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hexaflumuron (Ref: XRD 473)
** DE 473 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for hexaflumuron

Description: An insecticide used to control the larvae of Lepidoptera, Coleoptera, Homopetra and Diptera spp.

Example pests controlled: Termites

Example applications: Wood structures such as buildings, fences, decking

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1983, first reported

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur -
Date inclusion expires Expired
EU Candidate for substitution (CfS) -
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C16H8Cl2F6N2O3
Canonical SMILES C1=CC(=C(C(=C1)F)C(=O)NC(=O)NC2=CC(=C(C(=C2)Cl)OC(C(F)F)(F)F)Cl)F
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) RGNPBRKPHBKNKX-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C16H8Cl2F6N2O3/c17-7-4-6(5-8(18)12(7)29-16(23,24)14(21)22)25-15(28)26-13(27)11-9(19)2-1-3-10(11)20/h1-5,14H,(H2,25,26,27,28)
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide, Insect Growth Regulator
Substance group Benzoylurea
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Chitin synthesis inhibitor, systemic with stomach action
CAS RN 86479-06-3
EC number 401-400-1
CIPAC number 698
US EPA chemical code 118202
PubChem CID 91741
Molecular mass (g mol-1) 461.14
PIN (Preferred Identification Name) -
IUPAC name 1-[3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl]-3-(2,6-difluorobenzoyl)urea
CAS name N-(((3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl)amino)carbonyl)-2,6-difluorobenzamide
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 15
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Colourless solid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Dow AgroSciences
  • FCC Ltd
  • AgroCare
Example products using this active
  • Recruit
  • Sonet
  • Consult
  • Conhex
  • Sentricon
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually supplied as an emulsifiable concentrate or suspension concentrate.


ENVIRONMENTAL FATE

for hexaflumuron

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.027 L3 Low
Solubility - In organic solvents at 20oC (mg l-1) 162000 L3 - Acetone -
100000 L3 - Ethyl acetate -
5 L3 - Heptane -
2000 L3 - Octanol -
Melting point (oC) 203.5 L3 -
Boiling point (oC) Decomposes before boiling L3 -
Degradation point (oC) 300 L3 -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 4.79 X 1005 Calculated -
Log P 5.68 L3 High
Bulk density (g ml-1)/Specific gravity 1.68 L3 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 20oC (mPa) 0.059 L3 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.01 X 1000 L3 Moderately volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index -0.03 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 57 L3 Moderately persistent
DT50 (lab at 20oC) - - -
DT50 (field) 170 F3 Persistent
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note Best available data
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 3.0 R4 -
Note Published literature RL50 range 1.1-4.5 days, 4 field & undercover grown crops, various matrices, n=5
Aqueous photolysis DT50 (days) at pH 7 Value 6.3 L3 Moderately fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value - L3 -
Note Stable at pH 5
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - W3 Non-mobile
Koc 10391
Notes and range -
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl urea - - - -
3,5-dichloro-4-(1,1,2,2-tetrafluoroethoxy)phenyl amine - - - -
2,6-difluorobenzoic acid
(Ref: )
Note: Stable at pH 5
- - - -


ECOTOXICOLOGY

for hexaflumuron

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 4700 Q2 Threshold for concern
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) > 5000 L3 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 75 L2 Rat, 2 year High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 2000 L3 Colinus virginianus Moderate
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 100 L3 Lepomis macrochirus Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.0001 J4 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 3.2 L3 Raphidocelis subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) - - -
Oral acute 48 hour LD50 (μg bee-1) 0.1 L3 High
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 880 L3 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect 1.8 R4 Folsomia candida, NOEC: 0.1 mg kg-1 -
Other arthropod (1) LR50 g ha-1 - - -
% Effect Moderately harmful AA2 Typhlodromus pyri -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for hexaflumuron

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 L3 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 L3 Rabbit -
Mammals - Inhalation LC50 (mg l-1) 7.0 L3 Rat, 4 hr -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.02 L3 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 List II - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

-

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Potential blood toxicant

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes No information available
CLP classification 2013 -
EC Risk Classification Click here to view information omn the EU risk phrases Xi - Irritant: R36
N - Dangerous for the environment: R50/53
EC Safety Classification Click here to view information omn the EU safety phrases -
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) III, IV - Caution - Slightly toxic, Caution - Not acutely toxic
UN Number 3077
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for hexaflumuron

Language Name
English hexaflumuron
French hexaflumuron
German Hexaflumuron
Danish hexaflumuron
Italian esaflumuron
Spanish hexaflumuron
Greek -
Slovenian heksaflumuron
Polish heksaflumuron
Swedish -
Hungarian -
Dutch -

Record last updated: Wednesday 23 May 2018
Contact: aeru@herts.ac.uk