| heptachlor (Ref: ENT 15152) |
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GENERAL INFORMATION 
for heptachlor
Description: An obsolete insecticide once used to kill termites, ants and other insects in agricultural and domestic situations
Introduction: 1951, first reported
EC Regulation 1107/2009 (repealing 91/414):
| Status | Not approved |
| Dossier rapporteur/co-rapporteur | - |
| Date inclusion expires | Expired |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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Also registered in: Costa Rica
General status:
| Pesticide type | Insecticide | |||
| Substance group | Organochlorine | |||
| Substance origin | Synthetic | |||
| Mode of action | Persistent, non-systemic contact and stomach poison with some fumigant action. Is a chloride channel-blocking agent. | |||
| CAS RN | 76-44-8 | |||
| EC number | 200-962-3 | |||
| CIPAC number | 36 | |||
| US EPA chemical code | 044801 | |||
| Chiral molecule | Chiral, a specific isomer or a derivative of a chiral molecule | |||
| Chemical formula | C10H5Cl7 | |||
| SMILES | ClC1(C(Cl)2Cl)C(C=CC3Cl)C3C2(Cl)C(Cl)=C1Cl | |||
| International Chemical Identifier key (InChIKey) | FRCCEHPWNOQAEU-UHFFFAOYSA-N | |||
| International Chemical Identifier (InChI) | InChI=1S/C10H5Cl7/c11-4-2-1-3-5(4)9(15)7(13)6(12)8(3,14)10(9,16)17/h1-5H | |||
| Structure diagram/image available? | Yes | |||
| Molecular mass (g mol-1) | 373.32 | |||
| PIN (Preferred Identification Name) | - | |||
| IUPAC name | 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-4,7-methanoindene | |||
| CAS name | 1,4,5,6,7,8,8-heptachloro-3a,4,7,7a-tetrahydro-4,7-methano-1H-indene | |||
| Other status information | Chemical subject to PIC regulations; POP; LRTAP Annex 1; OSPAR soc; Severe Marine Pollutant; Rotterdam Convention (Class O) | |||
| Herbicide Resistance Classification (HRAC) | Not applicable | |||
| Herbicide Resistance Classification (WSSA) | Not applicable | |||
| Insecticide Resistance Classification (IRAC) | 2A | |||
| Fungicide Resistance Classification (FRAC) | Not applicable | |||
| Physical state | White to tan coloured crystals | |||
| Related substances & organisms | - | |||
Formulations:
| Property |
Value | |||
| Example manufacturers & suppliers of products using this active |
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| UK LERAP status | No UK approval for use or outside scope | |||
| Formulation and application details | Available in a wide variety of formulations. | |||
ENVIRONMENTAL FATE
for heptachlor
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Solubility - In water at 20oC (mg l-1) | 0.056 | G4 | Low | |
| Solubility - In organic solvents at 20oC (mg l-1) | 750000 | L3 - Acetone | - | |
| 1060000 | L3 - Benzene | - | ||
| 1020000 | L3 - Xylene | - | ||
| 45000 | L3 - Ethanol | - | ||
| Melting point (oC) | 95 | V3 | - | |
| Boiling point (oC) | 135 | L3 | - | |
| Degradation point (oC) | - | - | - | |
| Flashpoint (oC) | - | - | - | |
| Octanol-water partition coefficient at pH 7, 20oC | P | 2.75 X 1005 | Calculated | - |
| Log P | 5.44 | G4 | High | |
| Bulk density (g ml-1)/Specific gravity | 1.58 | L3 | - | |
| Dissociation constant (pKa) at 25oC | - | - | - | |
| Note: | ||||
| Vapour pressure at 25oC (mPa) | 53 | G4 | Intermediate state | |
| Henry's law constant at 25oC (Pa m3 mol-1) | 3.53 X 1002 | L3 | Volatile | |
| Henry's law constant at 20oC (dimensionless) | 4.47 X 10-02 | Q2 | Volatile | |
GUS leaching potential index  |
-0.93 | Calculated | Low leachability | |
| SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Value | 5.35 X 10-03 | Calculated | - |
| Note | Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW | |||
| Potential for particle bound transport index |
- | Calculated | High | |
| Maximum UV-vis absorption L mol-1 cm-1 | - | - | - | |
| Surface tension (mN m-1) | - | - | - | |
Degradation:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Soil degradation (days) (aerobic) | DT50 (typical) | 285 | L3 | Persistent |
| DT50 (lab at 20oC) | - | - | - | |
| DT50 (field) | 250 | F3 | Persistent | |
| DT90 (lab at 20oC) | - | - | - | |
| DT90 (field) | - | - | - | |
| Note | Other sources: DT50 around 2 yrs (R3), 9-10 months (R3) | |||
| Aqueous photolysis DT50 (days) at pH 7 | Value | - | - | - |
| Note | - | |||
| Aqueous hydrolysis DT50 (days) at 20oC and pH 7 | Value | 1 | R3 | Non-persistent |
| Note | - | |||
| Water-sediment DT50 (days) | - | - | - | |
| Water phase only DT50 (days) | - | - | - | |
