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tolylfluanid (Ref: BAY 49854)
** tolylfluanide ** BAY 5212 ** KUE 13183B ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

GENERAL INFORMATION Click here for an explantaion of the general chemical status information
for tolylfluanid

Description: A fungicide used for orchard and other crops particularly to control Venturia spp. but also used as a wood preservative

Example pests controlled: Black spot; Grey mould; Powdery mildew (suppression)

Example applications: Apples; Pears; Grapes; Raspberries; Blackberries; Currants; Gooseberries; Strawberries; Peppers

Efficacy & activity: -

Availability status: Current

Introduction & key dates: 1971, first marketed

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Finland
Date inclusion expires Not applicable
EU Candidate for substitution (CfS) Not applicable
Listed in EU database Yes

Approved for use () or known to be used () in the following European countries: Click to access a note on the approvals information on this site

AT

BE

BG

CY

CZ

DE

DK

EE

EL

ES

FI

FR

HR

HU

IE

IT

LT

LU

LV

MT

NL

PL

PT

RO

SE

SI

SK

UK

Also used in: Australia

Chemical structure: Click here for further information on the general chemical status information used on this site
Isomerism -
Chemical formula C10H13Cl2FN2O2S2
Canonical SMILES CC1=CC=C(C=C1)N(SC(F)(Cl)Cl)S(=O)(=O)N(C)C
Isomeric SMILES No data
International Chemical Identifier key (InChIKey) HYVWIQDYBVKITD-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C10H13Cl2FN2O2S2/c1-8-4-6-9(7-5-8)15(18-10(11,12)13)19(16,17)14(2)3/h4-7H,1-3H3
Structure diagram/image available? Yes

General status: Click here for further information on the general chemical status information used on this site
Pesticide type Fungicide, Wood preservative; Antifouling agent
Substance group Sulphamide
Minimum active substance purity 960 g/kg
Known relevant impurities EU dossier - None declared
Substance origin Synthetic
Mode of action Broad-spectrum, multi-site with protective action.
CAS RN 731-27-1
EC number 211-986-9
CIPAC number 275
US EPA chemical code 309200
PubChem CID Not
Molecular mass (g mol-1) 347.27
PIN (Preferred Identification Name) N-{[dichloro(fluoro)methyl]sulfanyl}-N',N'-dimethyl-N-(4-methylphenyl)sulfuric diamide
IUPAC name N-dichlorofluoromethylthio-N',N'-dimethyl-N-p-tolylsulfamide
CAS name 1,1-dichloro-N-((dimethylamino)sulfonyl)-1-fluoro-N-(4-methylphenyl)methanesulfenamide
Other status information Chemical subject to PIC regulations
Relevant Environmental Water Quality Standards -
Herbicide Resistance Classification (HRAC) Not applicable
Herbicide Resistance Classification (WSSA) Not applicable
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) M6
Examples of recorded resistance -
Physical state Colourless crystalline powder
Related substances & organisms -

Formulations:
Property Click here for information on the general product and branding information used on this site Value
Example manufacturers & suppliers of products using this active now or historically
  • Bayer CropScience
Example products using this active
  • Euparen M
UK LERAP status No UK approval for use as a pesticide under EC Regulation 1107/2009
Formulation and application details Usually supplied as wettable granules.


ENVIRONMENTAL FATE

for tolylfluanid

Property Click here for information on the parameters used to describe environmental fate on this site Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with fate data Interpretation Click here for information on the way in which we interpret environmental fate data
Solubility - In water at 20oC (mg l-1) 0.9 B5 Low
Solubility - In organic solvents at 20oC (mg l-1) 54000 A5 - n-Heptane -
190000 A5 - Xylene -
250000 A5 - Acetone -
250000 A5 - Ethyl acetate -
Melting point (oC) 93 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 200 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 7.94 X 1003 Calculated -
Log P 3.9 A5 High
Bulk density (g ml-1)/Specific gravity 1.52 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 20oC (mPa) 0.2 A5 Low volatility
Henry's law constant at 25oC (Pa m3 mol-1) 7.70 X 10-02 A5 Non-volatile
GUS leaching potential index Click here for a note on the limitations of the GUS index - - -
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Click here for a note on the limitations of the SCI-GROW index Value - - -
Note -
Potential for particle bound transport index Click here for a note on the limitations of the potential for particle bound transport index - - -
Maximum UV-vis absorption L mol-1 cm-1 Maxima at 210nm, no absorbance >290nm A5 -
Surface tension (mN m-1) 70.0 A5 at 20oC -

Degradation:
Property Click here for information on the parameters used to describe substance degradation Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with degradation data Interpretation Click here for information on the way in which we interpret substance degradation data
General biodegradability -
Soil degradation (days) (aerobic) DT50 (typical) 1.8 A5 Non-persistent
DT50 (lab at 20oC) 1.8 A5 Non-persistent
DT50 (field) 6 B5 Non-persistent
DT90 (lab at 20oC) 5.9 A5 -
DT90 (field) - - -
DT50 modelling endpoint - - -
Note EU dossier lab studies DT50 range 0.5-2.6 days, DT90 range 1.7-8.6 days
Dissipation rate RL50 on plant matrix Value - - -
Note -
Dissipation rate RL50 on and in plant matrix Value 8.4 R3 -
Note Undercover grown strawberry fruit, n=1
Aqueous photolysis DT50 (days) at pH 7 Value Stable A5 -
Note Not a significant degradation route
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value 1.9 A5 Non-persistent
Note pH sensitive: DT50 11.7 days at pH 4 and 22 degC, 10 minutes at pH 9 and 20 degC
Water-sediment DT50 (days) 14 K4 Fast
Water phase only DT50 (days) 14 K4 Slow

