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GET ADDITIONAL DATA HERE!

hexythiazox (Ref: NA 73)
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for hexythiazox

Description: An acaricide used for the control of eggs and larvae of many mites on a wide variety of food crops

Example pests controlled: Tetranychid mites

Example applications: Fruit including apples, pears, stone fruit, citrus, grapes; Nuts; Turf; Cotton; Cucumber

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1982, first reported; 1985, first registered Japan

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Finland/Sweden
Date inclusion expires 31/05/2021
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A molecule with 2 chiral centres
Chemical formula C17H21ClN2O2S
Canonical SMILES CC1C(SC(=O)N1C(=O)NC2CCCCC2)C3=CC=C(C=C3)Cl
Isomeric SMILES C[C@H]1[C@@H](SC(=O)N1C(=O)NC2CCCCC2)C3=CC=C(C=C3)Cl
International Chemical Identifier key (InChIKey) KYOUEHWYDNYHAL-IOORBXIBSA-N
International Chemical Identifier (InChI) InChI=1S/C17H21ClN2O2S/c1-11-15(12-7-9-13(18)10-8-12)23-17(22)20(11)16(21)19-14-5-3-2-4-6-14/h7-11,14-15H,2-6H2,1H3,(H,19,21)/t11-,15+/m0/s1
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Acaricide
Substance group Carboxamide
Minimum active substance purity 976 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Non-systemic with contact and stomach action
CAS RN 78587-05-0
EC number -
CIPAC number 439
US EPA chemical code 128849
PubChem CID 13218777
Molecular mass (g mol-1) 352.88
PIN (Preferred Identification Name) -
IUPAC name (4RS,5RS)-5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxo-1,3-thiazolidine-3-carboxamide
CAS name (4R,5R)-rel-5-(4-chlorophenyl)-N-cyclohexyl-4-methyl-2-oxo-3-thiazolidinecarboxamide
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 10A
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Brevipalpus phoenicis
Panonychus ulmi
Tetranychus urticae
Physical state White to beige coloured powder
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Anorgachim SA
  • Hellafarm SA
  • Nippon
  • FCC
Example products using this active
  • Hexythiazox 10 WP
  • Bulk 10 WP
  • Nissorun 10WP
  • Ocaren
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Often supplied as a wettable powder that is mixed with water and used as a spray.


ENVIRONMENTAL FATE

for hexythiazox

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.1 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 159000 A5 - Acetone -
22000 A5 - Ethanol -
17000 A5 - Methanol -
4600 A5 - n-Heptane -
Melting point (oC) 105.4 A5 -
Boiling point (oC) 222 A5 -
Degradation point (oC) 300 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 4.68 X 1002 Calculated -
Log P 2.67 A5 Low
Bulk density (g ml-1)/Specific gravity 1.31 L3 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 1.33 X 10-03 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 1.19 X 10-02 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.03 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.35 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution: 202nm = 24220,225nm = 18390; [Acidic solution: 225.5nm = 18310; [Basic solution: 224.5nm = 16990 A5 -
Surface tension (mN m-1) 71.8 A5 at 20oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 30 M4 Moderately persistent
DT50 (lab at 20oC) 23.7 A5 Non-persistent
DT50 (field) 17.7 A3 Non-persistent
DT90 (lab at 20oC) 103.5 A5 -
DT90 (field) 59.6 A5 -
DT50 modelling endpoint - - -
Note EU dossier Lab studies DT50 range 7.8-56.0 days, n=6, DT90 range 32.2-117.2 days, field studies DT50 range 10-29 days, DT90 range 35-96 days
Dissipation rate RL50 on plant matrix Value 12.0 R3 -
Note Green bean pods, n=1
Dissipation rate RL50 on and in plant matrix Value 3.6 R3 -
Note Strawberry fruit, n=1
Aqueous photolysis DT50 (days) at pH 7 Value 17 L3 Slow
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable Q3 -
Note -
Water-sediment DT50 (days) 37 A5 Moderately fast
Water phase only DT50 (days) 11.5 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 207 A5 Non-mobile
Kfoc 9455
1/n 0.99
Notes and range EU dossier Kf range 61-416, Kfoc range 6875-12823 mL/g, 1/n range 0.94-1.1, Soils=8
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
5-(4-chlorophenyl)-N-(4-oxocyclohexyl)-4-methyl-2-oxothiazolidine-3-carboxamide (Ref: PT-1-9) This metabolite may cause environmental pollution, click here for further information Soil   0.211   Major fraction, Not relevant
trans-5-(4-chlorophenyl)-4-methyl-2-oxothiazolidine-3-carboximide (Ref: PT-1-2) This metabolite may cause environmental pollution, click here for further information Soil   0.395   Major, Relevant
trans-5-(4-chlorophenyl)-4-methyl-2-oxothiazolidine (Ref: PT-1-3) Soil   0.090   Major, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
5-(4-chlorophenyl)-N-( cis-4-hydroxylcyclohexyl)-4-methyl-trans-2-oxothiazolidine-3-carboxamide PT-1-8 ( cis) Rat (Urinary, Faeces) - -


ECOTOXICOLOGY

for hexythiazox

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 1100 A5 Whole fish Threshold for concern
CT50 (days) 1 -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) - L3 Rat -
(ppm diet) > 70 -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) > 523 mg kg bw-1 day-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 3.2 A5 Lepomis macrochirus Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.04 A4 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) > 0.47 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.0061 A5 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 1.7 A5 Chironomus riparius, emergence Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) > 0.4 A5 Scenedemus subspicatus Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 200 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 112 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 105 A5 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 300 48 hour
A5 Aphidius rhopalosiphi
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 65.9 7 day
A4 Typhlodromus pyri
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect @ 42 days
Carbon mineralisation: No significant adverse effect @ 14 days
A5
Dose: 1.7 mg kg-1 soil
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for hexythiazox

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 2.0 A5 Rat, 4 hr (whole body) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.03 A2 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.009 A3 Dog, 1 year, SF=100 -
Dermal penetration studies (%) 1-10 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational Occupational exposure may occur through inhalation and dermal contact
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 0.1 EU Dir 89/778/EC limit; A5 -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Possible liver toxicant
USEPA - probable human carcinogen

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Dust may form an explosive mix with air
Not oxidising
CLP classification 2013 Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S60, S61
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) IV - Caution - Not acutely toxic
UN Number Usually 3077
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for hexythiazox

Language Name
English hexythiazox
French hexythiazox
German Hexythiazox
Danish hexythiazox
Italian exitiazox
Spanish hexitiazox
Greek hexythiazox
Slovenian heksitiazoks
Polish heksytiazoks
Swedish hexytiazox
Hungarian hexitiazox
Dutch hexythiazox

Record last updated: Thursday 23 August 2018
Contact: aeru@herts.ac.uk