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heptachlor (Ref: ENT 15152)
** heptachlore ** E3314 ** H-34 ** OMS 193 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Heptachlor in an insecticide that is not approved for use in the EU. It has a low aqueous solubility but is highly soluble in most organic solvents. It is volatile and has low potential for leaching to groundwater. heptachlor can be persistent in soil systems but is not generally persistent in water systems. It is moderately toxic to mammals and may bioaccumulate. heptachlor may also cause adverse reproduction/development effects and is a neurotoxin. It is moderately toxic to birds but highly toxic to honeybees and most aquatic species.

GENERAL INFORMATION
for heptachlor

Description: An obsolete insecticide once used to kill termites, ants and other insects in agricultural and domestic situations

Example pests controlled: Ants; Termites; Cutworms; Maggots; Spittlebugs; Weevils; Wireworms; Japanese beetles; Mosquitoes

Example applications: Corn; Sorghum; Small grains

Availability status: Obsolete, Banned

Introduction & key dates: 1951, first reported

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur -
Date inclusion expires Expired

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Costa Rica

General status:
Pesticide type Insecticide
Substance group Organochlorine
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Persistent, non-systemic contact and stomach poison with some fumigant action. Is a chloride channel-blocking agent.
CAS RN 76-44-8
EC number 200-962-3
CIPAC number 36
US EPA chemical code 044801
Chiral molecule Chiral, a specific isomer or a derivative of a chiral molecule
Chemical formula C10H5Cl7
SMILES ClC1(C(Cl)2Cl)C(C=CC3Cl)C3C2(Cl)C(Cl)=C1Cl
International Chemical Identifier key (InChIKey) FRCCEHPWNOQAEU-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C10H5Cl7/c11-4-2-1-3-5(4)9(15)7(13)6(12)8(3,14)10(9,16)17/h1-5H
Structure diagram/image available? Yes
Molecular mass (g mol-1) 373.32
PIN (Preferred Identification Name) -
IUPAC name 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindene
CAS name 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-4,7-methano-1H-indene
Other status information Chemical subject to PIC regulations; POP; LRTAP Annex 1; OSPAR soc; Severe Marine Pollutant; Rotterdam Convention (Class O)
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 2A
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Anthonomus grandis
Delia brassicae
Diabrotica longicornis
Psilia rosae
Conoderus falli
Diabrotica virgifera
many others
Physical state White to tan coloured crystals
Related substances & organisms -

Formulations:
Property Value
Example manufacturers & suppliers of products using this active now or historically
  • Velsicol Chemical Corp.
Example products using this active
  • Gold crest
  • Heptamul
  • Heptox
  • Drinox
UK LERAP status No UK approval for use or outside scope
Formulation and application details Available in a wide variety of formulations including wettable powders, emulsifiable concentrates, dusts and oil solutions.


ENVIRONMENTAL FATE

for heptachlor

Property Value Source/Quality Score/Other Information Interpretation
Solubility - In water at 20oC (mg l-1) 0.056 G4 Low
Solubility - In organic solvents at 20oC (mg l-1) 750000 L3 - Acetone -
1060000 L3 - Benzene -
1020000 L3 - Xylene -
45000 L3 - Ethanol -
Melting point (oC) 95 V3 -
Boiling point (oC) 135 L3 -
Degradation point (oC) - - -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 2.75 X 1005 Calculated -
Log P 5.44 G4 High
Bulk density (g ml-1)/Specific gravity 1.58 L3 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 25oC (mPa) 53 G4 Volatile
Henry's law constant at 25oC (Pa m3 mol-1) 3.53 X 1002 L3 Volatile
Henry's law constant at 20oC (dimensionless) 4.47 X 10-02 Q2 Volatile
GUS leaching potential index -0.93 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Value Source/Quality Score/Other Information Interpretation
Soil degradation (days) (aerobic) DT50 (typical) 285 L3 Persistent
DT50 (lab at 20oC) - - -
DT50 (field) 250 F3 Persistent
DT90 (lab at 20oC) - - -
DT90 (field) - - -
Note Other sources: DT50 around 2 yrs (R3), 9-10 months (R3)
Foliar DT50 (days) Value 1.7 R3 -
Note -
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 1 R3 Non-persistent
Note -
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Value Source/Quality Score/Other Information Interpretation
Linear Kd - G3 Non-mobile
Koc 24000
Notes and range Other sources: 21878 mL/g (R3)
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 91/414 relevancy
heptachlor epoxide (Ref: ENT 25584) Soil     Not assessed under 91/414


ECOTOXICOLOGY

for heptachlor

Property Value Source/Quality Score/Other Information Interpretation
Bio-concentration factor BCF (l kg-1) 2430 R3 (whole body) Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 147 L3 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - L1 Rat -
(ppm diet) 5 -
Birds - Acute LD50 (mg kg-1) > 2000 L3 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 0.007 L3 Oncorhynchus mykiss High
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.042 F4 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.027 F4 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 0.526 F4 High
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for heptachlor

General:
Property Value Source/Quality Score/Other Information Interpretation
Threshold of Toxicological Concern (Cramer Class) High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 147 L3 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) 195 R3 Rat -
Mammals - Inhalation LC50 (mg l-1) 2.0 R3 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.0001 JMPR -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 List I; List II - -
Exposure Limits - - -
Exposure Routes Public Risk of exposure via food is now considered negligible
Occupational May be absorbed through intact skin
European MRLs Click here for the EU MRL pesticide database
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

General human health issues Bioaccumulates
Liver toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Value Source/Quality Score/Other Information Interpretation
General Incompatible with alkaline substances
CLP classification 2013 Health: H301, H311, H351, H373
Environment: H400, H410
EC Risk Classification Carcinogen category 3: R40
T - Toxic: R24/25, R33
N - Dangerous for the environment: R50, R53
EC Safety Classification S1/2, S36/37, S45, S60, S61
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) II - Warning - Moderately toxic
UN Number -
Waste disposal & packaging -


TRANSLATIONS

for heptachlor

Language Name
English heptachlor
French heptachlore
German Heptachlor
Danish heptachlor
Italian eptaclor
Spanish heptaclor
Greek heptachlor
Slovenian heptaklor
Polish heptachlor
Swedish -
Hungarian -
Dutch heptachloor

Record last updated: Saturday 19 March 2016
Contact: aeru@herts.ac.uk