
Industry collaboration
Flufenacet (Ref: FOE 5043)
Last updated: 02/03/2024
(Also known as: fluthiamide; fluofenacet ; thiafluamide)

SUMMARY
Flufenacet is a selective herbicide. It is moderately soluble in water, is not highly volatile but may, under certain conditions, be persistent in soil and water/sediment systems. It is moderately toxic to humans via the oral route and is considered to be a skin sensitiser. With the exception of honeybees where the toxicity is low, flufenacet is either moderately or highly toxic to most fauna and flora.
Data alerts

The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.

Environmental fate Ecotoxicity Human health
Environmental fate
Moderate alert:
Moderately persistent; GUS: Transition state; Drainflow: Moderately mobile
Ecotoxicity
High alert:
Birds chronic ecotoxicity: High
Human health
Moderate alert:
Mammals acute toxicity: Moderate; Mammals chronic toxicity: Moderate; Reproduction/development effects
GENERAL INFORMATION
Description
A broad spectrum soil herbicide, often used in conjunction with other herbicides, used, post-emergence, to control grasses and some broad-leaved weeds
Example pests controlled
Certain annual grasses including black-grass, Broad-leaved weeds including velvet leaf, morning glory and common cocklebur
Example applications
Corn; Soybeans; Winter wheat; Winter barley; Potatoes; Sunflowers; Asparagus; Cotton; Chilli; Tobacco
Efficacy & activity
Efficiacy suuported by data derived from field experiments and extensive global use.
Availability status
Current
Introduction & key dates
1998, registered USA; 2004, registered EU
UK regulatory status
UK COPR regulatory status
Approved
Date COPR inclusion expires
31/10/2027
UK LERAP status
Check label - may vary with formulation
EC Regulation 1107/2009 (repealing 91/414)
EC Regulation 1107/2009 status
Approved
Dossier rapporteur/co-rapporteur
Poland/France
Date EC 1107/2009 inclusion expires
15/06/2025
EU Candidate for substitution (CfS)
Yes - two 'Persistent-Bioaccumulative-Toxic' criteria
Listed in EU database
Yes
Approved for use (✓) under EC 1107/2009 in the following EU Member States
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
   
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
 
Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries
ISIceland
NONorway
                 
Additional information
Also used in
Philippines; US, Canada, Chile, Kenya, China, iIsrael
Chemical structure
Isomerism
None
Chemical formula
C₁₄H₁₃F₄N₃O₂S
Canonical SMILES
CC(C)N(C1=CC=C(C=C1)F)C(=O)COC2=NN=C(S2)C(F)(F)F
Isomeric SMILES
No data
International Chemical Identifier key (InChIKey)
IANUJLZYFUDJIH-UHFFFAOYSA-N
International Chemical Identifier (InChI)
InChI=1S/C14H13F4N3O2S/c1-8(2)21(10-5-3-9(15)4-6-10)11(22)7-23-13-20-19-12(24-13)14(16,17)18/h3-6,8H,7H2,1-2H3
2D structure diagram/image available?
Yes
General status
Pesticide type
Herbicide
Substance groups
Anilide herbicide
Minimum active substance purity
970 g kg⁻¹
Known relevant impurities
EU dossier - None declared
Substance origin
Synthetic
Mode of action
Selective with meristematic activity. Inhibition of VLCFA (inhibition of cell division).
