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pyridafenthion (Ref: ENT 23968))
** piridafention ** pyridiphenthion ** CL 12503 ** NC-250 ** pyridiphenthion ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

SUMMARY

Pyridafenthion is an insecticide that does not have approval for use in the EU. It its moderately soluble in aqueous solution, is relatively volatile and is not persistent in soil. However, under certain conditions it may persist for a month or two in surface water. It is moderately toxic to mammals, is an acetyl cholinesterase inhibitor and a neurotoxicant. It is highly toxic to honeybees, earthworms and birds. data for aquatic organisms is limited but it is known to be moderately toxic to fish and algae.

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for pyridafenthion

Description: An organophosphate insecticide used to control sucking and chewing insects

Example pests controlled: Aphids; Thrips; Leafhoppers; Sawflies

Example applications: Rice; Vegetables; Fruit

Efficacy & activity: -

Availability status: Unknown

Introduction & key dates: 1973, first introduced Japan

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Not applicable
Date inclusion expires Expired
EU Candidate for substitution (CfS) Not applicable
Listed in EU database No

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C14H17N2O4PS
Canonical SMILES CCOP(=S)(OCC)OC1=NN(C(=O)C=C1)C2=CC=CC=C2
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) CXJSOEPQXUCJSA-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C14H17N2O4PS/c1-3-18-21(22,19-4-2)20-13-10-11-14(17)16(15-13)12-8-6-5-7-9-12/h5-11H,3-4H2,1-2H3
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Insecticide
Substance group Organophosphate
Minimum active substance purity -
Known relevant impurities -
Substance origin Synthetic
Mode of action Systemic, with stomach and contact action. Acetylcholinesterase (AChE) inhibitor.
CAS RN 119-12-0
EC number 204-298-5
CIPAC number 8269
US EPA chemical code -
PubChem CID 8381
Molecular mass (g mol-1) 340.33
PIN (Preferred Identification Name) O-(1,6-dihydro-6-oxo-1-phenyl-3-pyridazinyl) O,O-diethyl phosphorothioate
IUPAC name O-(1,6-dihydro-6-oxo-1-phenylpyridazin-3-yl) O,O-diethyl phosphorothioate
CAS name O-(1,6-dihydro-6-oxo-1-phenyl-3-pyridazinyl) O,O-diethyl phosphorothioate
Other status information PAN listed Highly Hazardous Chemical
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 1B
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance -
Physical state Pale yellow solid
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Mitsui Chemicals
  • Sipcan
Example products using this active
  • Ofunack
  • Oreste
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details -


ENVIRONMENTAL FATE

for pyridafenthion

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 100 L3 Moderate
Solubility - In organic solvents at 20oC (mg l-1) 3880 L3 - Hexane -
812000 L3 - Toluene -
930000 L3 - Acetone -
785000 L3 - Ethyl acetate -
Melting point (oC) 56.2 L3 -
Boiling point (oC) Decomposes before boiling L3 -
Degradation point (oC) 180 L3 -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 1.58 X 1003 Calculated -
Log P 3.2 L3 High
Bulk density (g ml-1)/Specific gravity 1.325 L3 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 20oC (mPa) 0.00147 L3 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 5.00 X 10-06 L3 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 0.18 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 6.39 X 10-03 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated Medium
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 18 L3 Non-persistent
DT50 (lab at 20oC) 18 L3 Non-persistent
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note General literature states DT50 11-24 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 9.5 R4 -
Note Published literature RL50 range 4.5-17.6 days, rice field crop, various matrices, n=3
Aqueous photolysis DT50 (days) at pH 7 Value 7 L3 Moderately fast
Note DT50 19 days in sterile water, 7 days in natural water
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 46 L3 Moderately persistent
Note pH sensitive: DT50 72 days at pH 5, 27 days at pH 9, all at 25 degC
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - W3 Non-mobile
Koc 7211
Notes and range -
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -


ECOTOXICOLOGY

for pyridafenthion

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 1.4 R3 Low potential
CT50 (days) Not available -
Mammals - Acute oral LD50 (mg kg-1) 769 L3 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) - - -
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 68 L3 Coturnix japonica High
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 7.5 F4 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) - - -
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 8.53 V3 Pseudokirchnerella subcapitata, 48hr Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) - - -
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) 0.08 L3 High
Earthworms - Acute 14 day LC50 (mg kg-1) > 2.87 R4 Eisenia foetida High
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for pyridafenthion

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 769 L3 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 2100 L3 Rat -
Mammals - Inhalation LC50 (mg l-1) > 1.13 L3 Rat, 4 hr -
Other Mammal toxicity endpoints Intraperitoneal LD50 = 64 V3 Mouse -
Subcutaneous LD50 = 305 mg kg-1 V3 Rat -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) - - -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 List I; List II - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Harmful if swallowed or inhalled

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes IMDG Transport Code is usually 6.1
CLP classification 2013 Handling: H224
Health: H319, H336
EU Hazard: EUH066
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R67
Xi - Irritant: R36, R66
H - Handling Risks: R11
EC Safety Classification Click here to view information omn the EU safety phrases S61
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number Usually 2783
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group II (medium danger)


TRANSLATIONS

for pyridafenthion

Language Name
English pyridafenthion
French pyridafenthion
German Pyridafenthion
Danish pyridafenthion
Italian piridafention
Spanish piridafention
Greek -
Slovenian piridafention
Polish pyridafention
Swedish -
Hungarian piridafentoin
Dutch -

Record last updated: Monday 28 May 2018
Contact: aeru@herts.ac.uk