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fluroxypyr (Ref: DOW 43304-H)
** fluroxypyr acid ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for fluroxypyr

Description: A post-emergence herbicide used to control economically important broad-leaved weeds

Example pests controlled: Annual and perennial broad-leaved weeds including kochia, lespedeza and dogfennel; Woody brush

Example applications: Rangeland; Permanent pasture; Non-crop areas; Cereals including wheat, corn; Orchards; Vineyards

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1983, first reported; 1985, first introduced UK

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Sweden/Slovenia
Date inclusion expires 31/12/2021
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism None - fluroxypyr is not itself isomeric but the meptyl ester has a pair of enantiomers.
Chemical formula C7H5Cl2FN2O3
Canonical SMILES C(C(=O)O)OC1=NC(=C(C(=C1Cl)N)Cl)F
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) MEFQWPUMEMWTJP-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C7H5Cl2FN2O3/c8-3-5(11)4(9)7(12-6(3)10)15-1-2(13)14/h1H2,(H2,11,12)(H,13,14)
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Pyridine compound
Minimum active substance purity 950 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Foliar uptake causing auxin-type response. Synthetic auxin.
CAS RN 69377-81-7
EC number -
CIPAC number 431
US EPA chemical code 128968
PubChem CID 50465
Molecular mass (g mol-1) 255.03
PIN (Preferred Identification Name) -
IUPAC name 4-amino-3,5-dichloro-6-fluoro-2-pyridyloxyacetic acid
CAS name ((4-amino-3,5-dichloro-6-fluoro-2-pyridinyl)oxy)acetic acid
Other status information Marine pollutant
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) O
Herbicide Resistance Classification (WSSA) 4
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state White crystalline solid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • AgriGuard
  • Dow AgroSciences
  • DuPont
  • Nufarm UK
  • Makhteshim-Agan
Example products using this active
  • Bastion T
  • Cabadex
  • Doxstar
  • Forefront
  • Galaxy
  • GL184
  • Starane
  • Tomahawk
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details Often supplied as an emulsion concentrate that is mixed with water and applied as a spray.


ENVIRONMENTAL FATE

for fluroxypyr

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 6500 A5 High
Solubility - In organic solvents at 20oC (mg l-1) 2 A5 - Hexane -
35000 A5 - Methanol -
300 A5 - Xylene -
9200 A5 - Acetone -
Melting point (oC) 232.5 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 360 A3 -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 1.10 X 1000 Calculated -
Log P 0.04 A5 Low
Bulk density (g ml-1)/Specific gravity 1.09 A5 -
Dissociation constant (pKa) at 25oC 2.94 A5 - @ 25DegC -
Note: Strong acid
Vapour pressure at 20oC (mPa) 0.0000038 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.69 X 10-10 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 2.42 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 7.83 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 pH 1.28: 210nm = 48780; [pH 10.1: 211nm = 48030; [pH 12.6: 218nm = 25980 A5 -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 13.1 A5 Non-persistent
DT50 (lab at 20oC) 13.1 A5 Non-persistent
DT50 (field) 51 A5 Moderately persistent
DT90 (lab at 20oC) 44.0 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 for Fluroxypr acid range 2.7-39.6 days, DT90 range 9.6-163.2 days, field studies range 34-68 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 5.5 R3 -
Note Rice, whole plant, n=1
Aqueous photolysis DT50 (days) at pH 7 Value Stable A3 -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 223 K4 Persistent
Note Stable pH 4 to pH 7, DT50 3.2 days at pH 9
Water-sediment DT50 (days) 34.7 A5 Moderately fast
Water phase only DT50 (days) 10.5 K4 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 1.20 A5 Mobile
Kfoc 68
1/n 0.93
Notes and range EU dossier (2011) kf range 0.11-1.90 mL/g, Kfoc range 51-81 mL/g, 1/n range 0.88-0.92, Soils=4
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
4-amino-3,5-dichloro-6-fluoro-2-pyridinol This metabolite may cause environmental pollution, click here for further information Soil   0.239   Major fraction, Relevant
4-amino-3,5-dichloro-6-fluoro-2-pirydynil-2-methoxypyridine Soil   0.084   Minor fraction, Relevant


ECOTOXICOLOGY

for fluroxypyr

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 62.1 F4 Whole fish Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A4 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) > 80 A5 Mice High
(ppm diet) > 200 -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) > 5000 ppm A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 14.3 A5 Lepomis macrochirus Moderate
Fish - Chronic 21 day NOEC (mg l-1) 100 A5 Oncorhynchus mykiss Low
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 100 A5 Daphnia magna Low
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 56 A5 Daphnia magna Low
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 12.3 A5 Lemna gibba Low
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 49.8 A4 Pseudokirchneriella subcapitata Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) 56 Q2 Unknown species Low
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 180 A5 Low
Oral acute 48 hour LD50 (μg bee-1) 37.1 A5 Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A3 as MHE Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: 0.578 kg ha-1 as MHE
A5 Aphidius rhopalosiphi, adult
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 33.3 Mortality
Dose 0.578 kg ha-1 as MHE
A5 Typhlodromus pyri, adult
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 2 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for fluroxypyr

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 2000 A4 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 1.0 A5 Rat, 4 hr -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.8 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.8 A4 Rat, 2 year, SF=100 -
Dermal penetration studies (%) 4.0-22 A5 concentration dependent -
Dangerous Substances Directive 76/464 List II - -
Exposure Limits - - -
Exposure Routes Public -
Occupational Occupational exposure to fluroxypyr may occur through inhalation and dermal contact
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Possible kidney toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is variable depending upon product, often either 3 or 9
CLP classification 2013 Environment: H412
EC Risk Classification Click here to view information omn the EU risk phrases N - Dangerous for the environment: R52, R53
EC Safety Classification Click here to view information omn the EU safety phrases S61
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number 1993
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for fluroxypyr

Language Name
English fluroxypyr
French fluroxypyr
German Fluroxypyr
Danish fluroxypyr
Italian fluroxipir
Spanish fluroxipir
Greek fluroxypyr
Slovenian fluroksipir
Polish fluroksypyr
Swedish fluroxipyr
Hungarian fluroxipir
Dutch fluroxypyr

Record last updated: Wednesday 31 October 2018
Contact: aeru@herts.ac.uk