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GET ADDITIONAL DATA HERE!

propiconazole (Ref: CGA 64250)
** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for propiconazole

Description: A systemic fungicide with a broad range of activity and a wide range of agricultural cropping applications

Example pests controlled: Diseases caused by Erysiphe graminis; Leptosphaeria nodorum; Pseudocerosporella herpotrichoides; Puccinia spp.; Pyrenophora teres; Rhynchosporium secalis; Septoria spp.

Example applications: Mushrooms; Corn; Wild rice; Peanuts; Amonds; Sorghum; Oats; Pecan; Fruit including apricots, plums, prunes, peaches & nectarines

Efficacy & activity: Wheat/Eyespot=Low; Wheat/Mildew=Low; Wheat/Septoria=Low; Wheat/Rust=Low; Barley/Rust=Low; Corn/Northern Leaf blight=Moderate; Corn/Rust=Moderate; Corn/Eyespot=High; Soybean/Blight=Low; Soybean/Anthracnose=High; Soybean/Brown spot=Moderate; Soybean/Rust=High

Availability status: Current

Introduction & key dates: 1980

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Finland/UK
Date inclusion expires 31/01/2019
EU Candidate for substitution (CfS) Yes - two 'Persistent-Bioaccumulative-Toxic' criteria
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A molecule with 2 chiral features leading to four stereoisomers.
Chemical formula C15H17Cl2N3O2
Canonical SMILES CCCC1COC(O1)(CN2C=NC=N2)C3=C(C=C(C=C3)Cl)Cl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) STJLVHWMYQXCPB-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C15H17Cl2N3O2/c1-2-3-12-7-21-15(22-12,8-20-10-18-9-19-20)13-5-4-11(16)6-14(13)17/h4-6,9-10,12H,2-3,7-8H2,1H3
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Triazole
Minimum active substance purity 930 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Systemic with curative and protective action, works via the demethylation of C-14 during ergosterol biosynthesis
CAS RN 60207-90-1
EC number 262-104-4
CIPAC number 408
US EPA chemical code 122101
PubChem CID 43234
Molecular mass (g mol-1) 342.22
PIN (Preferred Identification Name) -
IUPAC name (2RS,4RS;2RS,4SR)-1-[2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-ylmethyl]-1H-1,2,4-triazole
CAS name 1-((2-(2,4-dichlorophenyl)-4-propyl-1,3-dioxolan-2-yl)methyl)-1H-1,2,4-triazole
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 3
Examples of recorded resistance -
Physical state Clear to pale yellow viscous liquid depending on the ratio of isomers
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Greencrop
  • Makhteshim-Agan
  • Syngenta
  • Ciba Geigy
Example products using this active
  • Bumper 250EC
  • Cherokee
  • Menara
  • Tilt
  • Mantis
  • Banner Maxx
UK LERAP status None
Formulation and application details Often supplied as emulsifiable concentrates or wettable powder.


