Select Option
Home
A to Z
Search
Terms & Conditions
Support Information
Purchasing & Other Services
Video User Guides
GET ADDITIONAL DATA HERE!

gamma-cyhalothrin (Ref: DE 225)
** XDE 225 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Gamma-cyhalothrin is a broad-spectrum pyrethroid insecticide approvd for use in EU. It has a low aqueous solubility, volatile and, based on its chemical properties, would not be expected to leach to groundwater. It is non-persistent in soil systems and would not normally persist in aqueous systems. It has a high mammalian toxicity and there is some concern regarding its potential to bioaccumulate. It is considered to be a neurotoxicant. It is highly toxic to honey bees and many aquatic organisms and moderately toxic to birds and earthworms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for gamma-cyhalothrin

Description: A pyrethroid insecticide offering broad-spectrum control of insect pests in a wide range of agricultural crops

Example pests controlled: Sucking and chewing insect pests

Example applications: Corn; Oilseed rape; Cereals

Availability status: Current

Introduction & key dates: Late 1990s, Europe; 2003, Indonesia

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur UK
Date inclusion expires 31/03/2025

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, Argentina, Chile, China, Indonesia, South Africa, Mexico, Romania, USA

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide
Substance group Pyrethroid
Minimum active substance purity 980 g/kg
Known relevant impurities EU dossier: none declared
Substance origin Synthetic
Mode of action Non-systemic acting by contact and/or ingestion. Sodium channel modulator, distrupts nerve function
CAS RN 76703-62-3
EC number -
CIPAC number 768
US EPA chemical code 12887
Chiral molecule No
Chemical formula C23H19ClF3NO3
SMILES C1([C@@H]([C@@H]1\C=C(\C(F)(F)F)Cl)C(=O)O[C@@H](c1cc(ccc1)Oc1ccccc1)C#N)(C)C
International Chemical Identifier key (InChIKey) ZXQYGBMAQZUVMI-GCMPRSNUSA-N
International Chemical Identifier (InChI) InChI=1S/C23H19ClF3NO3/c1-22(2)17(12-19(24)23(25,26)27)20(22)21(29)31-18(13-28)14-7-6-10-16(11-14)30-15-8-4-3-5-9-15/h3-12,17-18,20H,1-2H3/b19-12-/t17-,18+,20-/m0/s1
Structure diagram/image available? Yes
Molecular mass (g mol-1) 449.85
PIN (Preferred Identification Name) -
IUPAC name (S)-α-cyano-3-phenoxybenzyl (1R,3R)-3-[(Z)-2-chloro-3,3,3-trifluoropropenyl]-2,2-dimethylcyclopropanecarboxylate
CAS name (S)-cyano(3-phenoxyphenyl)methyl (1R,3R)-3-[(1Z)-2-chloro-3,3,3-trifluoro-1-propenyl]-2,2-dimethylcyclopropanecarboxylate
Other status information Marine pollutant; PAN Listed as Highly Hazardous Chemical
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 3
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Helicoverpa armigera
Physical state Off-white coloured solid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Cheminova
  • Dow AgroSciences
Example products using this active
  • Fighter
  • Trojan
  • Bull
  • Vantex
  • Proaxis
  • Fentrol
  • Corello GF-317
UK LERAP status No UK approval for use or outside scope
Formulation and application details Typically formulated as suspension in a solvent.