Soil adsorption and mobility:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Linear | Kd | - | G3 | Non-mobile |
| Koc | 24000 | |||
| Notes and range | Other sources: 21878 mL/g (R3) | |||
| Freundlich | Kf | - | - | - |
| Kfoc | - | |||
| 1/n | - | |||
| Notes and range | - | |||
| pH sensitivity | - | |||
Key metabolites:
| Metabolite | Formation medium | Estimated maximum occurrence fraction | 91/414 relevancy |
|
| heptachlor epoxide (Ref: ENT 25584) | Soil | Not assessed under 91/414 | ||
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Bio-concentration factor | BCF | 2430 | R3 (whole body) | Threshold for concern |
| CT50 (days) | Not available | - | ||
| Bioaccumulation potential | - | Calculated | High | |
| Mammals - Acute oral LD50 (mg kg-1) | > 147 | L3 Rat | Moderate | |
| Mammals - Short term dietary NOEL | (mg kg-1) | - | L1 Rat | - |
| (ppm diet) | 5 | - | ||
| Birds - Acute LD50 (mg kg-1) | > 2000 | L3 Anas platyrhynchos | Moderate | |
| Birds - Short term dietary (LC50/LD50) | - | - | - | |
| Fish - Acute 96 hour LC50 (mg l-1) | 0.007 | L3 Oncorhynchus mykiss | High | |
| Fish - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) | 0.042 | F4 Daphnia magna | High | |
| Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) | - | - | - | |
| Aquatic plants - Acute 7 day EC50, biomass (mg l-1) | - | - | - | |
| Algae - Acute 72 hour EC50, growth (mg l-1) | 0.027 | F4 Pseudokirchneriella subcapitata | Moderate | |
| Algae - Chronic 96 hour NOEC, growth (mg l-1) | - | - | - | |
| Honeybees | Contact acute 48 hour LD50 (μg bee-1) | > 0.526 | F4 | High |
| Oral acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Unknown mode acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Earthworms - Acute 14 day LC50 (mg kg-1) | - | - | - | |
| Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) | - | - | - | |
| Other soil macro-organisms - e.g. Collembola | LR50 / EC50 / NOEC / % Effect | - | - | - |
| Other arthropod (1) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Other arthropod (2) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Soil micro-organisms | - | - | - | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
HUMAN HEALTH AND PROTECTION
for heptachlor
General:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Mammals - Acute oral LD50 (mg kg-1) | > 147 | L3 Rat | Moderate | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | 195 | R3 Rat | - | |
| Mammals - Inhalation LC50 (mg l-1) | 2.0 | R3 Rat | - | |
| Other Mammal toxicity endpoints | - | - | ||
| ADI - Acceptable Daily Intake (mg kg-1bw day-1) | 0.0001 | JMPR | - | |
| ARfD - Acute Reference Dose (mg kg-1bw day-1) | - | - | - | |
| AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | - | - | - | |
| Dermal penetration studies (%) | - | - | - | |
| Dangerous Substances Directive 76/464 | List I; List II | - | - | |
| Exposure Limits | - | - | - | |
| Exposure Routes | Public | Risk of exposure via food is now considered negligible | ||
| Occupational | May be absorbed through intact skin | |||
| Examples of European MRLs (mg kg-1) | Value | - | ||
| Note | For the EU pesticides database click here | |||
| Drinking Water MAC (μg l-1) | - | - | - | |
Health issues:
| Carcinogen | Mutagen | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | Respiratory tract irritant | Skin irritant | Eye irritant |
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| General human health issues | Bioaccumulates Liver toxicant |
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: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data
Handling issues:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| General |
Incompatible with alkaline substances | |||
| CLP classification 2013 | - | |||
| EC Risk Classification |
Carcinogen category 3: R40 T - Toxic: R24/25, R33 N - Dangerous for the environment: R50, R53 |
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| EC Safety Classification |
S1/2, S36/37, S45, S60, S61 | |||
| WHO Classification | II | - | Moderately hazardous | |
| US EPA Classification (formulation) | II | - | Warning - Moderately toxic | |
| UN Number | - | |||
| Waste disposal & packaging |
- | |||
| Language | Name |
| English | heptachlor |
| French | heptachlore |
| German | Heptachlor |
| Danish | heptachlor |
| Italian | eptaclor |
| Spanish | heptaclor |
| Greek | heptachlor |
| Slovenian | heptaklor |
| Polish | heptachlor |
| Swedish | - |
| Hungarian | - |
| Dutch | heptachloor |
Record last updated: Wednesday 14 January 2015
Contact: aeru@herts.ac.uk