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pyridaben (Ref: BAS 300l)
** piridabena ** NC 129 ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Pyridaben is an insecticide and acaricide that is approved for use in the EU and many other countries. It has a low aqueous solubility, relatively volatile and, based on its chemical properties, is not expected to leach to groundwater. It tends not to persist in soils or water systems. It is moderately toxic to mammals and not expected to bioaccumulate. It is highly toxic to most aquatic organisms and honey bees but less so to earthworms and birds.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for pyridaben

Description: An insecticide and acaricide affective against thrips, mites, aphids and leafhoppers

Example pests controlled: Spider mites; Rust mites; Pear Psylla; Whiteflies

Example applications: Field crops; Fruit trees; Strawberries; Ornamentals; Vegetables; Greenhouse crops including cucumbers, tomatoes & peppers

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1988, first reported; 1990, first marketed Belgium

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur Czech Republic/Belgium
Date inclusion expires 30/04/2021
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, Japan; Canada; USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C19H25CIN2OS
Canonical SMILES CC(C)(C)C1=CC=C(C=C1)CSC2=C(C(=O)N(N=C2)C(C)(C)C)Cl
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) DWFZBUWUXWZWKD-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C19H25ClN2OS/c1-18(2,3)14-9-7-13(8-10-14)12-24-15-11-21-22(19(4,5)6)17(23)16(15)20/h7-11H,12H2,1-6H3
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide, Acaricide
Substance group Pyridazinone
Minimum active substance purity 980 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Non-systemic with rapid knock down action and long residual activity. Inhibitor of mitochondrial electron transport at complex I.
CAS RN 96489-71-3
EC number 405-700-3
CIPAC number 583
US EPA chemical code 129105
PubChem CID 91754
Molecular mass (g mol-1) 364.93
PIN (Preferred Identification Name) -
IUPAC name 2-tert-butyl-5-(4-tert-butylbenzylthio)-4-chloropyridazin-3(2H)-one
CAS name 4-chloro-2-(1,1-dimethylethyl)-5-(((4-(1,1-dimethylethyl)phenyl)methyl)thio)-3(2H)-pyridazinone
Other status information PAN listed Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 21
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Tetranychus kanzawai
Tetranychus urticae
Physical state White crystals
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Nissan Chemicals
  • Vapco
  • BASF
  • Zeneca
Example products using this active
  • Nexter Pro
  • Sanmite 75WP
  • Pyramite
  • Poseidon
  • Starling
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually supplied as a wettable powder and suspension concentrates that are mixed with water and applied as a spray.


ENVIRONMENTAL FATE

for pyridaben

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.022 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 333000 A5 - Acetone -
345000 A5 - Xylene -
49400 A5 - Methanol -
14100 A5 - n-Hexane -
Melting point (oC) 109.4 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 200 A4 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 2.34 X 1006 Calculated -
Log P 6.37 A5 High
Bulk density (g ml-1)/Specific gravity 1.2 L3 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 0.001 A2 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 0.3 A2 Moderately volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index -1.67 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 5.35 X 10-03 Calculated -
Note Estimated concentrations of chemicals with Koc values greater than 9995 ml g-1 are beyond the scope of the regression data used in SCI-GROW development. If there are concerns for such chemicals, a higher tier groundwater exposure assessment should be considered, regardless of the concentration returned by SCI-GROW
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution 296.5nm = 11746, 236.2nm = 21102, 223.4nm = 23221; [Acidic solution: 296.9nm = 11785, 236.3nm= 21142, 223.3nm = 23327; [Basic solution 296.6nm = 11724, 236.3nm = 21015, 223.3nm = 23037 A5 -
Surface tension (mN m-1) Not applicable A5 Low aqueous solubility -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 55 K4 Moderately persistent
DT50 (lab at 20oC) 106 A5 Persistent
DT50 (field) 29 A5 Non-persistent
DT90 (lab at 20oC) 1520 A3 -
DT90 (field) 188 A5 -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 50-199 days, DT90 range 241-4522 days; field study DT50 range 5-128 days, DT90 range 98-424 days; Other sources: DT50 86 days (DW4)
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 6.1 R4 -
Note Published literature RL50 range 2.3-11.8 days, 10 field & undercover grown crops, various matrices, n=11
Aqueous photolysis DT50 (days) at pH 7 Value 0.005 A5 Fast
Note Rapid
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 5 to pH 9 at 25 degC
Water-sediment DT50 (days) 17.5 A5 Fast
Water phase only DT50 (days) 1.18 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 276 A5 Non-mobile
Kfoc 66503
1/n 0.95
Notes and range EU dossier kf range 108-445 mL/g, Kfoc range 34858-87918 mL/g, 1/n range 0.90-1.28, Soils=4
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
2-tert-butyl-5-(4-(1-carboxy-1-methylethyl) benzylthio)4-chloropyridazin-3 (2H)-one Soil   0.085   Minor fraction, Relevant
2-tert-butyl-4-chloropyridazin-3(2H)-one-5-sulfonic acid Soil   0.076   Minor fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
2-tert-butyl-4-chloro-5-[4-(1,1-dimethyl-2-hydroxyethyl)benzylthio]-chloropyridazin-3 (2H)-one PB-9 - - -


ECOTOXICOLOGY

for pyridaben

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 48 A5 Low potential
CT50 (days) 0.8 -
Mammals - Acute oral LD50 (mg kg-1) 161 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2250 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) > 4298 mg kg bw-1 day-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 0.0007 A5 Oncorhynchus mykiss High
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.001 A5 Daphnia magna High
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.000086 A5 Daphnia magna High
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 0.00054 F3 Americamysis bahia High
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.016 F3 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.017 A5 Pseudokirchneriella subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) 0.024 A5 High
Oral acute 48 hour LD50 (μg bee-1) 0.535 A5 High
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 19 A5 Eisenia foetida, corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 0.29 A5 Eisenia foetida Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect 3.28 A5 Folsomia candida, 28 day NOEC mg kg-1 -
Other arthropod (1) LR50 g ha-1 0.24 Mortality
A5 Aphidius rhopalosiphi, adult
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 0.59 Mortality
A5 Typhlodromus pyri
-
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for pyridaben

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 161 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 0.62 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.01 A3 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.05 A3 Rabbit, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.005 A3 Rat, SF=10 -
Dermal penetration studies (%) 0.4-1.2 A5 concentration dependent -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public Risk to bystanders if they enter greenhouses after spraying
Occupational No unacceptable risks to operators or other workers identified utilising PPE/PPC
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) 0.1 EU Dir 89/778/EC limit; Calc MAC=30 μg l-1; A5 -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Moderately toxic

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
IMDG Transport Code is usually 6.1
CLP classification 2013 Health: H301, H331
Environment: H400, H410
EC Risk Classification Click here to view information omn the EU risk phrases T - Toxic: R23/25
N - Dangerous for the environment: R50, R53
EC Safety Classification Click here to view information omn the EU safety phrases S1/2, S36/37, S45, S60, S61
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) I - Danger - Highly toxic
UN Number Usually 3077
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group II (medium danger)


TRANSLATIONS

for pyridaben

Language Name
English pyridaben
French pyridabene
German Pyridaben
Danish pyridaben
Italian piridaben
Spanish piridaben
Greek -
Slovenian piridaben
Polish pyridaben
Swedish -
Hungarian piridaben
Dutch pyridaben

Record last updated: Thursday 23 August 2018
Contact: aeru@herts.ac.uk