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thiofanox (Ref: DS 15647)
** thiofanocarb ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION
for thiofanox

Description: An insecticide and acaricide used to control a range of pests including aphids, capsids, flea beetles and leafhoppers

Introduction: circa 1973

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur -
Date inclusion expires Not applicable

Approved for use () or known to be used () in the following European countries:

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

General status:
Pesticide type Insecticide, Acaricide
Substance group Carbamate
Substance origin Synthetic
Mode of action Systemic. Acetylcholinesterase (AChE) inhibitor.
CAS RN 39196-18-4
EC number 254-346-4
CIPAC number 351
US EPA chemical code 109201
Chiral molecule No
Chemical formula C9H18N2O2S
SMILES O=C(O\N=C(/C(C)(C)C)CSC)NC
International Chemical Identifier key (InChIKey) FZSVSABTBYGOQH-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C9H18N2O2S/c1-9(2,3)7(6-14-5)11-13-8(12)10-4/h6H2,1-5H3,(H,10,12)/b11-7-
Structure diagram/image available? Yes
Molecular mass (g mol-1) 218.32
PIN (Preferred Identification Name) (5E)-6-tert-butyl-4-oxa-8-thia-2,5-diazanon-5-en-3-one
IUPAC name (EZ)-3,3-dimethyl-1-methylthiobutanone O-methylcarbamoyloxime
CAS name 3,3-dimethyl-1-(methylthio)-2-butanone O-[(methylamino)carbonyl]oxime
Other status information -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) 1A
Fungicide Resistance Classification (FRAC) Not applicable
Physical state Colourless solid
Related substances & organisms -

Formulations:
Property Value
Example manufacturers & suppliers of products using this active
  • Bayer CropScience
Example products using this active -
UK LERAP status No UK approval for use or outside scope
Formulation and application details -


ENVIRONMENTAL FATE

for thiofanox

Property Value Source/Quality Score/Other Information Interpretation
Solubility - In water at 20oC (mg l-1) 5200 K4 High
Solubility - In organic solvents at 20oC (mg l-1) - - -
Melting point (oC) 57 L3 -
Boiling point (oC) - - -
Degradation point (oC) - - -
Flashpoint (oC) - - -
Octanol-water partition coefficient at pH 7, 20oC P 1.45 X 1002 Calculated -
Log P 2.16 V3 Low
Bulk density (g ml-1)/Specific gravity 1.05 Q2 -
Dissociation constant (pKa) at 25oC - - -
Note:
Vapour pressure at 25oC (mPa) 22.6 L3 Intermediate state
Henry's law constant at 25oC (Pa m3 mol-1) 9.51 X 10-04 V3 Non-volatile
Henry's law constant at 20oC (dimensionless) 2.70 X 10-05 K3 Volatile
GUS leaching potential index 1.67 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Value 3.67 X 10-03 Calculated -
Note -
Potential for particle bound transport index - Calculated Low
Maximum UV-vis absorption L mol-1 cm-1 - - -
Surface tension (mN m-1) - - -

Degradation:
Property Value Source/Quality Score/Other Information Interpretation
Soil degradation (days) (aerobic) DT50 (typical) 4 K4 Non-persistent
DT50 (lab at 20oC) - - -
DT50 (field) - - -
DT90 (lab at 20oC) - - -
DT90 (field) - - -
Note General literature DT50 range 2-6 days (R3)
Aqueous photolysis DT50 (days) at pH 7 Value 0.9 K4 Fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 30 K4 Moderately persistent
Note -
Water-sediment DT50 (days) - - -
Water phase only DT50 (days) - - -

Soil adsorption and mobility:
Property Value Source/Quality Score/Other Information Interpretation
Linear Kd - W3 Mobile
Koc 17
Notes and range -
Freundlich Kf - - -
Kfoc -
1/n -
Notes and range -
pH sensitivity -

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 91/414 relevancy
thiofanox sulfoxide Soil   0.780   Major fraction
thiofanox sulfone Soil   0.440   Major fraction


ECOTOXICOLOGY

for thiofanox

Property Value Source/Quality Score/Other Information Interpretation
Bio-concentration factor BCF 14 Q2 Estimated Low potential
CT50 (days) Not available -
Bioaccumulation potential - Calculated Low
Mammals - Acute oral LD50 (mg kg-1) 8.5 L3 Rat High
Mammals - Short term dietary NOEL (mg kg-1) 1 L3 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) 43 L3 Colinus virginianus High
Birds - Short term dietary (LC50/LD50) - - -
Fish - Acute 96 hour LC50 (mg l-1) 0.13 L3 Oncorhynchus mykiss Moderate
Fish - Chronic 21 day NOEC (mg l-1) - - -
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.31 W3 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) - - -
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Algae - Acute 72 hour EC50, growth (mg l-1) 13 W2 Unknown species Low
Algae - Chronic 96 hour NOEC, growth (mg l-1) - - -
Honeybees Contact acute 48 hour LD50 (μg bee-1) 0.058 K4 High
Oral acute 48 hour LD50 (μg bee-1) - - -
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) - - -
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect - - -
Other arthropod (2) LR50 g ha-1 - - -
% Effect - - -
Soil micro-organisms - - -
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for thiofanox

General:
Property Value Source/Quality Score/Other Information Interpretation
Mammals - Acute oral LD50 (mg kg-1) 8.5 L3 Rat High
Mammals - Dermal LD50 (mg kg-1 body weight) 39.0 L3 Rabbit -
Mammals - Inhalation LC50 (mg l-1) - - -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) - - -
ARfD - Acute Reference Dose (mg kg-1bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) - - -
Dermal penetration studies (%) - - -
Dangerous Substances Directive 76/464 - - -
Exposure Limits - - -
Exposure Routes Public -
Occupational -
Examples of European MRLs (mg kg-1) Value -
Note For the EU pesticides database click here
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant Respiratory tract irritant Skin irritant Eye irritant

-

-

-

-

-

-

General human health issues No further information available

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data

Handling issues:
Property Value Source/Quality Score/Other Information Interpretation
General No information available
CLP classification 2013 -
EC Risk Classification T+ - Very toxic: R27/28
N - Dangerous for the environment: R50, R53
EC Safety Classification S1/2, S27, S36/37, S45, S60, S61
WHO Classification Ib - Highly hazardous
US EPA Classification (formulation) I - Danger - Highly toxic
UN Number 2757
Waste disposal & packaging -


TRANSLATIONS

for thiofanox

Language Name
English thiofanox
French thiofanox
German Thiofanox
Danish thiofanox
Italian tiofanox
Spanish tiofanox
Greek thiofanox
Slovenian tiofanoks
Polish tiofanoks
Swedish -
Hungarian -
Dutch thiofanox

Record last updated: Friday 01 August 2014
Contact: aeru@herts.ac.uk