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hexazinone (Ref: DPX A3674)
** DPX-3674 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION
for hexazinone

Description: A herbicide used to control many annual, biennial and perennial weeds, as well as some woody plants

Introduction: 1975, USA

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur -
Date inclusion expires Essential use only

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also registered in: Australia

General status:
Pesticide type Herbicide
Substance group Triazinone
Substance origin Synthetic
Mode of action Non-selective with contact action, absorbed through the roots and foliage of plants. Inhibits photosynthesis (photosystem II).
CAS RN 51235-04-2
EC number 257-074-4
CIPAC number 374
US EPA chemical code 107201
Chiral molecule No
Chemical formula C12H20N4O2
SMILES O=C1/N=C(\N(C(=O)N1C2CCCCC2)C)N(C)C
International Chemical Identifier (InChI) InChI=1/C12H20N4O2/c1-14(2)10-13-11(17)16(12(18)15(10)3)9-7-5-4-6-8-9/h9H,4-8H2,1-3H3
Structure diagram/image available? Yes
Molecular mass (g mol-1) 252.31
PIN (Preferred Identification Name) -
IUPAC name 3-cyclohexyl-6-dimethylamino-1-methyl-1,3,5-triazine-2,4(1H,3H)-dione
CAS name 3-cyclohexyl-6-(dimethylamino)-1-methyl-1,3,5-triazine-2,4(1H,3H)-dione
Other status information Potential groundwater contaminant
Herbicide Resistance Classification (HRAC) C1
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Physical state Colourless crystals
Related substances & organisms

Formulations:
Property Value
Example manufacturers of products using this active
  • DuPont
  • AgroCare
  • Makhteshim Agan Group
  • FCC Ltd
Example products using this active
  • Velpar Weed Killer
  • Pronone
  • Fertihexa
  • Elinone
UK LERAP status No UK approval for use or outside scope
Formulation and application details Available in a variety of formulations including wettable granules, suspension concentrates and tablets.


ENVIRONMENTAL FATE

for hexazinone

Property Value Source/Quality Score/Other Information Interpretation
Solubility - In water at 20oC (mg l-1) 33000 K4 High
Solubility - In organic solvents at 20oC (mg l-1) 626000 C4 - Acetone -
334000 C4 - Toluene -
2146500 C4 - Methanol -
837000 C4 - Benzene -
Melting point (oC) 113.5 L3 -
Boiling point (oC) Decomposes on distillation L2 -
Degradation point (oC) - - -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 1.48 X 1001 Calculated -
Log P 1.17 P4 Low
Bulk density (g ml-1)/Specific gravity 1.25 L3 -
Dissociation constant (pKa) at 25oC 2.2 L3 -
Note: Weak base
Vapour pressure at 25oC (mPa) 0.03 G4 Non-volatile
Henry's law constant at 25oC (Pa m3 mol-1) 1.10 X 10-07 H4 Non-volatile
Henry's law constant at 20oC (dimensionless) 8.30 X 10-11 K3 Non-volatile
GUS leaching potential index 4.58 Calculated High leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Value 2.15 X 10+00 Calculated -
Note -
Potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Value Source/Quality Score/Other Information Interpretation
Soil degradation (days) (aerobic) DT50 (typical) 105 L3 Persistent
DT50 (lab at 20oC) 90 F3 Moderately persistent
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
Note Other sources: DT50 30 (sand) - 180 (clay) days (R3); General literature DT50 range 59-64 days (R3)
Aqueous photolysis DT50 (days) at pH 7 Value 56 K4 Stable
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 56 K4 Moderately persistent
Note -
Water-Sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Value Source/Quality Score/Other Information Interpretation
Linear Kd - G3 Mobile
Koc 54
Notes and range Other sources: Koc 610 (P3)
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 91/414 relevancy
3-(4-hydroxycyclohexyl)-6-(dimethylamino)-1-methyl-1,3,5-triazine-2,4(1H,3H)dione Soil     -
3-cyclohexyl-6-(methylamino)-1-methyl-1,3,5-triazine-2,4-(1H,3H)-dione Soil     Major
3-(4-hydroxycyclohexyl)-6-(methylamino)-1-methyl-1,3,5-triazine-2,4(1H,3H)-dione Soil     Major


ECOTOXICOLOGY

for hexazinone

Property Value Source/Quality Score/Other Information Interpretation
Bio-concentration factor BCF 7 P4 Low potential
CT50 (days) Not available -
Bioaccumulation potential - Calculated Low
Mammals - Acute oral LD50 (mg kg-1) 1690 G4 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - L2 Rat, 2 year -
(ppm diet) > 200 -
Birds - Acute LD50 (mg kg-1) > 2258 G4 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) > 320 G4 Oncorhynchus mykiss Low
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 85 J4 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) > 50 F3 Daphnia magna, LOEC -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) > 0.072 F2 Lemna minor, 7 day Moderate
Algae - Acute 72 hour EC50, growth (mg l-1) 0.0145 F4 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees - Acute 48 hour LD50 (μg bee-1) > 60 L2 Moderate
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for hexazinone

General:
Property Value Source/Quality Score/Other Information Interpretation
Mammals - Acute oral LD50 (mg kg-1) 1690 G4 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 L3 Rabbit -
Mammals - Inhalation LC50 (mg l-1) 7.48 L3 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.05 L3 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
Examples of European MRLs (mg kg-1) Value -
Note For the EU pesticides database click here
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Acetyl cholinesterase inhibitor Neurotoxicant Respiratory tract irritant Skin irritant Eye irritant

-

-

General human health issues Highly toxic

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:
Property Value Source/Quality Score/Other Information Interpretation
General No information available
CLP classification 2013 -
EC Risk Classification Xn - Harmful: R22
Xi - Irritant: R36
N - Dangerous for the environment: R50, R53
EC Safety Classification S2, S60, S61
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) II - Warning - Moderately toxic
UN Number -
Waste disposal & packaging -


TRANSLATIONS

for hexazinone

Language Name
English hexazinone
French hexazinone
German Hexazinon
Danish hexazinon
Italian esazinone
Spanish hexazinona
Greek -
Slovenian heksazinon
Polish heksazynon
Swedish -
Hungarian hexazinone
Dutch -

Record last updated: Tuesday 20 August 2013
Contact: aeru@herts.ac.uk