| tetraconazole (Ref: M 14360) |
 |
Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
GENERAL INFORMATION 
for tetraconazole
Description: A fungicide used to control a range of fungal infections such as Septoria, and Rhynchosporium on cereals, sugarbeet and other crops
Example pests controlled: Powdery mildew; Rusts; Bunt; Loose smut; Scab; Leafspot
Example applications: Sugarbeet; Wheat; Grapes; Apple
Efficacy & activity: Corn/Grey leaf spot=High; Corn/Southern rust=Moderate; Soybean/Anthracnose=Moderate; Soybean/Brown spot=High; Soybean/Rust=High; Soybean/White mould=Moderate
Availability status: Current
Introduction & key dates: circa 1990
EC Regulation 1107/2009 (repealing 91/414):
| Status | Approved |
| Dossier rapporteur/co-rapporteur | France/Germany |
| Date inclusion expires | 31/12/2021 |
| EU Candidate for substitution (CfS) | No |
| Listed in EU database | Yes |
Approved for use (
) or known to be used (
) in the following European countries: 
AT |
BE |
BG |
CY |
CZ |
DE |
DK |
EE |
EL |
ES |
FI |
FR |
HR |
HU |
IE |
IT |
LT |
LU |
LV |
MT |
NL |
PL |
PT |
RO |
SE |
SI |
SK |
UK |
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Also used in: Australia, USA
Chemical structure:
| Isomerism | A chiral molecule. The technical material is an isomeric mixture of the R (+) and S (-) forms. |
| Chemical formula | C13H11Cl2F4N3O |
| Canonical SMILES | C1=CC(=C(C=C1Cl)Cl)C(CN2C=NC=N2)COC(C(F)F)(F)F |
| Isomeric SMILES | No data |
| International Chemical Identifier key (InChIKey) | LQDARGUHUSPFNL-UHFFFAOYSA-N |
| International Chemical Identifier (InChI) | InChI=1S/C13H11Cl2F4N3O/c14-9-1-2-10(11(15)3-9)8(4-22-7-20-6-21-22)5-23-13(18,19)12(16)17/h1-3,6-8,12H,4-5H2 |
| 2D structure diagram/image available? | Yes |
General status:
| Pesticide type | Fungicide | |
| Substance group | Triazole | |
| Minimum active substance purity | 950 g/kg racemic mixture | |
| Known relevant impurities | EU dossier - toluene 13g/kg | |
| Substance origin | Synthetic | |
| Mode of action | Systemic with protectant, eradicant and curative properties. Sterol biosynthesis inhibitor, acts mainly on the vegetative stages of fungi by blocking the mycelial growth either inside or on the surface of the host plant. | |
| CAS RN | 112281-77-3 | |
| EC number | 407-760-6 | |
| CIPAC number | 726 | |
| US EPA chemical code | 120603 | |
| PubChem CID | 80277 | |
| Molecular mass (g mol-1) | 372.15 | |
| PIN (Preferred Identification Name) | rac-1-[(2R)-2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl]-1H-1,2,4-triazole | |
| IUPAC name | (RS)-2-(2,4-dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl 1,1,2,2-tetrafluoroethyl ether | |
| CAS name | 1-(2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl)-1H-1,2,4-triazole | |
| Other status information | - | |
| Relevant Environmental Water Quality Standards | - | |
| Herbicide Resistance Classification (HRAC) | Not applicable | |
| Herbicide Resistance Classification (WSSA) | Not applicable | |
| Insecticide Resistance Classification (IRAC) | Not applicable | |
| Fungicide Resistance Classification (FRAC) | 3 | |
| Examples of recorded resistance | - | |
| Physical state | Colourless viscous liquid | |
| Related substances & organisms | ||
Formulations:
| Property |
Value | |||
| Example manufacturers & suppliers of products using this active now or historically |
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| Example products using this active |
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| UK LERAP status | Buffer probably required in UK - see product label | |||
| Formulation and application details | Formulations include microemulsions. | |||
ENVIRONMENTAL FATE
for tetraconazole
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Solubility - In water at 20oC (mg l-1) | 156.6 | A5 | Moderate | |
| Solubility - In organic solvents at 20oC (mg l-1) | 300000 | A5 - Xylene | - | |
| 300000 | A5 - Acetone | - | ||
| 300000 | A5 - Ethyl acetate | - | ||
| 15000 | A5 - n-Hexane | - | ||
| Melting point (oC) | -29.2 | A5 - | - | |
| Boiling point (oC) | Decomposes before boiling | A5 | - | |
| Degradation point (oC) | 235 | A5 | - | |
| Flashpoint (oC) | Not expected to self ignite; Not highly flammable | A5 | - | |
