| phosphamidon (Ref: OMS 1325) |
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Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
GENERAL INFORMATION 
for phosphamidon
Description: An insecticide and nematicide used to control a very wide range of pests including sucking, chewing and boring insects
Example pests controlled: Aphids; Leaf miners; Spruce budworm; Beetles; Thrips; Codling moth; Grasshoppers; Bollworms
Example applications: Rice; Citrus; Nuts; Cotton; Sugarcane; Potatoes; Peas & beans; Strawberries
Efficacy & activity: -
Availability status: Unknown
Introduction & key dates: circa 1960
EC Regulation 1107/2009 (repealing 91/414):
| Status | Not approved |
| Dossier rapporteur/co-rapporteur | Germany |
| Date inclusion expires | Expired |
| EU Candidate for substitution (CfS) | - |
| Listed in EU database | Yes |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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Chemical structure:
| Isomerism | Exists in both E- and Z- isomeric forms |
| Chemical formula | C10H19ClNO5P |
| Canonical SMILES | CCN(CC)C(=O)C(=C(C)OP(=O)(OC)OC)Cl |
| Isomeric SMILES | CCN(CC)C(=O)/C(=C(\C)/OP(=O)(OC)OC)/Cl |
| International Chemical Identifier key (InChIKey) | RGCLLPNLLBQHPF-UHFFFAOYSA-N |
| International Chemical Identifier (InChI) | InChI=1S/C10H19ClNO5P/c1-6-12(7-2)10(13)9(11)8(3)17-18(14,15-4)16-5/h6-7H2,1-5H3/b9-8- |
| 2D structure diagram/image available? | Yes |
General status:
| Pesticide type | Insecticide, Acaricide | |||
| Substance group | Organophosphate | |||
| Minimum active substance purity | - | |||
| Known relevant impurities | - | |||
| Substance origin | Synthetic | |||
| Mode of action | Strong stomach action and slight contact action. Cholinesterase inhibitor. | |||
| CAS RN | 13171-21-6 | |||
| EC number | 236-116-5 | |||
| CIPAC number | 110 | |||
| US EPA chemical code | 018201 | |||
| PubChem CID | 3032604 | |||
| Molecular mass (g mol-1) | 299.69 | |||
| PIN (Preferred Identification Name) | - | |||
| IUPAC name | (EZ)-2-chloro-2-diethylcarbamoyl-1-methylvinyl dimethyl phosphate | |||
| CAS name | 2-chloro-3-(diethylamino)-1-methyl-3-oxo-1-propenyl dimethyl phosphate | |||
| Other status information | Chemical subject to PIC regulations; Severe Marine Pollutant; Rotterdam Convention (Class Ia) | |||
| Relevant Environmental Water Quality Standards | - | |||
| Herbicide Resistance Classification (HRAC) | Not applicable | |||
| Herbicide Resistance Classification (WSSA) | Not applicable | |||
| Insecticide Resistance Classification (IRAC) | 1B | |||
| Fungicide Resistance Classification (FRAC) | Not applicable | |||
| Examples of recorded resistance | Amblyseius fallacis Boophilus microplus Myzus persicae Phorodon humuli tetranychus urticae many others |
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| Physical state | Pale yellow liquid | |||
| Related substances & organisms | - | |||
Formulations:
| Property |
Value | |||
| Example manufacturers & suppliers of products using this active now or historically |
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| Example products using this active |
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| UK LERAP status | No UK approval for use as a pesticide under EC Regulation 1107/2009 | |||
| Formulation and application details | Available as a liquid, soluble concentrate and ULV for waterless spraying. | |||
ENVIRONMENTAL FATE
for phosphamidon
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Solubility - In water at 20oC (mg l-1) | 1000000 | H4 | High | |
| Solubility - In organic solvents at 20oC (mg l-1) | Miscible | L3 - Acetone | - | |
| Miscible | L3 - Toluene | - | ||
| Miscible | L3 - Dichloromethane | - | ||
| Melting point (oC) | -45 | L3 | - | |
| Boiling point (oC) | - | - | - | |
| Degradation point (oC) | - | - | - | |
| Flashpoint (oC) | - | - | - | |
| Octanol-water partition coefficient at pH 7, 20oC | P | 6.24 X 1000 | Calculated | - |
| Log P | 0.795 | H4 | Low | |
| Bulk density (g ml-1)/Specific gravity | 1.21 | L3 | - | |
| Dissociation constant (pKa) at 25oC | - | - | - | |
| Note: | ||||
| Vapour pressure at 20oC (mPa) | 2.93 | H4 | Low volatility | |
| Henry's law constant at 25oC (Pa m3 mol-1) | 8.80 X 10-07 | H4 | Non-volatile | |
GUS leaching potential index  |
2.37 | Calculated | Transition state | |
| SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Value | 3.97 X 10-02 | Calculated | - |
| Note | - | |||
| Potential for particle bound transport index |
- | Calculated | Low | |
| Maximum UV-vis absorption L mol-1 cm-1 | - | - | - | |
| Surface tension (mN m-1) | - | - | - | |
Degradation:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
General biodegradability | - |
| Soil degradation (days) (aerobic) | DT50 (typical) | 9.2 | H4 | Non-persistent |
| DT50 (lab at 20oC) | 9 | H4 | Non-persistent | |
| DT50 (field) | 12 | H4 | Non-persistent | |
| DT90 (lab at 20oC) | - | - | - | |
| DT90 (field) | - | - | - | |
| DT50 modelling endpoint | - | - | - | |
| Note | Other sources: DT50 17 days (DW4) | |||
| Dissipation rate RL50 on plant matrix | Value | 4.0 | R4 | - |
| Note | Orange, various matrices, n=2 | |||
| Dissipation rate RL50 on and in plant matrix | Value | 6.1 | R4 | - |
| Note | Published literature RL50 range 1.0-11.0 days, 5 field crops, various matrices, n=7 | |||
