Select Option
Home
A to Z
Search
Terms & Conditions
Support Information
Purchasing & Other Services
Video User Guides
GET ADDITIONAL DATA HERE!

tetraconazole (Ref: M 14360)
** tetraconazol ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for tetraconazole

Description: A fungicide used to control a range of fungal infections such as Septoria, and Rhynchosporium on cereals, sugarbeet and other crops

Example pests controlled: Powdery mildew; Rusts; Bunt; Loose smut; Scab; Leafspot

Example applications: Sugarbeet; Wheat; Grapes; Apple

Efficacy & activity: Corn/Grey leaf spot=High; Corn/Southern rust=Moderate; Soybean/Anthracnose=Moderate; Soybean/Brown spot=High; Soybean/Rust=High; Soybean/White mould=Moderate

Availability status: Current

Introduction & key dates: circa 1990

EC Regulation 1107/2009 (repealing 91/414):
Status Approved
Dossier rapporteur/co-rapporteur France/Germany
Date inclusion expires 31/12/2021
EU Candidate for substitution (CfS) No
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia, USA

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism A chiral molecule. The technical material is an isomeric mixture of the R (+) and S (-) forms.
Chemical formula C13H11Cl2F4N3O
Canonical SMILES C1=CC(=C(C=C1Cl)Cl)C(CN2C=NC=N2)COC(C(F)F)(F)F
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) LQDARGUHUSPFNL-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C13H11Cl2F4N3O/c14-9-1-2-10(11(15)3-9)8(4-22-7-20-6-21-22)5-23-13(18,19)12(16)17/h1-3,6-8,12H,4-5H2
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide
Substance group Triazole
Minimum active substance purity 950 g/kg racemic mixture
Known relevant impurities EU dossier - toluene 13g/kg
Substance origin Synthetic
Mode of action Systemic with protectant, eradicant and curative properties. Sterol biosynthesis inhibitor, acts mainly on the vegetative stages of fungi by blocking the mycelial growth either inside or on the surface of the host plant.
CAS RN 112281-77-3
EC number 407-760-6
CIPAC number 726
US EPA chemical code 120603
PubChem CID 80277
Molecular mass (g mol-1) 372.15
PIN (Preferred Identification Name) rac-1-[(2R)-2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl]-1H-1,2,4-triazole
IUPAC name (RS)-2-(2,4-dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)propyl 1,1,2,2-tetrafluoroethyl ether
CAS name 1-(2-(2,4-dichlorophenyl)-3-(1,1,2,2-tetrafluoroethoxy)propyl)-1H-1,2,4-triazole
Other status information -
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) 3
Examples of recorded resistance -
Physical state Colourless viscous liquid
Related substances & organisms

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • AgriGuard
  • Isagro
  • Sipcam
Example products using this active
  • Trident
  • Eminent 40ME
UK LERAP status Buffer probably required in UK - see product label
Formulation and application details Formulations include microemulsions.


ENVIRONMENTAL FATE

for tetraconazole

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 156.6 A5 Moderate
Solubility - In organic solvents at 20oC (mg l-1) 300000 A5 - Xylene -
300000 A5 - Acetone -
300000 A5 - Ethyl acetate -
15000 A5 - n-Hexane -
Melting point (oC) -29.2 A5 - -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 235 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 3.63 X 1003 Calculated -
Log P 3.56 A5 High
Bulk density (g ml-1)/Specific gravity 1.459 A5 -
Dissociation constant (pKa) at 25oC 0.65 A4 -
Note: pKa range 0.8-0.5, Strong acid
Vapour pressure at 20oC (mPa) 0.18 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 3.60 X 10-04 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index 1.81 Calculated Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value 6.21 X 10-02 Calculated -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 281nm < 310, No significant aborption at >290 nm A5 -
Surface tension (mN m-1) 49.94 A5 at 20oC, 111.8 mg l-1 -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 61 Q3 Moderately persistent
DT50 (lab at 20oC) 83.8 A3 Moderately persistent
DT50 (field) 430 A5 Very persistent
DT90 (lab at 20oC) Stable A4 -
DT90 (field) 1428 A5 -
DT50 modelling endpoint - - -
Note EU dossier states no degradation during lab studies, field studies DT50 range 136-1688 days, DT90 range 453-5606 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 5.5 R4 -
Note Published literature RL50 range 4.0-7.0 days, 7 field & undercover grown crops, various matrices, n=11
Aqueous photolysis DT50 (days) at pH 7 Value 217 B5 Stable
Note Not expected to be an important degradation rate
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 -
Note Stable pH 4 to pH 9, 120 hrs
Water-sediment DT50 (days) 340 A5 Slow
Water phase only DT50 (days) 2 A5 Moderately fast