CAS RN
142459-58-3
EC number
604-290-5
CIPAC number
588
US EPA chemical code
121903
PubChem CID
86429
CLP index number
613-164-00-9
Molecular mass
363.33
PIN (Preferred Identification Name)
N-(4-fluorophenyl)-N-(propan-2-yl)-2-{[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]oxy}acetamide
IUPAC name
4'-fluoro-N-isopropyl-2-[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yloxy]acetanilide
CAS name
N-(4-fluorophenyl)-N-(1-methylethyl)-2-[[5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl]oxy]acetamide
Other status information
-
Relevant Environmental Water Quality Standards
-
Herbicide Resistance Class (HRAC MoA class)
K3
Herbicide Resistance Class (WSSA MoA class)
15
Insecticide Resistance Class (IRAC MoA class)
Not applicable
Fungicide Resistance Class (FRAC MOA class)
Not applicable
Examples of recorded resistance
-
Physical state
White to tan coloured, odourless solid
Formulations
Property
Value
Example manufacturers & suppliers of products using this active now or historically
  • Bayer CropScience
  • BASF
  • Standon
Example products using this active
  • Artist
  • Cadu Star
  • Firebird
  • Shooter
  • Regatta
  • Axiom
  • Herold SC
  • Fosbury
Formulation and application details
Usually supplied as a suspension concentrate and used as a foliar spray
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C (mg l⁻¹)
51
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Moderate
Solubility - In organic solvents at 20 °C (mg l⁻¹)
280000
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Acetone
-
200000
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Toluene
-
8700
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Hexane
-
170000
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Propanol
-
Melting point (°C)
76
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Boiling point (°C)
Decomposes before boiling
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Degradation point (°C)
150
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Flashpoint (°C)
- - -
Octanol-water partition coefficient at pH 7, 20 °C
P
3.16 X 1003 Calculated -
Log P
3.5
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
High
Fat solubility of residues
Solubility
- - -
Data type
- - -
Density (g ml⁻¹)
1.45
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Dissociation constant pKa) at 25 °C
Not applicable
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
No dissociation
Vapour pressure at 20 °C (mPa)
0.09
A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
4 = Verified data
as flufenacet-N-isomer
Low volatility
Henry's law constant at 25 °C (Pa m³ mol⁻¹)
1.3 X 10-03
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Non-volatile
Maximum UV-vis absorption L mol⁻¹ cm⁻¹
pH 2: 201nm=18131, 235nm=7307
pH 7: 235nm=7106
pH 10: 235nm=7161
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Surface tension (mN m⁻¹)
59.4
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Degradation
Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
-
Soil degradation (days) (aerobic)
DT₅₀ (typical)
19.7
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Non-persistent
DT₅₀ (lab at 20 °C)
19.7
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Non-persistent
DT₅₀ (field)
39.0
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Moderately persistent
DT₉₀ (lab at 20 °C)
77.5
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Moderately persistent
DT₉₀ (field)
132.4
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
DT₅₀ modelling endpoint
57.6
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
worse case not normalised.
-
Note
EU 2017 dossier lab studies DT₅₀ range 7.04-37.4 days, DT₉₀ range 24.4-191.4 days, Soils=10; field studies DT₅₀ range 14.2-68.1 days, DT₉₀ range 53.4-132.4, Soils=16 days
Dissipation rate RL₅₀ on plant matrix
Value
- - -
Note
-
Dissipation rate RL₅₀ on and in plant matrix
Value
- - -
Note
-
Aqueous photolysis DT₅₀ (days) at pH 7
Value
Stable
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Stable
Note
Not a significant degradation route
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
Stable
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Stable
Note
Stable pH 5 to pH 9
Water-sediment DT₅₀ (days)
81
A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
4 = Verified data
Moderately fast
Water phase only DT₅₀ (days)
54
A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
4 = Verified data
Stable
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd
-
DW3 DW = Don Wauchope personal database for Pka data: Wauchope, R. D. and Edwards, J. Dissociation constants for pesticide active ingredients: a database and comparison with predicted values. Dataset is no longer available.
