thiabendazole (Ref: MK 360) ** tiabendazole ** TBZ ** tebuzate ** Translations

---

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home
Further data may be found in the VSDB

GENERAL INFORMATION
for thiabendazole

Description: A mainly post-harvest fungicide used to control a wide range of diseases for fruit and other crops

Example pests controlled: Aspergillus; Botrytis; Cladosporium; Fusarium spp. including pod & stem blight, smut; damping-off, seedling blight, dwarf bunt, scab

Example applications: Fruit including apples, pears, citrus; Seed potatoes; Peas & chickpeas; Lentils; Cereals including wheat, barley, oats, rye, triticale, field corn; Popcorn; Sweetcorn

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1961, discovered; 1964, first reported

EC Regulation 1107/2009 (repealing 91/414):

Status	Approved
Dossier rapporteur/co-rapporteur	Spain/Netherlands
Date inclusion expires	30/03/2032
EU Candidate for substitution (CfS)	No
Listed in EU database	Yes

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure:

Isomerism	-
Chemical formula	C10H7N3S
Canonical SMILES	C1=CC=C2C(=C1)NC(=N2)C3=CSC=N3
Isomeric SMILES	No data
International Chemical Identifier key (InChIKey)	WJCNZQLZVWNLKY-UHFFFAOYSA-N
International Chemical Identifier (InChI)	InChI=1S/C10H7N3S/c1-2-4-8-7(3-1)12-10(13-8)9-5-14-6-11-9/h1-6H,(H,12,13)
2D structure diagram/image available?	Yes

Cambridge Crystallographic Data Centre diagrams:

Common Name	Relationship	Link
Thiabendazole	-

General status:

Pesticide type	Fungicide, Veterinary substance
Substance group	Benzimidazole
Minimum active substance purity	985 g/kg
Known relevant impurities	EU dossier - None declared
Substance origin	Synthetic
Mode of action	Systemic with curative and protective action. Acts by compromising the cytoskeleton through a selective interaction with ß-tubulin.
CAS RN	148-79-8
EC number	205-725-8
CIPAC number	323
US EPA chemical code	060101
PubChem CID	5430
Molecular mass (g mol-1)	201.25
PIN (Preferred Identification Name)	2-(1,3-thiazol-4-yl)-1H-1,3-benzimidazole
IUPAC name	2-(thiazol-4-yl)benzimidazole
CAS name	2-(4-thiazolyl)-1H-benzimidazole
Other status information	-
Relevant Environmental Water Quality Standards	UK Environment Agency non-statutory standard for the protection of freshwater and saltwater aquatic life 5 ug/L as annual average, 50 ug/L as max acceptable conc]
Herbicide Resistance Classification (HRAC)	Not applicable
Herbicide Resistance Classification (WSSA)	Not applicable
Insecticide Resistance Classification (IRAC)	Not applicable
Fungicide Resistance Classification (FRAC)	1
Examples of recorded resistance	-
Physical state	Colourless to yellow-white powder
Related substances & organisms	imazalil thiram

Formulations:

Property	Value
Example manufacturers & suppliers of products using this active now or historically	AgriGuard Merial Syngenta
Example products using this active	Hykeep Storite Tezate 220 SL Tecto Tobaz
UK LERAP status	None (may vary with mixtures)
Formulation and application details	Formulations include dry powders, soluble liquids and suspension concentrates.

ENVIRONMENTAL FATE
for thiabendazole

Property		Value	Source/Quality Score/Other Information	Interpretation
Solubility - In water at 20oC (mg l-1)		30	A5	Low
Solubility - In organic solvents at 20oC (mg l-1)		10	A5 - n-Heptane	-
		130	A5 - Xylene	-
		8230	A5 - Methanol	-
		2430	A5 - Acetone	-
Melting point (oC)		297	A5	-
Boiling point (oC)		-	-	-
Degradation point (oC)		-	-	-
Flashpoint (oC)		Not expected to self ignite; Not highly flammable	A5	-
Octanol-water partition coefficient at pH 7, 20oC	P	2.45 X 1002	Calculated	-
	Log P	2.39	A5	Low
Bulk density (g ml-1)/Specific gravity		1.4	A5	-
Dissociation constant (pKa) at 25oC		4.73	A5	-
		Note: pKa(2) 12.00
Vapour pressure at 20oC (mPa)		5.30 X 10-04	A5	Low volatility
Henry's law constant at 25oC (Pa m3 mol-1)		3.70 X 10-06	A5	Non-volatile
GUS leaching potential index		2.04	Calculated	Transition state
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate	Value	8.92 X 10-02	Calculated	-
	Note	-
Potential for particle bound transport index		-	Calculated	High
Maximum UV-vis absorption L mol-1 cm-1		Neutral: 234nm=15201, 242nm=15436, 299nm=23213, 312nm=16438; [Acidic: 244nm=11554, 303nm=25775, 316nm=16920; [Basic: 234nm=16013, 300nm=19700	A5	-
Surface tension (mN m-1)		72.7	A5	-

