| fluquinconazole (Ref: AE C597265) |
 |
Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
GENERAL INFORMATION 
for fluquinconazole
Description: A selective protectant and curative fungicide used to control various endophytic diseases mainly on cereals
Example pests controlled: Septoria leaf spot, Septoria glume blotch, Yellow rust, Prown rust, Powdery mildew
Example applications: Cereals including wheat
Efficacy & activity: Wheat/Mildew=Low; Wheat/Septoria=Low; Wheat/Rust=Moderate
Availability status: Current
Introduction & key dates: circa 1995
EC Regulation 1107/2009 (repealing 91/414):
| Status | Approved |
| Dossier rapporteur/co-rapporteur | UK/Slovakia |
| Date inclusion expires | 31/12/2021 |
| EU Candidate for substitution (CfS) | Yes - low ADI ARfD / AOEL; two 'Persistent-Bioaccumulative-Toxic' criteria |
| Listed in EU database | Yes |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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Also used in: Australia
Chemical structure:
| Isomerism | - |
| Chemical formula | C16H8Cl2FN5O |
| Canonical SMILES | C1=CC2=C(C=C1F)C(=O)N(C(=N2)N3C=NC=N3)C4=C(C=C(C=C4)Cl)Cl |
| Isomeric SMILES | No data |
| International Chemical Identifier key (InChIKey) | IJJVMEJXYNJXOJ-UHFFFAOYSA-N |
| International Chemical Identifier (InChI) | InChI=1S/C16H8Cl2FN5O/c17-9-1-4-14(12(18)5-9)24-15(25)11-6-10(19)2-3-13(11)22-16(24)23-8-20-7-21-23/h1-8H |
| 2D structure diagram/image available? | Yes |
General status:
| Pesticide type | Fungicide | |
| Substance group | Triazole | |
| Minimum active substance purity | 955 g/kg | |
| Known relevant impurities | EU dossier - None declared | |
| Substance origin | Synthetic | |
| Mode of action | Absorbed through foliage. Systemic with protectant and eradicant activity. Disrupts membrane function. Sterol biosynthesis inhibitor. | |
| CAS RN | 136426-54-5 | |
| EC number | 411-960-9 | |
| CIPAC number | 474 | |
| US EPA chemical code | - | |
| PubChem CID | 86417 | |
| Molecular mass (g mol-1) | 376.17 | |
| PIN (Preferred Identification Name) | - | |
| IUPAC name | 3-(2,4-dichlorophenyl)-6-fluoro-2-(1H-1,2,4-triazol-1-yl)quinazolin-4(3H)-one | |
| CAS name | 3-(2,4-dichlorophenyl)-6-fluoro-2-(1H-1,2,4-triazol-1-yl)-4(3H)-quinazolinone | |
| Other status information | - | |
| Relevant Environmental Water Quality Standards | - | |
| Herbicide Resistance Classification (HRAC) | Not applicable | |
| Herbicide Resistance Classification (WSSA) | Not applicable | |
| Insecticide Resistance Classification (IRAC) | Not applicable | |
| Fungicide Resistance Classification (FRAC) | 3 | |
| Examples of recorded resistance | - | |
| Physical state | Cream to white crystalline solid depending upon purity | |
| Related substances & organisms | ||
Formulations:
| Property |
Value | |||
| Example manufacturers & suppliers of products using this active now or historically |
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| Example products using this active |
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| UK LERAP status | None | |||
| Formulation and application details | Often supplied as a soluble concentrate which is mixed with water and applied as a spray. Other formulations include those specific for seed treatments. | |||
ENVIRONMENTAL FATE
for fluquinconazole
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Solubility - In water at 20oC (mg l-1) | 1.15 | A5 | Low | |
| Solubility - In organic solvents at 20oC (mg l-1) | 44000 | A4 - Acetone | - | |
| 34000 | A4 - Ethyl acetate | - | ||
| 3480 | A5 - Ethanol | - | ||
| 114 | A5 - Hexane | - | ||
| Melting point (oC) | 191 | A5 | - | |
| Boiling point (oC) | - | - | - | |
| Degradation point (oC) | 320 | A5 | - | |
| Flashpoint (oC) | Not expected to self ignite; Not highly flammable | A5 | - | |
| Octanol-water partition coefficient at pH 7, 20oC | P | 1.74 X 1003 | Calculated | - |
| Log P | 3.24 | A5 | High | |
| Bulk density (g ml-1)/Specific gravity | 1.58 | A5 | - | |
| Dissociation constant (pKa) at 25oC | 0.9 | A5 | - | |
| Note: Strong acid, pKa(2) -4.4, Very strong acid | ||||