3 = Unverified data of known source
Moderately mobile
Koc
401
Notes and range
-
Freundlich
Kf
4.38
A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
4 = Verified data
Moderately mobile
Kfoc
273.3
1/n
0.92
Notes and range
EU 2017 dossier Kf range 1.48-8.96 mL g⁻¹, kfoc range 161.6-643.5 mL g⁻¹, 1/n range 0.848-0.980, Soils=10
pH sensitivity
None
Fate indices
Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
2.49 Calculated Transition state
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
1.45 X 10-01 Calculated -
Note
-
Potential for particle bound transport index
Low Calculated -
Potential for loss via drain flow
Moderately mobile Calculated -
Bio-concentration factor
BCF (l kg⁻¹)
71.4
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Low potential
CT₅₀ (days)
Not available -
Known soil metabolites
Metabolite
Major/Minor fraction
Estimated maximum occurrence fraction
Notes
N-(4-fluorophenyl)-N-isopropyl-2-(methylsulfonyl)acetamide (Ref: BCS-CO62475; FOE methylsulfone)
Minor fraction - -
2-chloro-N-(4-fluorophenyl)-N-isopropylacetamide (Ref: BCS-AA70824)
Minor fraction - -
5-(trifluoromethyl)-1,3,4-thiadiazol-2-ol (Ref: BCS-AA41715; FOE thiadone)
Minor fraction - -
2,2,2-trifluoroethanesulfonic acid
Minor fraction - -
trifluoroacetic acid
Major fraction 0.815 -
2-[(4-fluorophenyl)(isopropyl)amino]-2-oxoethanesulfonic acid (Ref: AE 0841914; M02; FOE sulfonic acid)
Major fraction 0.263 Bayer verified
[(4-fluorophenyl)(isopropyl)amino](oxo)acetic acid (Ref: AE 0841913; M01; FOE oxalate)
Major fraction 0.156 CAS 201668-31-7; Bayer verified
({2-[(4-fluorophenyl)(isopropyl)amino]-2-oxoethyl}sulfinyl)acetic acid (Ref: AE 0841915)
Minor fraction - -
Known groundwater metabolites
Metabolite
EC SANCO/221/2000 relevancy
ADI (mg kg⁻¹ bodyweight day⁻¹)
WHO drinking water guidance value (μg L⁻¹ day⁻¹)
[(4-fluorophenyl)(isopropyl)amino](oxo)acetic acid (Ref: AE 0841913; M01; FOE oxalate)
Not relevant 0.005 -
2-[(4-fluorophenyl)(isopropyl)amino]-2-oxoethanesulfonic acid (Ref: AE 0841914; M02; FOE sulfonic acid)
Not relevant 0.005 -
Other known metabolites
Metabolite name and reference
Aliases
Formation medium / Rate
Estimated maximum occurrence fraction
Metabolising enzymes
N-acetyl-3-({2-[(4- fluorophenyl)(isopropyl)amino]-2- oxoethyl}sulfinyl)alanine FOE S-oxo cysteine Rat - -
N-(4-fluorophenyl)-N-isopropylacetamide FOE amine acetate Animal; Plant - -
N-(4-fluorophenyl)-2- (methylsulfinyl)acetamide FOE des-i-propyl methylsulfoxide Rat - -
N-(4-fluorophenyl)-2- (methylsulfonyl)acetamide FOE des-i-propyl methylsulfone Animal - -
fluoro-hydroxy-des-i-propyl methylsulfone - Rat - -
N-acetyl-S-(2-fluoro-5-{[(methylsulfonyl)acetyl]amino}phenyl)cysteine hydroxy-des-i-propyl methylsulfone Rat - -
hydroxy-des-i-propyl methylsulfone-glutaminic acid - Rat - -
2,2'-disulfanediylbis[N-(4-fluorophenyl)-Nisopropylacetamide] FOE disulfide Rat - -
N-(4-hydroxyphenyl)acetamide hydroxy-des-i-propyl amine acetate Rat - -
2-amino-5-fluorophenol 2-A-5-FP Rat - -
gamma-glutamyl-S-{2-[(4- fluorophenyl)(isopropyl)amino]-2- oxoethyl}cysteinylglycine FOE glutathione Rat; Animal - -
S-{2-[(4-fluorophenyl)(isopropyl)amino]-2- oxoethyl}cysteine FOE cysteine Rat; Animal; Plant - -
5-(trifluoromethyl)-1,3,4-thiadiazol-2-yl hexopyranosiduronic acid thiadone glucuronide Rat; Animal - -
3-hexopyranosyl-5-(trifluoromethyl)-2,3- dihydro-1,3,4-thiadiazol-2-one ThN glucoside Plant - -
2,4-dioxo-4-{[5-(trifluoromethyl)-1,3,4- thiadiazol-2-yl]oxy}butanoic acid Th oxalyl acetic acid Rat - -
({2-[(4-fluorophenyl)(isopropyl)amino]-2-oxoethyl}sulfinyl)acetic acid (Ref: AE 0841915) FOE thioglycolate sulfoxide Plant; Water - -
