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hexachlorobenzene (Ref: ENT 1719)
** HCB ** perchlorobenzene ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Hexachlorobenzene is a fungicide banned in the EU. It has a low aqueous solubility and is volatile with a low potential for leaching to groundwater. It may be very persistent in soil systems. Hexachlorobenzene las a low mammalian toxicity but a high potential to bioaccumulate. It may also be carcinogenic. It is highly toxic to fish and moderately toxic to birds, aquatic invertebrates, algae and earthworms.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for hexachlorobenzene

Description: An chlorinated hydrocarbon fungicide used to control bunt and a pesticide transformation product

Example pests controlled: Common and Dwarf bunt

Example applications: Wheat and some other cereals

Efficacy & activity: -

Availability status: Unknown, Banned

Introduction & key dates: circa 1947

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur -
Date inclusion expires Expired
EU Candidate for substitution (CfS) -
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism None
Chemical formula C6Cl6
Canonical SMILES C1(=C(C(=C(C(=C1Cl)Cl)Cl)Cl)Cl)Cl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) CKAPSXZOOQJIBF-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C6Cl6/c7-1-2(8)4(10)6(12)5(11)3(1)9
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide, Biocide, Metabolite, Wood preservative
Metabolite Type Soil
Substance group Chlorinated hydrocarbon
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Fumigant action on fungal spores
CAS RN 118-74-1
EC number 204-273-9
CIPAC number 161
US EPA chemical code 061001
PubChem CID 8370
Molecular mass (g mol-1) 284.80
PIN (Preferred Identification Name) -
IUPAC name perchlorobenzene
CAS name hexachlorobenzene
Other status information WFD priority substance; Chemical subject to PIC regulations; OSPAR candidate; Rotterdam Convention (Class Ia)
Relevant Environmental Water Quality Standards EU Directive 2008/105/EC EQS surface waters: annual average 0.01 ug/L; max measured 0.05 ug/L
UK Statutory standard for the protection of aquatic life in inland, coastal and territorial waters: 0.03 ug/L as annual average
Other standards are also available
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not known
Examples of recorded resistance -
Physical state Colourless crystals
Related substances & organisms -

Can be a metabolite of:
Parent Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
quintozene Soil     -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Bayer
Example products using this active
  • Anticarie
  • Bent-cure
  • Granero
  • No Bunt
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Often used as a seed dressing.


ENVIRONMENTAL FATE

for hexachlorobenzene

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.0047 G4 Low
Solubility - In organic solvents at 20oC (mg l-1) - - -
Melting point (oC) 226 L3 -
Boiling point (oC) 325 V3 -
Degradation point (oC) - - -
Flashpoint (oC) 242 V3 -
Octanol-water partition coefficient at pH 7, 20oC P 8.51 X 1003 Calculated -
Log P 3.93 H4 High
Bulk density (g ml-1)/Specific gravity 2.044 L3 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 20oC (mPa) 1.45 G4 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.03 X 1001 H4 Moderately volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index -2.31 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 2000 G3 Very persistent
DT50 (lab at 20oC) - - -
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note General literature states DT50 range 2.7-7.5 years, highly persistent
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 9.7 R3 -
Note Lettuce leaves, n=1
Aqueous photolysis DT50 (days) at pH 7 Value - - -
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value - - -
Note -
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - G3 Non-mobile
Koc 50000
Notes and range -
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -


ECOTOXICOLOGY

for hexachlorobenzene

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 35000 A3 (Other literature values Log BCF range 1.6-5.4 (R3); PIC DGD gives BCF range 375-35000) High potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 10000 L3 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 575 G4 Colinus virginianus Moderate
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 0.03 F4 Oncorhynchus mykiss High
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.5 F2 Daphnia magna, 24 hour Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.01 F4 Scenedesmus abundans Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) - - -
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 F4 Eisenia foetida Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for hexachlorobenzene

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 10000 L3 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) - - -
Mammals - Inhalation LC50 (mg l-1) - - -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) - - -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 List I - -
Exposure Limits - - -
Exposure Routes Public Primary source of exposure is via diet but risk is low as substance is banned
Occupational Risk via exhalation
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

General human health issues Extremely hazardous
IARC group 2B carcinogen
Endocrine issues - Severely disruption of thyroid hormone production

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes No information available
CLP classification 2013 Health: H350, H372
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Carcinogen category 2: R45
T - Toxic: R48/25
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S45, S53, S60, S61
WHO Classification Ia - Extremely hazardous
US EPA Classification (formulation) IV - Caution - Not acutely toxic
UN Number 2729
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for hexachlorobenzene

Language Name
English hexachlorobenzene
French hexachlorobenzĂȘne
German Hexachlorbenzol
Danish hexachlorbenzen
Italian esaclorobenzene
Spanish hexaclorobenceno
Greek -
Slovenian heksaklorbenzen
Polish heksachlorobenzen
Swedish -
Hungarian -
Dutch hexachloorbenzeen

Record last updated: Wednesday 31 October 2018
Contact: aeru@herts.ac.uk