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propargite (Ref: ENT 27226)
** BPPS ** DO-14 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

for propargite

Description: An acaricide used for mite control on various field, fruit, vegetable and ornamental crops

Example pests controlled: European red mite; Two-spotted mite; Spider mites

Example applications: Fruit including strawberries, cranberry, oranges, grapes, nectarines, jojobas; Ornamentals including roses, Christmas trees; Vegetables including beans; Walnuts & almonds; Cotton; Corn

Availability status: Current

Introduction & key dates: 1969, first introduced

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur France
Date inclusion expires Expired

Approved for use () or known to be used () in the following European countries:





























Also used in: Australia, USA

General status:
Pesticide type Acaricide
Substance group Sulphite ester
Minimum active substance purity 870 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Non-systemic with contact action, inhibits oxidative phosphorylation
CAS RN 2312-35-8
EC number 219-006-1
CIPAC number 216
US EPA chemical code 097601
Chiral molecule Chiral, a specific isomer or a derivative of a chiral molecule
Chemical formula C19H26O4S
International Chemical Identifier key (InChIKey) ZYHMJXZULPZUED-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C19H26O4S/c1-5-14-21-24(20)23-18-9-7-6-8-17(18)22-16-12-10-15(11-13-16)19(2,3)4/h1,10-13,17-18H,6-9,14H2,2-4H3
Structure diagram/image available? Yes
Molecular mass (g mol-1) 350.47
PIN (Preferred Identification Name) -
IUPAC name 2-(4-tert-butylphenoxy)cyclohexyl prop-2-ynyl sulphite
CAS name 2-[4-(1,1-dimethylethyl)phenoxy]cyclohexyl 2-propynyl sulphite
Other status information -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 12C
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Amblyseius fallacis
Oligonychus pratensis
Panonychus ulmi
Tetranychus pacificus
Tetranychus turkestani
Tetranychus urticae
Physical state Dark yellow-brown viscous liquid
Related substances & organisms

Property Value
Example manufacturers & suppliers of products using this active now or historically
  • Chemtura
  • Makhteshim
  • Uniroyal
Example products using this active
  • Omite 570EW
  • Fenpropar
  • Ornamite
  • Propachem
  • Comite
UK LERAP status No UK approval for use or outside scope
Formulation and application details Often supplied as emulsifiable concentrates, oil-water emuslsion, water-soluble bags or wettable powder.


for propargite

Property Value Source/Quality Score/Other Information Interpretation
Solubility - In water at 20oC (mg l-1) 0.215 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 200000 A5 - Hexane -
200000 A5 - Toluene -
200000 A5 - Dichloromethane -
200000 A5 - Acetone -
Melting point (oC) - - -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 210 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 5.01 X 1005 Calculated -
Log P 5.7 A5 High
Bulk density (g ml-1)/Specific gravity 1.113 L3 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 25oC (mPa) 0.00404 A5 Volatile
Henry's law constant at 25oC (Pa m3 mol-1) 6.4 X 10-02 A5 Non-volatile
Henry's law constant at 20oC (dimensionless) 2.70 X 10-06 Calculated Moderately volatile
GUS leaching potential index -1.31 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 No absorption >290nm A5 -
Surface tension (mN m-1) - - -

Property Value Source/Quality Score/Other Information Interpretation
Soil degradation (days) (aerobic) DT50 (typical) 56 W4 Moderately persistent
DT50 (lab at 20oC) 72.2 A5 Moderately persistent
DT50 (field) 16.7 A5 Non-persistent
DT90 (lab at 20oC) 301.0 A5 -
DT90 (field) 262.7 A5 -
Note EU dossier lab studies DT50 range 29.1-429.3 days, DT90 range 155-697 days; field studies DT50 range 10.2-24.2 days, DT90 range 148.6-467.8
Plant matrix DT50 (days) Value 5.1 R4 -
Note DT50 range 0.7 - 18.0 days, 6 crops/plants, various matrices
Aqueous photolysis DT50 (days) at pH 7 Value 13.2 A5 Moderately fast
Note DT50 5.5 days continuous irradiation, 13.2 days equivalent solar days
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 64.8 A5 Moderately persistent
Note pH and temperature sensitive: stable at pH 4, DT50 64.8 days pH 7 and 25 degC, 8.4 days at pH 7 and 40 degC, 1.1 days at pH 9 and 25 degC, 0.2 days at pH 9 and 40 degC
Water-sediment DT50 (days) 18.7 A5 Fast
Water phase only DT50 (days) 10.4 A5 Moderately fast