N-(4-fluorophenyl)acetamide DIFAAC: BCS-AA22989 Hen - -
N-(4-fluorophenyl)-N-(1-hydroxypropan-2-yl)- 2-(methylsulfonyl)acetamide HOIFAMSO2 Rat; Hen - -
N-(4-hydroxyphenyl)-N-(1-hydroxypropan-2- yl)-2-(methylsulfinyl)acetamide LMeOH-3 Hen - -
N-(4-fluorophenyl)-2-hydroxy-N-acetamide Des-isopropyl-FOE alcohol Rat - -
4-fluoro-N-isopropylaniline 4-Fluoro-N-(1- methylethyl)benzamine Rat - -
3-({2-[(4-fluorophenyl)(isopropyl)amino]-2- oxoethyl}sulfinyl)-2-hydroxypropanoic acid FOE sulfinyl lactic acid Plant - -
N-(carboxyacetyl)-3-[2-oxo-5-(trifluoromethyl)-1,3,4-thiadiazol-3(2H)- Th-malonylalanyl conjugate Soybean - -
[(4-fluorophenyl)amino](oxo)acetic acid FOE des-isopropyl oxalate Plant - -
N-(4-fluorophenyl)-N-isopropyl-2-(methylsulfanyl)acetamide (Ref: BCS-CP38571) FOE methylsulfide Water; Animal; Corn - -
N-(4-fluorophenyl)-N-isopropyl-2-(methylsulfinyl)acetamide FOE methylsulfoxide Water; Plant; Rat - -
[(4-fluoro-3-hydroxyphenyl)amino](oxo)acetic acid FOE 3-OH-des-isopropyl oxalate Plant - -
3-({2-[(4-fluorophenyl)(isopropyl)amino]-2-oxoethyl}sulfinyl)-2-(hexopyranosyloxy)propanoic acid FOE sulfinyl lactic acid glucoside Plant - -
3-({2-[(4-fluorophenyl)(isopropyl)amino]-2- oxoethyl}sulfinyl)-2- (hexopyranosyloxy)propanoic acid FOE sulfonyl lactic acid Plant - -
3-({2-[(4-fluorophenyl)(isopropyl)amino]-2- oxoethyl}sulfinyl)alanine FOE cysteine sulfoxide Fish; Plant - -
3-({2-[(4-fluorophenyl)(isopropyl)amino]-2- oxoethyl}sulfanyl)-2-hydroxypropanoic acid FOE sulfanyl lactic acid Plant - -
3-({2-[(4-fluorophenyl)(isopropyl)amino]-2- oxoethyl}sulfanyl)-2- (hexopyranosyloxy)propanoic acid FOE sulfanyl lactic acid glucoside Plant - -
N-(carboxyacetyl)-S-{2-[(4- fluorophenyl)(isopropyl)amino]-2- oxoethyl}cysteine FOE malonylcysteine conjugate FAM-MalCys IUPAC: N-(carboxyacetyl)-S-{2-[(4- fluorophenyl)(isopropyl)amino]-2- oxoethyl}cysteine Corn - -
N-(4-fluorophenyl)-N-isopropyl-2- sulfanylacetamide FOE free sulfide Animal; Corn - -
trifluoroacetic acid - Rat; Plant - -
4-fluoro-N-methylethylaniline thiodiacetic acid amide FOE thioglycolate sulfide Water - -
3-({2-[(4-fluorophenyl)(1-hydroxypropan-2- yl)amino]-2-oxoethyl}sulfinyl)alanine isopropyl hydroxy cysteine Fish - -
N-(4-fluorophenyl)-N-isopropyl-2-(methylsulfonyl)acetamide (Ref: BCS-CO62475) FOE methylsulfone Rat; Plant; Water - -
2-chloro-N-(4-fluorophenyl)-N-isopropylacetamide (Ref: BCS-AA70824) FOE chloroacetanilide Rat; Plant - -
5-(trifluoromethyl)-1,3,4-thiadiazol-2-ol (Ref: BCS-AA41715) FOE-thiadone Rat; Plant; Water - -
N-acetyl-S-{2-[(4-fluorophenyl)(isopropyl)amino]-2-oxoethyl}cysteine FOE acetyl cysteine Animal - -
N-acetyl-S-{2-[(4-fluorophenyl)amino]-2- oxoethyl}cysteine FOE des-i-propyl cysteine Rat - -
ECOTOXICOLOGY
Terrestrial ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
598
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat
Moderate
Mammals - Short term dietary NOEL
(mg kg⁻¹)
1.67
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat
High
(ppm diet)
97.5 -
Mammals - Chronic 21d NOAEL (mg kg⁻¹ bw d⁻¹)
37.4
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat Reproductive NOAEL
Moderate
Birds - Acute LD₅₀ (mg kg⁻¹)
1608
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Colinus virginianus
Moderate
Birds - Short term dietary (LC₅₀/LD₅₀)
> 4970 ppm
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Anas platyrhynchos
-
Birds - Chronic 21d NOEL (mg kg⁻¹ bw d⁻¹)
9.4
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Anas platyrhynchos NOEL
High
Earthworms - Acute 14 day LC₅₀ (mg kg⁻¹)
219