| Vapour pressure at 20oC (mPa) | 6.40 X 10-06 | A5 | Low volatility | |
| Henry's law constant at 25oC (Pa m3 mol-1) | 2.90 X 10-06 | A5 | Non-volatile | |
GUS leaching potential index  |
2.69 | Calculated | Transition state | |
| SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Value | 2.21 X 10-01 | Calculated | - |
| Note | - | |||
| Potential for particle bound transport index |
- | Calculated | Medium | |
| Maximum UV-vis absorption L mol-1 cm-1 | Neutral solution: 307nm = 4928; [Acidic solution: 307nm = 4894; [Basic solution: 321nm = 3876 | A5 | - | |
| Surface tension (mN m-1) | 70.91 | A5 at 20oC | - | |
Degradation:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
General biodegradability | - |
| Soil degradation (days) (aerobic) | DT50 (typical) | 350 | B5 | Persistent |
| DT50 (lab at 20oC) | 347 | A5 | Persistent | |
| DT50 (field) | 378 | A5 | Very persistent | |
| DT90 (lab at 20oC) | 319 | A5 | - | |
| DT90 (field) | 4083 | A5 | - | |
| DT50 modelling endpoint | - | - | - | |
| Note | EU dossier lab studies DT50 range 186-441 days, field studies DT50 range 17.5-777.4 days, DT90 range 261-9585 days; Other studies: lab DT50 range 211-562 days, field range 300-400 days (B5) | |||
| Dissipation rate RL50 on plant matrix | Value | - | - | - |
| Note | - | |||
| Dissipation rate RL50 on and in plant matrix | Value | 22.2 | R4 | - |
| Note | Published literature RL50 range 16.0-32.0 days, apple fruit, n=3 | |||
| Aqueous photolysis DT50 (days) at pH 7 | Value | Stable | A5 | - |
| Note | - | |||
| Aqueous hydrolysis DT50 (days) at 20oC and pH 7 | Value | 21.9 | A5 | Non-persistent |
| Note | pH sensitive: DT50 194 days at pH 4, 2024 days at pH 5, 0.4 days at pH 9, all at 25 degC | |||
| Water-sediment DT50 (days) | 13.7 | A5 | Fast | |
| Water phase only DT50 (days) | 3.5 | A5 | Moderately fast | |
Soil adsorption and mobility:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Linear | Kd | - | - | - |
| Koc | - | |||
| Notes and range | - | |||
| Freundlich | Kf | 14.8 | A5 | Slightly mobile |
| Kfoc | 870 | |||
| 1/n | 0.891 | |||
| Notes and range | EU dossier Kf range 5.3-25.9, Kfoc range 750-1153 mL/g, 1/n range 0.836-0.921, Soils=4 | |||
| pH sensitivity | No | |||
Key metabolites:
| Metabolite | Formation medium | Estimated maximum occurrence fraction | 1107/2009 relevancy |
|
| 3-(2,4-dichlorophenyl)-6-fluoro-quinazolin-2,4(3H)-dione (Ref: AE C596912) |
Soil | 0.287 | Major fraction, Relevant | |
| 1,2,4-triazole (Ref: CGA 71019) |
Soil | 0.189 | Major fraction, Relevant | |
Other known metabolites:
| Metabolite name and reference | Aliases | Formation medium / Rate | Estimated maximum occurrence fraction | Metabolising enzymes |
| 3-(1H-1,2,4-triazol-1-yl)-DL-alanine | triazolyl alanine | Plant | - | - |
| 1H-1,2,4-triazol-1-ylacetic acid | triazolyl acetic acid | Plant | - | - |
| 2-{[(2,4-dichlorophenyl)carbamoyl]amino}-5-fluorobenzoic acid | SN 616368 | - | - | - |
ECOTOXICOLOGY
for fluquinconazole
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Bio-concentration factor | BCF (l kg-1) | 87 | A5 | Low potential |
| CT50 (days) | 0.25 | - | ||
| Mammals - Acute oral LD50 (mg kg-1) | 112 | A5 Rat | Moderate | |
| Mammals - Short term dietary NOEL | (mg kg-1) | 0.36 | B5 Rat | High |
| (ppm diet) | 5 | - | ||
| Birds - Acute LD50 (mg kg-1) | > 2000 | A5 Anas platyrhynchos | Low | |
| Birds - Short term dietary (LC50/LD50) | > 5200 mg kg feed-1 | A5 Anas platyrhynchos | - | |
| Fish - Acute 96 hour LC50 (mg l-1) | 1.9 | A5 Oncorhynchus mykiss | Moderate | |
| Fish - Chronic 21 day NOEC (mg l-1) | 0.3 | A5 Oncorhynchus mykiss | Moderate | |
| Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) | > 5.0 | A5 Daphnia magna | Moderate | |
| Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) | 0.648 | A5 Daphnia magna | Moderate | |
| Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) | - | - | - | |
| Aquatic plants - Acute 7 day EC50, biomass (mg l-1) | 1.4 | A5 Lemna minor | Moderate | |
| Non-target plants | - | - | - | |
| - | - | - | ||
| Algae - Acute 72 hour EC50, growth (mg l-1) | 0.046 | B5 Pseudokirchneriella subcapitata | Moderate | |
