The following alerts are based on the data in the tables below. An absence of an alert does not imply the substance has no implications for human health, biodiversity or the environment but just that we do not have the data to form a judgement.
Environmental fate
Ecotoxicity
Human health
Environmental fate Moderate alert: GUS: Transition state; Drainflow: Moderately mobile
Ecotoxicity Moderate alert: Fish acute ecotoxicity: Moderate; Fish chronic ecotoxicity: Moderate; Daphnia acute ecotoxicity: Moderate; Daphnia chronic ecotoxicity: Moderate
Human health High alert: Endocrine disrupter; Reproduction/development effects
GENERAL INFORMATION
Description
A fungicide used mainly to control Botrytis, Monolinia and Sclerotinia spp.
Example pests controlled
Downy mildew; Powdery mildew; Crown & stem rot
Example applications
Oilseed rape; Grape vines; Fruit including strawberries, raspberries; Vegetables; Turf
Efficacy & activity
-
Availability status
-
Introduction & key dates
1976, registered Germany
GB regulatory status
GB COPR regulatory status
Not approved
Date COPR inclusion expires
Expired
GB LERAP status
No UK approval for use as a plant protection agent
EC Regulation 1107/2009 (repealing 91/414)
EC Regulation 1107/2009 status
Not approved
Dossier rapporteur/co-rapporteur
Not applicable
Date EC 1107/2009 inclusion expires
Expired
EU Candidate for substitution (CfS)
Not applicable
Listed in EU database
Yes
Approved for use (✓) under EC 1107/2009 in the following EU Member States
ATAustria
BEBelgium
BGBulgaria
CYCyprus
CZCzech Republic
DEGermany
DKDenmark
EEEstonia
ELGreece
ESSpain
FIFinland
FRFrance
HRCroatia
HUHungary
IEIreland
ITItaly
LTLithuania
LULuxembourg
LVLatvia
MTMalta
NLNetherlands
PLPoland
PTPortugal
RORomania
SESweden
SISlovenia
SKSlovakia
Approved for use (✓) under EC 1107/2009 by Mutual Recognition of Authorisation and/or national regulations in the following EEA countries
ISIceland
NONorway
Additional information
Also used in
-
Chemical structure
Isomerism
Chiral, a specific isomer or a derivative of a chiral molecule
Example manufacturers & suppliers of products using this active now or historically
BASF
Mallinckrodt
Example products using this active
Ornalin
Ronalin
Vorlan
Formulation and application details
Usually formulated as a wettable powder
ENVIRONMENTAL FATE
Property
Value
Source; quality score; and other information
Interpretation
Solubility - In water at 20 °C (mg l⁻¹)
3.4
G4 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) 4 = Verified data
Low
Solubility - In organic solvents at 20 °C (mg l⁻¹)
281000
C4 C = AGRITOX dataset. Dataset is no longer available. 4 = Verified data
Ethyl acetate
-
551000
C4 C = AGRITOX dataset. Dataset is no longer available. 4 = Verified data
Acetone
-
164000
C4 C = AGRITOX dataset. Dataset is no longer available. 4 = Verified data
Benzene
-
128000
C4 C = AGRITOX dataset. Dataset is no longer available. 4 = Verified data
Xylene
-
Melting point (°C)
108
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
-
Boiling point (°C)
-
-
-
Degradation point (°C)
-
-
-
Flashpoint (°C)
-
-
-
Octanol-water partition coefficient at pH 7, 20 °C
P
1.05 X 1003
Calculated
-
Log P
3.02
K4 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) 4 = Verified data
High
Fat solubility of residues
Solubility
Likely to be soluble
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
-
Data type
Based on chemical group
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
-
Density (g ml⁻¹)
1.51
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
-
Dissociation constant pKa) at 25 °C
-
-
-
-
Vapour pressure at 20 °C (mPa)
0.016
G4 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) 4 = Verified data
Low volatility
Henry's law constant at 25 °C (Pa m³ mol⁻¹)
1.35 X 10-03
H4 H = The US ARS pesticide properties database. Dataset is no longer available. 4 = Verified data
Non-volatile
Volatilisation as max % of applied dose lost
From plant surface
-
-
-
From soil surface
-
-
-
Maximum UV-vis absorption L mol⁻¹ cm⁻¹
-
-
-
Surface tension (mN m⁻¹)
-
-
-
Degradation
Property
Value
Source; quality score; and other information
Interpretation
General biodegradability
-
Soil degradation (days) (aerobic)
DT₅₀ (typical)
12
G4 G = Extension Toxicology network database EXTOXNET. Available online but no longer updated. (click here ) 4 = Verified data
Non-persistent
DT₅₀ (lab at 20 °C)
40.5
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
Moderately persistent
DT₅₀ (field)
20
H4 H = The US ARS pesticide properties database. Dataset is no longer available. 4 = Verified data
Non-persistent
DT₉₀ (lab at 20 °C)
-
-
-
DT₉₀ (field)
-
-
-
DT₅₀ modelling endpoint
-
-
-
Note
Other sources: lab studies DT₅₀ range 28-43 days, field studies DT₅₀ range 34-94 days (R3)
Dissipation rate RL₅₀ (days) on plant matrix
Value
4.1
R4 R = Peer reviewed scientific publications 4 = Verified data
-
Note
Published literature RL₅₀ range 1.5-9.2 days, 3 crops, field & undercover, various matrices, n=6
Dissipation rate RL₅₀ (days) on and in plant matrix
Value
10.6
R4 R = Peer reviewed scientific publications 4 = Verified data
-
Note
Published literature RL₅₀ range 6.6-10.8 days, 3 crops, field & undercover, various matrices, n=4
Aqueous photolysis DT₅₀ (days) at pH 7
Value
27
R4 R = Peer reviewed scientific publications 4 = Verified data
Slow
Note
-
Aqueous hydrolysis DT₅₀ (days) at 20 °C and pH 7
Value
1.3
K3 K = Research datasets (e.g. Pandora, Demetra; these datasets no longer available). Norman Ecotoxicology database. (click here ) 3 = Unverified data of known source
Non-persistent
Note
-
Water-sediment DT₅₀ (days)
15
Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source
Fast
Water phase only DT₅₀ (days)
46
Q2 Q = Miscellaneous data from online sources 2 = Unverified data of unknown source
Stable
Sediment phase only DT₅₀ (days)
-
-
-
Air degradation
As this parameter is not normally measured directly, a surrogate measure is used: ‘Photochemical oxidative DT₅₀’. Where data is available, this can be found in the Fate Indices section below.