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Eisenia foetida
Moderate
Earthworms - Chronic NOEC, reproduction (mg kg⁻¹)
> 1.2
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Eisenia foetida corr
Moderate
Soil micro-organisms
Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes

Dose: 4 mg kg⁻¹ soil
-
Collembola
Acute LC₅₀ (mg kg⁻¹)
- - -
Chronic NOEC (mg kg⁻¹)
31.5
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Folsomia candida corr
-
Non-target plants
- - -
- - -
Honeybees (Apis spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 109.2
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Apis mellifera
Low
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 100
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Apis mellifera
Low
Unknown mode acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Chronic as 10-day LC₅₀ µg bee⁻¹ day⁻¹
> 4.42
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Apis mellifera
-
Bumblebees (Bombus spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
> 100
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Bombus terrestris
Low
-
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
-
Mason bees (Osmia spp.)
Contact acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Oral acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg bee⁻¹)
- - -
Other bee species (1)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Other bee species (2)
Acute LD₅₀ (worst case from 24, 48 and 72 hour values - μg insect⁻¹)
- - -
Mode of exposure
-
Beneficial insects (Ladybirds)
- - -
Beneficial insects (Lacewings)
- - -
Beneficial insects (Parasitic wasps) as Mortality LR₅₀ g ha⁻¹
280
A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
4 = Verified data
Aphidius rhopalosiphi Adult
-
Beneficial insects (Predatory mites) as Mortality LR₅₀ g ha⁻¹
441
A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
4 = Verified data
Typhlodromus pyri Protonymph
-
Beneficial insects (Ground beetles)
- - -
Aquatic ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Temperate Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
2.13
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Lepomis macrochirus
Moderate
Temperate Freshwater Fish - Chronic 21 day NOEC (mg l⁻¹)
0.2
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Oncorhynchus mykiss
Moderate
Tropical Freshwater Fish - Acute 96 hour LC₅₀ (mg l⁻¹)
11.28
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment )
3 = Unverified data of known source
Danio rerio EC₅₀ Embryo
Moderate
Temperate Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
30.9
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Daphnia magna
Moderate
Temperate Freshwater Aquatic invertebrates - Chronic 21 day NOEC (mg l⁻¹)
3.26
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Daphnia magna
Moderate
Tropical Freshwater Aquatic invertebrates - Acute 48 hour EC₅₀ (mg l⁻¹)
- - -
Aquatic crustaceans - Acute 96 hour LC₅₀ (mg l⁻¹)
1.78
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment )
3 = Unverified data of known source
Americamysis bahia
Moderate
Sediment dwelling organisms - Acute 96 hour LC₅₀ (mg l⁻¹)
- - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l⁻¹)
- - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg⁻¹)
- - -
Aquatic plants - Acute 7 day EC₅₀, biomass (mg l⁻¹)
0.002
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Lemna gibba
High
Algae - Acute 72 hour EC₅₀, growth (mg l⁻¹)
0.00204
A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
4 = Verified data
Raphidocelis subcapitata 72 hour
High
Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)
- - -
Mesocosm study data
