| formothion (Ref: SAN 6913I) |
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Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
GENERAL INFORMATION 
for formothion
Description: An obsolete systemic, broad spectrum insecticide and acaricide
Example pests controlled: Spider mites; Aphids; Psyllids; Mealy bugs; Whiteflies
Example applications: Tree fruit; Vines; Olives; Hops; Cereals; Sugarcane; Rice
Availability status: Obsolete
Introduction & key dates: 1961, first reported
EC Regulation 1107/2009 (repealing 91/414):
| Status | Not approved |
| Dossier rapporteur/co-rapporteur | - |
| Date inclusion expires | Expired |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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General status:
| Pesticide type | Insecticide, Acaricide | |||
| Substance group | Organophosphate | |||
| Minimum active substance purity | - | |||
| Known relevant impurities | - | |||
| Substance origin | Synthetic | |||
| Mode of action | Systemic with contact action. Cholinesterase inhibitor. | |||
| CAS RN | 2540-82-1 | |||
| EC number | 219-818-6 | |||
| CIPAC number | 160 | |||
| US EPA chemical code | 366400 | |||
| Chiral molecule | No | |||
| Chemical formula | C6H12NO4PS2 | |||
| SMILES | O=C(N(C=O)C)CSP(=S)(OC)OC | |||
| International Chemical Identifier key (InChIKey) | AIKKULXCBHRFOS-UHFFFAOYSA-N | |||
| International Chemical Identifier (InChI) | InChI=1S/C6H12NO4PS2/c1-7(5-8)6(9)4-14-12(13,10-2)11-3/h5H,4H2,1-3H3 | |||
| Structure diagram/image available? | Yes | |||
| Molecular mass (g mol-1) | 257.27 | |||
| PIN (Preferred Identification Name) | - | |||
| IUPAC name | 2-dimethoxyphosphinothioylthio-N-formyl-N-methylacetamide | |||
| CAS name | S-[2-(formylmethylamino)-2-oxoethyl] O,O-dimethyl phosphorodithioate | |||
| Other status information | Phytotoxic to some varieties of peach, apricot and cherry | |||
| Herbicide Resistance Classification (HRAC) | Not applicable | |||
| Herbicide Resistance Classification (WSSA) | Not applicable | |||
| Insecticide Resistance Classification (IRAC) | 1B | |||
| Fungicide Resistance Classification (FRAC) | Not applicable | |||
| Examples of recorded resistance | Bactrocera dorsalis Myzus persicae Rhizoglyphus robini Tetranychus urticae Bemisia tabaci Boophilus microplus many others |
|||
| Physical state | Yellow viscous liquidy crystals | |||
| Related substances & organisms | - | |||
Formulations:
| Property |
Value | |||
| Example manufacturers & suppliers of products using this active now or historically |
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| Example products using this active |
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| UK LERAP status | No UK approval for use or outside scope | |||
| Formulation and application details | Usually formulated as an emulsifiable concentrate or ULV. | |||
ENVIRONMENTAL FATE
for formothion
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Solubility - In water at 20oC (mg l-1) | 2600 | K4 | High | |
| Solubility - In organic solvents at 20oC (mg l-1) | Miscible | L3 - Benzene | - | |
| Miscible | L3 - Xylene | - | ||
| Miscible | L3 - Toluene | - | ||
| Miscible | L3 - Chloroform | - | ||
| Melting point (oC) | 25 | L3 | - | |
| Boiling point (oC) | - | - | - | |
| Degradation point (oC) | - | - | - | |
| Flashpoint (oC) | - | - | - | |
| Octanol-water partition coefficient at pH 7, 20oC | P | 3.02 X 1001 | Calculated | - |
| Log P | 1.48 | G4 | Low | |
| Bulk density (g ml-1)/Specific gravity | 1.36 | L3 | - | |
| Dissociation constant (pKa) at 25oC | - | - | - | |
| Note: | ||||
| Vapour pressure at 25oC (mPa) | 0.113 | K4 | Volatile | |
| Henry's law constant at 25oC (Pa m3 mol-1) | 1.11 X 10-05 | V3 | Non-volatile | |
| Henry's law constant at 20oC (dimensionless) | 4.60 X 10-09 | K3 | Non-volatile | |
GUS leaching potential index  |
3.07 | Calculated | High leachability | |
| SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Value | 1.64 X 10-01 | Calculated | - |
| Note | - | |||
| Potential for particle bound transport index |
- | Calculated | Low | |
| Maximum UV-vis absorption L mol-1 cm-1 | - | - | - | |
| Surface tension (mN m-1) | - | - | - | |
Degradation:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Soil degradation (days) (aerobic) | DT50 (typical) | 14 | G4 | Non-persistent |
| DT50 (lab at 20oC) | - | - | - | |
| DT50 (field) | - | - | - | |
| DT90 (lab at 20oC) | - | - | - | |
| DT90 (field) | - | - | - | |
| Note | Literature states that DT50 is between 0.5 - 15 days. Loamy soil <1 day. | |||
| Plant matrix DT50 (days) | Value | 1.2 | R3 | - |
| Note | Green bean, leaf matrix | |||
