Propoxur (Ref: OMS 33)
Last updated: 19/01/2023
(Also known as: arprocarb; PHC; propotox; ENT 25671)
Propoxur is a carbamate pesticide. With a high aqueous solubilty, it has potential for being mobile in groundwaters although it is rarely reported. It is not highly volatile. In some instances it may persist in soil systems. It is highly toxic to humans if it is ingested but not other serious health issues have been identified. There are gaps in information relating to the toxicity of propoxur to biodiversity but based on information that is available it likely to be moderately to highly toxic. .
The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
A insecticide and acaricide active against a wide range of pests especially those that cause damage via sucking and chewing. Also used for flea control on domestic pets.
Cockroaches; Flies; Mosquitoes; Fleas; Ticks; Aphids; Leaf hoppers
Ornamentals; Lawns & turf; Glasshouse crops including tomatoes & cucumbers
-
Current
1959; first registered in the US in 1963.
Not approved
Expired
No UK approval for use
EC Regulation 1107/2009 (repealing 91/414)
Not approved
Not applicable
Expired
Not applicable
Yes
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
 
 
 
 
 
 
 
 
 
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
 
 
 
 
 
 
 
 
 
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
 
 
 
 
 
 
 
 
 
None
C₁₁H₁₅NO₃
CC(C)OC1=CC=CC=C1OC(=O)NC
-
ISRUGXGCCGIOQO-UHFFFAOYSA-N
InChI=1S/C11H15NO3/c1-8(2)14-9-6-4-5-7-10(9)15-11(13)12-3/h4-8H,1-3H3,(H,12,13)
Yes
Cambridge Crystallographic Data Centre diagrams
Common Name
Relationship
Link
propoxur
-
Insecticide, Acaricide, Veterinary substance
Carbamate insecticide; Carbamate acaricide; Phenyl methylcarbamate insecticide; Phenylk methylcarbamate acaricide
-
-
Synthetic
Non-systemic with contact and stomach action. Acetylcholinesterase (AChE) inhibitor.
114-26-1
204-043-8
80
047802
4944
006-016-00-4
209.24
-
2-isopropoxyphenyl methylcarbamate
2-(1-methylethoxy)phenyl methylcarbamate
Marine Pollutant
-
Not applicable
Not applicable
1A
Not applicable
Aedes aegypti , Amblyseius potentillae , Anopheles albimanus , Anopheles atroparvus , Anopheles funestus , many others
White crystalline solid
Bayer Makhteshim-Agan Mobay
Often supplied as emulsifiable concentrates, granules, dusts or wettable powders
1800
High
200000
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Isopropanol
-
94000
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Toluene
-
1300
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Hexane
-
90
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
-
Decomposes on distillation
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
-
-
-
-
-
-
-
1.38 X 1000
Calculated
-
0.14
Low
-
-
-
-
-
-
1.18
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
-
-
-
-
-
1.3
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Low volatility
1.50 X 10-04
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Non-volatile
-
-
-
-
-
-
-
79
K4 K = Research datasets, e.g. Pandora, Demetra 4 = Verified data
Moderately persistent
30
Q2 Q = Miscellaneous internet resources 2 = Unverified data of unknown source
Moderately persistent
28
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Non-persistent
-
-
-
-
-
-
-
-
-
Best available data
0.65
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
-
Leaves of ornamentals grown undercover, n=1
0.4
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
-
Beans, leaves, n=1
0.01
K4 K = Research datasets, e.g. Pandora, Demetra 4 = Verified data
Fast
-
180
K3 K = Research datasets, e.g. Pandora, Demetra 3 = Unverified data of known source
Persistent
-
2
K4 K = Research datasets, e.g. Pandora, Demetra 4 = Verified data
Fast
-
-
-
Soil adsorption and mobility
-
Mobile
30
-
-
-
-
-
-
-
-
3.65
Calculated
High leachability
5.62 X 10-01
Calculated
-
-
Medium
Calculated
-
Mobile
Calculated
-
Low risk
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Rapid aquatic degradation
Low risk
Not available
-
Known groundwater metabolites
None
dimethyl propoxus
-
Plant
0.27-0.36
-
Terrestrial ecotoxicology
~ 50
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rat
High
-
L2 L = Pesticide manuals and hard copy reference books / other sources 2 = Unverified data of unknown source
Rat 2 year
-
200
-
-
-
-
> 25.9
Colinus virginianus
High
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
< 0.112
Apis mellifera 24hr
High
-
-
-
> 1.35
Moderate
-
-
-
-
-
-
-
> 1.6
R4 R = Peer reviewed scientific publications 4 = Verified data
Bombus terrestris
Moderate
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
Harmful
AA2 AA = IOBC Database on classification of side effects to beneficial organisms, 2005 2 = Unverified data of unknown source
Chrysoperla carnea
-
-
-
-
-
-
-
-
-
-
6.2
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Lepomis macrochirus
Moderate
-
-
-
0.15
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Daphnia magna
Moderate
0.016
P3 P = Other governments and regulators 3 = Unverified data of known source
Daphnia magna survival 42 day
Moderate
-
-
-
38.1
Chironomus riparius 1 day
Moderate
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
HUMAN HEALTH AND PROTECTION
High (class III)
-
-
~ 50
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rat
High
5000
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rat
-
> 0.50
E3 E = Manufacturers safety data sheets 3 = Unverified data of known source
Rat
-
Intraperitoneal LD₅₀ = 30 mg kg⁻¹
Rat
-
Intramuscular LD₅₀ = 53 mg kg⁻¹
Rat
-
0.02
JMPR 1989
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
EU MRL pesticide database 
-
-
-
-
-
-
-
Absorbed through skin but in humans it is emininated, as its major metabolite 2-isopropoxyphenol (IPP), via urine within 24 hr of application
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
-
Carcinogen
Endocrine disruptor
?Possibly, status not identified
A3 A = Chromosome aberration (EFSA database) 3 = Negative
; B0 B = DNA damage/repair (EFSA database) 0 = No data
; C0 C = Gene mutation (EFSA database) 0 = No data
; D0 D = Genome mutation (EFSA database) 0 = No data
; E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
✓Yes, known to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
XNo, known not to cause a problem
?Possibly, status not identified
?Possibly, status not identified
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
XNo, known not to cause a problem
No data found
Eye irritant
Phototoxicant
 
?Possibly, status not identified
No data found
 
Toxic USEPA - probable human carcinogen Endocrine issues - Weak estrogenic effect
No information available
Health: H301 Environment: H400, H410
II (Moderately hazardous)
2757
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propoxur
propoxur
Propoxur
propoxur
propoxur
propoxur
propoxur
propoksur
-
-
propoxur
Record last updated:
19/01/2023
Contact:
aeru@herts.ac.uk
Please cite as:
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal , 22 (4), 1050-1064. DOI: 10.1080/10807039.2015.1133242