Degradation:

Property		Value	Source/Quality Score/Other Information	Interpretation
General biodegradability		-
Soil degradation (days) (aerobic)	DT50 (typical)	500	A2	Very persistent
	DT50 (lab at 20oC)	1000	A2	Very persistent
	DT50 (field)	724	A2	Very persistent
	DT90 (lab at 20oC)	1000	A2	-
	DT90 (field)	-	-	-
	DT50 modelling endpoint	-	-	-
	Note	EU dossier 2001
Dissipation rate RL50 on plant matrix	Value	-	-	-
	Note	-
Dissipation rate RL50 on and in plant matrix	Value	-	-	-
	Note	-
Aqueous photolysis DT50 (days) at pH 7	Value	1.2	A5	Moderately fast
	Note	-
Aqueous hydrolysis DT50 (days) at 20oC and pH 7	Value	203	A5	Persistent
	Note	Stable pH 5 to pH 9
Water-sediment DT50 (days)		4	A5	Fast
Water phase only DT50 (days)		1.6	A5	Moderately fast

Soil adsorption and mobility:

Property		Value	Source/Quality Score/Other Information	Interpretation
Linear	Kd	56	A5	Slightly mobile
	Koc	3983
	Notes and range	EU dossier 2014 Kd range 26-120 mL/g; Koc range 1200-11000 mL/g, Soils=6; Other data: Koc ~ 2500 mL/g (DW3)
Freundlich	Kf	35.5	A5	Slightly mobile
	Kfoc	2091
	1/n	0.79
	Notes and range	EU dossier 2014 Kf range 13-100 mL/g, Kfoc range 580-3921 mL/g, 1/n range 0.72-0.90, Soils =5
pH sensitivity		No

Other known metabolites:

Metabolite name and reference	Aliases	Formation medium / Rate	Estimated maximum occurrence fraction	Metabolising enzymes
5-hydroxythiabendazole	NOA415696	Animal	-	-
benzimidazole-2-carboxamide	-	Water	-	-
benzimidazole-2-carboxylic acid	-	-	-	-
1,2-dihydro-3-hydroxy-quinoxaline	-	-	-	-