NOEAEC mg l⁻¹
- - -
NOEAEC mg l⁻¹
- - -
HUMAN HEALTH AND PROTECTION
General
Property
Value
Source; quality score; and other information
Interpretation
Threshold of Toxicological Concern (Cramer Class)
High (class III) - -
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
598
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat
Moderate
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)
2000
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat
-
Mammals - Inhalation LC₅₀ (mg l⁻¹)
> 3.74
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat (nose only)
-
Other Mammal toxicity endpoints
- - -
ADI - Acceptable Daily Intake (mg kg⁻¹ bw day⁻¹)
0.005
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Rat SF=200
-
ARfD - Acute Reference Dose (mg kg⁻¹ bw day⁻¹)
0.017
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
Dog SF=100
-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg⁻¹ bw day⁻¹)
- - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg⁻¹ bw day⁻¹)
0.017
A4 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
4 = Verified data
Dog 90 day SF=100
-
Dermal penetration studies (%)
0.2-4.7
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
concentration dependent
-
Dangerous Substances Directive 76/464
List II - -
Exposure Routes
Public
Minimal risk from dietary exposure
Risk assessment indicates ARfD would not normally be execeeded
Occupational
No unacceptable risks to operators or other workers identified
MRLs
European
EU MRL pesticide database 
Great Britain
GB MRL Register 
Notes
-
Drinking Water Standards
- - -
Drinking Water MAC (μg l⁻¹)
- - -
Mammalian dose elimination route and rate
Extensively metabolised and mainly excreted via the urine (up to 89%)
A5 A = EU regulatory and evaluation data as published by EC, EFSA (RAR, DAR & Conclusion dossiers), EMA (e.g. EU Annex III PIC DGD) (EU - Pesticides database; EFSA Scientific Publications )
5 = Verified data used for regulatory purposes
-
Health issues
Specific human health issues
Carcinogen
Genotoxic
Endocrine disruptor
XNo, known not to cause a problem
A3 A = Chromosome aberration (EFSA database)
3 = Negative
;
B0 B = DNA damage/repair (EFSA database)
0 = No data
;
C0 C = Gene mutation (EFSA database)
0 = No data
;
D0 D = Genome mutation (EFSA database)
0 = No data
;
E3 E = Unspecified genotoxicity type (miscellaneous data source)
3 = Negative
No data found
Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant
?Possibly, status not identified
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant Skin irritant Skin sensitiser
?Possibly, status not identified
?Possibly, status not identified
Yes, known to cause a problem
Eye irritant Phototoxicant  
?Possibly, status not identified
XNo, known not to cause a problem
 
General human health issues
Potential liver, spleen and thyroid toxicant
Handling issues
Property
Value and interpretation
General
Not explosive or oxidising
IMDG Transport Hazard Class 9
Not expected to auto-ignite; Not highly flammable
CLP classification 2013
Health: H302, H317, H373
Environment: H400, H410
WHO Classification
II (Moderately hazardous)
UN Number
UN3077
Waste disposal & packaging
Packaging Group III (minor danger)
Shelf-life, storage, stability and reactivity
-
TRANSLATIONS
Language
Name
English
flufenacet
French
flufenacet
German
Flufenacet
Danish
flufenacet
Italian
flufenacet
Spanish
flufenacet
Greek
flufenacet
Polish
flufenacet
Swedish
flufenacet
Hungarian
flufenacet
Dutch
flufenacet
Norwegian
-

Record last updated: 02/03/2024
Contact: aeru@herts.ac.uk
Please cite as: Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242