ENVIRONMENTAL FATE

for propiconazole

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 150 A5 Moderate
Solubility - In organic solvents at 20oC (mg l-1) 1585 A5 - n-Heptane -
Miscible A5 - Acetone -
Miscible A5 - Methanol -
Miscible A5 - Xylene -
Melting point (oC) -23 A4 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 355 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 5.25 X 1003 Calculated -
Log P 3.72 A5 High
Bulk density (g ml-1)/Specific gravity 1.09 A5 -
Dissociation constant (pKa) at 25oC 1.09 A5 -
Note: Very weak base
Vapour pressure at 20oC (mPa) 0.056 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 9.20 X 10-05 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.89 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 6.96 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 220 nm = 11666 A5 -
Surface tension (mN m-1) 55.0 A5 at 20 degC, 90% -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 71.8 A5 Moderately persistent
DT50 (lab at 20oC) 71.8 A5 Moderately persistent
DT50 (field) 35.2 A5 Moderately persistent
DT90 (lab at 20oC) 344.8 A5 -
DT90 (field) 478 A3 -
DT50 modelling endpoint - - -
Note EU 2016 dossier lab studies DT50 range 26.6-115 days, DT90 range 107-1000 days, Soils=12; field studies DT50 range 15.3-96.3 days, DT90 range 108-525 days, Soils=6
Dissipation rate RL50 on plant matrix Value 6.4 R4 -
Note Published literature RL50 range 4.6-8.5 days, 2 field crops, various matrices, n=2
Dissipation rate RL50 on and in plant matrix Value 7.4 R4 -
Note Published literature RL50 range 1.0-16.9 days, 7 field crops, various matrices, n=8
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note Not a significant degradation route
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 53.5 A5 Moderately persistent
Note -
Water-sediment DT50 (days) 561 A5 Stable
Water phase only DT50 (days) 6 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd 33.7 A5 Slightly mobile
Koc 1086
Notes and range EU 2003 dossier Koc range 382-1789, Soils=9
Freundlich Kf 15.0 A5 Slightly mobile
Kfoc 955
1/n 0.86
Notes and range EU 2016 dossier: Kf range 1.20-59.0 mL/g, Kfoc range 387-1817 mL/g, 1/n range 0.81-0.89, Soils=9; Literature data: Kf range 27-1277 mL/g, Kfoc range 1440-3387 mL/g, 1/n range 0.75-0.88, Soils=3 (R4)
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
1,2,4-triazole (Ref: CGA 71019) This metabolite may cause environmental pollution, click here for further information Soil   0.430   Major fraction, Relevant
(2S,4S-2R,4R)-2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazol-1-ylmethyl)-1,3-dioxolane-4-carboxylic acid (Ref: SYN 547889) This metabolite may cause environmental pollution, click here for further information Soil   0.154   Major fraction, Relevant
1H-1,2,4-triazole-1-ethanol, alpha-(2,4-dichlorophenyl)- 2-(1,2,4) triazol-1-yl-ethanol (Ref: CGA 91305) Soil   0.08   Minor fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
- NOA 436613 Soil 0.123 -
2-(2,4-dichlorophenyl)--ethyl-2-(1H-1,2,4-riazol-1-yl-methyl)-1,3-dioxolane-4-methanol
Note: CAS Number:119725-85-8
CGA136735 Plant - -
3-chloro-4-(4-propyl-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-2-yl)-phenol GB-XLIII-42-1 Plant - -
1,3-dioxolane-4-ethanol, 2-(2,4-dichlorophenyl)--methyl-2-(1H-1,2,4-triazol-1-ylmethyl)-
Note: CAS Number 104390-57-0
CGA118244; CSAA107724 Plant; Rat; Livestock - -
3-[2-(2,4-dichlorophenyl)-2-[1,2,4]triazol-1-ylmethyl-[1,3]dioxolan-4-yl]-2-hydroxy-propionic acid SYN542636 Lactating goat - -
3-[2-(2,4-dichlorophenyl)-2-[1,2,4]triazol-1-yl-methyl-[1,3]dioxolan-4-yl]-propan-1-ol CGA118245 Wheat; Lactating goat - -


ECOTOXICOLOGY

for propiconazole

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 116 A5 Whole fish Threshold for concern
CT50 (days) 8 -
Mammals - Acute oral LD50 (mg kg-1) 550 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) 2.7 A4 Mice High
(ppm diet) 20 -
Birds - Acute LD50 (mg kg-1) > 2510 A5 Anas platyrhynchos Low
Birds - Short term dietary (LC50/LD50) > 5620 mg kg feed-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 2.6 A5 Leiostomus xanthurus Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.068 A5 Oncorhynchus mykiss Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 10.2 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.31 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 0.37 F3 Americamysis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 8.0 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) 25.0 A5 Chironomus riparius Moderate
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 4.9 F3 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.093 A4 Navicula seminulum, 11 day Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.32 Q2 Unknown species Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 686 A5 Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 0.833 P4 Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 100 Mortality
Dose: 0.25 kg ha-1
A5 Aphidius rhopalosiphi
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect 100 Beneficial capacity
Dose: 0.125 kg ha-1
A5 Typhlodromus pyri
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 6.7 mg kg-1 soil, 28 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for propiconazole

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 550 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 4000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 5.8 A5 Rat, 4 hr (nose only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.04 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.3 A5 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 9-14 A5 Rat, SF=100 -
Dermal penetration studies (%) 0.9-2.4 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

General human health issues USEPA - possible human carcinogen, EU - unlikely to pose a hazard to humans
Possible liver toxicant
Endocrine issues - Weak estrogen and aromatase activity inhibition

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 9
CLP classification 2013 Health: H302, H317
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R22, R43
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S36/37, S46, S60, S61
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) II - Warning - Moderately toxic
UN Number Usually 3082
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for propiconazole

Language Name
English propiconazole
French propiconazol
German Propiconazol
Danish propiconazol
Italian propiconazolo
Spanish propiconazol
Greek -
Slovenian propiokonazol
Polish propikonazol
Swedish propikonazol
Hungarian propikonazol
Dutch propiconazool

Record last updated: Wednesday 31 October 2018
Contact: aeru@herts.ac.uk