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PhD Oportunity with Syngenta & the University of Hertfordshire

hexazinone (Ref: DPX A3674)
** DPX-3674 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for hexazinone

Description: A broad-spectrum herbicide used to control many annual, biennial and perennial weeds.

Example pests controlled: Grasses; Broad-leaved weeds; Woody plants

Example applications: Fruit; Sugarcane; Alfalfa; Forestry; Pastures; Rangeland; Fallow land

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1975, USA

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur -
Date inclusion expires Expired
EU Candidate for substitution (CfS) -

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Herbicide
Substance group Triazinone
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Non-selective with contact action, absorbed through the roots and foliage of plants. Inhibits photosynthesis (photosystem II).
CAS RN 51235-04-2
EC number 257-074-4
CIPAC number 374
US EPA chemical code 107201
Isomerism -
Chemical formula C12H20N4O2
SMILES O=C1/N=C(\N(C(=O)N1C2CCCCC2)C)N(C)C
International Chemical Identifier key (InChIKey) CAWXEEYDBZRFPE-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C12H20N4O2/c1-14(2)10-13-11(17)16(12(18)15(10)3)9-7-5-4-6-8-9/h9H,4-8H2,1-3H3
Structure diagram/image available? Yes
Molecular mass (g mol-1) 252.31
PIN (Preferred Identification Name) -
IUPAC name 3-cyclohexyl-6-dimethylamino-1-methyl-1,3,5-triazine-2,4(1H,3H)-dione
CAS name 3-cyclohexyl-6-(dimethylamino)-1-methyl-1,3,5-triazine-2,4(1H,3H)-dione
Other status information Potential groundwater contaminant; Chemical subject to PIC regulations
Herbicide Resistance Classification (HRAC) C1
Herbicide Resistance Classification (WSSA) 5
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Colourless crystals
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • DuPont
  • AgroCare
  • Makhteshim Agan Group
  • FCC Ltd
Example products using this active
  • Velpar Weed Killer
  • Pronone
  • Fertihexa
  • Elinone
UK LERAP status No UK approval for use or outside scope
Formulation and application details Available in a variety of formulations including wettable granules, suspension concentrates and tablets.


ENVIRONMENTAL FATE
for hexazinone

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 33000 K4 High
Solubility - In organic solvents at 20oC (mg l-1) 626000 C4 - Acetone -
334000 C4 - Toluene -
2146500 C4 - Methanol -
837000 C4 - Benzene -
Melting point (oC) 113.5 L3 -
Boiling point (oC) Decomposes on distillation L2 -
Degradation point (oC) - - -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 1.48 X 1001 Calculated -
Log P 1.17 P4 Low
Bulk density (g ml-1)/Specific gravity 1.25 L3 -
Dissociation constant (pKa) at 25oC 2.2 L3 -
Note: Weak base
Vapour pressure at 25oC (mPa) 0.03 G4 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.10 X 10-07 H4 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 4.43 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 2.15 X 10+00 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 105 L3 Persistent
DT50 (lab at 20oC) 90 F3 Moderately persistent
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note Other sources: DT50 30 (sand) - 180 (clay) days (R3); General literature DT50 range 59-64 days (R3)
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 11.3 R4 -
Note Published literature RL50 range 10.5-12.0 days, 2 field crops, various matrices, n=2
Aqueous photolysis DT50 (days) at pH 7 Value 56 K4 Stable
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 56 K4 Moderately persistent
Note -
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - G3 Mobile
Koc 54
Notes and range Other sources: Koc 610 (P3)
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
3-(4-hydroxycyclohexyl)-6-(dimethylamino)-1-methyl-1,3,5-triazine-2,4(1H,3H)dione Soil     -
3-cyclohexyl-6-(methylamino)-1-methyl-1,3,5-triazine-2,4-(1H,3H)-dione Soil     Major
3-(4-hydroxycyclohexyl)-6-(methylamino)-1-methyl-1,3,5-triazine-2,4(1H,3H)-dione Soil     Major


ECOTOXICOLOGY
for hexazinone

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 7 P4 Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 1690 G4 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - L2 Rat, 2 year -
(ppm diet) > 200 -
Birds - Acute LD50 (mg kg-1) > 2258 G4 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) > 320 G4 Oncorhynchus mykiss Low
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 85 J4 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) > 50 F3 Daphnia magna, LOEC Low
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) > 0.072 F2 Lemna minor, 7 day Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.0145 F4 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 100 F4 Apis mellifera Low
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) 60 L2 Moderate
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION
for hexazinone

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 1690 G4 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 L3 Rabbit -
Mammals - Inhalation LC50 (mg l-1) 7.48 L3 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.05 L3 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

-

General human health issues Highly toxic

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes No information available
CLP classification 2013 Health: H302, H319
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R22
Xi - Irritant: R36
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S60, S61
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) II - Warning - Moderately toxic
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS
for hexazinone

Language Name
English hexazinone
French hexazinone
German Hexazinon
Danish hexazinon
Italian esazinone
Spanish hexazinona
Greek -
Slovenian heksazinon
Polish heksazynon
Swedish -
Hungarian hexazinone
Dutch -

Record last updated: Friday 18 August 2017
Contact: aeru@herts.ac.uk