| Octanol-water partition coefficient at pH 7, 20oC | P | 3.63 X 1003 | Calculated | - |
| Log P | 3.56 | A5 | High | |
| Bulk density (g ml-1)/Specific gravity | 1.459 | A5 | - | |
| Dissociation constant (pKa) at 25oC | 0.65 | A4 | - | |
| Note: pKa range 0.8-0.5, Strong acid | ||||
| Vapour pressure at 20oC (mPa) | 0.18 | A5 | Low volatility | |
| Henry's law constant at 25oC (Pa m3 mol-1) | 3.60 X 10-04 | A5 | Non-volatile | |
GUS leaching potential index  |
1.81 | Calculated | Transition state | |
| SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate |
Value | 6.21 X 10-02 | Calculated | - |
| Note | - | |||
| Potential for particle bound transport index |
- | Calculated | High | |
| Maximum UV-vis absorption L mol-1 cm-1 | 281nm < 310, No significant aborption at >290 nm | A5 | - | |
| Surface tension (mN m-1) | 49.94 | A5 at 20oC, 111.8 mg l-1 | - | |
Degradation:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
General biodegradability | - |
| Soil degradation (days) (aerobic) | DT50 (typical) | 61 | Q3 | Moderately persistent |
| DT50 (lab at 20oC) | 83.8 | A3 | Moderately persistent | |
| DT50 (field) | 430 | A5 | Very persistent | |
| DT90 (lab at 20oC) | Stable | A4 | - | |
| DT90 (field) | 1428 | A5 | - | |
| DT50 modelling endpoint | - | - | - | |
| Note | EU dossier states no degradation during lab studies, field studies DT50 range 136-1688 days, DT90 range 453-5606 days | |||
| Dissipation rate RL50 on plant matrix | Value | - | - | - |
| Note | - | |||
| Dissipation rate RL50 on and in plant matrix | Value | 5.5 | R4 | - |
| Note | Published literature RL50 range 4.0-7.0 days, 7 field & undercover grown crops, various matrices, n=11 | |||
| Aqueous photolysis DT50 (days) at pH 7 | Value | 217 | B5 | Stable |
| Note | Not expected to be an important degradation rate | |||
| Aqueous hydrolysis DT50 (days) at 20oC and pH 7 | Value | Stable | A5 | - |
| Note | Stable pH 4 to pH 9, 120 hrs | |||
| Water-sediment DT50 (days) | 340 | A5 | Slow | |
| Water phase only DT50 (days) | 2 | A5 | Moderately fast | |
Soil adsorption and mobility:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Linear | Kd | - | - | - |
| Koc | - | |||
| Notes and range | - | |||
| Freundlich | Kf | 145 | A5 | Slightly mobile |
| Kfoc | 1152 | |||
| 1/n | 0.92 | |||
| Notes and range | EU dossier kf range 8.53-548.9 mL/g, Kfoc range 531-1922 mL/g, 1/n range 0.88-0.99, Soils=4 | |||
| pH sensitivity | No | |||
Key metabolites:
| Metabolite | Formation medium | Estimated maximum occurrence fraction | 1107/2009 relevancy |
|
| 2-(2,4-dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)propanoic acid (Ref: M14360-acid) | Soil | 0.089 | Minor fraction, relevancy unknown | |
| 1H-1,2,4-triazol-1-ylacetic acid (Ref: CGA 142856) | Soil | 0.049 | Minor fraction, relevancy unknown | |
| 2-(2,4-dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-1-ol (Ref: M14360-alcohol) |
Soil | 0.470 | Major fraction, relevancy unknown | |
ECOTOXICOLOGY
for tetraconazole
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Bio-concentration factor | BCF (l kg-1) | 35.7 | A5 Whole fish | Low potential |
| CT50 (days) | 0.189 | - | ||
| Mammals - Acute oral LD50 (mg kg-1) | 1031 | A5 Rat | Moderate | |
| Mammals - Short term dietary NOEL | (mg kg-1) | > 0.8 | A5 Rat | High |
| (ppm diet) | > 10 | - | ||
| Birds - Acute LD50 (mg kg-1) | 132 | A5 Colinus virginianus | Moderate | |
| Birds - Short term dietary (LC50/LD50) | 55.5 mg kg bw-1 day-1 | A5 Anas platyrhynchos | - | |
| Fish - Acute 96 hour LC50 (mg l-1) | 4.3 | A5 Lepomis macrochirus | Moderate | |
| Fish - Chronic 21 day NOEC (mg l-1) | 0.3 | A5 Pimephales promelas, growth | Moderate | |
| Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) | 3.0 | A5 Daphnia magna | Moderate | |
| Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) | 0.19 | A5 Daphnia magna | Moderate | |
| Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) | 0.42 | E4 Mysidopsis bahia | Moderate | |
| Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) | - | - | - | |
| Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) | 4.45 | A5 Chironomus riparius | Moderate | |
| Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) | - | - | - | |
