| mevinphos (Ref: ENT 22374) |
 |
Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
SUMMARY
Mevinphos is a highly toxic organophosphate insecticide. Known to cause significant inhibition of cholinesterase (ChE) activity by all routes of exposure. Readily soluble in water, volatile, slow aquatic hydrolysis, rapidly degrades in soil. Whilst the molecule is potentially mobile, it would not be expected to leach into groundwater due to rapid soil degradation. Extremely toxic to aquatic invertebrates, birds and mammals. GENERAL INFORMATION 
for mevinphos
Description: An insecticide and acaricide used to control a broad spectrum of insects including aphids, grasshoppers, leafhoppers and caterpillars
Introduction: circa 1955
EC Regulation 1107/2009 (repealing 91/414):
| Status | Not approved |
| Dossier rapporteur/co-rapporteur | Sweden |
| Date inclusion expires | Expired |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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Also registered in: Australia
General status:
| Pesticide type | Insecticide, Acaricide | |||
| Substance group | Organophosphate racemic mixture | |||
| Substance origin | Synthetic | |||
| Mode of action | Systemic with contact, stomach and respiratory action. Acetylcholinesterase (AChE) inhibitor. | |||
| CAS RN | 7786-34-7 | |||
| Alternative/old CAS RN | 26718-65-0(E)/338-45-4(Z) | |||
| EC number | 232-095-1 | |||
| CIPAC number | 45 | |||
| US EPA chemical code | 015801 | |||
| Chiral molecule | No | |||
| Chemical formula | C7H13O6P | |||
| SMILES | O=P(O/C(=C/C(=O)OC)C)(OC)OC | |||
| International Chemical Identifier key (InChIKey) | GEPDYQSQVLXLEU-UHFFFAOYSA-N | |||
| International Chemical Identifier (InChI) | InChI=1S/C7H13O6P/c1-6(5-7(8)10-2)13-14(9,11-3)12-4/h5H,1-4H3/b6-5+ | |||
| Structure diagram/image available? | Yes | |||
| Molecular mass (g mol-1) | 224.1 | |||
| PIN (Preferred Identification Name) | - | |||
| IUPAC name | methyl (EZ)-3-(dimethoxyphosphinoyloxy)but-2-enoate | |||
| CAS name | methyl 3-[(dimethoxyphosphinyl)oxy]-2-butenoate | |||
| Other status information | Severe Marine Pollutant | |||
| Herbicide Resistance Classification (HRAC) | Not applicable | |||
| Herbicide Resistance Classification (WSSA) | Not applicable | |||
| Insecticide Resistance Classification (IRAC) | 1B | |||
| Fungicide Resistance Classification (FRAC) | Not applicable | |||
| Physical state | Colourless to pale yellow liquid | |||
| Related substances & organisms | - | |||
Formulations:
| Property |
Value | |||
| Example manufacturers & suppliers of products using this active |
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| Example products using this active |
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| UK LERAP status | No UK approval for use or outside scope | |||
| Formulation and application details | Usually available as a liquid concentrate. | |||
ENVIRONMENTAL FATE
for mevinphos
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Solubility - In water at 20oC (mg l-1) | 600000 | M4 | High | |
| Solubility - In organic solvents at 20oC (mg l-1) | Miscible | L2 - Acetone | - | |
| Melting point (oC) | 21 | Q3 | - | |
| Boiling point (oC) | - | - | - | |
| Degradation point (oC) | - | - | - | |
| Flashpoint (oC) | - | - | - | |
| Octanol-water partition coefficient at pH 7, 20oC | P | 1.34 X 1000 | Calculated | - |
| Log P | 0.127 | L3 | Low | |
| Bulk density (g ml-1)/Specific gravity | 1.24 | L3 | - | |
| Dissociation constant (pKa) at 25oC | - | - | - | |
| Note: | ||||
| Vapour pressure at 25oC (mPa) | 17 | L3 | Intermediate state | |
| Henry's law constant at 25oC (Pa m3 mol-1) | 6.30 X 10-06 | H4 | Non-volatile | |
| Henry's law constant at 20oC (dimensionless) | 6.00 X 10-08 | K3 | Non-volatile | |
GUS leaching potential index  |
0.19 | Calculated | Low leachability | |
| SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Value | 2.51 X 10-03 | Calculated | - |
| Note | - | |||
| Potential for particle bound transport index |
- | Calculated | Low | |
| Maximum UV-vis absorption L mol-1 cm-1 | - | - | - | |
| Surface tension (mN m-1) | - | - | - | |
Degradation:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Soil degradation (days) (aerobic) | DT50 (typical) | 1.2 | K4 | Non-persistent |
| DT50 (lab at 20oC) | 3 | DW4 | Non-persistent | |
| DT50 (field) | - | - | - | |
| DT90 (lab at 20oC) | - | - | - | |
| DT90 (field) | - | - | - | |
| Note | General studies: DT50 1-4 hrs aerobic conditions, 1-12 days anaerobic conditions (R3) | |||
| Aqueous photolysis DT50 (days) at pH 7 | Value | 27 | R3 | Slow |
| Note | - | |||