| Aqueous photolysis DT50 (days) at pH 7 | Value | - | - | - |
| Note | - | |||
| Aqueous hydrolysis DT50 (days) at 20oC and pH 7 | Value | 36 | K4 | Moderately persistent |
| Note | Other data: DT50 60 days at pH 5, 54 days at pH 7, 12 days at pH 9, all at 20 degC (L3) | |||
| Water-sediment DT50 (days) | 13 | K4 | Fast | |
| Water phase only DT50 (days) | - | - | - | |
Soil adsorption and mobility:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Linear | Kd | - | H3 | Mobile |
| Koc | 33 | |||
| Notes and range | Other sources: 7 mL/g (DW3) | |||
| Freundlich | Kf | - | - | - |
| Kfoc | - | |||
| 1/n | - | |||
| Notes and range | - | |||
| pH sensitivity | - | |||
ECOTOXICOLOGY
for phosphamidon
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Bio-concentration factor | BCF (l kg-1) | 75 | Q2 Estimated | Low potential |
| CT50 (days) | Not available | - | ||
| Mammals - Acute oral LD50 (mg kg-1) | 7.0 | F4 Rat | High | |
| Mammals - Short term dietary NOEL | (mg kg-1) | - | - | - |
| (ppm diet) | - | - | ||
| Birds - Acute LD50 (mg kg-1) | 3.1 | V3 Anas platyrhynchos | High | |
| Birds - Short term dietary (LC50/LD50) | - | - | - | |
| Fish - Acute 96 hour LC50 (mg l-1) | 6 | F4 Oncorhynchus mykiss | Moderate | |
| Fish - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) | 0.008 | J4 Daphnia magna | High | |
| Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) | > 0.090 | F3 Americamysis bahia | High | |
| Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) | - | - | - | |
| Aquatic plants - Acute 7 day EC50, biomass (mg l-1) | - | - | - | |
| Non-target plants | - | - | - | |
| - | - | - | ||
| Algae - Acute 72 hour EC50, growth (mg l-1) | > 260 | K3 Unknown species | Low | |
| Algae - Chronic 96 hour NOEC, growth (mg l-1) | - | - | - | |
| Honeybees | Contact acute 48 hour LD50 (μg bee-1) | - | - | - |
| Oral acute 48 hour LD50 (μg bee-1) | > 1.46 | R4 | Moderate | |
| Unknown mode acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Earthworms - Acute 14 day LC50 (mg kg-1) | - | - | - | |
| Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) | - | - | - | |
| Other soil macro-organisms - e.g. Collembola | LR50 / EC50 / NOEC / % Effect | - | - | - |
| Other arthropod (1) | LR50 g ha-1 | - | - | - |
| % Effect | Harmful | AA2 Typhlodromus pyri | - | |
| Other arthropod (2) | LR50 g ha-1 | - | - | - |
| % Effect | Harmful | AA2 Chrysoperla carnea | - | |
| Soil micro-organisms | - | - | - | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
HUMAN HEALTH AND PROTECTION
for phosphamidon
General:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Threshold of Toxicological Concern (Cramer Class) |
High (class III) | - | - | |
| Mammals - Acute oral LD50 (mg kg-1) | 7.0 | F4 Rat | High | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | 267 | L3 Rabbit | - | |
| Mammals - Inhalation LC50 (mg l-1) | 0.033 | L3 Mouse | - | |
| Other Mammal toxicity endpoints | - | - | ||
| ADI - Acceptable Daily Intake (mg kg-1bw day-1) | 0.0005 | JMPR 1986 | - | |
| ARfD - Acute Reference Dose (mg kg-1bw day-1) | - | - | - | |
| AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) | - | - | - | |
| AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | - | - | - | |
| Dermal penetration studies (%) | - | - | - | |
| Dangerous Substances Directive 76/464 | List I; List II | - | - | |
| Exposure Limits | - | - | - | |
| Exposure Routes | Public | - | ||
| Occupational | Readily absorbed from the gastrointestinal tract, through the skin and by inhalation of spray mists and dusts | |||
| European MRLs | Click here for the EU MRL pesticide database | |||
| Drinking Water Standards | - | - | - | |
| Drinking Water MAC (μg l-1) | - | - | - | |
Health issues:
| Carcinogen | Mutagen | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | |||
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| Respiratory tract irritant | Skin irritant | Skin sensitiser | Eye irritant | Phototoxicant | ||||
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| General human health issues | Extremely hazardous Mutagenic potential USEPA - possible human carcinogen |
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: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found
Handling issues:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| General |
No information available | |||
| CLP classification 2013 | Health: H300, H311, H341 Environment: H400, H410 |
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| EC Risk Classification |
Mutagenic category 3: R68 T+ - Very toxic: R28 T - Toxic: R24, R68 N - Dangerous for the environment: R50, R53 |
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| EC Safety Classification |
S2, S23, S36/37, S45, S60, S61 | |||
| WHO Classification | Ia | - | Extremely hazardous | |
| US EPA Classification (formulation) | I | - | Danger - Highly toxic | |
| UN Number | 3018 | |||
| Waste disposal & packaging |
- | |||
| Language | Name |
| English | phosphamidon |
| French | phosphamidon |
| German | Phosphamidon |
| Danish | phosphamidon |
| Italian | fosamidone |
| Spanish | fosfamidon |
| Greek | phosphamidon |
| Slovenian | fosfamidon |
| Polish | fosfamidon |
| Swedish | - |
| Hungarian | foszamidon |
| Dutch | fosfamidon |
Record last updated: Thursday 24 May 2018
Contact: aeru@herts.ac.uk