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trifluralin (Ref: EL 152)
** trifluraline ** treflan ** Translations

Environmental Fate - Ecotoxicology - Human Health - A to Z Index - Home

for trifluralin

Description: A pre-emergence soil-incorporated herbicide for use in various crops to control many annual grasses and broad-leaved weeds

Example pests controlled: Annual ryegrass; Barnyardgrass; Canary grass; Grabgrass; Wild oats; Redshank; Pigweed; Yellow vine; Wireweed

Example applications: Oilseed rape; Sunflowers; Cotton; Soybeans; Wetch; Linseed; Peanuts; Broccoli; Tomatoes; Cabbage; Carrots; Chicory; Orchards and vineyards

Availability status: Current

Introduction & key dates: 1961, USA

EC Regulation 1107/2009 (repealing 91/414):
Status Not approved
Dossier rapporteur/co-rapporteur Greece
Date inclusion expires Expired

Approved for use () or known to be used () in the following European countries:





























Also used in: Australia, USA

General status:
Pesticide type Herbicide
Substance group Dinitroaniline
Minimum active substance purity 950 g/kg
Known relevant impurities EU dossier - N-nitroso-di-n-propylamine 1mg/kg
Substance origin Synthetic
Mode of action Selective. Inhibition of mitosis and cell division. Microtubule assembly inhibition.
CAS RN 1582-09-8
EC number 216-428-8
CIPAC number 183
US EPA chemical code 036101
Chiral molecule No
Chemical formula C13H16F3N3O4
SMILES [O-][N+](=O)c1cc(cc([N+]([O-])=O)c1N(CCC)CCC)C(F)(F)F
International Chemical Identifier key (InChIKey) ZSDSQXJSNMTJDA-UHFFFAOYSA-N
International Chemical Identifier (InChI) InChI=1S/C13H16F3N3O4/c1-3-5-17(6-4-2)12-10(18(20)21)7-9(13(14,15)16)8-11(12)19(22)23/h7-8H,3-6H2,1-2H3
Structure diagram/image available? Yes
Molecular mass (g mol-1) 335.28
PIN (Preferred Identification Name) 2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)aniline
IUPAC name α,α,α-trifluoro-2,6-dinitro-N,N-dipropyl-p-toluidine
CAS name 2,6-dinitro-N,N-dipropyl-4-(trifluoromethyl)benzenamine
Other status information OSPAR pfa/soc; WFD pps; Chemical subject to PIC regulations
Herbicide Resistance Classification (HRAC) K1
Herbicide Resistance Classification (WSSA) 3
Insecticide Resistance Classification (IRAC) Not applicable
Fungicide Resistance Classification (FRAC) Not applicable
Examples of recorded resistance Lolium rigidum
Setaria viridis
Physical state Orange-yellow crystalline solid
Related substances & organisms

Property Value
Example manufacturers & suppliers of products using this active now or historically
  • Bayer CropScience
  • Dow AgroSciences
  • Makhteshim-Agan
  • Syngenta
  • Elanco
Example products using this active
  • Alpha Trifluralin 48EC
  • Ardent
  • Fargro Axit
  • Treflan
  • Uranus
  • Elancolan
UK LERAP status No UK approval for use or outside scope
Formulation and application details Usually formulated as an emulsifiable concentrate or granules.


for trifluralin

Property Value Source/Quality Score/Other Information Interpretation
Solubility - In water at 20oC (mg l-1) 0.221 A5 Low
Solubility - In organic solvents at 20oC (mg l-1) 250000 A5 - Hexane -
250000 A5 - Toluene -
250000 A5 - Acetone -
142000 A5 - Methanol -
Melting point (oC) 47.2 A5 -
Boiling point (oC) Decomposes before boiling A5 -
Degradation point (oC) 202 A5 -
Flashpoint (oC) Not expected to self ignite; Not highly flammable A5 -
Octanol-water partition coefficient at pH 7, 20oC P 1.86 X 1005 Calculated -
Log P 5.27 A5 High
Bulk density (g ml-1)/Specific gravity 1.36 A5 -
Dissociation constant (pKa) at 25oC Not applicable A5 -
Note: No dissociation
Vapour pressure at 25oC (mPa) 9.5 A5 Volatile
Henry's law constant at 25oC (Pa m3 mol-1) 10.2 A5 Moderately volatile
Henry's law constant at 20oC (dimensionless) 4.00 X 10-02 K3 Volatile
GUS leaching potential index 0.13 Calculated Low leachability
SCI-GROW groundwater index (μg l-1) for a 1 kg ha-1 or 1 l ha-1 application rate Value 6.13 X 10-03 Calculated -
Note -
Potential for particle bound transport index - Calculated High
Maximum UV-vis absorption L mol-1 cm-1 Neutral solution 209nm = 19400, 272nm = 8460, 385nm = 2440 A5 -
Surface tension (mN m-1) 71.4 A5 at 24.5oC, saturated solution -

