Fomesafen (Ref: PP 021)
Last updated: 23/01/2023
(Also known as: fomesafene; fomesafen acid)
Fomesafen is a selective herbicide. It is moderately soluble in aqueous solution, is relatively volatile but does have potential to leach to groundwater. It is persistent in soils and aquatic systems. It is moderately toxic to mammals and although a recognised irritant no other significant health issues have been identified. It is not toxic to birds or fish but considered moderately toxic to aquatic crustaceans, honeybees and earthworms.
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
A pre-emergence herbicide for use in leguminous crops for post-emergence control of broad-leaved weeds
Pigweed, Black nightshade, Velvetleaf, Cocklebur
Legumes; Cotton; Soybeans; Potatoes; Tomatoes
-
Unknown
1983, first reported
Not approved
Expired
No UK approval for use
EC Regulation 1107/2009 (repealing 91/414)
Not approved
-
Expired
-
Yes
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
 
 
 
 
 
 
 
 
 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
 
 
 
 
 
 
 
 
 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
 
 
 
 
 
 
 
 
 
-
C₁₅H₁₀ClF₃N₂O₆S
CS(=O)(=O)NC(=O)C1=C(C=CC(=C1)OC2=C(C=C(C=C2)C(F)(F)F)Cl)[N+](=O)[O-]
-
BGZZWXTVIYUUEY-UHFFFAOYSA-N
InChI=1S/C15H10ClF3N2O6S/c1-28(25,26)20-14(22)10-7-9(3-4-12(10)21(23)24)27-13-5-2-8(6-11(13)16)15(17,18)19/h2-7H,1H3,(H,20,22)
Yes
Herbicide
Organochloride fungicide; Organofluoride fungicide; Amide fungicide; Nitrophenol etther fungicide
-
-
Synthetic
Selective, absorbed by leaves and roots. Inhibits protoporphyrinogen oxidase (PROTOX), leading to irreversible cell membrane damage.
72178-02-0
276-439-9
None allocated
123802
51556
604-040-00-5
438.76
5-(2-chloro-α,α,α-trifluoro-p-tolyloxy)-N-mesyl-2-nitrobenzamide
5-(2-chloro-α,α,α-trifluoro-p-tolyloxy)-N-mesyl-2-nitrobenzamide
5-[2-chloro-4-(trifluoromethyl)phenoxy]-N-(methylsulfonyl)-2-nitrobenzamide
-
-
E
14
Not applicable
Not applicable
Amaranthus rudis , Euphorbia heterophylla
White crystals
FCC Ltd King Tech AgroCare ICI Plant Protection
Eagrow Reflex Flexstar Format
Usually supplied as an soluble concentrate or liquid concentratate.
50
Moderate
300000
Acetone
-
25000
Methanol
-
1900
Xylene
-
10000
Dichloromethane
-
219
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
-
-
-
-
-
-
-
-
-
-
6.31 X 10-02
Calculated
-
-1.2
Low
Likely to be soluble
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
-
Based on chemical group
Q3 Q = Miscellaneous internet resources 3 = Unverified data of known source
-
1.61
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
-
2.83
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
-
Forms water soluble salts, strong acid
4.00 X 10-03
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Low volatility
2.00 X 10-07
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Non-volatile
-
-
-
-
-
-
-
86
Moderately persistent
-
-
-
86
Moderately persistent
-
-
-
-
-
-
-
-
-
Field studies DT₅₀ range 59-112 days
-
-
-
-
-
-
-
-
Stable
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Stable
-
-
-
-
-
7
Fast
-
-
-
Soil adsorption and mobility
-
Mobile
50
Literature studies state Koc range 150-1200 (R3)
1.89
R4 R = Peer reviewed scientific publications 4 = Verified data
Moderately mobile
228
0.77
Literature data: Kf range 1.38-3.02 mL g⁻¹, Kfoc range 115-348 mL g⁻¹, 1 /n range 0.65-0.83, soils=6
R4
3.18
Calculated
High leachability
4.08 X 10-01
Calculated
-
-
Medium
Calculated
-
Mobile
Calculated
-
6
Whole fish
Low potential
Not available
-
None
Terrestrial ecotoxicology
1250
Rat
Moderate
0.25
Rat
High
5
-
-
-
-
> 5000
Anas platyrhynchos
Low
-
-
-
-
-
-
1000
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Moderate
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
50
Moderate
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
> 170
Oncorhynchus mykiss
Low
-
-
-
> 330
Daphnia magna
Low
> 100
Daphnia magna LOEC
Low
22.1
Americamysis bahia
Moderate
-
-
-
-
-
-
-
-
-
-
-
-
0.17
L2 L = Pesticide manuals and hard copy reference books / other sources 2 = Unverified data of unknown source
Unknown species
Moderate
-
-
-
-
-
-
-
-
-
HUMAN HEALTH AND PROTECTION
High (class III)
-
-
1250
Rat
Moderate
1000
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rabbit
-
> 4.97
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rat
-
-
-
-
0.003
UK ACP 1999
-
-
-
-
-
-
-
-
-
-
-
-
-
List I
-
-
-
Occupational exposure may occur through inhalation of spray mists and aerosols and dermal contact
EU MRL pesticide database 
-
-
-
-
-
-
-
-
-
-
Carcinogen
Endocrine disruptor
XNo, known not to cause a problem
A3 A = Chromosome aberration (EFSA database) 3 = Negative
; B3 B = DNA damage/repair (EFSA database) 3 = Negative
; C3 C = Gene mutation (EFSA database) 3 = Negative
; D0 D = Genome mutation (EFSA database) 0 = No data
; E0 E = Unspecified genotoxicity type (miscellaneous data source) 0 = No data
No data found
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
?Possibly, status not identified
XNo, known not to cause a problem
XNo, known not to cause a problem
Respiratory tract irritant
Skin irritant
Skin sensitiser
✓Yes, known to cause a problem
✓Yes, known to cause a problem
?Possibly, status not identified
Eye irritant
Phototoxicant
 
✓Yes, known to cause a problem
No data found
 
Probably liver toxicant
No information available
Health: H302
II (Moderately hazardous)
-
-
fomesafen
fomesafen
Fomesafen
fomesafen
fomosafen
fomesafen
-
fomesafen
-
fomezafen
-
Record last updated:
23/01/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242