| Aquatic plants - Acute 7 day EC50, biomass (mg l-1) | 0.52 | A5 Lemna gibba | Moderate | |
| Non-target plants | > 112 | A5 10 tested species Vegetative vigour, ER50 as g/ha |
- | |
| > 112 | A5 10 tested species Seedling emergence, ER50 as g/ha |
- | ||
| Algae - Acute 72 hour EC50, growth (mg l-1) | 2.4 | B4 Ankistodesmus bibaiamus< | Moderate | |
| Algae - Chronic 96 hour NOEC, growth (mg l-1) | - | - | - | |
| Honeybees | Contact acute 48 hour LD50 (μg bee-1) | 63 | A5 | Moderate |
| Oral acute 48 hour LD50 (μg bee-1) | > 130 | A5 | Low | |
| Unknown mode acute 48 hour LD50 (μg bee-1) | - | - | - | |
| Earthworms - Acute 14 day LC50 (mg kg-1) | 71 | A5 Eisenia foetida | Moderate | |
| Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) | 8.2 | A5 Eisenia foetida | Moderate | |
| Other soil macro-organisms - e.g. Collembola | LR50 / EC50 / NOEC / % Effect | - | - | - |
| Other arthropod (1) | LR50 g ha-1 | - | - | - |
| % Effect | Harmless | Dose: 40 g ha-1 AA3 Aphidius rhopalosiphi |
- | |
| Other arthropod (2) | LR50 g ha-1 | - | - | - |
| % Effect | Harmful | Dose: 40 g ha-1 AA2 Typhlodromus pyri |
- | |
| Soil micro-organisms | Nitrogen mineralisation: No significant adverse effect Carbon mineralisation: No significant adverse effect |
A5 Dose: 0.5 mg kg-1 soil, 28 days |
- | |
| Mesocosm study data | NOEAEC mg l-1 | - | - | - |
| NOEAEC mg l-1 | - | - | - | |
HUMAN HEALTH AND PROTECTION
for tetraconazole
General:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| Threshold of Toxicological Concern (Cramer Class) |
High (class III) | - | - | |
| Mammals - Acute oral LD50 (mg kg-1) | 1031 | A5 Rat | Moderate | |
| Mammals - Dermal LD50 (mg kg-1 body weight) | > 2000 | A5 Rat | - | |
| Mammals - Inhalation LC50 (mg l-1) | 3.66 | A5 Rat, 4 hr (whole body) | - | |
| Other Mammal toxicity endpoints | - | - | ||
| ADI - Acceptable Daily Intake (mg kg-1bw day-1) | 0.004 | A5 Rat, SF=100 | - | |
| ARfD - Acute Reference Dose (mg kg-1bw day-1) | 0.05 | A5 Rat, SF=100 | - | |
| AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) | - | - | - | |
| AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) | 0.03 | A5 Dog, SF=100 | - | |
| Dermal penetration studies (%) | 1.0-20.0 | A5 concentration dependent | - | |
| Dangerous Substances Directive 76/464 | List II | - | - | |
| Exposure Limits | - | - | - | |
| Exposure Routes | Public | No unacceptable risks to bystanders identified | ||
| Occupational | No unacceptable risks to operators or other workers identified with PPE/PPC | |||
| European MRLs | Click here for the EU MRL pesticide database | |||
| Drinking Water Standards | - | - | - | |
| Drinking Water MAC (μg l-1) | - | - | - | |
Health issues:
| Carcinogen | Mutagen | Endocrine disrupter | Reproduction / development effects | Cholinesterase inhibitor | Neurotoxicant | |||
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| Respiratory tract irritant | Skin irritant | Skin sensitiser | Eye irritant | Phototoxicant | ||||
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| General human health issues | Liver toxicant USEPA - possible human carcinogen at high doses |
|||||||
: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found
Handling issues:
| Property |
Value | Source/Quality Score/Other Information |
Interpretation |
|
| General |
Not explosive or oxidising | |||
| CLP classification 2013 | Health: H302, H332 Environment: H411 |
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| EC Risk Classification |
Xn - Harmful: R20/22 N - Dangerous for the environment: R51, R53 |
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| EC Safety Classification |
S2, S36, S61 | |||
| WHO Classification | II | - | Moderately hazardous | |
| US EPA Classification (formulation) | No consensus across products or no products available | - | - | |
| UN Number | - | |||
| Waste disposal & packaging |
- | |||
TRANSLATIONS
for tetraconazole
| Language | Name |
| English | tetraconazole |
| French | tetraconazole |
| German | Tetraconazol |
| Danish | tetraconazol |
| Italian | tetraconazolo |
| Spanish | tetraconazol |
| Greek | - |
| Slovenian | tetrakonazol |
| Polish | tetrakonazol |
| Swedish | - |
| Hungarian | tetrakonazol |
| Dutch | - |
Record last updated: Thursday 23 August 2018
Contact: aeru@herts.ac.uk