| bendiocarb (Ref: NC 6897) |
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Environmental Fate - Ecotoxicology - Human Health
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SUMMARY
Bendiocarb is a carbamate insecticide and veterinary treatment that does not have EU regulatory approval for use. It has a moderate aqueous solubility, moderate volatility, is moderately mobile but, based on its chemical properties, would not be expected to leach to groundwater. It is highly toxic to mammals but tends not to bioaccumulate. It has a moderate to high toxicity for most aquatic organisms. It is highly toxic to birds and honey so but slightly less to earthworms. GENERAL INFORMATION 
for bendiocarb
Description: A carbamate insecticide with a wide range of uses including storage, soil-dwelling and some foliar pests. Also has some veterinary applications.
Example pests controlled: Beetles; Aphids; Mites; caterpillars; Spiders; Wasps; Ants; Flies
Example applications: Non-cropped areas including paths, railroads; Residences and commercial buildings; Turf; Ornamentals
Efficacy & activity: -
Availability status: Current
Introduction & key dates: 1971
EC Regulation 1107/2009 (repealing 91/414):
| Status | Not approved |
| Dossier rapporteur/co-rapporteur | - |
| Date inclusion expires | Expired |
| EU Candidate for substitution (CfS) | - |
| Listed in EU database | Yes |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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Also used in: Australia, USA
Chemical structure:
| Isomerism | - |
| Chemical formula | C11H13NO4 |
| Canonical SMILES | CC1(OC2=C(O1)C(=CC=C2)OC(=O)NC)C |
| Isomeric SMILES | No data |
| International Chemical Identifier key (InChIKey) | XEGGRYVFLWGFHI-UHFFFAOYSA-N |
| International Chemical Identifier (InChI) | InChI=1S/C11H13NO4/c1-11(2)15-8-6-4-5-7(9(8)16-11)14-10(13)12-3/h4-6H,1-3H3,(H,12,13) |
| 2D structure diagram/image available? | Yes |
General status:
| Pesticide type | Insecticide, Veterinary substance | |||
| Substance group | Carbamate | |||
| Minimum active substance purity | - | |||
| Known relevant impurities | - | |||
| Substance origin | Synthetic | |||
| Mode of action | Systemic, with contact and stomach action resulting in rapid knock-down. Acetylcholinesterase (AChE) inhibitor. | |||
| CAS RN | 22781-23-3 | |||
| EC number | 245-216-8 | |||
| CIPAC number | 232 | |||
| US EPA chemical code | 105201 | |||
| PubChem CID | 2314 | |||
| Molecular mass (g mol-1) | 223.23 | |||
| PIN (Preferred Identification Name) | 2,2-dimethyl-2H-1,3-benzodioxol-4-yl methylcarbamate | |||
| IUPAC name | 2,2-dimethyl-1,3-benzodioxol-4-yl methylcarbamate | |||
| CAS name | 2,2-dimethyl-1,3-benzodioxol-4-yl methylcarbamate | |||
| Other status information | Marine Pollutant | |||
| Relevant Environmental Water Quality Standards | - | |||
| Herbicide Resistance Classification (HRAC) | Not applicable | |||
| Herbicide Resistance Classification (WSSA) | Not applicable | |||
| Insecticide Resistance Classification (IRAC) | 1A | |||
| Fungicide Resistance Classification (FRAC) | Not applicable | |||
| Examples of recorded resistance | Anopheles albimanus Aonidella aurantii Culex pipiens pipiens plus others |
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| Physical state | White odoureless crystals | |||
| Related substances & organisms | - | |||
Formulations:
| Property |
Value | |||
| Example manufacturers & suppliers of products using this active now or historically |
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| Example products using this active |
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| UK LERAP status | No UK approval for use as a pesticide under EC Regulation 1107/2009 | |||
| Formulation and application details | Usually supplied in formulations for topical administration including impregnated collars . | |||