ECOTOXICOLOGY
for thiabendazole

Property		Value	Source/Quality Score/Other Information	Interpretation
Bio-concentration factor	BCF (l kg-1)	96.5	A5	Low potential
	CT50 (days)	Not available		-
Mammals - Acute oral LD50 (mg kg-1)		> 5000	A5 Rat	Low
Mammals - Short term dietary NOEL	(mg kg-1)	> 10	A5 Rat	High
	(ppm diet)	-		-
Birds - Acute LD50 (mg kg-1)		> 2250	A5 Colinus virginianus	Low
Birds - Short term dietary (LC50/LD50)		> 5620 mg kg feed-1	A5 Colinus virginianus	-
Fish - Acute 96 hour LC50 (mg l-1)		0.55	A5 Oncorhynchus mykiss	Moderate
Fish - Chronic 21 day NOEC (mg l-1)		0.012	A5 Oncorhynchus mykiss	Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1)		0.81	A5 Daphnia magna	Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1)		0.042	A5 Daphnia magna	Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1)		0.34	F3 Americamysis bahia	Moderate
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1)		-	-	-
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1)		2.0	A5 Chironomus riparius	Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1)		3.0	A5 Chironomus riparius	Moderate
Aquatic plants - Acute 7 day EC50, biomass (mg l-1)		-	-	-
Non-target plants		-	-	-
		-	-	-
Algae - Acute 72 hour EC50, growth (mg l-1)		9.0	C4 Raphidocelis subcapitata	Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1)		3.2	A4 Unknown species	Low
Honeybees	Contact acute 48 hour LD50 (μg bee-1)	> 34	A5	Moderate
	Oral acute 48 hour LD50 (μg bee-1)	> 4.0	A5	Moderate
	Unknown mode acute 48 hour LD50 (μg bee-1)	-	-	-
Earthworms - Acute 14 day LC50 (mg kg-1)		> 1000	A5 Eisenia foetida	Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1)		4.2	A5 Eisenia foetida	Moderate
Other soil macro-organisms - e.g. Collembola	LR50 / EC50 / NOEC / % Effect	-	-	-
Other arthropod (1)	LR50 g ha-1	1800	> A5 Typhlodromus pyri	-
	% Effect	0 62	Mortality Fecundity Dose: 1.8 kg ha-1 A5 Aphidius rhopalosiphi	-
Other arthropod (2)	LR50 g ha-1	1800	> A5 Typhlodromus pyri	-
	% Effect	3 5	Mortality Fecundity Dose: 1.8 kg ha-1 A5 Typhlodromus pyri	-
Soil micro-organisms		Nitrogen mineralisation: No significant adverse effect Carbon mineralisation: No significant adverse effect	A5 Dose: 9 mg kg-1 soil	-
Mesocosm study data	NOEAEC mg l-1	-	-	-
	NOEAEC mg l-1	-	-	-

HUMAN HEALTH AND PROTECTION
for thiabendazole

General:

Property		Value	Source/Quality Score/Other Information	Interpretation
Threshold of Toxicological Concern (Cramer Class)		High (class III)	-	-
Mammals - Acute oral LD50 (mg kg-1)		> 5000	A5 Rat	Low
Mammals - Dermal LD50 (mg kg-1 body weight)		> 5000	A5 Rat	-
Mammals - Inhalation LC50 (mg l-1)		> 0.53	A5 Rat	-
Other Mammal toxicity endpoints		-		-
ADI - Acceptable Daily Intake (mg kg-1bw day-1)		0.1	A5	-
ARfD - Acute Reference Dose (mg kg-1bw day-1)		None allocated	A5	-
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1)		-	-	-
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1)		0.1	A5	-
Dermal penetration studies (%)		0.15-1.84%	A5 concentration dependent	-
Dangerous Substances Directive 76/464		-	-	-
Exposure Limits		-	-	-
Exposure Routes	Public	No unacceptable risks to bystanders identified
	Occupational	No unacceptable risks to operators or other workers identified
European MRLs		Click here for the EU MRL pesticide database
Drinking Water Standards		-	-	-
Drinking Water MAC (μg l-1)		-	-	-

Health issues:

Carcinogen	Mutagen	Endocrine disrupter	Reproduction / development effects	Cholinesterase inhibitor	Neurotoxicant
		-		-
Respiratory tract irritant	Skin irritant	Skin sensitiser	Eye irritant	Phototoxicant
		-		-
General human health issues		Possible thyroid, liver, spleen and kidney toxicant USEPA - possible human carcinogen at high doses

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:

Property		Value	Source/Quality Score/Other Information	Interpretation
General		Not explosive or oxidising IMDG Transport Code is usually 9
CLP classification 2013		Environment: H400, H410
EC Risk Classification		N - Dangerous for the environment: R50, R53
EC Safety Classification		S60, S61
WHO Classification		III	-	Slightly hazardous
US EPA Classification (formulation)		III	-	Caution - Slightly toxic
UN Number		Variable with product, usually 3077 or 3082
Waste disposal & packaging		Packaging Group III (minor danger)

TRANSLATIONS
for thiabendazole

Language	Name
English	thiabendazole
French	thiabendazole
German	Thiabendazol
Danish	E 233, thiabendazole
Italian	tiabendazolo
Spanish	tiabendazol
Greek	thiabendazol
Slovenian	tiabendazol
Polish	tiabendazol
Swedish	tiabendazol
Hungarian	thiabendazole
Dutch	thiabendazool

---

Record last updated: Wednesday 31 October 2018
Contact: aeru@herts.ac.uk