ENVIRONMENTAL FATE

for gamma-cyhalothrin

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.0021 A4 Low
Solubility - In organic solvents at 20oC (mg l-1) 500000 A5 - Acetone -
500000 A5 - Ethyl acetate -
138000 A5 - Methanol -
30700 A5 - Heptane -
Melting point (oC) 55.6 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 245 A5 -
Flashpoint (oC) 398 A5 - (auto-ignition) -
Octanol-water partition coefficient at pH 7, 20oC P 9.12 X 1004 Calculated -
Log P 4.96 A5 High
Bulk density (g ml-1)/Specific gravity 1.32 A5 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 25oC (mPa) 3.45 X 10-04 A5 Volatile
Henry's law constant at 25oC (Pa m3 mol-1) 0.0221 A5 Non-volatile
Henry's law constant at 20oC (dimensionless) 3.03 X 10-05 Calculated Volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index -1.11 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 Acidic soln.: 204nm=45600
Neutral soln.: 204nm=45700
Basic soln.: 219nm=29600
- -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
Soil degradation (days) (aerobic) DT50 (typical) 26.8 A5 Non-persistent
DT50 (lab at 20oC) 26.8 A5 Non-persistent
DT50 (field) 26.5 A5 Non-persistent
DT90 (lab at 20oC) - - -
DT90 (field) 76 A5 -
Note EU dossier lab studies DT50 range 16.6-33.8 days; Manufacturers published literature lab studies DT50 28-51 days, Field studies DT50 range 18-30 days, DT90 range 58-94 days; There are a few other literature references available but indications are that DT50 is a few weeks.
Plant matrix DT50 (days) Value - - -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 136 E4 Persistent
Note pH sensitive: stable at pH 5, 1.1 days at pH 9
Water-sediment DT50 (days) 34.5 A5 Moderately fast
Water phase only DT50 (days) 6.4 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 622 A5 Non-mobile
Koc 59677
Notes and range EU dossier Kd range 239-826 mL/g, Koc range 34133-92692 mL/g, soils=4
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 91/414 relevancy Click here for further information on 91/414 relevancy
(RS)-alpha-cyano-3-(4-hydroxyphenoxy)benzyl-(Z)-(1RS)-cis-3-(2-chloro-3, 3, 3-trifluoropropenyl)-2, 2-dimethylcyclopropanecarboxylate Soil     Minor fraction
3-phenoxybenzoic acid Soil     Minor fraction
3-(4-hydroxyphenoxy)benzaldehyde This metabolite may cause environmental pollution, click here for further information Soil   0.122   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
3-(2-chloro-3,3,3-trifluoro-prop-1-enyl)-2-hydroxy-methyl-2-methyl-cyclopropane carboxylic acid Cyhalothrin compound XI Animal - -
3-(4'-hydroxy)-phenoxy-benzoic acid Cyhalothrin compound XXIII Rat (Urinary); Animal - -
(Z)-3-(2-chloro-3,3,3-trifluoro-propenyl)-2,2-dimethylcyclo-propane carboxylic acid Cyhalothrin compound 1a - - -
(1RS)-trans-3-(2-chloro-3,3,3-trifluoropropenyl)-2,2-dimethyl-cyclopropane carboxylic acid Cyhalothrin compound 1b - - -
(RS)- -cyano-3-phenoxy-benzyl alcohol Cyhalothrin compound III - - -
3-phenoxybenzaldehyde Cyhalothrin compound IV - - -
(RS)-3-phenoxymandelamide Cyhalothrin compound IX - - -


ECOTOXICOLOGY

for gamma-cyhalothrin

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 2240 A5 (whole fish) Threshold for concern
CT50 (days) 9.1 -
Mammals - Acute oral LD50 (mg kg-1) 55 A5 Rat High
Mammals - Short term dietary NOEL (mg kg-1) 2 F4 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 0.000035 A5 Lepomis macrochirus High
Fish - Chronic 21 day NOEC (mg l-1) 0.00013 P3 Oncorhynchus mykiss High
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.000045 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.0000022 E4 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.000047 A5 Chironomus riparius High
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) 0.000126 A5 Chironomus riparius High
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 2.85 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) 0.005 A5 High
Oral acute 48 hour LD50 (μg bee-1) 4.2 A5 Moderate
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 650 A5 Eisenia foetida, corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 0.25 A5 Eisenia foetida, 56 day corr Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 0.23 Mortality
A5 Aphidius rhopalosiphi, adult
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 0.0006 Mortality
A5 Typhlodromus pyri
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 375g/kg soil
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for gamma-cyhalothrin

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 55 A5 Rat High
Mammals - Dermal LD50 (mg kg-1 body weight) 1643 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 0.028 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.0012 A5 Rat, SF=400 as cyhalothrin -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.0025 A5 Dog, SF=200 as lambda cyhalothrin -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.0003 A5 Rat, SF=1600 as cyhalothrin -
Dermal penetration studies (%) 2-32% A5 concentration dependant -
Dangerous Substances Directive 76/464 List II - -
Exposure Limits [LT TWA 8hr: 0.1 mg/m3] Occupation Exposure -
Exposure Routes Public Acceptable for proposed uses
Occupational Acceptable for proposed uses with PPE/PPC
European MRLs Click here for the EU MRL pesticide database
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Harmful by inhalation
Possible liver toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 None allocated at this time
EC Risk Classification Click here to view information omn the EU risk phrases T+ - Very toxic: R26
T - Toxic: R25
Xn - Harmful: R21, R43, R48
N - Dangerous for the environment: R50/53
EC Safety Classification Click here to view information omn the EU safety phrases S24, S37, S60
WHO Classification NL - Not listed
US EPA Classification (formulation) III, IV - Caution - Slightly toxic, Caution - Not acutely toxic
UN Number 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packging group III (minor danager)


TRANSLATIONS

for gamma-cyhalothrin

Language Name
English gamma-cyhalothrin
French Gamma-cyhalothrine
German gamma-Cyhalothrin
Danish gamma-cyhalothrin
Italian gamma-cialotrina
Spanish gamma-cihaltrina
Greek -
Slovenian gama-cihalotrin
Polish gamma-cyhalotryna
Swedish -
Hungarian -
Dutch -

Record last updated: Monday 17 October 2016
Contact: aeru@herts.ac.uk