Decay in stored produce DT₅₀
[White grape juice: 11 days @ 40 DegC; Lab study]
Soil adsorption and mobility
Property
Value
Source; quality score; and other information
Interpretation
Linear
Kd (mL g⁻¹)
-
R3 R = Peer reviewed scientific publications 3 = Unverified data of known source
Moderately mobile
Koc (mL g⁻¹)
300
Notes and range
Koc range 260-535 mL g⁻¹; Other studies: Koc - 100 (M4)
Freundlich
Kf (mL g⁻¹)
-
-
-
Kfoc (mL g⁻¹)
-
1/n
-
Notes and range
-
pH sensitivity
-
Fate indices
Property
Value
Source; quality score; and other information
Interpretation
GUS leaching potential index
1.98
Calculated
Transition state
SCI-GROW groundwater index (μg l⁻¹) for a 1 kg ha⁻¹ or 1 l ha⁻¹ application rate
Value
6.26 X 10-02
Calculated
-
Note
-
Potential for particle bound transport index
Low
Calculated
-
Potential for loss via drain flow
Moderately mobile
Calculated
-
Photochemical oxidative DT₅₀ (hrs) as indicator of long-range air transport risk
-
-
-
Bio-concentration factor
BCF (l kg⁻¹)
6.5
P4 P = Other non-EU, UK or US Governments and Regulators 4 = Verified data
Low potential
CT₅₀ (days)
Not available
-
Known metabolites
None
ECOTOXICOLOGY
Terrestrial ecotoxicology
Property
Value
Source; quality score; and other information
Interpretation
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 15000
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rat
Low
Mammals - Short term dietary NOEL
(mg kg⁻¹)
2.8
Q3 Q = Miscellaneous data from online sources 3 = Unverified data of known source
F3 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 3 = Unverified data of known source
F2 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 2 = Unverified data of unknown source
F2 F = U.S. EPA ECOTOX database / U.S. EPA pesticide fate database / Miscellaneous WHO documents / FAO data, IPCS INCHEM data (US EPA Databases Related to Pesticide Risk Assessment ) 2 = Unverified data of unknown source
Pseudokirchneriella subcapitata 5 day
Moderate
Algae - Chronic 96 hour NOEC, growth (mg l⁻¹)
-
-
-
Mesocosm study data
NOEAEC mg l⁻¹
-
-
-
NOEAEC mg l⁻¹
-
-
-
Marine bivalves
-
-
-
HUMAN HEALTH AND PROTECTION
General
Property
Value
Source; quality score; and other information
Interpretation
Threshold of Toxicological Concern (Cramer Class)
High (class III)
-
-
Mammals - Acute oral LD₅₀ (mg kg⁻¹)
> 15000
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rat
Low
Mammals - Dermal LD₅₀ (mg kg⁻¹ body weight)
5000
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
Rat
-
Mammals - Inhalation LC₅₀ (mg l⁻¹)
29.1
L3 L = Pesticide manuals and hard copy reference books / other sources 3 = Unverified data of known source
A3 A = Chromosome aberration (EFSA database) 3 = Negative
;
B0 B = DNA damage/repair (EFSA database) 0 = No data
;
C0 C = Gene mutation (EFSA database) 0 = No data
;
D0 D = Genome mutation (EFSA database) 0 = No data
;
E3 E = Unspecified genotoxicity type (miscellaneous data source) 3 = Negative
✓Yes, known to cause a problem
Reproduction / development effects
Acetyl cholinesterase inhibitor
Neurotoxicant
✓Yes, known to cause a problem
XNo, known not to cause a problem
No data found
Respiratory tract irritant
Skin irritant
Skin sensitiser
No data found
✓Yes, known to cause a problem
✓Yes, known to cause a problem
Eye irritant
Phototoxicant
No data found
No data found
General human health issues
Renal and prostate gland toxicant- androgen US EPA - possible human carcinogen; CLP data - suspected carcinogen Endocrine issues - Competitive binding to androgen receptor
Lewis, K.A., Tzilivakis, J., Warner, D. and Green, A. (2016) An international database for pesticide risk assessments and management. Human and Ecological Risk Assessment: An International Journal, 22(4), 1050-1064. DOI: 10.1080/10807039.2015.1133242
Environmental fate
Human health