ENVIRONMENTAL FATE
for bendiocarb
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Solubility - In water at 20oC (mg l-1) | 280 | B4 | Moderate | |
| Solubility - In organic solvents at 20oC (mg l-1) | 250 | L2 - Dichlorobenzene | - | |
| 175000 | L2 - Acetone | - | ||
| 40000 | L3 - Ethanol | - | ||
| 225 | L3 - n-Hexane | - | ||
| Melting point (oC) | 126.7 | L3 | - | |
| Boiling point (oC) | Decomposes before boiling | V3 | - | |
| Degradation point (oC) | - | - | - | |
| Flashpoint (oC) | Not expected to self ignite; Not highly flammable | V3 | - | |
| Octanol-water partition coefficient at pH 7, 20oC | P | 5.01 X 1001 | Calculated | - |
| Log P | 1.7 | B4 | Low | |
| Bulk density (g ml-1)/Specific gravity | 1.29 | B5 | - | |
| Dissociation constant (pKa) at 25oC | 8.8 | DW4 | - | |
| Note: Very weak acid | ||||
| Vapour pressure at 20oC (mPa) | 4.6 | B5 | Low volatility | |
| Henry's law constant at 25oC (Pa m3 mol-1) | 4.00 X 10-03 | H4 | Non-volatile | |
GUS leaching potential index  |
0.99 | Calculated | Low leachability | |
| SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Value | 3.84 X 10-03 | Calculated | - |
| Note | - | |||
| Potential for particle bound transport index |
- | Calculated | Low | |
| Maximum UV-vis absorption L mol-1 cm-1 | - | - | - | |
| Surface tension (mN m-1) | - | - | - | |
Degradation:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
General biodegradability | - |
| Soil degradation (days) (aerobic) | DT50 (typical) | 3.5 | H4 | Non-persistent |
| DT50 (lab at 20oC) | 5.0 | Q3 | Non-persistent | |
| DT50 (field) | 3.5 | H4 | Non-persistent | |
| DT90 (lab at 20oC) | - | - | - | |
| DT90 (field) | - | - | - | |
| DT50 modelling endpoint | - | - | - | |
| Note | Literature values vary from a few days to a few weeks depending on soil type | |||
| Dissipation rate RL50 on plant matrix | Value | 18.3 | R3 | - |
| Note | Azelea leaves, undercover, n=1 | |||
| Dissipation rate RL50 on and in plant matrix | Value | 4.9 | R4 | - |
| Note | Published literature RL50 range 3.6-8.0 days, 5 field crops, various matrices, n=10 | |||
| Aqueous photolysis DT50 (days) at pH 7 | Value | 13 | K4 | Moderately fast |
| Note | - | |||
| Aqueous hydrolysis DT50 (days) at 20oC and pH 7 | Value | 25 | K4 | Non-persistent |
| Note | Hydrolysed rapidly in alkali media, slows under acid and neutral conditions | |||
| Water-sediment DT50 (days) | 2 | K4 | Fast | |
| Water phase only DT50 (days) | 2 | K4 | Moderately fast | |
Soil adsorption and mobility:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Linear | Kd | - | H3 | Moderately mobile |
| Koc | 385 | |||
| Notes and range | Other sources Koc 570 mL/g (DW3) | |||
| Freundlich | Kf | - | - | - |
| Kfoc | - | |||
| 1/n | - | |||
| Notes and range | - | |||
| pH sensitivity | - | |||
Key metabolites:
| Metabolite | Formation medium | Estimated maximum occurrence fraction | 1107/2009 relevancy |
|
| 2,2-dimethyl-1,3-benzodioxol-4-ol (Ref: NC-7312) | Soil | - | - | |
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Bio-concentration factor | BCF (l kg-1) | 64.8 | E3 Lepomis macrochirus | Low potential |
| CT50 (days) | Not available | - | ||
| Mammals - Acute oral LD50 (mg kg-1) | 34 | B3 Rat | High | |
| Mammals - Short term dietary NOEL | (mg kg-1) | 0.75 | B3 Rat | High |
| (ppm diet) | - | - | ||
| Birds - Acute LD50 (mg kg-1) | > 3.1 | L3 Anas platyrhynchos | High | |
| Birds - Short term dietary (LC50/LD50) | - | - | - | |
| Fish - Acute 96 hour LC50 (mg l-1) | > 1.55 | L3 Oncorhynchus mykiss | Moderate | |
| Fish - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) | 0.03 | J4 Daphnia magna | High | |
| Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) | - | - | - | |
| Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) | 0.006 | F3 Americamysis bahia | High | |
| Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) | - | - | - | |
| Aquatic plants - Acute 7 day EC50, biomass (mg l-1) | - | - | - | |
| Non-target plants | - | - | - | |
| - | - | - | ||
| Algae - Acute 72 hour EC50, growth (mg l-1) | > 1.71 | K3 Unknown species | Moderate | |
| Algae - Chronic 96 hour NOEC, growth (mg l-1) | 0.32 | Q2 Unknown species | Moderate | |
| Honeybees | Contact acute 48 hour LD50 (μg bee-1) | - | - | - |
| Oral acute 48 hour LD50 (μg bee-1) | > 0.1 | E4 | High | |
| Unknown mode acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Earthworms - Acute 14 day LC50 (mg kg-1) | 188 | F4 Eisenia foetida | Moderate | |
| Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) | - | - | - | |
| Other soil macro-organisms - e.g. Collembola | LR50 / EC50 / NOEC / % Effect | - | - | - |
| Other arthropod (1) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Other arthropod (2) | LR50 g ha-1 | - | - | - |
| % Effect | - | - | - | |
| Soil micro-organisms | - | - | - | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
HUMAN HEALTH AND PROTECTION
for bendiocarb
General:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Threshold of Toxicological Concern (Cramer Class) |
High (class III) | - | - | |
| Mammals - Acute oral LD50 (mg kg-1) | 34 | B3 Rat | High | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | 566 | L3 Rat | - | |
| Mammals - Inhalation LC50 (mg l-1) | 0.55 | L3 Rat | - | |
| Other Mammal toxicity endpoints | - | - | ||
| ADI - Acceptable Daily Intake (mg kg-1bw day-1) | 0.004 | UK ACP 2002 | - | |
| ARfD - Acute Reference Dose (mg kg-1bw day-1) | - | - | - | |
| AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) | - | - | - | |
| AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | - | - | - | |
| Dermal penetration studies (%) | - | - | - | |
| Dangerous Substances Directive 76/464 | - | - | - | |
| Exposure Limits | - | - | - | |
| Exposure Routes | Public | - | ||
| Occupational | - | |||
| European MRLs | Click here for the EU MRL pesticide database | |||
| Drinking Water Standards | - | - | - | |
| Drinking Water MAC (μg l-1) | - | - | - | |
Health issues:
| Carcinogen | Mutagen | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | |||
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| Respiratory tract irritant | Skin irritant | Skin sensitiser | Eye irritant | Phototoxicant | ||||
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| General human health issues | May cause hepatic and renal diseases May cause respiratory problems Endocrine issues - Weak estrogen effect |
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: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found
Handling issues:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| General |
No information available | |||
| CLP classification 2013 | Health: H301, H331, H312 Environment: H400, H410 |
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| EC Risk Classification |
T - Toxic: R23/25 Xn - Harmful: R21 N - Dangerous for the environment: R50, R53 |
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| EC Safety Classification |
S1/2, S22, S45, S61, S36/37, S60 | |||
| WHO Classification | II | - | Moderately hazardous | |
| US EPA Classification (formulation) | II | - | Warning - Moderately toxic | |
| UN Number | 2757 | |||
| Waste disposal & packaging |
- | |||
| Language | Name |
| English | bendiocarb |
| French | bendiocarbe |
| German | Bendiocarb |
| Danish | bendiocarb |
| Italian | bendiocarb |
| Spanish | bendiocarb |
| Greek | bendiocarb |
| Slovenian | bendiokarb |
| Polish | bendiokarb |
| Swedish | - |
| Hungarian | - |
| Dutch | bendiocarb |
Record last updated: Wednesday 23 May 2018
Contact: aeru@herts.ac.uk