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf 145 A5 Slightly mobile
Kfoc 1152
1/n 0.92
Notes and range EU dossier kf range 8.53-548.9 mL/g, Kfoc range 531-1922 mL/g, 1/n range 0.88-0.99, Soils=4
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
2-(2,4-dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)propanoic acid (Ref: M14360-acid) Soil   0.089   Minor fraction, relevancy unknown
1H-1,2,4-triazol-1-ylacetic acid (Ref: CGA 142856) Soil   0.049   Minor fraction, relevancy unknown
2-(2,4-dichlorophenyl)-3-(1H-1,2,4-triazol-1-yl)propan-1-ol (Ref: M14360-alcohol) This metabolite may cause environmental pollution, click here for further information Soil   0.470   Major fraction, relevancy unknown


ECOTOXICOLOGY

for tetraconazole

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 35.7 A5 Whole fish Low potential
CT50 (days) 0.189 -
Mammals - Acute oral LD50 (mg kg-1) 1031 A5 Rat Moderate
Mammals - Short term dietary NOEL (mg kg-1) > 0.8 A5 Rat High
(ppm diet) > 10 -
Birds - Acute LD50 (mg kg-1) 132 A5 Colinus virginianus Moderate
Birds - Short term dietary (LC50/LD50) 55.5 mg kg bw-1 day-1 A5 Anas platyrhynchos -
Fish - Acute 96 hour LC50 (mg l-1) 4.3 A5 Lepomis macrochirus Moderate
Fish - Chronic 21 day NOEC (mg l-1) 0.3 A5 Pimephales promelas, growth Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 3.0 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.19 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 0.42 E4 Mysidopsis bahia Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 4.45 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.52 A5 Lemna gibba Moderate
Non-target plants > 112 A5 10 tested species
Vegetative vigour, ER50
as g/ha
-
> 112 A5 10 tested species
Seedling emergence, ER50
as g/ha
-
Algae - Acute 72 hour EC50, growth (mg l-1) 2.4 B4 Ankistodesmus bibaiamus< Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) 63 A5 Moderate
Oral acute 48 hour LD50 (μg bee-1) > 130 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) 71 A5 Eisenia foetida Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 8.2 A5 Eisenia foetida Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect Harmless Dose: 40 g ha-1
AA3 Aphidius rhopalosiphi
-
Other arthropod (2) LR50 g ha-1 - - -
% Effect Harmful Dose: 40 g ha-1
AA2 Typhlodromus pyri
-
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
A5
Dose: 0.5 mg kg-1 soil, 28 days
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for tetraconazole

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) 1031 A5 Rat Moderate
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) 3.66 A5 Rat, 4 hr (whole body) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.004 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.05 A5 Rat, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.03 A5 Dog, SF=100 -
Dermal penetration studies (%) 1.0-20.0 A5 concentration dependent -
Dangerous Substances Directive 76/464 List II - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified with PPE/PPC
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Liver toxicant
USEPA - possible human carcinogen at high doses

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive or oxidising
CLP classification 2013 Health: H302, H332
Environment: H411
EC Risk Classification Click here to view information omn the EU risk phrases Xn - Harmful: R20/22
N - Dangerous for the environment: R51, R53
EC Safety Classification Click here to view information omn the EU safety phrases S2, S36, S61
WHO Classification II - Moderately hazardous
US EPA Classification (formulation) No consensus across products or no products available - -
UN Number -
Waste disposal & packaging Click here for a description of UN packaging marks -


TRANSLATIONS

for tetraconazole

Language Name
English tetraconazole
French tetraconazole
German Tetraconazol
Danish tetraconazol
Italian tetraconazolo
Spanish tetraconazol
Greek -
Slovenian tetrakonazol
Polish tetrakonazol
Swedish -
Hungarian tetrakonazol
Dutch -

Record last updated: Thursday 23 August 2018
Contact: aeru@herts.ac.uk