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fluquinconazole (Ref: AE C597265)
** SN 597265 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for fluquinconazole

Description: A selective protectant and curative fungicide used to control various endophytic diseases mainly on cereals

Example pests controlled: Septoria leaf spot, Septoria glume blotch, Yellow rust, Prown rust, Powdery mildew

Example applications: Cereals including wheat

Efficacy & activity: Wheat/Mildew=Low; Wheat/Septoria=Low; Wheat/Rust=Moderate

Availability status: Current

Introduction & key dates: circa 1995

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur UK/Slovakia
Date inclusion expires 31/12/2021
EU Candidate for substitution (CfS) Yes - low ADI ARfD / AOEL; two 'Persistent-Bioaccumulative-Toxic' criteria
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C16H8Cl2FN5O
Canonical SMILES C1=CC2=C(C=C1F)C(=O)N(C(=N2)N3C=NC=N3)C4=C(C=C(C=C4)Cl)Cl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) IJJVMEJXYNJXOJ-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C16H8Cl2FN5O/c17-9-1-4-14(12(18)5-9)24-15(25)11-6-10(19)2-3-13(11)22-16(24)23-8-20-7-21-23/h1-8H
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Triazole
Minimum active substance purity 955 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Absorbed through foliage. Systemic with protectant and eradicant activity. Disrupts membrane function. Sterol biosynthesis inhibitor.
CAS RN 136426-54-5
EC number 411-960-9
CIPAC number 474
US EPA chemical code -
PubChem CID 86417
Molecular mass (g mol-1) 376.17
PIN (Preferred Identification Name) -
IUPAC name 3-(2,4-dichlorophenyl)-6-fluoro-2-(1H-1,2,4-triazol-1-yl)quinazolin-4(3H)-one
CAS name 3-(2,4-dichlorophenyl)-6-fluoro-2-(1H-1,2,4-triazol-1-yl)-4(3H)-quinazolinone
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 3
Examples of recorded resistance -
Physical state Cream to white crystalline solid depending upon purity
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • BASF
  • Bayer CropScience
  • Aventis
Example products using this active
  • Jockey
  • Galmano
  • Sahara, Flamenco
UK LERAP status None
Formulation and application details Often supplied as a soluble concentrate which is mixed with water and applied as a spray. Other formulations include those specific for seed treatments.


ENVIRONMENTAL FATE

for fluquinconazole

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 1.15 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 44000 A4 - Acetone -
34000 A4 - Ethyl acetate -
3480 A5 - Ethanol -
114 A5 - Hexane -
Melting point (oC) 191 A5 -
Boiling point (oC) - - -
Degradation point (oC) 320 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.74 X 1003 Calculated -
Log P 3.24 A5 High
Bulk density (g ml-1)/Specific gravity 1.58 A5 -
Dissociation constant (pKa) at 25oC 0.9 A5 -
Note: Strong acid, pKa(2) -4.4, Very strong acid
Vapour pressure at 20oC (mPa) 6.40 X 10-06 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 2.90 X 10-06 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.69 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 2.21 X 10-01 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 307nm = 4928; [Acidic solution: 307nm = 4894; [Basic solution: 321nm = 3876 A5 -
Surface tension (mN m-1) 70.91 A5 at 20oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 350 B5 Persistent
DT50 (lab at 20oC) 347 A5 Persistent
DT50 (field) 378 A5 Very persistent
DT90 (lab at 20oC) 319 A5 -
DT90 (field) 4083 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 186-441 days, field studies DT50 range 17.5-777.4 days, DT90 range 261-9585 days; Other studies: lab DT50 range 211-562 days, field range 300-400 days (B5)
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 22.2 R4 -
Note Published literature RL50 range 16.0-32.0 days, apple fruit, n=3
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 21.9 A5 Non-persistent
Note pH sensitive: DT50 194 days at pH 4, 2024 days at pH 5, 0.4 days at pH 9, all at 25 degC
Water-sediment DT50 (days) 13.7 A5 Fast
Water phase only DT50 (days) 3.5 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 14.8 A5 Slightly mobile
Kfoc 870
1/n 0.891
Notes and range EU dossier Kf range 5.3-25.9, Kfoc range 750-1153 mL/g, 1/n range 0.836-0.921, Soils=4
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
3-(2,4-dichlorophenyl)-6-fluoro-quinazolin-2,4(3H)-dione (Ref: AE C596912) This metabolite may cause environmental pollution, click here for further information Soil   0.287   Major fraction, Relevant
1,2,4-triazole (Ref: CGA 71019) This metabolite may cause environmental pollution, click here for further information Soil   0.189   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
3-(1H-1,2,4-triazol-1-yl)-DL-alanine triazolyl alanine Plant - -
1H-1,2,4-triazol-1-ylacetic acid triazolyl acetic acid Plant - -
2-{[(2,4-dichlorophenyl)carbamoyl]amino}-5-fluorobenzoic acid SN 616368 - - -


ECOTOXICOLOGY

for fluquinconazole

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 87 A5 Low potential
CT50 (days) 0.25 -
Mammals - Acute oral LD50 (mg kg-1) 112 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) 0.36 B5 Rat High
(ppm diet) 5 -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) > 5200 mg kg feed-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 1.9 A5 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.3 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 5.0 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.648 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 1.4 A5 Lemna minor Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.046 B5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 Eisenia foetida corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 149.4 <, Mortality
A5 Typhlodromus pyri
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 149.4 <, Mortality
A5 Aphidius rhopalosiphi
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 2.5 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for fluquinconazole

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 112 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) 625 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 0.514 A5 Rat, 4 hr (head only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.002 A4 Dog, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.02 A2 Dog, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.001 A2 Dog, SF=167 -
Dermal penetration studies (%) 1-4 A5 concentration dependent -
Dangerous Substances Directive 76/464 List II - -
Exposure Limits - - -
Exposure Routes Public Risk to bystanders acceptable for proposed uses
Occupational Possible risk to operators and other farm workers - PPE/PPC advised
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 0.1 EU Dir 89/778/EC limit; Calc MAC=0.9 μg l-1; A5 -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Possible kidney & liver toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Prevent generation of mists
Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Health: H301, H312, H315, H331, H372
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases T - Toxic: R23/25, R48/25
Xn - Harmful: R21
Xi - Irritant: R38
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S1/2, S36/37/39, S38, S45, S60, S61
WHO Classification NL - Not listed
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number Usually 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for fluquinconazole

Language Name
English fluquinconazole
French fluquinconazole
German Fluquinconazol
Danish fluquinconazol
Italian fluquinconazolo
Spanish fluquinconazol
Greek -
Slovenian flukvinkonazol
Polish fluchinkonazol
Swedish -
Hungarian fluquinkonazol
Dutch -

Record last updated: Thursday 23 August 2018
Contact: aeru@herts.ac.uk