Property Value Source/Quality Score/Other Information Interpretation
Soil degradation (days) (aerobic) DT50 (typical) 181 A5 Persistent
DT50 (lab at 20oC) 181 A5 Persistent
DT50 (field) 170 A5 Persistent
DT90 (lab at 20oC) 602 A5 -
DT90 (field) 565 A5 -
Note EU dossier lab studies DT50 range 81-356 days, DT90 range 270-1181 days; field studies DT50 range 35-375 days, DT90 range 116-1246 days; Other sources: DT50 57-126 days (R3), 169 days @ 25 DegC (R3)
Plant matrix DT50 (days) Value 4.0 R4 -
Note DT50 range 0.7 - 10.1 days, 3 crops/plants, various matrices
Aqueous photolysis DT50 (days) at pH 7 Value 0.4 A5 Fast
Note -
Aqueous hydrolysis DT50 (days) at 20oC and pH 7 Value Stable A5 Very persistent
Note Stable at pH 7 and pH 9, 5% degradation after 5 days at pH 4
Water-sediment DT50 (days) 5.5 A5 Fast
Water phase only DT50 (days) 13 A4 Moderately fast

Soil adsorption and mobility:
Property Value Source/Quality Score/Other Information Interpretation
Linear Kd - R3 Non-mobile
Koc 15800
Notes and range Other sources: 105-30903 mL/g (R3), Log Koc 4.14 @25 DegC (R4)
Freundlich Kf 79.4 A5 Non-mobile
Kfoc 8765
1/n 0.972
Notes and range EU dossier kf range 18.6-156, Kfoc range 6414-13414 mL/g, 1/n range 0.962-0.986, Soils=4; Literature mean: Kf = 62.8 mL.g, Kfoc = 4742 mL/g, 1/n = 1.06, Soils = 17
pH sensitivity No

Key metabolites:
Metabolite Formation medium Estimated maximum occurrence fraction 91/414 relevancy
3-nitro-N2,N2-dipropyl-5-(trifluoromethyl)benzene-1,2-diamine (Ref: TR-4) Soil   0.132   Major, Relevant

Other known metabolites:
Metabolite name and reference Aliases Formation medium / Rate Estimated maximum occurrence fraction Metabolising enzymes
(Ref: TR-14)
- Soil; Plant; Sediment; Groundwater - -
(Ref: TR-15)
- Soil (Photolysis); Surface water - -
3,5-dinitro-4-(propylamino)-benzoic acid
(Ref: TR-22)
- Animal (Faeces) - -
(Ref: TR-28)
- Animal - -
(Ref: TR-6)
- Soil (Photolysis) - -
(Ref: TR-7)
- Sediment - -


