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mevinphos (Ref: ENT 22374)
** phosdrin ** duraphos ** mevinox ** phosdrine ** menite ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Mevinphos is a highly toxic organophosphate insecticide. Known to cause significant inhibition of cholinesterase (ChE) activity by all routes of exposure. Readily soluble in water, volatile, slow aquatic hydrolysis, rapidly degrades in soil. Whilst the molecule is potentially mobile, it would not be expected to leach into groundwater due to rapid soil degradation. Extremely toxic to aquatic invertebrates, birds and mammals.

GENERAL INFORMATION
for mevinphos

Description: An insecticide and acaricide used to control a broad spectrum of sucking and chewing insects

Example pests controlled: Aphids; Grasshoppers; Leafhoppers; Caterpillars; Spider mites; Cutworms

Example applications: Vegetables; Fruit; Field crops

Availability status: Obsolete

Introduction & key dates: circa 1955

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Sweden
Date inclusion expires Expired

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

General status:
Pesticide type Insecticide, Acaricide
Substance group Organophosphate racemic mixture
Minimum active substance purity -
Known relevant impurities May contain sulfotep, N-nitrosamines, halogenated dibenzo-pi-dioxins, halogenated dibenzofurans & PCBs
Substance origin Synthetic
Mode of action Systemic with contact, stomach and respiratory action. Acetylcholinesterase (AChE) inhibitor.
CAS RN 7786-34-7
Alternative/old CAS RN 26718-65-0(E)/338-45-4(Z)
EC number 232-095-1
CIPAC number 45
US EPA chemical code 015801
Chiral molecule No
Chemical formula C7H13O6P
SMILES O=P(O/C(=C/C(=O)OC)C)(OC)OC
International Chemical Identifier key (InChIKey) GEPDYQSQVLXLEU-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C7H13O6P/c1-6(5-7(8)10-2)13-14(9,11-3)12-4/h5H,1-4H3/b6-5+
Structure diagram/image available? Yes
Molecular mass (g mol-1) 224.1
PIN (Preferred Identification Name) -
IUPAC name methyl (EZ)-3-(dimethoxyphosphinoyloxy)but-2-enoate
CAS name methyl 3-[(dimethoxyphosphinyl)oxy]-2-butenoate
Other status information Severe Marine Pollutant
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 1B
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Musca domestica
Myzus persicae
Panonychus ulmi
Plusia gamma
Tetranychus urticae
many others
Physical state Colourless to pale yellow liquid
Related substances & organisms -

Formulations:
Property Value
Example manufacturers & suppliers of products using this active now or historically
  • AMVAC Chemical Corp
  • Huikwang Corp.
  • Shell
  • Kenogard
Example products using this active
  • Phosdrin
  • Mevidrin
  • Apavinphos
UK LERAP status No UK approval for use or outside scope
Formulation and application details Usually available as a liquid or emulsifiable concentrate.


ENVIRONMENTAL FATE

for mevinphos

Property Value Source/Quality Score/Other Information Interpretation
Solubility - In water at 20oC (mg l-1) 600000 M4 High
Solubility - In organic solvents at 20oC (mg l-1) Miscible L2 - Acetone -
Melting point (oC) 21 Q3 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 1.34 X 1000 Calculated -
Log P 0.127 L3 Low
Bulk density (g ml-1)/Specific gravity 1.24 L3 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 25oC (mPa) 17 L3 Volatile
Henry's law constant at 25oC (Pa m3 mol-1) 6.30 X 10-06 H4 Non-volatile
Henry's law constant at 20oC (dimensionless) 6.00 X 10-08 K3 Non-volatile
GUS leaching potential index 1.12 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Value 2.51 X 10-03 Calculated -
Note -
Potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Value Source/Quality Score/Other Information Interpretation
Soil degradation (days) (aerobic) DT50 (typical) 1.2 K4 Non-persistent
DT50 (lab at 20oC) 3 DW4 Non-persistent
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
Note General studies: DT50 1-4 hrs aerobic conditions, 1-12 days anaerobic conditions (R3)
Plant matrix DT50 (days) Value 0.8 R4 -
Note DT50 range 0.4 - 2.1 days, 7 crops/plants, various matrices
Aqueous photolysis DT50 (days) at pH 7 Value 27 R3 Slow
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 17 K4 Non-persistent
Note -
Water-sediment DT50 (days) 21 K4 Fast
Water phase only DT50 (days) 5 K4 Moderately fast

Soil adsorption and mobility:
Property Value Source/Quality Score/Other Information Interpretation
Linear Kd - G3 Mobile
Koc 44
Notes and range Other studies: 50.5-86.2 mL/g (R3)
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -


ECOTOXICOLOGY

for mevinphos

Property Value Source/Quality Score/Other Information Interpretation
Bio-concentration factor BCF (l kg-1) Low risk Q3 Based on LogP < 3 Low potential
CT50 (days) - -
Mammals - Acute oral LD50 (mg kg-1) 3.5 G4 Rat High
Mammals - Short term dietary NOEL (mg kg-1) 4 L2 Rat, 2 year High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 4.63 G4 Anas platyrhynchos High
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 0.012 G4 Oncorhynchus mykiss High
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.00016 F4 Daphnia pulex High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) > 71 W2 Unknown species Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) - - -
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) 0.027 G3 High
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect Harmful AA2 Typhlodromus pyri -
Other arthropod (2) LR50 g ha-1 - - -
% Effect Moderately harmful AA2 Chrysoperla carnea -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for mevinphos

General:
Property Value Source/Quality Score/Other Information Interpretation
Threshold of Toxicological Concern (Cramer Class) High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 3.5 G4 Rat High
Mammals - Dermal LD50 (mg kg-1 body weight) 4.0 L3 Rat -
Mammals - Inhalation LC50 (mg l-1) 7.3 R3 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.0008 JMPR 1996 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.003 JMPR 1996 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 List II - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational Absorbed by the skin, inhalation and via the gastrointestinal tract - PPE/PPC essential
European MRLs Click here for the EU MRL pesticide database
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues No further information available

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Value Source/Quality Score/Other Information Interpretation
General No information available
CLP classification 2013 Health: H300, H310
Environment: H400, H410
EC Risk Classification T+ - Very toxic: R27/28
N - Dangerous for the environment: R50, R53
EC Safety Classification S1/2, S23, S28, S36/37, S45, S60, S61
WHO Classification Ia - Extremely hazardous
US EPA Classification (formulation) I - Danger - Highly toxic
UN Number 3018
Waste disposal & packaging -


TRANSLATIONS

for mevinphos

Language Name
English mevinphos
French mévinphos
German Mevinphos
Danish mevinphos
Italian mevinfos
Spanish mevinfos
Greek mevinphos
Slovenian mevinfos
Polish mewinfos
Swedish mevinfos
Hungarian -
Dutch mevinfos

Record last updated: Sunday 14 August 2016
Contact: aeru@herts.ac.uk