| Algae - Chronic 96 hour NOEC, growth (mg l-1) | - | - | - | |
| Honeybees | Contact acute 48 hour LD50 (μg bee-1) | > 100 | A5 | Low |
| Oral acute 48 hour LD50 (μg bee-1) | > 100 | A5 | Low | |
| Unknown mode acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Earthworms - Acute 14 day LC50 (mg kg-1) | > 500 | A5 Eisenia foetida corr | Moderate | |
| Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) | - | - | - | |
| Other soil macro-organisms - e.g. Collembola | LR50 / EC50 / NOEC / % Effect | - | - | - |
| Other arthropod (1) | LR50 g ha-1 | 149.4 | <, Mortality A5 Typhlodromus pyri |
- |
| % Effect | - | - | - | |
| Other arthropod (2) | LR50 g ha-1 | 149.4 | <, Mortality A5 Aphidius rhopalosiphi |
- |
| % Effect | - | - | - | |
| Soil micro-organisms | Nitrogen mineralisation: No significant adverse effect Carbon mineralisation: No significant adverse effect |
A5 Dose: 2.5 kg ha-1 |
- | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
HUMAN HEALTH AND PROTECTION
for fluquinconazole
General:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Threshold of Toxicological Concern (Cramer Class) |
High (class III) | - | - | |
| Mammals - Acute oral LD50 (mg kg-1) | 112 | A5 Rat | Moderate | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | 625 | A5 Rat | - | |
| Mammals - Inhalation LC50 (mg l-1) | 0.514 | A5 Rat, 4 hr (head only) | - | |
| Other Mammal toxicity endpoints | - | - | ||
| ADI - Acceptable Daily Intake (mg kg-1bw day-1) | 0.002 | A4 Dog, SF=100 | - | |
| ARfD - Acute Reference Dose (mg kg-1bw day-1) | 0.02 | A2 Dog, SF=100 | - | |
| AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) | - | - | - | |
| AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | 0.001 | A2 Dog, SF=167 | - | |
| Dermal penetration studies (%) | 1-4 | A5 concentration dependent | - | |
| Dangerous Substances Directive 76/464 | List II | - | - | |
| Exposure Limits | - | - | - | |
| Exposure Routes | Public | Risk to bystanders acceptable for proposed uses | ||
| Occupational | Possible risk to operators and other farm workers - PPE/PPC advised | |||
| European MRLs | Click here for the EU MRL pesticide database | |||
| Drinking Water Standards | - | - | - | |
| Drinking Water MAC (μg l-1) | 0.1 | EU Dir 89/778/EC limit; Calc MAC=0.9 μg l-1; A5 | - | |
Health issues:
| Carcinogen | Mutagen | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | |||
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| Respiratory tract irritant | Skin irritant | Skin sensitiser | Eye irritant | Phototoxicant | ||||
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| General human health issues | Possible kidney & liver toxicant | |||||||
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found
Handling issues:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| General |
Prevent generation of mists Not explosive or oxidising IMDG Transport Code is usually 9 |
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| CLP classification 2013 | Health: H301, H312, H315, H331, H372 Environment: H400, H410 |
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| EC Risk Classification |
T - Toxic: R23/25, R48/25 Xn - Harmful: R21 Xi - Irritant: R38 N - Dangerous for the environment: R50, R53 |
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| EC Safety Classification |
S1/2, S36/37/39, S38, S45, S60, S61 | |||
| WHO Classification | NL | - | Not listed | |
| US EPA Classification (formulation) | No consensus across products or no products available | - | - | |
| UN Number | Usually 3082 | |||
| Waste disposal & packaging |
Packaging Group III (minor danger) | |||
TRANSLATIONS
for fluquinconazole
| Language | Name |
| English | fluquinconazole |
| French | fluquinconazole |
| German | Fluquinconazol |
| Danish | fluquinconazol |
| Italian | fluquinconazolo |
| Spanish | fluquinconazol |
| Greek | - |
| Slovenian | flukvinkonazol |
| Polish | fluchinkonazol |
| Swedish | - |
| Hungarian | fluquinkonazol |
| Dutch | - |
Record last updated: Thursday 23 August 2018
Contact: aeru@herts.ac.uk