for trifluralin

Property Value Source/Quality Score/Other Information Interpretation
Bio-concentration factor BCF (l kg-1) 5674 A5 High potential
CT50 (days) 47 -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Short term dietary NOEL (mg kg-1) 2.4 L3 Rat High
(ppm diet) - -
Birds - Acute LD50 (mg kg-1) > 2250 A5 Colinus virginianus Low
Birds - Short term dietary (LC50/LD50) 573.9 mg kg bw-1 day-1 A5 Colinus virginianus -
Fish - Acute 96 hour LC50 (mg l-1) 0.088 A5 Oncorhynchus mykiss High
Fish - Chronic 21 day NOEC (mg l-1) 10 A4 Pimephales promelas, 35 day Moderate
Aquatic invertebrates - Acute 48 hour EC50 (mg l-1) 0.245 A5 Daphnia magna Moderate
Aquatic invertebrates - Chronic 21 day NOEC (mg l-1) 0.051 A5 Daphnia magna Moderate
Aquatic crustaceans - Acute 96 hour LC50 (mg l-1) 0.074 F3 Americamysis bahia High
Sediment dwelling organisms - Acute 96 hour LC50 (mg l-1) 1.0 F3 Chironomus riparius, 2 day Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, static, water (mg l-1) 0.25 A5 Chironomus riparius Moderate
Sediment dwelling organisms - Chronic 28 day NOEC, sediment (mg kg-1) 810 A5 Chironomus riparius Low
Aquatic plants - Acute 7 day EC50, biomass (mg l-1) 0.0435 A5 Lemna gibba Moderate
Non-target plants - - -
- - -
Algae - Acute 72 hour EC50, growth (mg l-1) 0.0122 A5 Raphidocelis subcapitata Moderate
Algae - Chronic 96 hour NOEC, growth (mg l-1) 0.005 Q2 Unknown species Moderate
Honeybees Contact acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Oral acute 48 hour LD50 (μg bee-1) > 100 A5 Low
Unknown mode acute 48 hour LD50 (μg bee-1) - - -
Earthworms - Acute 14 day LC50 (mg kg-1) > 500 A5 Eisenia foetida, corr Moderate
Earthworms - Chronic 14 day NOEC, reproduction (mg kg-1) 14.19 A5 Eisenia foetida, corr Moderate
Other soil macro-organisms - e.g. Collembola LR50 / EC50 / NOEC / % Effect - - -
Other arthropod (1) LR50 g ha-1 - - -
% Effect 84.8 Mortality
Dose: 1.2 kg ha-1
A5 Aphidius rhopalosiphi, adult
Other arthropod (2) LR50 g ha-1 - - -
% Effect 58.9
Dose: 1.2 kg ha-1
A5 Typhlodromus pyri, protonymph
Soil micro-organisms Nitrogen mineralisation: No significant adverse effect
Carbon mineralisation: No significant adverse effect
Dose: 8.5 mg kg-1 soil
Mesocosm study data NOEAEC mg l-1 - - -
NOEAEC mg l-1 - - -


for trifluralin

Property Value Source/Quality Score/Other Information Interpretation
Threshold of Toxicological Concern (Cramer Class) High (class III) - -
Mammals - Acute oral LD50 (mg kg-1) > 5000 A5 Rat Low
Mammals - Dermal LD50 (mg kg-1 body weight) > 2000 A5 Rat -
Mammals - Inhalation LC50 (mg l-1) > 1.252 A5 Rat, 4 hr (head only) -
Other Mammal toxicity endpoints - -
ADI - Acceptable Daily Intake (mg kg-1bw day-1) 0.015 A5 Dog, SF=2000 -
ARfD - Acute Reference Dose (mg kg-1bw day-1) None allocated A5 -
AOEL - Acceptable Operator Exposure Level - Systemic (mg kg-1bw day-1) 0.026 A2 Rat, SF=100 -
Dermal penetration studies (%) 10 A3 default -
Dangerous Substances Directive 76/464 List II - -
Exposure Limits - - -
Exposure Routes Public Bystanders may be exposed briefly but risk considered low
Occupational No unacceptable risks to operators or other workers identified
European MRLs Click here for the EU MRL pesticide database
Drinking Water MAC (μg l-1) - - -

Health issues:
Carcinogen Mutagen Endocrine disrupter Reproduction / development effects Cholinesterase inhibitor Neurotoxicant


Respiratory tract irritant Skin irritant Skin sensitiser Eye irritant Phototoxicant


General human health issues Blood, liver and kidney toxicant
May cause respiratory depression
IARC Group 3 carcinogen; USEPA - possible human carcinogen

: Yes, known to cause a problem
: No, known not to cause a problem
: Possibly, status not identified
- : No data found

Handling issues:
Property Value Source/Quality Score/Other Information Interpretation
General Prevent generation of dust
Not explosive
CLP classification 2013 Health: H317, H351
Environment: H400, H410
EC Risk Classification Carcinogen category 3: R40
Xn - Harmful: R43
N - Dangerous for the environment: R50, R53
EC Safety Classification S2, S36/37, S46, S60, S61
WHO Classification U - Unlikely to present an acute hazard
US EPA Classification (formulation) III, IV - Caution - Slightly toxic, Caution - Not acutely toxic
UN Number Usually 2588
Waste disposal & packaging -


for trifluralin

Language Name
English trifluralin
French trifluraline
German Trifluralin
Danish trifluralin
Italian trifluralin
Spanish trifluralina
Greek -
Slovenian trifluralin
Polish trifluralina
Swedish -
Hungarian trifluralin
Dutch rifluraline

Record last updated: Monday 17 October 2016