| Aqueous photolysis DT50 (days) at pH 7 | Value | - | - | - |
| Note | - | |||
| Aqueous hydrolysis DT50 (days) at 20oC and pH 7 | Value | 0.17 | K3 | Non-persistent |
| Note | - | |||
| Water-sediment DT50 (days) | - | - | - | |
| Water phase only DT50 (days) | - | - | - | |
Soil adsorption and mobility:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Linear | Kd | - | P3 | Mobile |
| Koc | 21 | |||
| Notes and range | Best available data | |||
| Freundlich | Kf | - | - | - |
| Kfoc | - | |||
| 1/n | - | |||
| Notes and range | - | |||
| pH sensitivity | - | |||
Key metabolites:
| Metabolite | Formation medium | Estimated maximum occurrence fraction | 91/414 relevancy |
|
| dimethoate (Ref: OMS 94) |
Soil | 0.700 | Major fraction, Relevant | |
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Bio-concentration factor | BCF (l kg-1) | 0.07 | Q2 Estimated | Low potential |
| CT50 (days) | Not available | - | ||
| Mammals - Acute oral LD50 (mg kg-1) | > 365 | G4 Rat | Moderate | |
| Mammals - Short term dietary NOEL | (mg kg-1) | - | - | - |
| (ppm diet) | - | - | ||
| Birds - Acute LD50 (mg kg-1) | 630 | G3 Columbidae | Moderate | |
| Birds - Short term dietary (LC50/LD50) | - | - | - | |
| Fish - Acute 96 hour LC50 (mg l-1) | 38.3 | L3 Oncorhynchus mykiss | Moderate | |
| Fish - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) | 16.1 | W3 Daphnia magna | Moderate | |
| Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) | - | - | - | |
| Aquatic plants - Acute 7 day EC50, biomass (mg l-1) | - | - | - | |
| Non-target plants | - | - | - | |
| - | - | - | ||
| Algae - Acute 72 hour EC50, growth (mg l-1) | 42.3 | L3 Scenedesmus subspicatus | Low | |
| Algae - Chronic 96 hour NOEC, growth (mg l-1) | - | - | - | |
| Honeybees | Contact acute 48 hour LD50 (μg bee-1) | 0.15 | K4 | High |
| Oral acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Unknown mode acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Earthworms - Acute 14 day LC50 (mg kg-1) | 157.7 | L3 | Moderate | |
| Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) | - | - | - | |
| Other soil macro-organisms - e.g. Collembola | LR50 / EC50 / NOEC / % Effect | - | - | - |
| Other arthropod (1) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Other arthropod (2) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Soil micro-organisms | - | - | - | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
HUMAN HEALTH AND PROTECTION
for formothion
General:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Threshold of Toxicological Concern (Cramer Class) |
High (class III) | - | - | |
| Mammals - Acute oral LD50 (mg kg-1) | > 365 | G4 Rat | Moderate | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | - | - | - | |
| Mammals - Inhalation LC50 (mg l-1) | - | - | - | |
| Other Mammal toxicity endpoints | - | - | ||
| ADI - Acceptable Daily Intake (mg kg-1bw day-1) | - | - | - | |
| ARfD - Acute Reference Dose (mg kg-1bw day-1) | - | - | - | |
| AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | - | - | - | |
| Dermal penetration studies (%) | - | - | - | |
| Dangerous Substances Directive 76/464 | - | - | - | |
| Exposure Limits | - | - | - | |
| Exposure Routes | Public | - | ||
| Occupational | - | |||
| European MRLs | Click here for the EU MRL pesticide database | |||
| Drinking Water MAC (μg l-1) | - | - | - | |
Health issues:
| Carcinogen | Mutagen | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | |||
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| Respiratory tract irritant | Skin irritant | Skin sensitiser | Eye irritant | Phototoxicant | ||||
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| General human health issues | May cause blurred vision, muscle spasms or loss of coordination | |||||||
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found
Handling issues:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| General |
Incompatible with alkaline substances | |||
| CLP classification 2013 | Health: H302, H312 | |||
| EC Risk Classification |
Xn - Harmful: R21/22 | |||
| EC Safety Classification |
S2, S36/37 | |||
| WHO Classification | II | - | Moderately hazardous | |
| US EPA Classification (formulation) | - | - | ||
| UN Number | - | |||
| Waste disposal & packaging |
- | |||
| Language | Name |
| English | formothion |
| French | formothion |
| German | Formothion |
| Danish | formothion |
| Italian | formothion |
| Spanish | formotion |
| Greek | formothion |
| Slovenian | formotion |
| Polish | formotion |
| Swedish | - |
| Hungarian | - |
| Dutch | formothion |
Record last updated: Sunday 14 August 2016
Contact: aeru@herts.ac.uk