Soil adsorption and mobility:
Property Click here for information on the parameters used to describe substance adsorption and mobility Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with adsorption and mobility data Interpretation Click here for information on the way in which we interpret substance adsorption and mobility
Linear Kd - - -
Koc -
Notes and range -
Freundlich Kf - Q3 -
Kfoc -
1/n 0.9
Notes and range -
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 1107/2009 relevancy Click here for further information on 1107/2009 relevancy
N,N-dimethyl-N'-p-tolysulphamide This metabolite may cause environmental pollution, click here for further information Soil   0.737   Major fraction, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
4-(dimethylaminosulfonylamino)-benzoic acid - Rat - -
thiazolidine-2-thione-4-carbonic acid - Rat - -
4-hydroxymethyl-DMST-glucoside - Plant 0.460 -
2-hydroxyphenyl-DMST-glucoside - Plant 0.130 -
4-(dimethylaminosulfonylamino)hippuric acid
(Ref: KUE 5156)
TTCA Rat - -


ECOTOXICOLOGY

for tolylfluanid

Property Click here for information on the parameters used to describe substance ecotoxicology Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with ecotoxicology data Interpretation Click here for information on the way in which we interpret substance ecotoxicology
Bio-concentration factor BCF (l kg-1) 74 A5 Whole fish Low potential
CT50 (days) 0.38 -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) > 50 B5 Rat High
(ppm diet) > 1000 -
Birds - Acute LD50 (mg kg-1) > 2000 A5 Coturnix japonica Low
Birds - Short term dietary (LC50/LD50) > 5000 mg kg feed-1 A5 Coturnix japonica -
Fish - Acute 96 hour LC50 (mg l-1) 0.045 A5 Oncorhynchus mykiss High
Fish - Chronic 21 day NOEC (mg l-1) 0.0098 A5 Oncorhynchus mykiss High
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.19 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.1 Q2 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) - - -
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) - - -
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) - - -
Non-target plants > 15600 A4 Unknown species
Vegetative vigour, EC50
as g/ha
-
> 15600 A4 Unknown species
Seedling emergence, EC50
as g/ha
-
Algae - Acute 72 hour EC50, growth (mg l-1) 1.5 K3 Unknown species Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.1 Q2 Unknown species Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 196 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 197 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 1000 A5 Eisenia foetida Low
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) - - -
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 912 48 hour
A5 Aphidius rhopalosiphi, adult
-
% Effect - - -
Other arthropod (2) LR50 g ha-1 247 7 day, reproduction
A5 Typhlodromus pyri
-
% Effect - - -
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect A5
Dose: 8.9 kg ha-1
-
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


HUMAN HEALTH AND PROTECTION

for tolylfluanid

General:
Property Click here for information on the parameters used to describe human health and protection issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with human health and protection data Interpretation Click here for information on the way in which we interpret human health and protection data
Threshold of Toxicological Concern (Cramer Class) Click here for a note on the limitations of the Cramer class High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 5000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 1.04 A5 Rat -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.1 A5 Rat, SF=100 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) 0.25 A5 Rabbit, SF=100 -
AAOEL - Acute Acceptable Operator Exposure Level (mg kg-1 bw day-1) - - -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.3 A5 Dog, SF=100 -
Dermal penetration studies (%) 5.0-7.0 A5 concentration dependent -
Dangerous Substances Directive 76/464 List II - -
Exposure Limits - - -
Exposure Routes Public No unacceptable risks to bystanders identified
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water Standards - - -
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant

-

-

Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant

-

-

General human health issues Liver and thyroid toxicant
Linked to insulin resistance
USEPA - probable human carcinogen

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Click here for information on the parameters used to describe substance handling issues Value Source/Quality Score/Other Information Click here for information on the primary data sources used to populate this database with data on handling issues Interpretation Click here for information on the way in which we interpret data on handling issues
General Click here for a description of the International Maritime Dangerous Goods (IMDG) codes Not explosive
IMDG Transport Code is usually 6.1
CLP classification 2013 Health: H315, H317, H319, H335
Environment: H400
EC Risk Classification Click here to view information omn the EU risk phrases T+ - Very toxic: R26
Xn - Harmful: R43, R48/23
Xi - Irritant: R36/27/38
N - Dangerous for the environment: R50
EC Safety Classification Click here to view information omn the EU safety phrases S1/2, S28, S36/37/39, S45, S61, S63
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) II - Warning - Moderately toxic
UN Number Usually 2588
Waste disposal & packaging Click here for a description of UN packaging marks Packaging Group III (minor danger)


TRANSLATIONS

for tolylfluanid

Language Name
English tolylfluanid
French tolylfluanide
German Tolylfluanid
Danish tolylfluanid
Italian tolilfluanide
Spanish tolifluanida
Greek -
Slovenian tolilfluanid
Polish tolylfluanid
Swedish tolylfluanid
Hungarian -
Dutch tolylfluanide

Record last updated: Wednesday 30 May 2018
Contact: aeru@herts.ac.uk