| Aqueous hydrolysis DT50 (days) at 20oC and pH 7 | Value | 17 | K4 | Non-persistent |
| Note | - | |||
| Water-sediment DT50 (days) | 21 | K4 | Fast | |
| Water phase only DT50 (days) | 5 | K4 | Moderately fast | |
Soil adsorption and mobility:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Linear | Kd | - | G3 | Mobile |
| Koc | 44 | |||
| Notes and range | Other studies: 50.5-86.2 mL/g (R3) | |||
| Freundlich | Kf | - | - | - |
| Kfoc | - | |||
| 1/n | - | |||
| Notes and range | - | |||
| pH sensitivity | - | |||
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Bio-concentration factor | BCF | Low risk | Q3 Based on LogP < 3 | High potential |
| CT50 (days) | - | - | ||
| Bioaccumulation potential | - | Calculated | Low | |
| Mammals - Acute oral LD50 (mg kg-1) | 3.5 | G4 Rat | High | |
| Mammals - Short term dietary NOEL | (mg kg-1) | 4 | L2 Rat, 2 year | High |
| (ppm diet) | - | - | ||
| Birds - Acute LD50 (mg kg-1) | > 4.63 | G4 Anas platyrhynchos | High | |
| Birds - Short term dietary (LC50/LD50) | - | - | - | |
| Fish - Acute 96 hour LC50 (mg l-1) | 0.012 | G4 Oncorhynchus mykiss | High | |
| Fish - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) | 0.00016 | F4 Daphnia pulex | High | |
| Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) | - | - | - | |
| Aquatic plants - Acute 7 day EC50, biomass (mg l-1) | - | - | - | |
| Algae - Acute 72 hour EC50, growth (mg l-1) | > 71 | W2 Unknown species | Low | |
| Algae - Chronic 96 hour NOEC, growth (mg l-1) | - | - | - | |
| Honeybees | Contact acute 48 hour LD50 (μg bee-1) | - | - | - |
| Oral acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Unknown mode acute 48 hour LD50 (μg bee-1) | 0.027 | G3 | High | |
| Earthworms - Acute 14 day LC50 (mg kg-1) | - | - | - | |
| Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) | - | - | - | |
| Other soil macro-organisms - e.g. Collembola | LR50 / EC50 / NOEC / % Effect | - | - | - |
| Other arthropod (1) | LR50 g ha-1 | - | - | - |
| % Effect | Harmful | AA2 Typhlodromus pyri | Harmful | |
| Other arthropod (2) | LR50 g ha-1 | - | - | - |
| % Effect | Moderately harmful | AA2 Chrysoperla carnea | Moderately harmful | |
| Soil micro-organisms | - | - | - | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
HUMAN HEALTH AND PROTECTION
for mevinphos
General:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Mammals - Acute oral LD50 (mg kg-1) | 3.5 | G4 Rat | High | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | 4.0 | L3 Rat | - | |
| Mammals - Inhalation LC50 (mg l-1) | 7.3 | R3 Rat | - | |
| Other Mammal toxicity endpoints | - | - | ||
| ADI - Acceptable Daily Intake (mg kg-1bw day-1) | 0.0008 | JMPR 1996 | - | |
| ARfD - Acute Reference Dose (mg kg-1bw day-1) | 0.003 | JMPR 1996 | - | |
| AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | - | - | - | |
| Dermal penetration studies (%) | - | - | - | |
| Dangerous Substances Directive 76/464 | List II | - | - | |
| Exposure Limits | - | - | - | |
| Exposure Routes | Public | No unacceptable risks to bystanders identified | ||
| Occupational | Absorbed by the skin, inhalation and via the gastrointestinal tract - PPE/PPC essential | |||
| Examples of European MRLs (mg kg-1) | Value | - | ||
| Note | For the EU pesticides database click here | |||
| Drinking Water MAC (μg l-1) | - | - | - | |
Health issues:
| Carcinogen | Mutagen | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | Respiratory tract irritant | Skin irritant | Eye irritant |
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| General human health issues | No further information available | |||||||
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data
Handling issues:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| General |
No information available | |||
| CLP classification 2013 | - | |||
| EC Risk Classification |
T+ - Very toxic: R27/28 N - Dangerous for the environment: R50, R53 |
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| EC Safety Classification |
S1/2, S23, S28, S36/37, S45, S60, S61 | |||
| WHO Classification | Ia | - | Extremely hazardous | |
| US EPA Classification (formulation) | I | - | Danger - Highly toxic | |
| UN Number | 3018 | |||
| Waste disposal & packaging |
- | |||
| Language | Name |
| English | mevinphos |
| French | mévinphos |
| German | Mevinphos |
| Danish | mevinphos |
| Italian | mevinfos |
| Spanish | mevinfos |
| Greek | mevinphos |
| Slovenian | mevinfos |
| Polish | mewinfos |
| Swedish | mevinfos |
| Hungarian | - |
| Dutch | mevinfos |
Record last updated: Wednesday 12 March 2014
Contact: aeru@herts.ac.uk