Soil adsorption and mobility:
Property Value Source/Quality Score/Other Information Interpretation
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 226 A5 Non-mobile
Kfoc 50491
1/n 1.343
Notes and range EU dossier Kf range 113-427 mL/g, Kfoc range 5293-95918 mL/g, 1/n range 0.97-1.59, Soils=6
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 91/414 relevancy
tert-butylphenoxycyclohexanol Soil   0.104   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
- TBPC-diol Mice (Faeces) - -
- HOMe-TBPC Rats - -
- HOMe-TBPC-diol; Propargite metabolite M05 Rats (Urinary, Faeces); Plants - -
- carboxy-TBPC Rats (Urinary, Faeces) - -
- TBPC-sulfate Soil 0.076 -


for propargite

Property Value Source/Quality Score/Other Information Interpretation
Bio-concentration factor BCF (l kg-1) 13964 A5 High potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 2639 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 4 L1 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 4640 L3 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 0.043 A5 Oncorhynchus mykiss High
Fish - Chronic 21 day NOEC (mg l-1) 0.0057 A5 Pimephales promelas High
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.014 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.009 A5 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 320 A5 Chironomus riparius Low
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 64 F3 Lemna gibba Low
Non-target plants > 2750 A5 Tomato, Cucumber, Lettuce, Soybean, Ryegrass, Onion, Vegetative vigour, ER50, Vegetative vigour, ER50, as g/ha -
> 2750 A5 Tomato, Cucumber, Lettuce, Soybean, Ryegrass, Onion, Seedling emergence, as g/ha -
Algae - Acute 72 hour EC50, growth (mg l-1) > 1.08 A5 Scenedesmus capricornutum Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) 47.9 A5 Moderate
Oral acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 378 A5 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 7.2 A5 Aphidius rhopalosiphi -
% Effect - - -
Other arthropod (2) LR50 g ha-1 4.5 A5 Typhlodromus pyri -
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
Dose: 6.4 kg ha-1, 28 days
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


for propargite

Property Value Source/Quality Score/Other Information Interpretation
Threshold of Toxicological Concern (Cramer Class) High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 2639 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 4000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 0.8 A5 Rat, 4 hr (aerosol, nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.007 A2 Rat, SF=500 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.03 A2 Rabbit, SF=500 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.0225 A2 Dog, SF=500 -
Dermal penetration studies (%) 5-14 A4 concentration dependant -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Small risk to bystanders identified
Occupational No unacceptable risks to operators or other workers identified with PPE/PPC
European MRLs Click here for the EU MRL pesticide database
Drinking Water MAC (μg l-1) 0.1 EU Dir 89/778/EC limit; A5 Calc MAC=15 μg l-1 -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant



Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant


General human health issues Toxic via inhalation
May cause dermatitis
USEPA - probable human carcinogen

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Value Source/Quality Score/Other Information Interpretation
General Not explosive or oxidising
Will decompose rapidly in the presence of strong acids or alkalis
IMDG Transport Code is usually 9
CLP classification 2013 Health: H315, H318, H331, H351
Environment: H400, H410
EC Risk Classification Carcinogen category 3: R40
T - Toxic: R23
Xn - Harmful: R41
Xi - Irritant: R38
N - Dangerous for the environment: R50, R53
EC Safety Classification S1/2, S26, S36/37/39, S45, S60, S61
WHO Classification III - Slightly hazardous
US EPA Classification (formulation) III - Caution - Slightly toxic
UN Number Usually 2810
Waste disposal & packaging Packaging Group III (minor danger)


for propargite

Language Name
English propargite
French propargite
German Propargit
Danish propargit
Italian propargite
Spanish propargita
Greek propargite
Slovenian propargit
Polish propargit
Swedish -
Hungarian propargit
Dutch propargite

Record last updated: Monday 17 October 2016